Knockdown of Long Noncoding RNA IPCRL1 Mitigates Myocardial Ischemia/Reperfusion Injury via miR-185-3p/JIP3 Axis and JNK Pathway.

Purpose: Myocardial ischemia/reperfusion injury (MIRI) represents a significant culprit leading to adverse consequences after cardiac surgery. This study aims to clarify the function and related pathway of ischemic preconditioning related lncRNA-1 (IPCRL1) in MIRI.

Methods: MIRI model was established in C57BL/6J mice via the myocardial reperfusion method, and hypoxia/reoxygenation (H/R) model was constructed using HL-1 cell.

A Paper-Based Human Kidney Proximal Tubule-on-a-Chip for Efficacy of SGLT2 Inhibitors and Methotrexate-Induced Nephrotoxicity Assessment.

The human kidney proximal tubule is responsible for glucose reabsorption and serves as a primary target for exogenous toxins. While conventional in vitro cell-based models offer cost-effective alternatives to animal testing, they often fail to replicate the structural and functional complexity of the native proximal tubule. Here, we developed a paper-based human kidney proximal tubule-on-a-chip that mimicked key physiological functions, bridging between traditional cell cultures and animal models.

Electroacupuncture stimulation induced M1/M2 polarization in white adipose tissues by activating the Y1 receptor in obese mice to reduce chronic inflammation.

Chronic inflammation in obesity can induce complications such as diabetes and cardiovascular disease. Visceral adipose tissue is the main source of inflammation, but it is difficult to regulate effectively. Here, we investigated whether ES suppressed inflammation in eWAT and reduced chronic inflammation in obese individuals.

Smartphone-assisted portable immunosensor toward on-site detection of tumor necrosis factor-α inhibitor adalimumab for personalized treatment.

A decentralized electrochemical immunosensor was developed using a smartphone and a portable electrochemical workstation. The system employs a gold nanoflower-modified screen-printed carbon electrode (AuNFs/SPCE) for the sensitive measurement of adalimumab (ADL) in human serum via antigen‒antibody recognition. Scanning electron microscopy, X-ray photoelectron spectroscopy, and atomic force microscopy were used to investigate the AuNFs/SPCE.

Lipid Droplet-Derived Biomimetic Nanocarriers for the Enhancement of Porcine Intermuscular Fat Content.

Intramuscular fat (IMF) content is a critical factor influencing the quality and palatability of pork. However, established breeding and nutritional methods lead to systemic fat deposition. The efficient and specific methods to increase IMF content in livestock remain a challenge.

Unravelling lumbar disc herniation severity beyond MRI : integrated transcriptomic and metabolomic analyses highlight glycerophospholipid metabolism and inform a machine-learning diagnostic model: a pilot study.

Aims: While MRI serves as a tool for assessing the severity of lumbar disc herniation (LDH), it has been observed that imaging diagnoses do not always align with clinical symptoms in nearly half of patients. The absence of dependable prognostic biomarkers impedes the early and accurate diagnosis of LDH, which is critical for the development of further treatment approaches. Thus, the aim of this study was to elucidate the molecular mechanisms that determine pain and LDH severity.

Surface Oxygen Vacancy Engineering for Enhanced Volatile Organic Compounds Removal in Solar-Interfacial Water Evaporation.

Solar-interfacial water-vapor conversion has emerged as a promising method for clean water production, particularly in water-scarce regions, but a major challenge is the volatile organic compounds (VOCs) along with water vapor, leading to polluted condensed water. This study introduces a novel design strategy that leverages surface oxygen vacancies (OVs) in photocatalysts to maximize both oxygen (O) utilization from the air and photocarrier efficiency at the air-water interface, building upon previous research that demonstrated that oxygen concentration at the interface can be significantly higher than that in bulk water. By enhancing oxygen adsorption and facilitating charge carrier separation, OVs significantly improve reactive oxygen species (ROS, including ·O and ·OH) generation and overall photocatalytic activity.

Telomere-to-telomere genome assembly of Electrophorus electricus provides insights into the evolution of electric eels.

Background: Electric eels evolved remarkable electric organs that enable them to instantaneously discharge hundreds of volts for predation, defense, and communication. However, the absence of a high-quality reference genome has extremely constrained the studies of electric eels in various aspects.

Results: Using high-depth, multiplatform sequencing data, we successfully assembled the first telomere-to-telomere high-quality reference genome of Electrophorus electricus, which has a genome size of 833.

Clinical diagnosis and treatment experience of 21 case report of isolated sphenoid sinus lesions.

Rationale: With the rapid development of medical science and technology, imaging has become an important part of the diagnosis of diseases, which can provide important information about the morphology and scope of the lesion and its relationship with the surrounding tissues. However, due to the fact that isolated pterygoid sinus lesions often have atypical clinical symptoms, and the location of the lesion is deep and the anatomical structure is complex, its diagnosis still faces one of the important challenges, and the misdiagnosis rate is high. The aim of this study was to explore the clinical symptoms, imaging manifestations, and postoperative pathological features of isolated pterygoid sinus lesions, and to summarize the key points of their diagnosis through systematic retrospective analysis, with a view to providing references for clinicians, reducing the misdiagnosis rate of this disease, and improving the level of diagnosis and treatment.

A smartphone-based portable electrochemical sensor enabled ultrasensitive detection of paclitaxel in serum and injection samples.

A point-of-care testing platform, consisting of smartphone, miniature electrochemical workstation, and screen-printed carbon electrode (SPCE) modified by gold nanoparticle (AuNPs) and multi-walled carbon nanotubes (MWCNTs), is fabricated for the ultrasensitive detection of paclitaxel (PTX) in human serum and injection solution. To enhance conductivity of the sensing system, MWCNTs concentration and AuNPs electrodeposition time were optimized. The AuNPs/MWCNTs effectively increase the working electrode area of SPCE by a factor of 1.

A pathway study of factors influencing anxiety in patients with gestational diabetes mellitus.

Background: This study aims to assess anxiety severity among patients with and to elucidate the predominant psychological factors, informing the development of targeted anxiety management strategies.

Methods: The cross-sectional study recruited 421 GDM patients via convenience sampling from Guangdong Province, China. Self-administered questionnaires, including the Pregnancy-related Anxiety Scale, Simplified Coping Style Questionnaire, Type D Personality Scale, Perceived Social Support Scale, and General Self-Efficacy Scale, were utilized to gather data.

Therapeutic drug monitoring of methotrexate by disposable SPCE biosensor for personalized medicine.

Background: Methotrexate (MTX) is widely used in clinical practice for the treatment of malignant tumors and autoimmune diseases. High-dose MTX has been shown to be an effective approach for treating various malignant tumors, but it is accompanied by numerous toxic side effects, necessitating therapeutic drug monitoring (TDM) for patients and timely "folinic acid rescue." High-performance liquid chromatography and fluorescent immunoassay (FIA) are currently used to detect MTX, but these methods are limited by complex sample preparation, time consumption, and high cost.

An in-depth study of integrating cascaded photocatalytic HO generation and activation with solar-driven interfacial evaporation for in-situ organic contaminant remediation.

Integrating cascaded photocatalytic HO generation and subsequent activation of HO (into ·OH radicals) with solar-driven interfacial evaporation techniques offers an effective and sustainable approach for in-situ treating water contaminated with organic substances. Unlike traditional water-dispersed catalysts, the interfacial evaporation approach presents unique challenges in photocatalytic reactions. We explored these dynamics using an AgI/PPy/MF interfacial photothermal set, achieving HO production efficiency (approximately 1.

Quercetin induces itaconic acid-mediated M1/M2 alveolar macrophages polarization in respiratory syncytial virus infection.

Background: Quercetin has received extensive attention for its therapeutic potential treating respiratory syncytial virus (RSV) infection diseases. Recent studies have highlighted quercetin's ability of suppressing alveolar macrophages (AMs)-derived lung inflammation. However, the anti-inflammatory mechanism of quercetin against RSV infection still remains elusive.

Thyroid function variations within the reference range and cognitive function: A two-sample Mendelian randomization study.

Background: The causal relationship between thyroid function variations within the reference range and cognitive function remains unknown. We aimed to explore this causal relationship using a Mendelian randomization (MR) approach.

Methods: Summary statistics of a thyroid function genome-wide association study (GWAS) were obtained from the ThyroidOmics consortium, including reference range thyroid stimulating hormone (TSH) (N = 54,288) and reference range free thyroxine (FT4) (N = 49,269).

Broadband Green Luminescence and Phase Transition in Low-Dimensional Organic-Inorganic Hybrid Iodate.

Organic-inorganic hybrid iodide systems, which can form highly ordered chromophores and uniformly oriented transition dipole moments, serve as optimal host-guest systems for the fabrication of micrometer-scale optical devices. In particular, those with low-dimensional structures can exhibit strong quantum-limited and highly localized charges, enabling the generation of high exciton energies and stable excitation emission. In this study, we report a novel instance of an organic-inorganic hybrid iodate, (CHN)(IO), which was synthesized by incorporating the optically active organic compound, 9-aminoacridine.

Decoupled oxidation process enabled by atomically dispersed copper electrodes for in-situ chemical water treatment.

In-situ wastewater treatment has gained popularity due to cost and energy savings tailored to water sources and user needs. However, this treatment, particularly through advanced oxidation processes (AOPs), poses ecological risks due to the need for strong oxidizing agents. Here, we present a decoupled oxidation process (DOP) using single-atom copper-modified graphite felt electrodes.

Chromosome-level genome assembly and annotation of eel goby (Odontamblyopus rebecca).

The eel gobies fascinate researchers with many important features, including its unique body structure, benthic lifestyle, and degenerated eyes. However, genome assembly and exploration of the unique genomic composition of the eel gobies are still in their infancy. This has severely limited research progress on gobies.

Effects of altitude on thyroid disorders according to Chinese three-rung, ladder-like topography: national cross-sectional study.

Background: Chinese topography appears a three-rung ladder-like distribution of decreasing elevation from northwest to southeast, which is divided by two sloping edges. Previous studies have reported that prevalence of thyroid diseases differed by altitude, and geographical factors were associated with thyroid disorders. To explore the association between three-rung ladder-like regions and thyroid disorders according to unique Chinese topographic features, we conducted an epidemiological cross-sectional study from 2015-2017 that covered all 31 mainland Chinese provinces.

Electroacupuncture stimulation ameliorates cognitive impairment induced by long-term high-fat diet by regulating microglial BDNF.

Long-term high-fat diet (HFD) in adolescents leads to impaired hippocampal function and increases the risk of cognitive impairment. Studies have shown that HFD activates hippocampal microglia and induces hippocampal inflammation, which is an important factor for cognitive impairment. Electroacupuncture stimulation (ES), a nerve stimulation therapy, is anti-inflammatory.