IGFBP6 orchestrates anti-infective immune collapse in murine sepsis via prohibitin-2-mediated immunosuppression.

The persistent challenge of sepsis-related mortality underscores the necessity for deeper insights, with our multi-center cross-age cohort study identifying insulin-like growth factor binding protein 6 (IGFBP6) as a critical regulator in sepsis diagnosis, prognosis, and mortality risk evaluation. Mechanistically, IGFBP6 engages in IGF-independent binding to prohibitin2 (PHB2) on epithelial cells, driving PHB2 tyrosine phosphorylation during sepsis. This process disrupts STAT1 phosphorylation, nuclear translocation, and its recruitment to the CCL2 promoter, ultimately impairing CCL2 transcription and macrophage chemotaxis.

Oxidative stress and antioxidant biomarker responses in fish exposed to heavy metals: a review.

Heavy metal pollution represents a serious threat to aquatic environments and human health. In aquatic ecosystems, heavy metals can lead to toxicity in fish by inducing oxidative stress, which disrupts the balance between reactive oxygen species and the body's antioxidant defense system. This review summarizes how heavy metal exposure triggers oxidative stress in fish and highlights the role of key antioxidant enzymes.

Activin A exacerbates neonatal necrotizing enterocolitis via ALK4-mediated apoptosis and barrier disruption.

Background: Necrotizing enterocolitis (NEC) is a life-threatening gastrointestinal disorder in neonates, yet the role of Activin A (ACV A) in NEC pathogenesis remains unclear.

Methods: NEC was induced in neonatal mice through hypoxia, hypothermia, LPS, and formula feeding. An in vitro intestinal epithelial injury model was established using LPS-stimulated IEC-6 cells.

Characterization and correlation analysis of oral NET markers and inflammatory factor levels in patients after orthodontic treatment: a pilot study.

Introduction: Changes in oral neutrophil number and function may occur in patients after orthodontic treatment, affecting the oral immune microenvironment. However, the specific mechanisms are unclear. In this study, we describe the changes in the levels of neutrophil extracellular traps (NET) markers and inflammatory factors in the gingival crevicular fluid (GCF) and saliva of patients after orthodontic treatment and further explore the correlation between them.

Soil heavy metals assessment of the Zhoukou riparian zone base of Shaying river basin, China: spatial distribution, source analysis and ecological risk.

The riparian zone serves as an ecological transition area between aquatic and terrestrial environments. Understanding the spatial distribution and origins of heavy metals within this zone is crucial for studying riverine ecosystems. In this research, we assessed the occurrence forms and spatial patterns of heavy metals in the riparian zone of the Shaying River Basin in Zhoukou City.

The injury effect of osteopontin in sepsis-associated lung injury.

Background: Sepsis is a severe condition causing organ failure due to an abnormal immune reaction to infection, characterized by ongoing excessive inflammation and immune system issues. Osteopontin (OPN) is secreted by various cells and plays a crucial role in inflammatory responses and immune regulation. Nonetheless, the precise function of OPN in sepsis remains to be elucidated.

Exploring the impact of fulvic acid and humic acid on heavy metal availability to alfalfa in molybdenum contaminated soil.

Humic substances, such as Fulvic acid (FA) and humic acid (HA), are widely used for the remediation of heavy metal-contaminated soils due to their ability to enhance metal mobility and facilitate plant uptake. In this study, we conducted a pot experiment with alfalfa to investigate the effects of FA and HA amendments on the mobility of molybdenum (Mo) in the soil, its uptake by alfalfa plants, and subsequent changes in the microbial community. The results demonstrated that both FA and HA influence Mo accumulation in the soil and plants.

CCL3 as a novel biomarker in the diagnosis of necrotizing enterocolitis.

Objectives: Neonatal necrotizing enterocolitis (NEC) is a common intestinal disease that threatens the lives of newborns and is characterized by ischemic necrosis of the small intestine and colon. As early diagnosis of NEC improves prognosis, the identification of new or complementary biomarkers is of great importance. In this study, we evaluate the diagnostic value of CCL3 in NEC and compare its effectiveness with other commonly used biomarkers, such as procalcitonin (PCT) and C-reactive protein (CRP).

Influence of in situ biochar capping on microbial dynamics and ammonia nitrogen release in sediment.

To study the influence of in situ biochar (BC) capping technique on the release of ammonia nitrogen (NH-N) from sediments, a field mesocosm experiment was conducted in Baiyangdian Lake (BYDL), a critical water body often referred to as the "kidney of North China" where sediment pollution poses a significant threat to water quality. This study also assessed the impact of BC on sediment microorganisms. The results showed that the NH-N concentration in the overlying water of the BC-treated mesocosms was the lowest among four treatments, decreasing to 0.

FGF8 Protects Against Polymicrobial Sepsis by Enhancing the Host's Anti-infective Immunity.

Background: Sepsis is characterized by a life-threatening syndrome caused by an unbalanced host response to infection. Fibroblast growth factor 8 (FGF8) has been newly identified to play important roles in inflammation and innate immunity, but its role in host response to sepsis is undefined.

Methods: A cecal ligation and puncture (CLP)-induced mouse sepsis model was established to evaluate the immunomodulatory function of FGF8 during sepsis.

Biomechanical effects of functional clear aligners on the stomatognathic system in teens with class II malocclusion: a new model through finite element analysis.

Objectives: The Functional Clear Aligner (FCA) is a novel orthodontic appliance designed for the treatment of Class II malocclusion with mandibular retrognathia in adolescents. The aim of this study was to investigate the biomechanical characteristics of the masticatory muscles, jawbone, and temporomandibular joint (TMJ) during mandibular advancement using either FCA or Class II elastics combined with clear aligner (Class II elastics) through finite element analysis.

Materials And Methods: A 3D finite element model of the 'muscle-jawbone-TMJ-appliance' system was constructed based on CBCT and MRI images of a boy with skeletal Class II malocclusion.

Feasibility and mechanism of adsorption and bioreduction of hexavalent chromium using Rhodopseudomonas palustris immobilized on multiple materials.

Rhodopseudomonas palustris immobilized on multiple materials was used to invistigate Cr(VI) adsorption and bioreduction. The highest Cr(VI) removal (97.5%) was achieved at 276h under the opitimed conditions of 2.

Phytoremediation of molybdenum (Mo)-contaminated soil using plant and humic substance.

The severity of soil molybdenum (Mo) pollution is increasing, and effective management of contaminated soil is essential for the sustainable development of soil. To investigate this, a pot experiment was carried out to assess the impact of different rates of humic acid (HA) and fulvic acid (FA) on the mobility of Mo in soil solution and its uptake by alfalfa, wheat and green bristlegrass. The concentration of Mo in Plants and soil was determined using an Atomic Absorption Spectrophotometer.

Clinical value of prokineticin 2 in the diagnosis of neonatal necrotizing enterocolitis.

Background: Necrotizing enterocolitis (NEC) is an inflammatory and necrotizing intestinal emergency that occurs in preterm infants and low birth weight newborns; however, no specific serum biomarkers for the diagnosis of NEC has been identified so far.

Methods: Serum samples were collected from healthy neonatal controls and patients with NEC newly admitted to the Children's Hospital of Chongqing Medical University. ELISA was used to measure serum PK2 levels, and ROC curve analysis was sued to evaluate the diagnostic efficacy of PK2 and other clinical biomarkers.

Development and external validation of a predictive model for type 2 diabetic retinopathy.

Diabetes retinopathy (DR) is a critical clinical disease with that causes irreversible visual damage in adults, and may even lead to permanent blindness in serious cases. Early identification and treatment of DR is critical. Our aim was to train and externally validate a prediction nomogram for early prediction of DR.

Effect of humic substances on the fraction of heavy metal and microbial response.

Contamination of soils by Molybdenum (Mo) has raised increasing concern worldwide. Both fulvic acid (FA) and humic acid (HA) possess numerous positive properties, such as large specific surface areas and microporous structure that facilitates the immobilization of the heavy metal in soils. Despite these characteristics, there have been few studies on the microbiology effects of FA and HA.

Incidence, severity, and risk factors for white spot lesions in adolescent patients treated with clear aligners.

Objectives: This study was aimed to clarify the incidence, severity, and clinical risk factors for white spot lesions (WSLs) in adolescent patients treated with clear aligners.

Methods: Pre-treatment and post-treatment intraoral photographs of 203 adolescent patients undergoing clear aligner therapy were retrospectively evaluated to assess the occurrence and severity of WSLs. Information on patients' general oral condition and orthodontic treatment was collected from clinical medical documents, retrospective questionnaires, and ClinCheck® software.

A review and analysis of key biomarkers in Alzheimer's disease.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects over 50 million elderly individuals worldwide. Although the pathogenesis of AD is not fully understood, based on current research, researchers are able to identify potential biomarker genes and proteins that may serve as effective targets against AD. This article aims to present a comprehensive overview of recent advances in AD biomarker identification, with highlights on the use of various algorithms, the exploration of relevant biological processes, and the investigation of shared biomarkers with co-occurring diseases.

Carboxylated Hexagonal Boron Nitride/Graphene Configuration for Electrosynthesis of High-Concentration Neutral Hydrogen Peroxide.

The electrosynthesis of hydrogen peroxide (H O ) via two-electron (2e ) oxygen (O ) reduction reaction (ORR) has great potential to replace the traditional energy-intensive anthraquinone process, but the design of low-cost and highly active and selective catalysts is greatly challenging for the long-term H O production under industrial relevant current density, especially under neutral electrolytes. To address this issue, this work constructed a carboxylated hexagonal boron nitride/graphene (h-BN/G) heterojunction on the commercial activated carbon through the coupling of B, N co-doping with surface oxygen groups functionalization. The champion catalyst exhibited a high 2e ORR selectivity (>95 %), production rate (up to 13.

Correlation between salivary cytokine profiles and white spot lesions in adolescent patients receiving clear aligner orthodontic treatment.

Background: To explore the relationship between changes in salivary cytokine levels and the occurrence of white spot lesions in adolescents receiving clear aligner orthodontic treatment and investigate the predictive value of various factors for lesion occurrence.

Methods: We retrospectively analyzed sixthy eight adolescent in the permanent dentition period, who received clear aligner orthodontics in our hospital were randomly divided into two groups according to the occurrence or aggravation of white spot lesions after treatment. The general condition of the oral cavity was analyzed, saliva was collected, and inflammation-related cytokines with varying transcription levels between groups were screened by transcriptome analysis.

Prokineticin 2 as a potential biomarker for the diagnosis of Kawasaki disease.

Kawasaki disease is a pressing acute self-limiting inflammatory disorder disease which lack of specific biomarkers. Our research aims to investigate the serum expression of a novel immune regulator PK2 in children with Kawasaki disease and to evaluate the ability of PK2 to predict Kawasaki disease. A total of 70 children with Kawasaki disease in the Children's Hospital of Chongqing Medical University who were first diagnosed, 20 children with common fever admitted to hospital due to bacterial infection during the same period, and 31 children underwent physical examination were included in this study.

Microbiome and metabolome associated with white spot lesions in patients treated with clear aligners.

White spot lesions (WSLs) have long been a noteworthy complication during orthodontic treatment. Recently, an increasing number of orthodontists have found that adolescents undergoing orthodontic treatment with clear aligners are at a higher risk of developing WSLs. The oral microbiota and metabolites are considered the etiologic and regulatory factors of WSLs, but the specific impact of clear aligners on the oral microbiota and metabolites is unknown.

CCL3 aggravates intestinal damage in NEC by promoting macrophage chemotaxis and M1 macrophage polarization.

Background: NEC is a life-threatening gastrointestinal disease in neonates, the pathogenesis of which remains poorly understood.

Methods: CCL3 levels in intestinal tissue of mice were measured and analyzed. HE staining was used to assess pathological changes in intestinal tissue.

Prediction study of electric energy production in important power production base, China.

Xinjiang is an important power production base in China, and its electric energy production needs not only meet the demand of Xinjiang's electricity consumption, but also make up for the shortage of electricity in at least 19 provinces or cities in China. Therefore, it is of great significance to know ahead of time the electric energy production of Xinjiang in the future. In such terms, accurate electric energy production forecasts are imperative for decision makers to develop an optimal strategy that includes not only risk reduction, but also the betterment of the economy and society as a whole.