Hybrid pneumatic-hydraulic actuation for MRI-guided robotic stereotactic neurointervention.

Stereotactic neurointervention is a common procedure for biopsy, injection, ablation, and implantation of electrodes for deep brain stimulation. Guided by preoperative imaging, conventional approaches are mostly performed manually, lacking operation stability and interactive feedback. The intraoperative magnetic resonance imaging (MRI) guidance enables both structural and functional assessment during operation, permitting interactive adaptation to tissue deformation and avoidance of critical anatomical regions.

CRISPR/Cas9-Engineered Triple-Fusion Reporter Gene Imaging System for Monitoring Transplanted Neural Progenitor Cells in Ischemic Stroke.

Background Neural progenitor cell therapy holds great potential for repairing brain damage induced by ischemic stroke, and molecular imaging plays a crucial role in evaluating the therapeutic efficacy of neural progenitor cell transplantation. However, the presence of the blood-brain barrier significantly limits the effectiveness of such imaging methods. Purpose To enable long-term monitoring of transplanted human neural progenitor cells (hNPCs) in a rat model of ischemic stroke by combining a clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease 9 (CRISPR/Cas9)-engineered triple-fusion (TF) reporter gene system with a noninvasive adenosine agonistic micelle (AM)-based probe delivery strategy.

Design and mechanical evaluation of a novel dynamic growth rod to improve the surgical treatment of early-onset scoliosis.

Aims: Growth rods are the gold standard for treating early-onset scoliosis (EOS), but current treatments often fail to optimally promote spinal growth and require frequent distraction surgeries, leading to complications and significant burdens on patients.

Methods: We designed a novel growth rod (NGR) with unidirectional sliding and external regulation capabilities. Using a 3D model, we simulated the implantation of traditional growth rod (TGR) and NGR, applying a 400 N compressive load and a 1 Nm moment to test stiffness.

Comparable perioperative performance between three robotic system for robot-assisted partial nephrectomy to treat early renal cancer.

This study aimed to compare the safety and efficacy of robot-assisted partial nephrectomy with the two Chinese Robotic systems versus the da Vinci Xi Surgical System. This prospective analytical study included 170 patients who underwent robotic-assisted partial nephrectomy between February 2023 to June 2024. The study included 85 patients who received treatment using two Chinese robotic systems (KangDuo SR 2000: KD-SR-2, EDGE MP1000) and 85 who underwent the da Vinci (DV) surgical system during the same period.

Circadian Disruption Induces Cognitive Impairment Through Tryptophan-5-HT Metabolic Pathway Dysregulation.

Circadian disruption is a common phenomenon that can cause various physiological and psychological problems, including cognitive impairment. The tryptophan-5-HT pathway, a crucial neurotransmitter system, plays a vital role in regulating circadian rhythms and cognitive functions. However, whether it mediates the cognitive impairment induced by circadian disruption remains unclear.

Estimating CO2 emissions due to present and future suborbital space tourism industry.

Estimating and predicting CO2 emissions are the keys to achieving the overall greenhouse gas emission goals for 2030 and 2050. Recent surges in space tourism have generated significant interest and concern. However, the associated CO2 emission and potential future increase remain largely uncertain due to limited publicly available information from the industry.

Perioperative Outcomes of Robot-Assisted Partial Nephrectomy with MP1000 Surgical System da Vinci Xi Surgical System and Evaluation of the MP1000 Learning Curve.

To compare the perioperative outcomes between the MP1000 and da Vinci Xi surgical systems in robot-assisted partial nephrectomy (RAPN) and examine the MP1000 learning curve. In this prospective single-center study, 90 patients undergoing RAPN were equally allocated to the MP1000 ( = 45) or da Vinci Xi ( = 45) groups. Perioperative outcomes were analyzed, and the learning curve was assessed for MP1000 group operative times.

CircEGLN1 alleviates calcium oxalate-induced renal injury via miR-212-5p/STARD7 axis, offering a potential strategy for kidney stone prevention.

Renal tubular injury driven by calcium oxalate (CaOx)-induced oxidative stress constitutes a major contributor to kidney stone formation, while the regulatory role of circRNAs in this process remains poorly characterized. Through high-throughput circRNA sequencing using a calcium oxalate monohydrate (COM)-induced HK-2 cell model, we identified the evolutionarily conserved circEGLN1 as a critical protective factor against oxidative damage. Functional assays in a CaOx nephrolithiasis mouse model and in COM-treated cells, including rescue experiments, demonstrated that circEGLN1 reduces oxidative injury by sequestering miR-212-5p, thereby upregulating STARD7 and mitigating oxidative stress.

A DeepSeek-powered locally deployed closed-loop system for enhancing quality control in electronic nursing documentation: development and clinical validation.

Objectives: To develop a locally deployed DeepSeek-powered closed-loop system for electronic nursing documentation quality control (QC) and evaluate its clinical efficacy through a multidimensional validation framework.

Materials And Methods: We implemented a three-dimensional (3D) QC framework (real-time, final, and vertical QC). A retrospective analysis of 556 electronic nursing records was conducted to evaluate pre- and postimplementation outcomes, with documentation accuracy and audit efficiency assessed via blinded nurse evaluations.

Prognostic biomarkers in treatment-naïve central retinal vein occlusion with macular edema.

Significance Of This Study: Reduced pulse pressure (PP) reflects impaired systemic perfusion and may exacerbate retinal ischemia in central retinal vein occlusion-induced macular edema (CRVO-ME) by compromising ocular blood flow autoregulation. This hemodynamic dysfunction is hypothesized to worsen clinical outcomes and neovascular risks.

Purposes: To investigate the associations between potential prognostic biomarkers and clinical outcomes in treatment-naïve CRVO-ME and assess their predictive utilities.

An elusive causal link between epilepsy and vitamin D in children: More questions than answers? A narrative review.

When discussing childhood epilepsy and children's serum vitamin D status together, the matter becomes complex and intriguing. A long-standing question has been whether there is a causal link between epilepsy itself and the serum vitamin D status: does vitamin D deficiency lead to seizures, or do seizures occur alongside or result in vitamin D deficiency, or is the deficiency caused by anti-seizure medication therapy? Clarifying these questions would significantly enhance our understanding of the relationship between them and improve the treatment and management for childhood epilepsy. This narrative review summarized existing literature on vitamin D and pediatric epilepsy and collected those clinical and non-clinical researches in this field to see if sufficient evidence has accumulated to address these questions.

Visible Light-Activatable Organoboron Complexes Featuring Salicylaldehyde Azine Ligands for Rapid Cationic Polymerization and Mechanism Studies.

Rapid polymerization controlled by visible light holds great potential for advancing 3D printing technologies. However, a significant challenge limiting the implementation of visible-light-activated polymerizations is its low efficiency compared to UV light driven processes. To address this, we developed a series of visible-light-activatable organoboron (BOSHY) complexes featuring salicylaldehyde azine ligands for rapid cationic polymerization.

Efficacy of 6. 3Fr disposable digital flexible ureteroscope versus 7. 5Fr disposable digital flexible ureteroscope in the treatment of upper urinary tract stones < 1. 5 cm: a randomized controlled trial.

Objective: To compare the curative effect of 6. 3Fr disposable digital flexible ureteroscope and 7. 5Fr disposable digital flexible ureteroscope in the treatment of upper urinary tract stones < 1.

Digital study and correlation analysis of sagittal balance parameters in adolescents with idiopathic scoliosis: A comparative study with healthy adolescents.

Purpose: This study aimed to compare sagittal spinal parameters between healthy adolescents and those with adolescent idiopathic scoliosis (AIS), identify factors influencing disease progression, and provide insights for optimizing preoperative assessments.

Methods: Sagittal full-spine radiographs from 40 healthy adolescents and 41 AIS patients (aged 10-18 years) were analyzed using Mimics 21.0 software.

EVI5 Drives Lung Adenocarcinoma Progression through Modulation of the ERK1/2-c-Myc Signaling Axis.

Introduction: Lung adenocarcinoma (LUAD) remains a lethal disease worldwide with a poor prognosis. The ecotropic viral integration site 5 (EVI5) is a crucial oncogene and mediator of cell division processes, and it extensively participates in tumorigenesis and progression. However, the role of EVI5 in LUAD progression remains elusive.

Magnetic-Driven Hydrogel Robots Loaded with Mitomycin for Active Therapy of Bladder Cancer.

Intravesical drug instillation is a common treatment for bladder cancer, but it suffers from poor targeting and suboptimal patient experience due to the influence of gravity. Here, we innovatively designed a bladder cancer treatment method using sodium alginate hydrogel magnetic robots as mitomycin drug carriers. The magnetic-driven hydrogel robots with mitomycin (MHRMs) are fabricated by uniformly mixing alginate solution, neodymium-iron-boron nanoparticles, and mitomycin, followed by the formation of MHRMs capable of carrying mitomycin in a calcium chloride solution.

Right-to-left shunt detection in patent foramen ovale: The value of synchronized contrast transcranial Doppler and contrast transthoracic echocardiography.

Patent foramen ovale (PFO) is a common congenital heart disorder associated with stroke, decompression sickness and migraine. Combining synchronized contrast transcranial Doppler with contrast transthoracic echocardiography has important clinical significance and can improve the accuracy of detecting right-left shunts (RLSs) in patients with PFO. In this letter, regarding an original study presented by Yao , we present our insights and discuss how to better help clinicians evaluate changes in PFO-related RLS.

Single-Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment.

Penile squamous cell carcinoma (PSCC) is a highly aggressive malignancy without effective treatment due to limited knowledge of its development and tumor microenvironment (TME). In this study, single-nucleus RNA sequencing (snRNA-seq) and high-resolution spatial transcriptomics are employed to comprehensively investigate the development trajectories and the TME. The results revealed that PSCC cells mimicked the differentiation and tissue organization of normal penile epithelium, independent of the human papillomavirus (HPV) infection status.

B.T.C.H. nephrolithometry score: a novel scoring system to predict stone-free rate and complexity for ultrasound-guided percutaneous nephrolithotomy.

Background: The existing scoring systems for percutaneous nephrolithotomy fail to adequately consider the influence of renal anatomy, leading to limited predictive accuracy. This study introduces and validates a novel B.T.

Evaluating the learning curve of total ultrasound guided percutaneous nephrolithotomy in complex renal stones using"30-degree triangulation"technique.

Purpose: To investigate the learning curve of in the training of total ultrasound(US) guided percutaneous nephrolithotomy(PCNL) in complex renal stones using "30-degree principle" technique.

Patients And Methods: A total of 80 patients were included in this study to evaluate the learning curve of US guided PCNL in an inexperienced novice. They were divided into 8 groups based on timing of the surgery to evaluate the outcomes within the groups.

Whole-brain 3D imaging of dopaminergic neurons and glial cells in the mouse model of Parkinson's disease induced by 6-OHDA.

Objective: Parkinson's disease (PD) is the second most common neurodegenerative disease. Current understanding of the abnormal neural network in PD is limited, which may be one of the reasons for the lack of effective treatments. Tissue-clearing techniques allow visualization of neurons and gliocytes that form the structural basis of the abnormal neuronal network, thus enabling a deeper understanding of the pathological neuronal network in PD and contributing to the study of therapeutic strategies.

Short-term outcomes comparison of KangDuo 2.0 and Da Vinci Xi in radical cystectomy.

In urological surgery, the Da Vinci Xi robotic system has many advantages, but it also has limitations such as high equipment costs and the need for professional training. Kangduo is a laparoscopic surgical robot developed in China, and SR2000 is its newly approved four-arm laparoscopic surgical robot. This study compares the short-term outcomes of the two in radical cystectomy.