Clinical Feature and Predictive Model for Transplanted Patients With Functional High-Risk Multiple Myeloma.

Objective: A subset of patients with multiple myeloma (MM) experience early relapse despite the absence of any high-risk features at diagnosis, defined as functional high-risk (FHR) MM with inferior prognosis. This study compared FHR and standard risk (SR) MM cohorts to investigate clinical risk factors and establish a validated prognostic model for early prediction of FHR in patients with MM that were transplanted.

Methods: A retrospective cohort study was conducted to analyze the clinical data of patients with MM.

Endometriosis as a risk factor: impact on IVF outcomes and reproductive parameters: a systematic review and meta-analysis.

Background: Endometriosis and body mass index (BMI) are known to influence reproductive outcomes, but their combined impact on in vitro fertilization (IVF) success remains uncertain.

Objective: To evaluate the relationship between BMI and the risk of endometriosis, and to assess how endometriosis-with or without prior surgical treatment-affects IVF outcomes, including oocyte yield, maturity, clinical pregnancy rates, and live birth rates.

Methods: This meta-analysis included 19 studies identified through comprehensive searches of databases including PUBMED, MEDLINE, and EMBASE.

Acid-triggered ultralong hydrogen release from AB-loaded hollow mesoporous silica nanoparticles enhances salt tolerance in sweetpotato.

Soil salinization severely restricts crop growth and productivity worldwide. Hydrogen (H) has demonstrated considerable potential in enhancing plant stress tolerance. However, its agricultural application is limited by the rapid dissipation of H in traditional electrolysis-generated hydrogen-rich water (HRW).

Breaking Electronic Symmetry Via Axial Asymmetric Coordination at Co Site in Dual-Channel Catalyst Boosts High-Performance Li-S Batteries.

Lithium-sulfur (Li-S) batteries face challenges from polysulfide shuttling and sluggish redox kinetics. Single-atom Co-N-C catalysts are promising but require precise coordination modulation to optimize the activity. Herein, an axial Co-O asymmetric configuration integrated into oxygen-doped dual-channel mesoporous carbon (CoN-O@CMK-5) is engineered via a theoretical-guided design.

Research on low-Impact development layouts in old urban residential communities based on multi-objective optimization.

Challenges such as poor drainage systems and limited space for renovation often arise during the sponge city transformation of old urban residential communities. This research focuses on an old residential community in Beijing utilizing the SWMM in combination with the NSGA-II algorithm. A Pareto optimal curve was identified iteratively, with construction costs, runoff reduction effects, and node overload time as the optimization objectives and the maximum area for the low impact development (LID) layout as a constraint.

A review on the insights into redox-based regeneration strategies for LiFePO batteries.

In recent years, the market share of lithium iron phosphate (LiFePO: LFP) batteries within the power battery sector has witnessed substantial growth. In light of low-carbon initiatives and environmental sustainability, the recycling of spent LiFePO (SLFP) batteries, especially their regeneration, is of paramount importance for environmental protection, resource conservation, and enhancement of economic efficiency. Current literature reviews predominantly concentrate on synthesizing existing research from the perspective of regeneration methodologies.

Early Identification of the Non-Transplanted Functional High-Risk Multiple Myeloma: Insights from a Predictive Nomogram.

: Patients with multiple myeloma (MM) who have a suboptimal response to induction therapy or early relapse are classified as functional high-risk (FHR) patients and have been shown to have a dismal prognosis. The aim of this study was to establish a predictive nomogram for patients with non-transplanted FHR MM. : The group comprised 215 patients in our center between 1 January 2006 and 1 March 2024.

Supported Mindfulness-Based Self-Help Intervention as an Adjunctive Treatment for Rapid Symptom Change in Emotional Disorders: A Practice-Oriented Multicenter Randomized Controlled Trial.

Introduction: Rapid symptom relief is crucial for individuals with emotional disorders. The current study aimed to determine whether facilitator-supported mindfulness-based self-help (MBSH) intervention as an adjunctive treatment could provide rapid improvement for individuals with emotional disorders.

Methods: A practice-oriented randomized controlled trial was conducted on a sample of 302 patients with emotional disorders from four centers.

Establishing age-group specific reference intervals of human salivary proteome and its preliminary application for epilepsy diagnosis.

Salivary proteins serve multifaceted roles in maintaining oral health and hold significant potential for diagnosing and monitoring diseases due to the non-invasive nature of saliva sampling. However, the clinical utility of current saliva biomarker studies is limited by the lack of reference intervals (RIs) to correctly interpret the testing result. Here, we developed a rapid and robust saliva proteome profiling workflow, obtaining coverage of >1,200 proteins from a 50-µL unstimulated salivary flow with 30 min gradients.

Multivalent Weak Protections Ultimately Enable Customizable DNA Grafting on Pristine Ag Colloids for Nanoplasmonics.

Silver nanoparticles (AgNPs) have superior plasmonic properties surpassing other metals. However, a long-standing difficulty in valence/density-tunable DNA grafting of AgNPs disfavors their use in DNA-directed nanoplasmonics. Herein a close-to-ideal surface protection of pristine AgNPs against various notorious stability issues of Ag is achieved based on multidentate weak nucleobase bindings of non-programming FSDNA (fish sperm DNA).

identification of bioactive components of for adjusting mitochondria against metabolic dysfunction-associated fatty liver disease.

Currently, no specific treatment exists to alleviate metabolic dysfunction-associated fatty liver (MAFLD). Previously, (PC) effectively relieved MAFLD, but its bioactive components are still unknown. The bioactive substances in PC that regulate mitochondria function to alleviate MAFLD were thus determined.

Changes of coagulation function and platelet parameters in preeclampsia and their correlation with pregnancy outcomes.

Preeclampsia (PE) is a severe pregnancy complication characterized by significant alterations in coagulation function. This study aims to analyze the correlation between coagulation function, platelet parameters, and pregnancy outcomes in PE patients. Clinical data, along with blood and urine samples, were collected from 168 PE patients and 128 healthy pregnant women.

Recognition on pharmacodynamic ingredients of natural products.

Natural products (NPs) play an irreplaceable role in the intervention of various diseases and have been considered a critical source of drug development. Many new pharmacodynamic compounds with potential clinical applications have recently been derived from NPs. These compounds range from small molecules to polysaccharides, polypeptides, proteins, self-assembled nanoparticles, and extracellular vesicles.

Causal associations of birth body size and adult body size with systemic lupus erythematosus: a bidirectional mendelian randomization study.

Objective: Body size is associated with the onset of systemic lupus erythematosus (SLE). However, the evidence for this association is inconclusive. In this study, we aimed to investigate the causal relationship between body size and SLE.

Niobium Boride/Graphene Directing High-Performance Lithium-Sulfur Batteries Derived from Favorable Surface Passivation.

Efficient catalysts are needed to accelerate the conversion and suppress the shuttling of polysulfides (LiPSs) to promote the further development of lithium-sulfur (Li-S) batteries. Intermetallic niobium boride (NbB) has indefinite potential due to superior catalytic activity. Nonetheless, the lack of a rational understanding of catalysis creates a challenge for the design of catalysts.

Distress tolerance as a mediator of mindfulness-based intervention for anxiety and depression: Evidence from two randomized controlled trials.

Objective: We aimed to investigate whether distress tolerance mediated the effects of mindfulness-based intervention (MBI) on anxiety and depression with two randomized controlled studies.

Method: In Study 1, 374 participants with at least moderate emotional distress were randomized to an intervention group ( = 174) and a waitlist control group ( = 173). Mindfulness, distress tolerance, anxiety, and depression were measured at the pre-test, week 3, week 5, and post-test.

Prolonged infusion time of cyclophosphamide plus granulocyte colony-stimulating factor (G-CSF) as a mobilization regimen may improve mobilization efficiency in newly diagnosed multiple myeloma patients: a single center experience.

Objectives: This study aimed to clarify the effectiveness and safety of two different infusion durations of cyclophosphamide (CTX) plus granulocyte colony-stimulating factor (G-CSF) for peripheral blood stem cell mobilization in patients with newly diagnosed multiple myeloma (NDMM).

Methods: One hundred and fifty-six consecutive NDMM patients receiving CTX plus G-CSF mobilization and autologous stem cell transplantation during the period of September 2008 to May 2020 were selected for retrospective analysis. According to differences in prolonged infusion time of CTX, they were divided into a 24-h group (24-h continuous infusion) and a control group (4-6 h of infusion).

TiO-coated MoP/phosphorus doped carbon nanorods for ultralong-life sodium ion batteries with high capacity.

How to green synthesize and construct MoP anode electrode materials with advanced structures for sodium-ion batteries still faces great challenges. Herein, a TiO-coated MoP/phosphorus doped carbon (MoP@TiO/P-C) nanorod with a new structure is constructed using TiO-coated Mo-MOF as the precursor through an topological conversion technique. In the synthesis process, the traditional highly toxic PH phosphorus is avoided.

The role of experiential avoidance in the early stages of an online mindfulness-based intervention: Two mediation studies.

There is evidence to suggest that only 2-4 weeks of mindfulness-based interventions (MBIs) can already alleviate emotional stress. The current studies sought to examine whether experiential avoidance mediated the effects of MBIs on emotional distress during an early stage of the intervention. Chinese participants with high emotional distress were recruited.