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| http://dx.doi.org/10.3324/haematol.2025.287889 | DOI Listing |
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Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis.
Br J Cancer
September 2025
School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Background: Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results.
Methods: This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer.
Cancer and Post-Therapy Cardiotoxicity Risk in Adolescents, Young Adults, and Adults With Down Syndrome.
Compr Physiol
October 2025
Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.
The median life expectancy of people with Down syndrome has increased substantially over the past several decades, from 4 years in 1970 to 53 years in 2010. Despite the recent improvement in survival, there is little data about the prevalence of age-related diseases, including age-related malignancies, and the impact of standard cancer treatments on cardiovascular health. We retrospectively reviewed medical records for age- and sex-matched patients ≥ 15 years old with and without Down syndrome using the TriNetX platform to identify the prevalence of malignancies and explore cardiovascular outcomes after treatment with anthracyclines.
View Article and Find Full Text PDFReal-World Comparison of Treatment Outcomes for Multiple Myeloma in Elderly Transplant Ineligible Patients Receiving First-Line VRd, Rd and VCd: Results From the Australian and New Zealand Myeloma and Related Diseases Registry.
Clin Lymphoma Myeloma Leuk
August 2025
Middlemore Hospital, Auckland, New Zealand.
Background: Real-world data on treatment outcomes for elderly transplant-ineligible patients with newly diagnosed multiple myeloma are limited. The difference in treatment subsidization in Australia compared with New Zealand enables comparison of bortezomib-cyclophosphamide-dexamethasone (VCd), lenalidomide-bortezomib-dexamethasone (VRd) with Rd maintenance, and continuous Rd.
Methods: Using data from the ANZ Myeloma and Related Diseases Registry, we evaluated 1092 patients over 70 years of age between February 2013 and February 2024.
[Representation of infectious risk in patients with multiple myeloma: A multicentric prospective study aimed at adapting the role of advanced practice nurses].
Bull Cancer
September 2025
Direction des soins, centre hospitalier de Brive, 2, boulevard du Dr-Verlhac, 19100 Brive, France. Electronic address:
Multiple myeloma is a haematologic malignancy of the bone marrow with an increasing incidence, primarily affecting an elderly and frail population. It benefits from innovative treatments that have been shown to extend patient survival. However, 2% of patients die from infections during the first year of treatment, despite the availability of prophylactic treatments.
View Article and Find Full Text PDFClinical Feature and Predictive Model for Transplanted Patients With Functional High-Risk Multiple Myeloma.
Arch Med Res
September 2025
Department of Hematology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China. Electronic address:
Objective: A subset of patients with multiple myeloma (MM) experience early relapse despite the absence of any high-risk features at diagnosis, defined as functional high-risk (FHR) MM with inferior prognosis. This study compared FHR and standard risk (SR) MM cohorts to investigate clinical risk factors and establish a validated prognostic model for early prediction of FHR in patients with MM that were transplanted.
Methods: A retrospective cohort study was conducted to analyze the clinical data of patients with MM.