Clinical Feature and Predictive Model for Transplanted Patients With Functional High-Risk Multiple Myeloma.

Objective: A subset of patients with multiple myeloma (MM) experience early relapse despite the absence of any high-risk features at diagnosis, defined as functional high-risk (FHR) MM with inferior prognosis. This study compared FHR and standard risk (SR) MM cohorts to investigate clinical risk factors and establish a validated prognostic model for early prediction of FHR in patients with MM that were transplanted.

Methods: A retrospective cohort study was conducted to analyze the clinical data of patients with MM.

Risk factors for renal impairment in primary aldosteronism: a retrospective study.

Objective: This study aimed to investigate the risk factors associated with renal impairment among patients diagnosed with primary aldosteronism (PA).

Methods: This study enrolled 147 PA patients who were initially classified into hypokalemic (n=56) and normokalemic (n=91) groups according to serum potassium levels, followed by subgroup stratification using combined adrenal venous sampling (AVS) and computed tomography (CT) diagnostic data. For comparison, 280 patients diagnosed with essential hypertension (EH) served as the control group.

Betamethasone injection at different stages showing different effect on tendon-to-bone healing in a rat rotator cuff tear model.

Background: Corticosteroid injection (CSI) has been used to relieve shoulder pain postoperatively, although its adverse effect on tendon-to-bone healing has been proved. However, whether there is any difference in the adverse effect caused by CSI at different stages on rotator cuff healing is still unknown. This study aimed to evaluate the effect of subacromial betamethasone injection on tendon-to-bone healing at different time points in a rat rotator cuff tear model.

The role of iron competition in the antagonistic action of Metschnikowia pulcherrima against three major pathogenic fungi on postharvest citrus fruit.

This study systematically investigated how Metschnikowia pulcherrima XX04 competes with Penicillium digitatum, Penicillium italicum, and Geotrichum citri-aurantii for iron ions to control these major postharvest citrus pathogens. Exogenous Fe addition significantly reduced the inhibitory activity of the pigment-producing yeast against these pathogens on both agar medium and fruit. Pearson correlation analysis revealed a strong positive relationship between pigment production and antagonistic effectiveness of M.

MASS-4 is more suitable than MASS-3 for prognostic stratification in transplant-eligible patients with newly diagnosed multiple myeloma.

Objectives: Real-world studies have shown that Mayo Additive Staging System (MASS) -3 and MASS-4 are suitable for prognostic stratification in Chinese patients with newly diagnosed multiple myeloma (NDMM), but there is no clear evidence of their utility in transplant-eligible NDMM patients. We aimed to evaluate and compare the prognostic stratification value of MASS-3 and MASS-4 in transplant-eligible patients with NDMM in China.

Patients And Methods: A retrospective analysis of the clinical data of 215 NDMM patients who received 'induction therapy-autologous hematopoietic stem cell transplantation (ASCT)' in our center from 2013 to 2022 was performed.

[Toric-ICL shows better predictability and efficacy than FS-LASIK for myopia correction in patients with moderate to high myopia and astigmatism].

Objectives: To compare the efficacy of toric implantable collamer lens (Toric-ICL) and femtosecond laser-assisted keratomileusis (FS-LASIK) for myopia correction in patients with moderate to high myopia complicated with astigmatism.

Methods: We retrospectively collected data from 64 patients (aged 18-42 years) with moderate to high myopia complicated with astigmatism (128 eyes) undergoing either Toric-ICL (28 patients/56 eyes) or FS-LASIK (36 patients/72 eyes) at our department between January, 2019 and December, 2020. The changes of uncorrected distance visual acuity (UCVA), spherical equivalent (SE), mean astigmatism correction index (CI), corneal endothelial cell density (ECD) and intraocular pressure (IOP) following the procedures were compared between the two groups.

Barriers to Using Mobile App-Based Cognitive Testing in Older Adults with Probable Alzheimer's Disease: A Qualitative Study.

: Smart technologies have the potential to be rapid, sensitive, and cost-effective tools for real-life monitoring of cognitive function among older adults. Identifying barriers to using remote cognitive testing in older adults' daily lives is essential. However, obstacles of utilizing digital cognitive tests in community-dwelling older adults with probable Alzheimer's Disease (AD) remain unclear.

[Chemical constituents of Sophorae Flavescentis Radix and its residue based on UPLC-Q-TOF-MS].

Sophorae Flavescentis Radix is one of the commonly used traditional Chinese medicine in China, and a large amount of pharmaceutical residue generated during its processing and production is discarded as waste, which not only wastes resources but also pollutes the environment. Therefore, elucidating the chemical composition of the residue of Sophorae Flavescentis Radix and the differences between the residue and Sophorae Flavescentis Radix itself is of great significance for the comprehensive utilization of the residue. This study, based on ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS) technology combined with multivariate statistical methods, provides a thorough characterization, identification, and differential analysis of the overall components of Sophorae Flavescentis Radix and its residue.

Transcriptomics of Various Diseases Reveals the Core Role of Immune System Pathways in Retinal Damage Repair and Nerve Regeneration.

Retinal ganglion cells (RGCs) are the only neuronal bridges connecting retinal inputs to the brain's visual processing centers, enabling visual perception. The axon of RGCs forms the optic nerve, which transmits visual information to the visual cortex. Damage to RGCs and their axons results in irreversible visual impairment.

Sustainable development with Artificial Intelligence: Examining the absorptive capacity pathways to green innovation.

Artificial intelligence holds a lot of promise in tackling global societal challenges. However, there is still no consensus on how companies can effectively harness AI to promote green innovation (GI). We develop a moderated mediation model grounded in absorptive capacity theory to fill this research gap.

Genome-wide identification of the SmPHR gene family in Salvia miltiorrhiza and SmPHR7-mediated response to phosphate starvation in Arabidopsis thaliana.

This study reveals the transcripts of S. miltiorrhiza in response to phosphate deficiency, identifies 18 SmPHRs in the genome, and tentatively establishes a role for SmPHR7 in regulating phosphate starvation. Phosphorus is essential for plant growth and development, and phosphate deficiency is a common nutritional stress.

Molecular evolution of dietary shifts in ladybird beetles (Coleoptera: Coccinellidae): from fungivory to carnivory and herbivory.

Background: Dietary shifts are major evolutionary steps that shape ecological niches and biodiversity. The beetle family Coccinellidae, commonly known as ladybirds, first transitioned from a fungivorous to an insectivorous and subsequently a plant diet. However, the molecular basis of this dietary diversification remained unexplored.

Influence of Host Species, Location, and Aphid Prey on Microbial Diversity and Community Dynamics of Aphidophagous Ladybird Beetles in Guangxi, China.

Host species, locations, and diet can significantly impact microbial diversity and community in insects. Several ladybird beetles are known as key predators and potential biological control agents for aphids. However, there is limited understanding of how host species, locations, and aphid prey influence the microbial diversity and community of aphidophagous ladybird beetles in natural environments.

Early Identification of the Non-Transplanted Functional High-Risk Multiple Myeloma: Insights from a Predictive Nomogram.

: Patients with multiple myeloma (MM) who have a suboptimal response to induction therapy or early relapse are classified as functional high-risk (FHR) patients and have been shown to have a dismal prognosis. The aim of this study was to establish a predictive nomogram for patients with non-transplanted FHR MM. : The group comprised 215 patients in our center between 1 January 2006 and 1 March 2024.

Single Axillary Incision Versus Triple Lateral Chest Wall Incisions in Endoscopic Mastectomy for Gynecomastia: A Single-Center Retrospective Analysis with Propensity Score Matching.

Background: Endoscopic mastectomy has gradually become an important surgical modality for the treatment of breast diseases, and is the preferred procedure for gynecomastia. However, endoscopic mastectomy presents challenges such as a steep learning curve, prolonged surgical duration, increased hospitalization costs, and high technical difficulty. This study aimed to evaluate the clinical efficacy and patient satisfaction of endoscopic mastectomy using a single axillary incision versus a triple lateral chest wall incision for gynecomastia.

The characteristics of patients with multiple myeloma surviving over 10 years.

Objective: To explore the characteristics of patients with multiple myeloma (MM) who have achieved long-term survival of over 10 years in the context where novel agents and autologous stem cell transplantation (ASCT) serve as the primary therapeutic modalities.

Methods: A retrospective analysis was conducted on 168 MM patients diagnosed and treated in our institution from January 2004 to January 2014. 44 patients with a survival period exceeding 10 years were categorized into the long-term survival group, while 124 patients with a survival period of less than 10 years were categorized into the non-long-term survival group.

Clinical characteristics and risk factors of infection in initially treated patients with multiple myeloma during the induction period.

Background: Multiple myeloma (MM) is a common hematologic malignancy and immune dysfunction is a hallmark of the disease. It leads to an increased infection risk, which is still a major cause of mortality. The infection spectrum and characteristics have evolved with the introduction of novel agents.

The identification and correction of pseudohypercalcemia.

Background: We found that a subset of patients with monoclonal gammopathy exhibited hypercalcemia without apparent causes or clinical manifestations In a cohort of 289 monoclonal gammopathy patients, 2.4% presented with such atypical hypercalcemia, with one notable case exhibiting normal ionized calcium levels, suggesting the presence of pseudohypercalcemia.

Objective: The aim of this study is to elucidate the factors contributing to pseudohypercalcemia in monoclonal gammopathy and to develop a novel globulin-corrected calcium formula for clinical application.

Bioinformatic analysis constructs an optimal prognostic index for survival-related variables (OPISV) based on whole-genome expression data in Glioblastoma.

Purpose: Using clinical information and transcriptomic sequencing data from glioblastoma (GBM) patients in the TCGA database to perform gene-by-gene analysis that is aligned with individual patient characteristics and develop an optimal prognostic index of survival-related variables (OPISV) through iterative machine learning techniques to predict the prognosis of GBM patients.

Study Design: The TCGA dataset was utilized as the training dataset, while two GEO datasets served as independent validation cohorts. Initially, survival analysis (p < 0.

Clinical presentations, systemic inflammation response and ANDC scores in hospitalized patients with COVID-19.

The association of anosmia/ageusia with a positive severe respiratory syndrome coronavirus 2 (SARS-CoV-2) test is well-established, suggesting these symptoms are reliable indicators of coronavirus disease 2019 (COVID-19) infection. This study investigates the clinical characteristics and systemic inflammatory markers in hospitalized COVID-19 patients in Taiwan, focusing on those with anosmia/ageusia. We conducted a retrospective observational study on 231 hospitalized COVID-19 patients (alpha variant) from April to July 2021.

Effect of Eggs on Development and Transcriptome of the Ladybird Beetle .

The eggs of the Mediterranean flour moth, , are frequently utilized as alternative diets and have demonstrated promising outcomes when consumed by various insects. Nonetheless, the specific reasons for their effectiveness remain unclear. In our study, we assessed the developmental performance of the ladybird when fed eggs, alongside 12 factitious prey or artificial diets.

Comparative analysis of the expression patterns of TM9SF family members in mice.

Transmembrane 9 superfamily proteins (TM9SFs) define a highly conserved protein family, each member of which is characterized by a variable extracellular domain and presumably nine transmembrane domains. Although previous studies have delineated the potential cytological roles of TM9SFs like autophagy and secretory pathway, their functions during development are largely unknown. To establish the basis for dissecting the functions of TM9SFs in vivo, we employed the open-source database, structure prediction, immunofluorescence and Western blot to describe the gene and protein expression patterns of TM9SFs in human and mouse.

The association between blood pressure variability and renal damage in patients with primary aldosteronism.

This research examines the association between blood pressure variability (BPV) and renal damage in a cohort of 129 primary aldosteronism (PA) patients, employing ambulatory blood pressure monitoring (ABPM) for comparative analysis with individuals diagnosed with essential hypertension (EH). The study reveals that PA patients exhibited significantly elevated levels of cystatin C and urine microalbumin/creatinine ratio (UACR). Additionally, a higher prevalence of non-dipping blood pressure patterns in PA patients suggests an increased risk of circadian blood pressure regulation disturbances.