Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Blood and cerebrospinal fluid (CSF) biomarkers are essential tools for the rapid diagnosis and monitoring of neurodegenerative diseases like Alzheimer's disease (AD). However, even minor variations in sample collection and storage procedures can significantly impact biomarker measurements, emphasizing the importance of standardized operating procedures. This review discusses the main pre-analytical factors that influence biomarker stability, outlines the best practices for blood and CSF collection and storage, and extensively analyzes recent research findings to ensure optimal reproducibility in biomarker studies. It also discusses the future directions and recommendations for enhancing biomarker research methodologies, including advancements in automated processing and quality control measures.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310336 | PMC |
| http://dx.doi.org/10.12779/dnd.2025.24.3.162 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Drought and liming impacts of mine-impacted wetland sediments.
Ecotoxicol Environ Saf
September 2025
CanmetMINING, Natural Resources Canada, Ottawa, ON, Canada. Electronic address:
Acid mine drainage (AMD) is a serious environmental problem at legacy and active mine sites around the world. Climate associated drought and rewetting events can increase the severity of AMD impacts through oxidation and release of stored metal(loid)s and acidity from contaminated sediments. The area surrounding Sudbury, Ontario, with its massive mining and smelting complexes, appears especially vulnerable to drought-driven effects.
View Article and Find Full Text PDFThe role of ammonia in virus inactivation: A systematic and meta-analysis review.
Water Res
September 2025
Department of Civil and Architecture, School of Engineering, Tohoku University, Aoba 6-6-06, Aramaki, Aoba-ku, Sendai, Miyagi 980-8579, Japan. Electronic address:
Ammonia (NH), a naturally occurring disinfectant in wastewater, plays an important role in inactivating pathogens, including viruses. Despite its importance in non-sewered sanitation systems, the inactivation rate constant attributed solely to ammonia ( [Formula: see text] ) remains unclear, owing to the diverse range of disinfection conditions in existing studies. Determining [Formula: see text] is critical for quantifying the contribution of ammonia to viral inactivation and distinguishing it from other environmental factors.
View Article and Find Full Text PDFStability testing of HPCs and MNCs from apheresis products.
Immunobiology
August 2025
Center for Cellular Engineering, Department of Transfusion Medicine and Center for Cellular Engineering, NIH Clinical Center, Bethesda, MD 20892, USA. Electronic address:
Background: Hematopoietic progenitor cells (HPCs) and mononuclear cells (MNCs) are critical components of cell-based therapies, including bone marrow transplantation and regenerative treatments. Evaluation of the characteristics of these products during collection, storage, and transport is essential for maintaining cell viability and functionality. In this study, we evaluated the functional and molecular stability of samples collected for the evaluation of fresh HPC and MNC products.
View Article and Find Full Text PDFRemote Blood Collection for Telomere Length Measurement: Assessing the Impact of Sample Characteristics and Handling on DNA Quality and Assay Outcomes.
Am J Hum Biol
September 2025
University of California, San Francisco, San Francisco, California, USA.
Background: Telomere length (TL) is a valuable marker of aging and stress that reflects both genetic and environmental influences. Quantitative PCR (qPCR) TL measurement is a powerful and cost-effective assay, especially in population studies with limited quantities of source material. Nevertheless, collecting and transporting high-quality blood samples can be logistically challenging, and research suggests that several preanalytical and analytical factors can influence the reliability and precision of the qPCR assay.
View Article and Find Full Text PDFDesign and establishment of a biofilter for treatment of manure methane emissions.
Waste Manag
September 2025
Technical University of Denmark, Department of Environment and Resource Engineering, Bygningstorvet, Building 115, 2800 Kongens Lyngby, Denmark. Electronic address:
During the storage of livestock manure in tanks, anaerobic degradation of organic material results in the production and emission of CH. This study tested a biofilter designed for CH oxidation as a potential technology for mitigating CH emissions from covered manure storage tanks. A full-scale biofilter (400 m) was built next to a pig manure tank (4.
View Article and Find Full Text PDF