SLEEP AND NEURODEGENERATION: EXAMINING POTENTIAL PHYSIOLOGICAL MECHANISMS.

Purpose Of The Review: The purpose of this review is to provide an overview of potential mechanisms mediating the bi-directional relationship between sleep and neurodegenerative diseases such as Alzheimer's disease. We provide updates on previously proposed mechanisms and identify new mechanisms particularly concerning how sleep disturbances affect memory-related neural circuits.

Recent Findings: In this review, we focus on the multiple mechanisms that potentially mediate the relationship between sleep and Alzheimer's disease.

A Promising Prognostic Signature Consisting of Fatty Acid Metabolism Genes based on Machine Learning Predicts Biochemical Recurrence and Aids ARSI Therapy in Prostate Cancer.

Fatty acid metabolism (FAM) is a crucial metabolic characteristic of tumor cells, playing a role in various pathological processes during tumor development. Till now, the prognostic role of FAM-related genes of prostate cancer (PCa) is far from fully investigation. The combinations of 10 machine learning algorithms were applied in this study.

Strategies to rescue mitochondria in Parkinson's disease: The significance of mitochondrial transfer.

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by dopaminergic neuronal degeneration and pathological α-synuclein accumulation. Mitochondrial dysfunction is a central feature in PD pathogenesis, contributing to impaired bioenergetics, oxidative stress, neuroinflammation, and defective organelle communication. This review synthesizes the current understanding of mitochondrial quality control mechanisms, including fission, fusion, mitophagy, and biogenesis, and their disruption in PD.

Facile crystallized-AIE-photosensitizer functionalized hydrogel for antimicrobial photodynamic therapy and wound recovery.

The development of wound dressings with high antibacterial efficacy is critical for the treatment of bacterial infections. Antimicrobial photodynamic therapy (aPDT) is a promising approach, and aggregation-induced emission photosensitizers (AIE-PSs) have garnered significant attention for their enhanced performance in the aggregated state, where the restriction of intramolecular motion serves as the underlying mechanism. However, conventional aggregation often leads to loosely packed PSs, leaving space for intramolecular motion.

FRET-Based TURN-ON Aptasensor for the Sensitive Detection of CK-MB.

A fluorescent sandwich assay was devised to quantify CK-MB. In a typical immunoassay, antibodies bind to the target, and the detected signal is quantified according to the target's concentration. We innovated a unique fluorescence assay known as the "enzyme-linked aptamer assay" (ELAA) by substituting antibodies with a pair of high-affinity aptamers labelled with biotin, namely apt.

Microgravity-Induced Cognitive Decline: Investigating the Pathogenic Mechanisms of RyR2 Hyperphosphorylation and S107 Intervention.

Cognitive function is crucial for astronauts to successfully complete space missions. Therefore, investigating the mechanisms by which one of the primary stressors in the space environment-microgravity-affects cognitive function is of great significance. Although synaptic plasticity is recognized as being highly associated with cognitive function, the mechanisms underlying its changes under microgravity remain unclear.

Highly Specific and Fast-Responsive Semicarbazide-Sensitive Amine Oxidase Nanoprobe for the Serological Diagnosis of Parkinson's Patients.

Semicarbazide-sensitive amine oxidase (SSAO), a multifunctional enzyme associated with various diseases, including neurodegenerative disorders, has emerged as a potential biomarker for Parkinson's disease (PD). However, current SSAO detection methods, such as immunoassays and mass spectrometry, are limited by their complexity, nonselectivity, high cost, and the use of hazardous radioactive materials. In this study, we developed a highly specific, sensitive, and cost-effective method for SSAO activity detection based on optical gold nanoparticles (AuNPs).

Novel insight into the role of Src family kinases in hepatocellular carcinoma and therapeutic potential.

Hepatocellular carcinoma remains a highly aggressive malignancy, with the 5-year survival rate for advanced-stage patients persisting below 20 % despite progress in targeted therapies and immunotherapy. This clinical reality underscores the critical need for identifying novel therapeutic targets. Src family kinases (SFKs), critical regulators of cellular metabolism, coordinate regenerative repair through STAT3/ERK signaling in normal hepatic regeneration and preserve cellular polarity via FAK-mediated mechanisms following hepatic injury.

A tungsten polyoxometalate mediated aqueous redox flow battery with high open-circuit voltage up to 2 V.

As a promising stationary energy storage device, aqueous redox flow battery (ARFB) still faces the challenge of low open-circuit voltage, due to the limitation of the potential of water splitting (1.23 V theoretically). Herein, we present a low potential anolyte design by using Na substituted phosphotungstic acid (3Na-PW) for an aqueous redox flow battery with the high open-circuit voltage up to 2.

Characterization of the Biochemical Recurrence Prediction Ability and Progression Correlation of Peroxiredoxins Family in Prostate Cancer Based on Integrating Single-Cell RNA-Seq and Bulk RNA-Seq Cohorts.

Introduction: The peroxiredoxins (PRDXs) family plays a crucial role in balancing reactive oxygen species (ROS) levels in tumor cells. However, its potential role in prognosis and therapy response of prostate cancer (PCa) remains unknown.

Methods: In this study, we utilized 2 public single-cell RNA datasets and 8 bulk-RNA datasets to investigate the clinical value of six PRDXs family members in PCa.

Mechanical and Covalent Tailoring of Copper Catenanes for Selective Aqueous Nitrate-to-Ammonia Electrocatalysis.

Electrocatalytic nitrate reduction reaction (NORR) for the selective generation of ammonia (NH) enables the removal of deleterious nitrate pollutants while simultaneously upcycling them into a value-added fertilizer. The development of nonprecious metal-derived catalysts such as those featuring copper (Cu) as earth-abundant alternatives for the state-of-the-art precious metal catalysts is of urgent need yet suffering from the activity-selectivity-durability trilemma. Rational design of molecular Cu complexes with well-defined coordination structures permitting systematic structure-activity relationship (SAR) investigations is key to addressing the challenge.

A Copper(I) Catenane Decorated Metal-Organic Layer as a Heterogenous Catalyst for Dehydrogenative Cross-Coupling.

While earth-abundant metals are green and sustainable alternatives to precious metals for catalytic chemical conversions, the fast ligand exchange involving most of the base metals renders their development into robust, reusable catalysts very challenging. Described in this work is a new type of heterogeneous catalyst derived from a 2D metal-organic layer (MOL) grafted with catenane-coordinated Cu(I) complexes. In addition to the good substrate accessibility, easy functionalization, and other favorable features due to the MOL support, the mechanical bond in the anchored catenane ligands also represents a new mechanism to dynamically confine the coordination environment and kinetically stabilize the coordinated Cu(I) to give a well-defined, active yet stable heterogeneous catalyst.

Metformin inhibits the progression of castration-resistant prostate cancer by regulating PDE6D induced purine metabolic alternation and cGMP / PKG pathway activation.

The castration-resistant prostate cancer (CRPC) remains an incurable disease. Metformin has demonstrated a potential therapeutic effect on CRPC. However, the poor clinical performance of metformin against cancer may be due to its clinical dose being much lower than the anticancer concentration used in pre-clinical experiments.

Distinct astrocyte activation patterns associated with neuroinflammation induced by gamma and proton beam irradiation.

The aim of this study was to investigate the impact of radiation exposure on astrocyte response and assess their potential roles and mechanisms in surrounding neural cells. Healthy male rats were irradiated different radiation types to induce the neural inflammation. U87-MG cells were exposed respectively to gamma rays (2 Gy and 10 Gy) and proton irradiation (0.

Exploring Non-Coding RNA Regulation of the Blood-Brain Barrier in Neurodegenerative Diseases: A Systematic Review.

Neurodegenerative diseases (NDs) are characterized by progressive neuronal loss and dysfunction, leading to significant cognitive and motor impairments. The disruption of the blood-brain barrier (BBB) integrity, a key regulator of central nervous system homeostasis, emerges as a critical factor in the pathogenesis of these disorders. Accumulating evidence implicates non-coding RNAs, particularly microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), in BBB regulation.

Nerve block techniques utilized in post-bariatric surgery: a narrative review.

Pain relief following bariatric surgery (BS) can be difficult because many patients have obstructive sleep apnea and are more prone to breathing problems caused by excessive opioid use post-surgery. Using nerve blocks is an effective alternative since they enhance patient comfort and decrease the side effects of opioids. In our review, we comprehensively reviewed present methods to alleviate pain after BS including the transversus abdominis plane block (TAPB), the erector spinae plane block (ESPB), the quadratus lumborum block (QLB), the external oblique intercostal block (EOIB), and the rectus sheath block (RB), aiming to summarized the respective and relative advantages of each nerve block for post-BS analgesia.

Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling.

Heart-on-a-chip (HoC) devices have emerged as a powerful tool for studying the human heart's intricate functions and dysfunctions in vitro. Traditional preclinical models, such as 2D cell cultures model and animal model, have limitations in accurately predicting human response to cardiovascular diseases and treatments. The HoC approach addresses these shortcomings by recapitulating the microscale anatomy, physiology, and biomechanics of the heart, thereby providing a more clinically relevant platform for drug testing, disease modeling, and personalized therapy.

A POCT assay based on commercial HCG strip for miRNA21 detection by integrating with RCA-HCR cascade amplification and CRISPR/Cas12a.

A point-of-care testing (POCT) assay based on commercial HCG strip was proposed for miRNA21 detection by integrating RCA-HCR cascaded isothermal amplification with CRISPR/Cas12a. Three modules were integrated in the proposed platform: target amplification module composed of rolling circle amplification (RCA) cascaded with hybridization chain reaction (HCR), signal transduction module composed of CRISPR/Cas12a combined with HCG-agarose gel beads probes, and signal readout module composed of commercial HCG strips. The proposed RCA-HCR-CRISPR/Cas12a-HCG strip assay for miRNA21 detection had high sensitivity, and the limit of detection was as low as 37 fM.

Growing meat on autoclaved vegetables with biomimetic stiffness and micro-patterns.

Cultured meat needs edible bio-scaffolds that provide not only a growth milieu for muscle and adipose cells, but also biomimetic stiffness and tissue-sculpting topography. Current meat-engineering technologies struggle to achieve scalable cell production, efficient cell differentiation, and tissue maturation in one single culture system. Here we propose an autoclaving strategy to transform common vegetables into muscle- and adipose-engineering scaffolds, without undergoing conventional plant decellularization.

Novel Multimode Assay Based on Asymmetrically Competitive CRISPR and Raman Barcode Spectra for Multiple Hepatocellular Carcinoma Biomarkers Detection.

Commercial pregnancy test strips (PTS) possess the advantages of lower price, higher stability, and better repeatability and have been popularized to integrate with novel sensing strategies to detect other disease biomarkers, which accelerates the commercialization process of those novel sensing strategies. However, the current integration of novel sensing strategies into commercial PTS still faced the problems of insufficient quantification, low sensitivity, and lack of multiple detection capabilities. Hence, we proposed the concept of "visual classification recognition, spectral signal subdivision" for multiple hepatocellular carcinoma biomarkers (miRNA122 and miRNA233) detection with dual signals based on asymmetric competitive CRISPR (acCRISPR) and surface-enhanced Raman spectroscopy coupling with PTS, named the acCRISPR-PTS-SERS assay.

N1-methyladenosine RNA methylation patterns are associated with an increased risk to biochemical recurrence in prostate cancer and serve as a potential novel biomarker for patient stratification.

Introduction: N1-methyladenosine (m1A) RNA methylation is an emerging epigenetic modification. Its potential role in lipid metabolism and prognosis of prostate cancer (PCa) remains unexplored.

Objectives: This study investigated the impact of m1A on lipid metabolism and PCa prognosis.