Advanced power structure for enhanced optical performance of AMOLED displays at low luminance levels.

To improve the image quality of active-matrix organic light-emitting diode (AMOLED) displays at low luminance levels, a novel power structure is proposed. Its effectiveness was validated by fabricating a 13-inch AMOLED panel with a tandem OLED and evaluating its optical performance. Compared to the conventional structure, the proposed structure reduced panel luminance deviation by 12% and color deviation by 41%, while also achieving a 41% reduction in hysteresis-induced color shift.

Comprehensive profiling of RNA modification-related genes identifies RNA mG binding protein CBP20 as a therapeutic target for tumor growth inhibition.

RNA modifications add a crucial layer to gene expression regulation, though the roles of many RNA modification-related genes in cancer remain largely unexplored. Here we profile 76 RNA modification-associated genes across nine distinct types of modification (N-methyladenosine, 5-methylcytosine, N,2'-O-dimethyladenosine, 2'-O-dimethyladenosine, N-methylguanosine, pseudouridine, uridylation, 2'-O-methylation, N-acetylcytidine and adenosine-to-inosine editing) in four cancer types-breast, colon, liver and lung-through a comprehensive analysis of The Cancer Genome Atlas data. Our analysis identified three candidate genes with increased expression in cancer tissues, with elevated levels associated with poor survival across multiple cancer types: the 5-methylcytosine methyltransferases NSUN2 and DNMT3B and CBP20, an N-methylguanosine binding protein.

Splenic hamartoma mimicking angiosarcoma: A case report.

Background: Primary splenic lesions are rare and often detected incidentally through imaging, biopsy, or autopsy, typically without distinct clinical symptoms. Although imaging can help differentiate benign from malignant lesions, splenic hamartomas, and angiosarcomas may exhibit overlapping features, making diagnosis challenging. This report presents a case of splenic hamartoma suspected to be an angiosarcoma based on preoperative imaging.

Anti-Neuroinflammation Effect of Standardized Ethanol Extract of Leaves of var. on Aβ-Induced Alzheimer's Disease-like Mouse Model.

var. Kudo, a member of the Lamiaceae family, has been previously reported to reduce neuroinflammation and potentially decrease Aβ plaque accumulation in 5XFAD mice. In this study, we aimed to evaluate the anti-neuroinflammatory potential of a standardized 60% ethanol extract of Perilla leaves (PE), optimized for commercial application.

One-Pot Monomer-Level Fabrication of Anion Exchange Membranes for High-Performance Water Electrolysis.

Anion exchange membrane (AEM) water electrolysis (AEMWE) is considered an economical technology for producing green hydrogen energy. However, conventional AEMs comprising polymer backbones with anisotropically aligned cationic pendant groups exhibit unsatisfactory AEMWE performance and durability, limiting their practical implementation. Herein, a facile method for fabricating a durable high-performance AEM via a one-pot monomer-level Menshutkin (m-Men) reaction in a porous mechanical support is proposed.

Bioinspired Hierarchical Soft Gripper with Hexagonal and Suction Interfaces for Strain-Guided Object Handling.

Bioinspired soft adhesive systems capable of stable and intelligent object manipulation are critical for next-generation robotics. In this study, a soft gripper combining an octopus-inspired suction mechanism with a frog-inspired hexagonal friction pattern was developed to enhance adhesion performance under diverse surface conditions and orientations. The hexagonal pattern, inspired by frog toe pads, contributed to improved stability against tilting and shear forces.

Comprehensive analysis of aberrations in pan-cancer, with a focus on prognostic and therapeutic implications.

Background: is one of the most frequently mutated oncogenes in humans. aberrations play a significant role in various solid tumors, affecting patient prognosis and treatment outcomes.

Objectives: We identified features of genetic alterations in , including single amino acid substitutions and amplifications, based on the results of next-generation sequencing tests in 1667 advanced solid tumor patients.

Optimized Ion-Transport Properties of Diallylammonium-Cyclopolymerized Anion-Exchange Membranes for High-Performance Water Electrolysis.

Anion-exchange membranes (AEMs) are the key components of AEM-based water electrolysis (AEMWE) for green hydrogen production. Unfortunately, many AEMs have unsatisfactory ion conductivity, and the factors governing their ion transport remain unclear. To address these limitations, herein, a new pyrrolidinium-containing diallylammonium-cyclopolymerized (PDT) AEM is proposed.

The Validity and Reliability of the Mini-Mental State Examination-2 for Detecting Vascular Mild Cognitive Impairment and Vascular Dementia in a Korean Population.

Background: This study aimed to evaluate the validity and reliability of the Mini-Mental State Examination, 2nd Edition (MMSE-2), as a cognitive screening tool for patients with vascular mild cognitive impairment (VaMCI) and vascular dementia (VD) in a Korean population. Specifically, we investigated whether the MMSE-2 effectively detects early cognitive changes associated with vascular cognitive impairment (VCI) that might be overlooked by the original Mini-Mental State Examination (MMSE).

Methods: A total of 66 patients with VaMCI, 46 patients with VD, and 75 cognitively healthy older adults participated in this study.

Radiotherapy quality assurance program of ongoing clinical trial using stereotactic ablative radiation therapy for recurrent ovarian cancer (SABR-ROC): a dummy run study of a prospective, randomized, multicenter phase III trial (KGOG 3064/KROG 2204).

Background: Recurrent ovarian cancer is often treated with chemotherapy, but many patients experience multiple recurrences with progressively shorter intervals and poorer prognosis. Repeated chemotherapy reduces patients' quality of life. Stereotactic Ablative Radiation Therapy for Recurrent Ovarian Cancer (SABR-ROC) (KGOG3064/KROG 2204) is an ongoing trial investigating the clinical efficacy of stereotactic ablative radiation therapy (SABR) for recurrent ovarian cancer.

Efficacy, safety, and health-related quality of life in transplant-ineligible newly diagnosed multiple myeloma patients receiving bortezomib maintenance therapy: a study of the Korean Multiple Myeloma Working Party (KMMWP-174 study).

Not available.

Preventive Effect of Eradication on Osteoporosis in Females: A 20-Year Prospective Observational Cohort Study.

Background/aims: The relationship between (HP) eradication and osteoporosis development remains inadequately elucidated. This study aimed to ascertain whether HP eradication therapy confers protective effects against osteoporosis progression.

Methods: Subjects without osteoporosis who underwent esophagogastroduodenoscopy with concurrent HP testing were prospectively recruited between May 2003 and February 2023 at Seoul National University Bundang Hospital.

TSH Cut-Offs and Recurrence Risk in Differentiated Thyroid Carcinomas: A Systematic Review and Meta-Analysis.

Purpose: This meta-analysis aimed to investigate the risk of recurrence in patients with differentiated thyroid cancer (DTC), stratified by the American Thyroid Association (ATA) risk of recurrence, according to variable thyrotropin (TSH) cut-offs (0.1, 0.5, and 2.

Clinicopathological Factors Influencing PD-L1 Expression and The Effect of Immune Checkpoint Inhibitors on Survival Outcomes in Patients with Gastric Cancer Depending on Sex in a Tertiary Hospital in South Korea.

Purpose: Programmed cell death ligand-1 (PD-L1) negatively regulates T-cell activation, and exhibits sex-based differences in expression and immune responses. This study investigated sex-related differences in clinicopathological factors influencing PD-L1 expression and the effect of immune checkpoint inhibitors (ICIs) on survival in gastric cancer (GC) patients in South Korea.

Materials And Methods: We analyzed a prospective cohort of 468 GC patients who underwent PD-L1 immunohistochemistry.

Comparison of Artificial Intelligence-Derived Heart Age with Chronological Age Using Normal Sinus Electrocardiograms in Patients with No Evidence of Cardiac Disease.

: Chronological age (CA) is commonly used in clinical decision-making, yet it may not accurately reflect biological aging. Recent advances in artificial intelligence (AI) allow estimation of electrocardiogram (ECG)-derived heart age, which may serve as a non-invasive biomarker for physiological aging. This study aimed to develop and validate a deep learning model to predict ECG-heart age in individuals with no structural heart disease.

Changes in Patient Marker Coordinates with High-Definition Motion Management System during Frameless Gamma Knife Radiosurgery.

Objective: The Leksell Gamma Knife (LGK) Icon™ facilitates frameless (mask-based) fixation through its high-definition motion management (HDMM) system. However, the HDMM only records the intra-fractional motion values of patient marker without specifying changes along the X, Y, and Z axes. This study investigates the coordinate shifts in patient markers using the HDMM system during frameless gamma knife radiosurgery (GKRS) in patients with meningioma and metastases.

An Automated Assay for Carbapenemase Detection in Enterobacterales: a Real-World Performance.

Background: Carbapenem-resistant Gram-negative organisms pose a significant challenge to global healthcare, making the reliable detection and classification of carbapenemases essential for informed therapy and infection control. The BD Phoenix CPO detect assay offers simultaneous carbapenemase detection and Ambler classification in routine antimicrobial susceptibility testing. Accordingly, this study analyzed real-world data on the BD Phoenix CPO test to evaluate its performance in clinical settings over a period of two years.

ETS1 Orchestrates a Hybrid EMT Program Driving in vivo Metastasis and Immune Evasion.

Transcriptional Intratumoral heterogeneity (ITH) is a hallmark of aggressive cancers, yet how transcriptional ITH programs drive tumor metastasis and immune evasion in upper aerodigestive squamous cell carcinoma (UASCC) remains unclear. Through single-cell RNA sequencing analysis of UASCC cells and patient tumors, we uncovered a hybrid epithelial mesenchymal transition (hEMT) ITH program linked to metastatic dissemination. The transcription factor ETS1 was identified as a master regulator of the hEMT program, directly activating pro-metastatic genes and promoting distant spread in vivo.

miR-423-5p and miR-92a-3p in Alzheimer's disease: relationship with pathology and cognition.

Background: MicroRNAs (miRNAs), small and highly conserved non-coding RNA molecules, have emerged as promising molecular biomarkers due to their regulatory roles in gene expression and stability in blood.

Methods: We used measurements of 64 plasma miRNAs from 145 participants in the Alzheimer's disease Neuroimaging Initiative cohort, including 74 probable AD patients and 71 cognitively normal (CN) older adults. We performed principal component analysis (PCA) with factor rotation for dimension reduction to identify AD-associated principal components (PCs) and their key miRNAs with factor loadings higher than 0.

Standardized Procedures for Blood and Cerebrospinal Fluid Collection and Storage in Neurodegenerative Biomarker Research: A Comprehensive Review.

Blood and cerebrospinal fluid (CSF) biomarkers are essential tools for the rapid diagnosis and monitoring of neurodegenerative diseases like Alzheimer's disease (AD). However, even minor variations in sample collection and storage procedures can significantly impact biomarker measurements, emphasizing the importance of standardized operating procedures. This review discusses the main pre-analytical factors that influence biomarker stability, outlines the best practices for blood and CSF collection and storage, and extensively analyzes recent research findings to ensure optimal reproducibility in biomarker studies.

Voxel-Based Morphometric Analysis of the Mini-Mental State Examination and the Mini-Mental State Examination-2 in Patients With Mild Cognitive Impairment and Alzheimer's Disease in Korea.

Background: This study investigated the association between the Mini-Mental State Examination-2 (MMSE-2) and the Korean version of the Mini-Mental State Examination (K-MMSE) scores with global cortical gray matter volume changes in healthy older adults, patients with mild cognitive impairment (MCI), and Alzheimer's Disease (AD) in Korea. Using voxel-based morphometry analysis of structural magnetic resonance imaging (MRI), we explored how these correlations evolve with the progression of cognitive impairment. Additionally, we identified brain regions linked to the newly added components of MMSE-2, such as story memory and processing speed.

Identification of Simultaneous Occurrence of Amphibian Chytrid Fungi and Ranavirus in South Korea.

Emerging infectious diseases such as chytridiomycosis and ranavirosis, caused by () and ranavirus (RV), respectively, are major contributors to global amphibian declines. Despite their significance, comprehensive data on the spatial epidemiology of these pathogens in South Korea remain limited. This study aimed to assess the nationwide co-occurrence and prevalence of and RV across four anuran species in five administrative regions.