Advancements in hydrogel applications for osteoarthritis therapy.

Osteoarthritis (OA) is a prevalent degenerative joint disorder that significantly impacts patient quality of life. Conventional interventions, including pharmacological and surgical approaches, have demonstrated numerous limitations and are inadequate for cartilage regeneration. Recently, hydrogels, as biomaterials characterized by a distinctive three-dimensional network structure, superior biocompatibility, and adjustable mechanical properties, have shown promising potential in OA therapy.

A label-free fluorescence polarization technology for the detection of food additives.

A novel label-free fluorescence polarization (FP) assay utilizing bovine serum albumin nanoparticles (BSA NPs) in conjunction with manganese dioxide nanosheets (MnO NS) has been developed for the simultaneous detection of glucose, choline and lactate. This method eliminated the need for antibodies, aptamers, or labeled dyes. The BSA NPs exhibit a weak FP signal, while the MnO NS significantly amplificates the FP signal of the BSA NPs.

Irisin Protects Against Diabetic Cardiomyopathy by Suppressing Ferroptosis.

Diabetic cardiomyopathy (DCM) is a major cause of mortality in patients with diabetes, particularly those with type 2 diabetes. Ferroptosis is closely linked to the onset and progression of various cardiovascular diseases. Irisin, a myokine produced by exercising skeletal muscle, has been shown to mitigate DCM.

B, N co-doped graphite carbon confined CoNiFe core-shell nanocatalyst for highly efficient oxygen evolution reaction in alkaline seawater splitting.

Seawater splitting can effectively produce clean hydrogen as well as alleviate the problem of fresh water shortage. Herein, CoNiFe@BCN core-shell nanocatalyst is successfully prepared by a facile pyrolysis method, where the formed B, N co-doped C (BCN) shell not only protects the CoNiFe alloy from dissolving under harsh conditions, but also repels chloride ions. In addition, the synergistic effect between metal alloy and BCN shell helps to improve the catalytic activity due to the confinement effect, so that the CoNiFe@BCN only needs overpotentials of 247 and 306 mV at 10 and 100 mA cm in alkaline medium.

Nano-Scale ZrN Film Modified Zn Anode with Ultra-Long Cycle Life Over 5000 H.

Dendrite growth, corrosion, and hydrogen evolution are major issues for Zn anodes, which seriously hinder the further practical application of aqueous zinc-ion batteries. To address these issues, Zirconium Nitride (ZrN) layer with a thickness of 110 nm is uniformly deposited on the surface of Zn anode using plasma-enhanced atomic layer deposition (PE-ALD). In/ex situ characterizations verify that the as-introduced ZrN layer has excellent anticorrosive and zincophilic ability, which can suppress corrosion and hydrogen evolution, lower the nucleation energy barrier for Zn deposition, and effectively inhibit dendrite growth.

RALYL Overexpression Suppresses Colorectal Cancer via Modulating HNRNPC-Mediated MNK2 Alternative Splicing.

Background: Colorectal cancer (CRC) stands as the second most prevalent cause of cancer-related mortality globally, while its incidence holds the third position among newly diagnosed cancer cases worldwide. Colorectal carcinogenesis is complicated, and the processes are triggered by the complex interaction of some genetic and environmental factors, including DNA methylation. Previous studies showed that RALYL is hypermethylated in CRC.

Vestibular and Ocular Motor Properties in Cerebellar Infarction.

Background: The study aimed to determine the patterns of the vestibular and ocular motor findings in cerebellar infarction (CI).

Methods: We retrospectively analyzed vestibular and ocular motor test results in 23 CI patients and 32 acute unilateral vestibulopathy (AUVP) patients.

Results: Among CI cases, the posterior inferior cerebellar artery (PICA) was the most commonly affected territory.

Lesion Location and Possible Etiology of Acute Unilateral Vestibulopathy.

Objective: Acute unilateral vestibulopathy (AUVP) is quite common in clinical practice, but lesion localization and etiological diagnosis of AUVP remain the current clinical challenges, and have always been the focus for researchers. The study aimed to explore the lesion site and possible etiology of AUVP.

Methods: This study is a retrospective study.

Improving the Quality of Laser Drilling by Assisted Process Methods of Static Solution and Mist Blowing.

The use of static solution-assisted laser drilling can effectively improve hole roundness, decrease taper angle, and reduce recast layer thickness and hole wall slag adhesion. However, the enormous energy of the laser will evaporate the solution to form a suspension droplet and reduce the quality and efficiency of laser drilling. To deal with this defect, the mist-blowing method was used to reduce the influence of droplets on the taper angle and recast layer.

Determination of trace chelating carboxylic acids in rice by green extraction combined with liquid chromatography-mass spectrometry analysis and its application in the evaluation of old and new rice.

Rationale: Accurate identification of old rice samples from new ones benefits their market circulation and consumers. However, the current detection methods are still not satisfactory because of their insufficient accuracy or (and) time-consuming process.

Methods: Chelating carboxylic acids (CCAs) were selectively extracted from rice, by stirring with chelating resin and a dilute NaCO solution.

Role and molecular mechanisms of SGLT2 inhibitors in pathological cardiac remodeling (Review).

Cardiovascular diseases are caused by pathological cardiac remodeling, which involves fibrosis, inflammation and cell dysfunction. This includes autophagy, apoptosis, oxidative stress, mitochondrial dysfunction, changes in energy metabolism, angiogenesis and dysregulation of signaling pathways. These changes in heart structure and/or function ultimately result in heart failure.

and Volatile Oils Liposomes-Loaded Thermosensitive in situ Gel for Allergic Rhinitis Management.

Purpose: The aim of the present study was to fabricate a and volatile oils liposomes-loaded thermosensitive in situ gel (gel/LIP/volatile oil) for effectively treating allergic rhinitis via intranasal administration.

Patients And Methods: Particle size, polymer dispersity index (PDI), entrapment effectiveness, and cumulative drug permeation of the developed liposomes were assessed. Then, a thermoreversible in situ gel was created using the liposomes loaded with volatile oils of and .

Uptake, translocation, and metabolism of organophosphate esters (OPEs) in plants and health perspective for human: A review.

Plant uptake, accumulation, and transformation of organophosphate esters (OPEs) play vital roles in their geochemical cycles and exposure risks. Here we reviewed the recent research advances in OPEs in plants. The mean OPE concentrations based on dry/wet/lipid weight varied in 4.

Comparison of clinical and economic evaluation between selected generic and original febuxostat tablets in Chinese gout patients with hyperuricemia: A real-world multicenter retrospective study.

Generic febuxostat tablets were listed in China's third-round centralized drug procurement program. However, there are no sufficient data available on the use of febuxostat in a real-world setting. This study aimed to compare the efficacy, safety, and cost of selected generic febuxostat with original febuxostat in primary gout and hyperuricemia.

Nano-Drug Delivery Systems Based on Natural Products.

Natural products have proven to have significant curative effects and are increasingly considered as potential candidates for clinical prevention, diagnosis, and treatment. Compared with synthetic drugs, natural products not only have diverse structures but also exhibit a range of biological activities against different disease states and molecular targets, making them attractive for development in the field of medicine. Despite advancements in the use of natural products for clinical purposes, there remain obstacles that hinder their full potential.

Application of the Six-Minute Walk Test in Assessment of the Cardiopulmonary Function of Children With Idiopathic Scoliosis.

Study Design: A retrospective observational study.

Objective: To assess whether the six-minute walk test (6MWT) can predict cardiopulmonary function in children with idiopathic scoliosis (IS) as an alternative to the cardiopulmonary exercise test (CPET).

Summary Of Background Data: Cardiopulmonary functional impairment in the setting of IS is a common health problem.

Effects of Wuzhi Capsule on Whole-Blood Tacrolimus Concentration Levels: A Systematic Review and Meta-Analysis.

Background: Wuzhi Capsule (WZC) is a traditional Chinese medicinal herb widely used to treat drug-induced hepatitis or liver dysfunction and is usually prescribed in China to increase tacrolimus concentration. Several studies with small sample sizes have shown that WZC can increase tacrolimus concentration levels in clinical practice. This study aimed to evaluate the effect of WZC on whole-blood tacrolimus concentration levels and safety.

Inhibition of Pi4kb activity causes malformation of vestibular apparatus in zebrafish by downregulating hey1.

Phosphatidylinositol 4 kinase-β (PI4KB) plays critical roles in human genetic diseases. In zebrafish, Pi4kb is strongly expressed in hair cells (HCs), which are necessary for detecting sound vibrations, head movements, and water motion. However, the role of PI4KB in HC or semicircular canal development is unclear.

Lower circulating irisin levels in type 2 diabetes mellitus patients with chronic complications: A meta-analysis.

Purpose: The aim of this study was to provide evidence of the differences in circulating irisin levels between type 2 diabetes mellitus (T2DM) patients with and without chronic complications.

Methods: We performed a meta-analysis to compare circulating irisin levels between different groups. Literature search was conducted in PubMed, Cochrane Library, Embase, WanFang, and China National Knowledge Infrastructure databases from inception through December 2022.

An exploratory study of drug concentration and inhibitory effect of cetylpyridinium chloride buccal tablets on SARS-CoV-2 infection among 10 Chinese subjects.

Background: It was evidenced that cetylpyridinium-chloride (CPC) mouthwash could inhibit SARS-COV-2 activity and reduce salivary viral load, thus reducing SARS-CoV-2 transmission. However, due to insufficient residence time in the oral cavity, CPC-containing mouthwashes have no prolonged antiviral effect. The duration of action of the CPC buccal tablet is expected to be longer than that of the mouthwash.

Uptake mechanism, translocation, and transformation of organophosphate esters in water hyacinth (Eichhornia crassipes): A hydroponic study.

Owing to their dominant wastewater origin, bioavailability, and toxicity, the occurrence and behavior of organophosphate esters (OPEs) in aquatic systems have attracted considerable attention over the past two decades. Aquatic plants can accumulate and metabolize OPEs in water, thereby playing an important role in their behavior and fate in waterbodies. However, their uptake, translocation and transformation mechanisms in plants remain incompletely characterized.

Thyroid dysfunction induced by immune checkpoint inhibitors and tumor progression during neoadjuvant therapy of non‑small cell lung cancer: A case report and literature review.

Immune checkpoint inhibitors (ICIs) have a demonstrable treatment response in patients with resectable non-small cell lung cancer (NSCLC). However, immune-related adverse events and tumor progression in patients administered ICIs are of great concern. The present case study is of a 59-year-old male with NSCLC (squamous, stage IIIA) who received neoadjuvant immunotherapy combined with chemotherapy before surgery.

Individualized treatment with voriconazole in the Chinese population: Inflammation level as a novel marker for dose optimization.

Aims: The aim of this study was to explore the influence and possible mechanisms of pharmacokinetics-related gene polymorphisms, especially CYP2C19 polymorphisms, and non-genetic factors combined with the inflammatory status on the voriconazole (VRC) metabolism of the Chinese population.

Methods: Clinical studies were performed by collecting more than one VRC trough concentration and C-reactive protein (CRP) level. A total of 265 blood samples were collected from 120 patients.

Selective oxidation of p-phenylenediamine for blood glucose detection enabled by Se-vacancy-rich TiSe@Au nanozyme.

Nanozymes with enzyme-like characteristics have drawn wide interest but the catalytic activity and substrate selectivity of nanozymes still need improvement. Herein, Se-vacancy-rich TiSe@Au nanocomposites are designed and demonstrated as nanozymes. The TiSe@Au nanocomposites show excellent peroxidase-like activity and the chromogenic substrate p-phenylenediamine (PPD) can be selectively oxidized to compounds that exhibit an absorption peak at 413 nm that differs from that of self-oxidation or generally oxidized species, suggesting high catalytic activity and strong substrate selectivity.