Water-Driven Oxygen and Nitric Oxide Release from Porphyrin- and Mn-Based Metal-Organic Framework Enables Accelerated Acute Wound Healing.

Medical gases, particularly oxygen and nitric oxide (NO), have attracted significant interest in clinical applications, notably wound healing, due to their role in enhancing cell proliferation, angiogenesis, and collagen deposition. However, the use of these gases has been limited by challenges such as inefficient gas delivery and potential toxicity to normal tissues. In this study, we elucidate a feasible approach using a porphyrin-based metal-organic framework (MOF), a unique material that shows immense potential for dual-gas-assisted wound healing.

Colorectal cancer cells hijack a brain-gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth.

The bidirectional interaction between the brain and peripheral tumors is critical but poorly understood. Here we show GABAergic neurons in the lateral septum, a key brain region implicated in emotional regulation, connect via a polysynaptic circuit to enteric cholinergic neurons that send nerve fibers into the tumor microenvironment, which were then hijacked by colorectal cancer cells to sustain tumor growth in mice. Functionally, activation of this septo-enteric circuit induces GABA release from enteric cholinergic neurons, which in turn activates epsilon-subunit-containing GABA receptors on tumor cells.

Predicting ICU Admission in Patients with Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy.

Introduction: Autoimmune glial fibrillary acidic protein astrocytopathy (A-GFAP-A) is an increasingly recognized neurological disorder with significant clinical management challenges, particularly in predicting the need for intensive care unit (ICU) admission. This study aimed to develop and validate predictive models to identify A-GFAP-A patients at increased risk for ICU admission.

Methods: We retrospectively analyzed 107 patients (January 2021 - August 2024), randomly assigned to training and validation cohorts (7:3).

Astrocytic BDNF Modulates Sensitivity to Stress-Induced Anxiety-Like Behaviors.

Chronic stress exposure is a potent risk factor for anxiety, disrupting adaptive responses and increasing vulnerability. Astrocytes, as essential regulators of synaptic function and neuroimmune homeostasis, are implicated in mood regulation and neuropsychiatric pathogenesis. However, the precise molecular mechanisms of astrocytes involved in stress-induced anxiety remain poorly understood.

Bell-Bloom magnetometer based on square optical path.

We present a single-beam Bell-Bloom magnetometer using a compact, square optical path in a vapor cell with intensity modulation of the light beam. This design achieves dead-zone-free three-axis magnetic field measurements and, additionally, can determine the magnitude and direction of the magnetic field gradient. Experimental results demonstrate the dead-zone-free operation, with sensitivity in each axis scaling with the effective optical path length along that direction.

Hydroxytyrosol induced ferroptosis through Nrf2 signaling pathway in colorectal cancer cells.

In recent years, the incidence of colorectal cancer is still on the rise. The killing of tumor cells through chemotherapy and/or radiation therapy is the mainstay of clinical anticolorectal cancer therapy, but is limited by drug and radiation resistance of tumor cells. Ferroptosis, a novel mode of programmed cell death, plays an important role in antitumor therapy.

Gold and Bismuth Trimetallic Synergistic Redox Catalysis for Non-Directed C─H Arylation with Aryl Bismuth.

The influence of substituent effects plays an important role on the efficiency and regioselectivity toward C─H activation of non-directed arenes. Here, an unprecedented trimetallic synergistic redox catalysis system has been developed to achieve a highly efficient and orthogonal C─H arylation of non-directed arenes with aryl bismuth. Both electron-rich and -deficient aryl bismuth can proceed C─H arylation readily, thus affording an elegant strategy for the synthesis of challenging electron-rich and sterically hindered biaryls by means of gold catalysis.

Clinical Efficacy of Modified and Conventional Aspiration for Breast Abscess: A Comparative Analysis.

Introduction: Breast abscess is common among lactating women with the main contributory factors being galactostasis and bacterial invasion. Traditional incision and drainage surgery for breast abscesses has been progressively replaced by minimally invasive treatment. Our department has contributed to improvements on the traditional approach.

Selection and Validation of Stable Reference Genes for RT-qPCR in (Lepidoptera: Noctuidae).

The clover cutworm, Rottemberg (Lepidoptera: Noctuidae), is a globally distributed polyphagous pest causing significant economic losses to agricultural crops. RT-qPCR is a gold-standard technique for gene expression analysis, yet its accuracy depends critically on stable reference genes for data normalization. To address the lack of validated reference genes in , we evaluated six candidate genes (, , , , , and ) across four developmental stages (egg, larva, pupa, and adult) and six adult tissues (head, thorax, abdomen, wings, legs, and antennae) using geNorm, NormFinder, BestKeeper, and RefFinder algorithms.

A tungsten polyoxometalate mediated aqueous redox flow battery with high open-circuit voltage up to 2 V.

As a promising stationary energy storage device, aqueous redox flow battery (ARFB) still faces the challenge of low open-circuit voltage, due to the limitation of the potential of water splitting (1.23 V theoretically). Herein, we present a low potential anolyte design by using Na substituted phosphotungstic acid (3Na-PW) for an aqueous redox flow battery with the high open-circuit voltage up to 2.

Serine-Grafted CuO Electrode Enabling Specific β-Hydroxybutyrate Detection by Surface Sensitization-Promoted Electrolysis in Amperometry.

As the global prevalence of diabetes continues to rise, the home health testing market has experienced rapid growth. Although blood glucose monitoring is widespread among diabetic patients, there remains a significant lack of testing methods for diabetic ketoacidosis. The present study developed a feasible electrochemical technique for ketoacid detection using serine-immobilized copper(I) oxide nanoparticles (CuO NPs) as the primary electrode material.

Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy.

Cancer remains a global health challenge necessitating innovative therapies. We introduce a strategy to disrupt cancer cell redox balance using gold nanoparticles (Au NPs) as electron sinks combined with electroactive membranes. Utilizing Shewanella oneidensis MR-1 membrane proteins, we develop liposomes enriched with c-type cytochromes.

Utilizing Electron-Sink-Enhanced Nanoshells for Amplified Nanoplasmonic SERS-Based In Situ Detection of Cancer Cells, Linking Signal Enhancement with Cellular Damage.

A novel method is presented for detecting cancer cells and assessing apoptosis using electron-sink-enhanced surface-enhanced Raman scattering (SERS) via active electron transfer. By coating gold (Au) shells with electroactive liposome membranes (ELMs) derived from Shewanella oneidensis MR-1, the SERS signal is enhanced through chemical mechanism (CM) enhancement driven by electron transfer. The ELMs first donate electrons to the Au shells, which, upon laser excitation, amplify the local electromagnetic field, resulting in stronger Raman signals from the attached probing molecules.

IDO1 modulates pain sensitivity and comorbid anxiety in chronic migraine through microglial activation and synaptic pruning.

Background: Chronic migraine is a prevalent and potentially debilitating neurological disorder that is often comorbid with mental health conditions (such as anxiety and depression), but the underlying mechanisms linking these conditions remain poorly understood. Indoleamine 2,3-dioxygenase 1 (IDO1) has been implicated in inflammatory processes, including neuroinflammation and pain. However, its role as a link between neuroinflammation and pain sensitization in chronic migraine is not well defined.

Highly printable, strong, and ductile ordered intermetallic alloy.

Ordered intermetallic alloys are renowned for their impressive mechanical, chemical, and physical properties, making them appealing for various fields. However, practical applications of them have long been severely hindered due to their severe brittleness and poor fabricability. It is difficult to fabricate such materials into components with complex geometries through traditional subtractive manufacturing methods.

Ultra-high electrostriction and ferroelectricity in poly (vinylidene fluoride) by 'printing of charge' throughout the film.

Electrostriction is an important electro-mechanical property in poly (vinylidene fluoride) (PVDF) films, which describes the proportional relation between the electro-stimulated deformation and the square of the electric field. Generally, traditional methods to improve the electrostriction of PVDF either sacrifice other crystalline-related key properties or only influence minimal regions around the surface. Here, we design a unique electret structure to fully exploit the benefits of internal crystal in PVDF films.

Photoinduced Late-Stage Radical Decarboxylative and Deoxygenative Coupling of Complex Carboxylic Acids and Their Derivatives.

The simple and efficient conversion of carboxylic acids into structurally diverse organic molecules is highly desirable in chemical synthesis. This review covers recent developments in photocatalytic methodology for late-stage transformations of complex carboxylic acids and their derivatives enabled by radical decarboxylation and deoxygenation, highlighting some representative and significant contributions in this field. These advancements are categorized based on the reactivity patterns exhibited by the carboxylic acids.

N-butylphthalide (NBP) ameliorated ischemia/reperfusion-induced skeletal muscle injury in male mice via activating Sirt1/Nrf2 signaling pathway.

N-butylphthalide (NBP) has been reported to have potential protective effects in ischemic stroke via its antioxidative properties. The present study was aimed to investigate the protective effects of NBP on ischemia/reperfusion (I/R)-induced skeletal muscle injury. Mouse model of I/R-induced skeletal muscle injury and hypoxia/reoxygenation (H/R)-induced C2C12 myotube injury model were constructed to test the protective effects of NBP both in vivo and in vitro.

Precise Methylation Detection of Tumor Suppressor Gene Promoters by Magnetic Enrichment and Nano Silver Adduct-Promoted Surface-Enhanced Raman Scattering.

Noninvasive liquid biopsies can be used for early tumor diagnosis by identifying the methylation level of the tumor suppressor genes (TSGs)-a reliable index for cancer evaluation. However, identifying trace circulating genes from specimens remains challenging. This work introduces a novel method that combines magnetic isolation and surface-enhanced Raman scattering (SERS) to concentrate and detect the methylated TSG promotors.

Magnetic iron-based waterworks sludge modified by chitosan and FeS for aqueous Cr(vi) adsorption and reduction.

Heavy metals have been considered an evolving environmental concern due to their harmful and long-lasting impacts. We synthesized a composite of FeS/CS@MIBWS for aqueous Cr(vi) adsorption and reduction utilizing the iron-based waterworks sludge modified by chitosan and FeS. After determining the optimal conditions for the FeS/CS@MIBWS preparation, its Cr(vi) removal capability was evaluated using material characterisation and static Cr(vi) adsorption assays.

Frontiers and hotspots in anxiety disorders: A bibliometric analysis from 2004 to 2024.

Objective: This study aimed to analyze research on anxiety disorders using VOSviewer and CiteSpace to identify research hotspots and future directions.

Methods: We conduct ed a comprehensive search on the Web of Science Core Collection (WoSCC) for relevant studies about anxiety disorders published within the past two decades (from 2004 to 2024). VOSviewer and CiteSpace were mainly used to analyze the authors, institutions, countries, publishing journals, reference co-citation patterns, keyword co-occurrence, keyword clustering, and other aspects to construct a knowledge atlas.

Clinical application value of long non-coding RNAs signatures of genomic instability in predicting prognosis of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) presents challenges due to its high recurrence and metastasis rates and poor prognosis. While current clinical diagnostic and prognostic indicators exist, their accuracy remains imperfect due to their biological complexity. Therefore, there is a quest to identify improved biomarkers for HCC diagnosis and prognosis.

Association between the triglyceride glucose-body mass index and future cardiovascular disease risk in a population with Cardiovascular-Kidney-Metabolic syndrome stage 0-3: a nationwide prospective cohort study.

Background: The American Heart Association (AHA) has recently introduced the concept of Cardiovascular-Kidney-Metabolic (CKM) syndrome, which is the result of an increasing emphasis on the interplay of metabolic, renal and cardiovascular diseases (CVD). Furthermore, there is substantial evidence of a correlation between the triglyceride glucose-body mass index (TyG-BMI ) and CVD as an assessment of insulin resistance (IR). However, it remains unknown whether this correlation exists in population with CKM syndrome.