A cross-tissue transcriptome-wide association study identifies novel susceptibility genes for atrial fibrillation.

Background: Atrial fibrillation (AF), the most common cardiac arrhythmia, has been linked to numerous loci identified by genome-wide association studies (GWAS). However, the causal genes and underlying mechanisms remain unclear.

Methods: We conducted a cross-tissue transcriptome-wide association studies (TWAS) using the unified test for molecular signatures (UTMOST), integrating genetic data from the FinnGen R11 cohort (287 805 individuals) with gene expression profiles from the genotype-tissue expression (GTEx) project.

Mediational role of metabolic syndrome between physical activity, sedentary behavior and non-alcoholic fatty liver disease: a cross-sectional study.

Background: Physical activity (PA), sedentary behavior (SB), metabolic syndrome (MetS), and non-alcoholic fatty liver disease (NAFLD) have been linked in previous studies. Nevertheless, it is unclear whether MetS has a mediating influence on the relationships among physical activity, sedentary behavior, and non-alcoholic fatty liver disease. This study aims to assess the connections between physical activity, sedentary behavior, and non-alcoholic fatty liver disease and to explore the extent to which metabolic syndrome acts as a mediator in this association.

COVID-19＆depression: New and detailed evidence from NHANES.

This study aimed to investigate the changes in depression prevalence among American adults following the COVID-19 pandemic. A cross-sectional study design was employed. Data were acquired from three cycles of the National Health and Nutrition Examination Survey (NHANES) spanning from 2017 to 2023.

Attributable risk factors and trends in global burden of falls from 1990 to 2021: A comprehensive analysis based on Global Burden Of Disease Study 2021.

Background: Falls are a leading cause of disability-adjusted life years (DALYs) and mobility difficulties. Previous estimates have relied on restricted regional scope and lack a thorough global study. This study, for the first time, examines the evolving trends in the global burden of falls from 1990 to 2021, focusing on geographic variation in disease burden and risk factors, predicting the development of burden of falls.

Heterogeneous Structures Consisting of Rod-like ZnO Interspersed with CeS Nanoparticles for Photo-Sensitive Supercapacitors with Enhanced Capacitive Performance.

Photosensitive supercapacitors incorporate light-sensitive materials on capacitive electrodes, enabling solar energy conversion and storage in one device. In this study, heterogeneous structures of rod-shaped ZnO decorated with CeS nanoparticles on nickel foam (ZnO@CeS/NF) are synthesized using a two-step hydrothermal method as photosensitive supercapacitor electrodes for capacitance enhancement under visible light. The formation of ZnO@CeS heterogeneous structures is confirmed using various structural characterization techniques.

The neutrophil-to-lymphocyte ratio is a potential biomarker for the occurrence of atrial fibrillation in patients with obstructive sleep apnea: A BIOMARKER OF AF IN OSA PATIENTS.

Background: Obstructive sleep apnea (OSA) affects the occurrence of atrial fibrillation (AF) and usually coexists with AF. Chronic inflammation has been identified as an important factor in the development of AF, and the neutrophil-to-lymphocyte ratio (NLR) has been identified as a biomarker that positively correlates with the degree of inflammation. However, little information regarding how NLR correlates with AF in OSA patients.

Porous prussian blue analogs derived nickel-iron bimetallic phosphide nanocubes on conductive hollow mesoporous carbon nanospheres for stable and flexible high-performance supercapacitor electrode.

Nickel-iron bimetallic phosphide (Ni-Fe-P) is the ideal battery-type materials for supercapacitor in virtue of high theoretical specific capacitance. Nevertheless, its actual adhibition is astricted on account of inferior rate capability and cyclic stability. Herein, we constructed hierarchical core-shell nanocomposites with hollow mesoporous carbon nanospheres (HMCS) packaged via prussian blue analogs derived Ni-Fe-P nanocubes (Ni-Fe-P@HMCS), as a positive electrode for hybrid supercapacitor (HSC).

Mediterranean diet lowers all-cause and cardiovascular mortality for patients with metabolic syndrome.

A Mediterranean-style diet (MED) can promote people lengthen the span of life and avoid atherosclerotic cardiovascular disease (ASCVD) in primary prevention. Metabolic syndrome (MetS) can significantly reduce life expectancy and increase the risk of ASCVD. However, few studies have focused on the role of the Mediterranean diet in patients with MetS.

Sleep disorder, Mediterranean diet, and all-cause and cause-specific mortality: a prospective cohort study.

Background: There is a bidirectional effect between sleep disorders and Mediterranean diet (MED), but the joint effect of MED and sleep disorders on mortality is unclear. The aim of this study was to investigate whether there is a synergistic effect of adherence to MED and sleep disorders on all-cause and cause-specific mortality.

Methods: The study included 23,212 individuals in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2014.

Gut microbiota and cardiac arrhythmia.

One of the most prevalent cardiac diseases is cardiac arrhythmia, however the underlying causes are not entirely understood. There is a lot of proof that gut microbiota (GM) and its metabolites have a significant impact on cardiovascular health. In recent decades, intricate impacts of GM on cardiac arrythmia have been identified as prospective approaches for its prevention, development, treatment, and prognosis.

The monocyte-to-high-density lipoprotein ratio is associated with the occurrence of atrial fibrillation among NAFLD patients: A propensity-matched analysis.

Background: Accumulating evidence suggests that patients with nonalcoholic fatty liver disease (NAFLD) have a significantly high risk of incident atrial fibrillation (AF). Systemic inflammation, metabolic disorders and oxidative stress could be the potential mechanisms by which NAFLD drives AF. Monocyte-to- high-density lipoprotein ratio (MHR) has emerged as a novel biomarker of inflammation and oxidative stress that has not been studied in AF with NAFLD patients.

Elevated stress hyperglycemia and the presence of intracranial artery stenosis increase the risk of recurrent stroke.

Background: Stress hyperglycemia has served as a reliable biomarker to predict poor outcomes after ischemic stroke. However, recent studies have reported some contrary conclusions. Different stroke subtypes may respond inconsistently to stress hyperglycemia.

Microbiome Signature of Endophytes in Wheat Seed Response to Wheat Dwarf Bunt Caused by Tilletia controversa Kühn.

Wheat dwarf bunt leads to the replacement of seeds with fungal galls containing millions of teliospores of the pathogen Tilletia controversa Kühn. As one of the most devastating internationally quarantined wheat diseases, wheat dwarf bunt spreads to cause distant outbreaks by seeds containing teliospores. In this study, based on a combination of amplicon sequencing and isolation approaches, we analyzed the seed microbiome signatures of endophytes between resistant and susceptible cultivars after infection with T.

A Cuproptosis-Related lncRNAs Signature Could Accurately Predict Prognosis in Patients with Clear Cell Renal Cell Carcinoma.

Background: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancers. As cuproptosis, a new cell death mechanism proposed recently, differs from all other known mechanisms regulating cell death, we aimed to create prognostic markers using cuproptosis-related long non-coding ribonucleic acids (RNAs; lncRNAs) and elucidate the molecular mechanism.

Methods: Data from transcriptome RNA sequencing of ccRCC samples and the relevant clinical data were downloaded from The Cancer Genome Atlas, and Pearson's correlation analysis was implemented to obtain the cuproptosis-related lncRNAs.

Development of real-time PCR and droplet digital PCR based marker for the detection of inciting common bunt of wheat.

This is the first study reporting droplet digital PCR and quantitative real time PCR for detection of (syn. ), which causes common bunt of wheat and leads to yield losses of 80% in many wheat growing areas worldwide. To establish an accurate, rapid and quantifiable detection method, we tested 100 inter simple sequence repeats (ISSR) primers and obtained a species-specific fragment (515 bp) generated by ISSR 827.

TyG index is positively associated with risk of CHD and coronary atherosclerosis severity among NAFLD patients.

Background: Insulin resistance (IR), endothelial dysfunction, inflammation, glucose and lipid metabolism disorders, and thrombosis are believed involved in coronary heart disease (CHD) and non-alcoholic fatty liver disease (NAFLD). Triglyceride-glucose (TyG) index, a new IR indicator, is correlated with NAFLD occurrence and severity, but its relationship with CHD risk remains unclear. This study investigated the correlation between TyG index and CHD risk among NAFLD patients.

Highly sensitive metal ion sensing by graphene oxide functionalized micro-tapered long-period fiber grating.

An accurate as well as highly sensitive label-free chemical sensing platform for the detection of various metal ions was demonstrated. The chemical sensor was derived from the micro-tapered long-period fiber grating (MLPG) by depositing graphene oxide (GO) by chemical-bonding and optical-tweezer effects. The enhancement in refractive index (RI) sensitivity as well as reusability was obtained by evaluating the deposition thickness in the range of approximately 97.

Ultra-high harmonic mode-locking with a micro-fiber knot resonator and Lyot filter.

We report on ultra-high harmonic mode-locking with a repetition rate of up to ∼1 THz by combining a microfiber knot resonator (MKR) and a Lyot filter. The harmonic mode-locked pulses are tunable by changing the diameter of MKR, which agrees well with the theoretical calculation. Our results indicate that the ultrafast pulse generation mechanism is due to the dissipative four-wave mixing mode-locking technique.

Supervised and weakly supervised deep learning models for COVID-19 CT diagnosis: A systematic review.

Artificial intelligence (AI) and computer vision (CV) methods become reliable to extract features from radiological images, aiding COVID-19 diagnosis ahead of the pathogenic tests and saving critical time for disease management and control. Thus, this review article focuses on cascading numerous deep learning-based COVID-19 computerized tomography (CT) imaging diagnosis research, providing a baseline for future research. Compared to previous review articles on the topic, this study pigeon-holes the collected literature very differently (i.

Transcriptomics Analysis of Wheat Tassel Response to Kühn, Which Causes Common Bunt of Wheat.

Kühn [synonym (Wallr.) Liro] can lead to a wheat common bunt, which is one of the most serious diseases affecting kernels, a serious reduction in grain yield, and losses can reach up to 80% in favorable environments. To understand how wheat tassels respond to , based on an RNA-Seq technology, we analyzed a host transcript accumulation on healthy wheat tassels and on tassels infected by the pathogen.

All-optical TiCT modulator based on a sandwich structure.

All-optical modulators based on a - have recently garnered much attention due to their broadband light-matter interactions and ultrafast carrier dynamics. To investigate the modulation characteristics of pump intensity and pump light modulation frequency, we establish an all-optical modulator with a sandwich structure based on -/ (polyvinyl alcohol) film. The result shows that this modulator can achieve a high modulation depth of 12.

Review and classification of AI-enabled COVID-19 CT imaging models based on computer vision tasks.

This article presents a systematic overview of artificial intelligence (AI) and computer vision strategies for diagnosing the coronavirus disease of 2019 (COVID-19) using computerized tomography (CT) medical images. We analyzed the previous review works and found that all of them ignored classifying and categorizing COVID-19 literature based on computer vision tasks, such as classification, segmentation, and detection. Most of the COVID-19 CT diagnosis methods comprehensively use segmentation and classification tasks.

Characteristics of the Infection of Tilletia laevis Kühn (syn. Tilletia foetida (Wallr.) Liro.) in Compatible Wheat.

Tilletia laevis Kühn (syn. Tilletia foetida (Wallr.) Liro.