Duplicated Genes on Homologous Chromosomes Decipher the Dominant Epistasis of the Fiberless Mutant in Cotton.

Cotton fiber initiation determines the fiber yield, yet the genetic basis underlying lint and fuzz initiation has still not been fully uncovered. Here, map-based cloning was carried out to identify the fiberless mutant genes derived from a cross between acc. WT and a natural fiberless mutant, .

ZBED4: A Prognostic Biomarker and Therapeutic Target in Hepatocellular Carcinoma.

Background: Hepatocellular carcinoma (HCC) is a prevalent lethal cancer that remains challenging to treat. Therefore, investigation of novel targets and therapeutic strategies is essential. The role of ZBED4 in cancer remains unclear.

Neoadjuvant therapy demonstrates both safety and clinical feasibility for renal cell carcinoma patients with tumor thrombus.

Background: While the applications of neoadjuvant therapies on patients diagnosed with renal cell carcinoma (RCC) with tumor thrombus (TT) is growing, the safety of preoperative therapies has yet to be clarified.

Methods: 451 patients diagnosed with RCC with TT undergoing radical nephrectomy and thrombectomy were included. Propensity score-matched cohorts were used to investigate the safety and feasibility of neoadjuvant therapies.

Molecular design of cross-linked single-ion polymer electrolytes enabling robust LiF-rich solid electrolyte interface for stable lithium metal batteries.

Solid polymer electrolytes (SPEs) with high ionic conductivity, high lithium-ion transference number (t), and good mechanical properties are highly desired for solid-state lithium metal batteries. However, developing SPEs with both high ionic conductivity and high t remains a challenge. Herein, a novel network structure single-ion polymer electrolyte (SIPU) with high ionic conductivity (0.

De Novo Design of Specific Heterotrimeric Collagen-Like Peptides via Genetic Algorithm.

Collagen, the most abundant protein by mass in mammals, features a triple-helical structure composed of three intertwined peptide strands. Nonequivalent strands can assemble, forming heterotrimeric structures, which are more prevalent among natural collagens. However, the design and application of heterotrimeric collagen mimetic peptides (CMPs) are constrained by the potential formation of competing compositions and registers, which impede the formation of target assemblies.

Stretchable, Adhesive, Anti-Freezing Hydrogel Electrolytes with Dual-Functional Water Regulation Enabled by Amide Group-Salt-Water Interactions for All-Climate Zinc-Ion Batteries.

Aqueous zinc-ion batteries (AZIBs) are promising candidates for next-generation energy storage due to their intrinsic safety and environmental compatibility. However, parasitic reactions induced by active water molecules in conventional aqueous electrolytes severely degrade electrochemical performance and cycling stability. Herein, a stretchable, adhesive, anti-freezing hydrogel electrolyte with dual-functional water regulation is synthesized via a one-pot radical polymerization strategy, where acetate (Ac) anions and hydrophilic amide (─CONH) groups on polyacrylamide (PAM) chains synergistically regulate water activity.

A special machine for solving NP-complete problems.

A specialized computer named as the Electronic Probe Computer (EPC) has been developed to address large-scale NP-complete problems. The EPC employs a hybrid serial/parallel computational model, structured around four main subsystems: a converting system, an input/output system, and an operating system. The converting system is a software component that transforms the target problem into the graph coloring problem, while the operating system is designed to solve these graph coloring challenges.

Afforestation Surpasses Abandonment in the Recovery of Post-Agricultural Soil Organic Carbon in China as Estimated by Machine Learning Models.

The surface soil organic carbon (SOC) dynamics typically follow a trend of initial loss followed by subsequent accumulation after cropland abandonment. However, the timing of SOC stock increase (referred to as the threshold in this study) remains insufficiently explored in spatial terms. While afforestation incentives are considered an effective nature-based strategy, the benefits of SOC recovery still require further investigation.

Mitochondrial inflexibility ignites tumor immunogenicity in postoperative glioblastoma.

Cellular and molecular heterogeneity contributes to the insufficient immunogenicity of glioblastoma multiforme (GBM), a lethal malignancy characterized by post-resection relapse, ultimately leading to limited immune cell infiltration. Here, we report a strategy to boost tumor immunity by activating the endogenous cGAS-STING signaling pathway through in-situ manipulation of the mitochondrial electron transport chain (ETC), thereby augmenting the immune responsiveness of GBM. Under white light irradiation, the synthetic butterfly-shaped photosensitizer B-TTPy disrupts the mitochondrial ETC by producing excessive reactive oxygen species.

Phosphorylation-assisted cell wall engineering enables ultra-strong, highly ion-conductive bio-membranes for high-power salinity gradient energy harvesting.

Nanofluidic membranes derived from cellulose-based biomaterials have garnered increasing attention for ion transport and regulation due to their modifiable nature, ordered structures, sustainability, and excellent compatibility. However, their practical applications in ionic circuits, energy conversion, and sensing have been limited by insufficient mechanical strength and suboptimal ion transport properties. In this study, we report ultra-strong, highly ion-conductive bio-membranes fabricated through phosphorylation-assisted cell wall engineering.

Disulfidptosis-related genes RPN1 inhibits the progression of hepatocellular carcinoma by regulating cell cycle, may be a new therapeutic targets.

Background: Hepatocellular carcinoma (HCC) is the predominant type of liver cancer with a poor prognosis. Treatment methods include surgery, ablation, liver transplantation, and immunotherapy. Programmed cell death (PCD) plays a significant role in the occurrence and treatment of HCC, and disulfidoptosis, as a novel type of PCD, is associated with tumor prognosis and anti-tumor immunity.

A Bioinspired Gradient Hydrogel Electrolyte Network with Optimized Interfacial Chemistry toward Robust Aqueous Zinc-Ion Batteries.

Hydrogel electrolytes are regarded as a promising option for high-performance aqueous zinc-ion batteries (ZIBs), but they frequently fail to balance the reaction kinetics and Zn deposition stability. Inspired by articular cartilage, here we develop a gradient-networked hydrogel electrolyte comprising poly(vinyl alcohol) (PVA), cellulose nanofiber (CNF), and graphene oxide (GO) for ZIBs. The low-network-density PVA/CNF (PC) hydrogel layer (cathode side) with extensive channels and a higher water content ensures the rapid transport of ions, while the interfacial hydrogel layer in contact with the Zn anode exhibits a high-density PVA/CNF/GO (PCG) network with enriched carboxyl and hydroxyl groups, which facilitates the desolvation of Zn, decreases the activity of water, and homogenizes the Zn flux.

Crop Statistic to Annual Map: Tracking spatiotemporal dynamics of crop-specific areas through machine learning and statistics disaggregating.

Mapping spatiotemporal dynamics of crop-specific areas is of great significance in addressing challenges faced by agricultural systems. But comparable multi-phase crop maps in year series have not yet been developed in most regions of the global. In this study, we developed a framework for updating annual crop-specific area maps at 10 km resolution based on crop statistics disaggregating, multi-source data integrating and machine learning.

Newly established forests dominated global carbon sequestration change induced by land cover conversions.

Land cover conversions (LCC) have substantially reshaped terrestrial carbon dynamics, yet their net impact on carbon sequestration remains uncertain. Here, we use the remote sensing-driven BEPS model and high-resolution HILDA+ data to quantify LCC-induced changes in net ecosystem productivity (NEP) from 1981 to 2019. Despite global forest loss and cropland/urban expansion, LCC led to a net carbon gain of 229 Tg C.

Rapidly making biodegradable and recyclable paper plastic based on microwave radiation driven dynamic carbamate chemistry.

In response to the looming concerns of plastic pollution, replacing plastic with paper is a very promising way, but its realization seems a long way off due to the poor water resistance and unsatisfied mechanical strength of cellulose fibril-based materials. Herein, we develop a versatile functionalizing material consisting of mainly biobased cyclic carbonate-bearing compounds and amine compound, which can enable the rapid transformation (within 2 min under microwave radiation) of the cellulose paper into plastic-like material (named paper plastic) having an unprecedently high tensile strength of ~126 MPa. Through a systematic experimental and theoretical study, the paper plastic's combination of excellent mechanical properties and water/solvent resistance is attributed to the easy formation of carbamate abundant non-isocyanate polyurethane cooperated with the intermolecular bond exchange mechanism between the dynamic carbamate moiety and hydroxyl of the cellulose.

Molecular classification and construction of the risk signature for diffuse large B-cell lymphoma based on vitamin B6 metabolism.

Background And Objectives: Diffuse large B-cell lymphoma (DLBCL), characterized by high heterogeneity, shows significant differences in treatment responses and prognosis among patients. The underlying mechanisms of vitamin B6 metabolism in DLBCL remain unclear. This study aims to explore vitamin B6 metabolism characteristics, identify novel DLBCL molecular subtypes, and establish a predictive signature for prognosis.

Low prognostic nutritional index predicts poor outcome in newly diagnosed angioimmunoblastic T-cell lymphoma.

Background: Angioimmunoblastic T-cell lymphoma (AITL) is a rare subtype of peripheral T-cell lymphoma, characterized by an aggressive disease course and poor prognosis. The prognostic nutritional index (PNI), which reflects nutritional and immune status, has emerged as a potential prognostic factor in various cancers.

Methods: In this multicenter retrospective study, a total of 173 patients with AITL between January 2010 and December 2022 were enrolled from three institutes in China.

The regional impact of exercise on bone density in older adults: a meta-analysis with molecular mechanism insights.

Objective: To systematically evaluate the effects of physical exercise on bone mineral density (BMD) in older adults and to explore the potential underlying mechanisms.

Methods: A meta-analysis was conducted through a systematic search of randomized controlled trials (RCTs) published up to May 14, 2025, in Web of Science, PubMed, and the Cochrane Library. The study adhered to PRISMA 2020 guidelines to ensure rigorous literature screening and methodological transparency.

Machine learning-driven programmed cell death signature for prognosis and drug candidate discovery in diffuse large B-cell lymphoma: Multi-cohort study and experimental validation.

Background: Relapse and drug resistance are major contributor to chemotherapy failure in diffuse large B-cell lymphoma (DLBCL). Programmed cell death (PCD), a key mechanism in tumor progression and resistance, has emerged as a promising biomarker for predicting prognosis and chemotherapy sensitivity in DLBCL.

Materials And Methods: This study integrated 15 PCD patterns and RNA-seq data from 3428 DLBCL patients (eight cohorts).

YAP Upregulation Contributes to Acquired Resistance to BET Inhibitors in Uveal Melanoma.

BET inhibitors have the potential to treat malignant tumors via the epigenetic modification mechanism. Although BET inhibitors show promise as anticancer agents for uveal melanoma (UM), the emergence of acquired resistance significantly limits their clinical efficacy. We developed isogenic OTX015-resistant UM cell models (OMM2.

Association Between Spinal Cord Injury and Cognitive Impairment, and the Mediating Role of Inflammation.

Background: Spinal cord injury (SCI), typically resulting from trauma or cranial surgery, often causes motor and sensory deficits and may also impair brain function, leading to cerebral edema, elevated intracranial pressure, and cognitive decline. Growing evidence implicates systemic inflammation as a key mediator of SCI-related cognitive impairment, yet clinical validation remains limited. This study explores the association between SCI and cognitive dysfunction, with a focus on the mediating role of inflammation.

Chromosome X Open Reading Frame 38 (CXorf38) Is a Tumor Suppressor and Potential Prognostic Biomarker in Lung Adenocarcinoma: The First Characterization.

Previously, we found that an uncharacterized protein CXorf38 is significantly downregulated in human ZIP8-knockout (KO) cells. Given that ZIP8 regulates essential micronutrients linked to diseases including cancer, this study aims to characterize CXorf38 and evaluate its role in lung adenocarcinoma. iTRAQ-based proteomics was previously used to identify the abundance of proteins in ZIP8-KO cells.

Assessing the Video Content Quality of TikTok and Bilibili as Health Information Sources for Systemic Lupus Erythematosus: A Cross-Sectional Study.

Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease, and the quality of health information shared on social media is critical for patient education. The aim of this study was to evaluate the content and quality of SLE-related videos on TikTok and Bilibili platforms.

Methods: We retrieved the first 200 Chinese SLE-related videos sorted by default ranking on TikTok and Bilibili.

New guidelines and definitions for type I photodynamic therapy.

The advent of photochemical technologies has revolutionized biology and medicine, offering groundbreaking innovations in cancer treatment and beyond. Among these, photodynamic therapy (PDT) has emerged as a promising approach to cancer therapy, leveraging cytotoxic reactive oxygen species (ROS) to eliminate cancer cells. While traditional type II PDT relies on high oxygen levels and consumes substantial amounts of oxygen, type I PDT requires less oxygen and holds great potential in addressing the hypoxic microenvironments characteristic of solid tumors.

Probiotic-mediated tumor microenvironment reprogramming with protease-sensitive interleukin-15 and photothermal therapy.

T cell inadequacy or exhaustion often causes the failure of immune checkpoint blockade (ICB)-based immunotherapy. Interleukin-15 (IL-15) has been used to prime the tumor microenvironment (TME) to boost the efficiency of immunotherapy. However, its clinical application is hindered by systemic toxicity and low intratumoral concentrations.