Origin, Distribution, and Influential Factors of Organic Acids in Deep and Ultradeep Clastic Reservoirs within the Fukang Sag of the Junggar Basin.

In deep and ultradeep clastic reservoirs, secondary porosity functions as the primary space for hydrocarbon storage, intricately associated with the dissolution processes of water-soluble organic acids (WSOAs). However, conventional theories concerning secondary porosity predominantly emphasize medium-depth or shallow reservoirs, lacking a thorough investigation into how WSOA-driven mechanisms affect deeper strata formations. To bridge this gap, our research involved selecting 36 samples from Mesozoic Permian clastic rock formations situated in western China's Fukang Sag within the Junggar Basin region.

Comparative Study on Flow Characteristics in Deep Marine and Marine-Continental Transitional Shale in the Southeastern Sichuan Basin, China.

Permeability is a significant characteristic of porous media and a crucial parameter for shale gas development. This study focuses on deep marine and marine-continental transitional shale in the southeastern Sichuan area using the gas pulse decay testing method to systematically analyze the gas permeability, stress sensitivity, and gas transport mechanisms of shale under different pressure conditions and directions. The results show that the porosity and gas permeability of the deep marine shale are greater compared to those of the marine-continental transitional shale.

Inhibition of Pi4kb activity causes malformation of vestibular apparatus in zebrafish by downregulating hey1.

Phosphatidylinositol 4 kinase-β (PI4KB) plays critical roles in human genetic diseases. In zebrafish, Pi4kb is strongly expressed in hair cells (HCs), which are necessary for detecting sound vibrations, head movements, and water motion. However, the role of PI4KB in HC or semicircular canal development is unclear.

Inhibition of NA(+)/H(+) Exchanger 1 Attenuates Renal Dysfunction Induced by Advanced Glycation End Products in Rats.

It has been recognized that sodium hydrogen exchanger 1 (NHE1) is involved in the development of diabetic nephropathy. The role of NHE1 in kidney dysfunction induced by advanced glycation end products (AGEs) remains unknown. Renal damage was induced by AGEs via tail vein injections in rats.

Paraoxon attenuates vascular smooth muscle contraction through inhibiting Ca2+ influx in the rabbit thoracic aorta.

We investigated the effect of paraoxon on vascular contractility using organ baths in thoracic aortic rings of rabbits and examined the effect of paraoxon on calcium homeostasis using a whole-cell patch-clamp technique in isolated aortic smooth muscle cells of rabbits. The findings show that administration of paraoxon (30 microM) attenuated thoracic aorta contraction induced by phenylephrine (1 microM) and/or a high K+ environment (80 mM) in both the presence and absence of thoracic aortic endothelium. This inhibitory effect of paraoxon on vasoconstrictor-induced contraction was abolished in the absence of extracellular Ca2+, or in the presence of the Ca2+ channel inhibitor, verapamil.

Involvement of Na+/H+ exchanger 1 in advanced glycation end products-induced proliferation of vascular smooth muscle cell.

In this present study, we examined the role of Na(+)/H(+) exchanger 1 (NHE1) in the cultured rat vascular smooth muscle cell (VSMC) proliferation induced by advanced glycation end products (AGEs). AGEs significantly increased the [(3)H] thymidine incorporation of VSMC. Cariporide, an NHE1 inhibitor, dose-dependently attenuated the AGEs-induced increase in cell DNA synthesis.