Magnetic-Driven Hydrogel Robots Loaded with Mitomycin for Active Therapy of Bladder Cancer.

Intravesical drug instillation is a common treatment for bladder cancer, but it suffers from poor targeting and suboptimal patient experience due to the influence of gravity. Here, we innovatively designed a bladder cancer treatment method using sodium alginate hydrogel magnetic robots as mitomycin drug carriers. The magnetic-driven hydrogel robots with mitomycin (MHRMs) are fabricated by uniformly mixing alginate solution, neodymium-iron-boron nanoparticles, and mitomycin, followed by the formation of MHRMs capable of carrying mitomycin in a calcium chloride solution.

Internal Capsulation Via Self-Cross-linking and π-Effects Achieves Highly Stable Perovskite Solar Cells.

Pursuing high stability becomes the core challenge in realizing the widespread application of perovskite solar cells (PerSCs). Here, a practical internal-capsulation strategy is proposed by introducing cross-linkable methacrylate analogs upon the perovskite layer, hindering ion migration and preventing lead leakage to achieve stable PerSCs. Butyl methacrylate (UMA) and benzyl methacrylate (BMA) can chemically interact with the perovskite layer, especially for the BMA dimer with significant π-interactions among the hanging benzene rings.

LncRNA CTBP1-AS inhibits TP63-mediated activation of S100A14 during prostate cancer progression.

Long noncoding RNAs (lncRNAs) have emerged as important molecules and potential new targets for human cancers. This study investigates the function of lncRNA CTBP1 antisense RNA (CTBP1-AS) in prostate cancer (PCa) and explores the entailed molecular mechanism. Aberrantly expressed genes potentially correlated with PCa progression were probed using integrated bioinformatics analyses.

A Light Multi-View Stereo Method with Patch-Uncertainty Awareness.

Multi-view stereo methods utilize image sequences from different views to generate a 3D point cloud model of the scene. However, existing approaches often overlook coarse-stage features, impacting the final reconstruction accuracy. Moreover, using a fixed range for all the pixels during inverse depth sampling can adversely affect depth estimation.

Bright Blue Emission Lead-Free Halides with Narrow Bandwidth Enabled by Oversaturated Europium Doping.

Eu-based lead-free metal halide nanocrystals (LFMH NCs), including CsEuCl NCs and CsX:Eu NCs (X = Cl or Br), exhibit highly efficient narrow-band blue photoluminescence, making them competitive candidates for next-generation lighting and displays. However, the growing mechanism of the aforementioned NCs lacks in-depth study, which hinders the development of Eu-based nanomaterials. Herein, we demonstrate the colloidal synthesis of CsBr:Eu NCs based on an air-stable europium source.

Crosslinkable and Chelatable Organic Ligand Enables Interfaces and Grains Collaborative Passivation for Efficient and Stable Perovskite Solar Cells.

The organic-inorganic halide perovskite solar cell (PerSC) is the state-of-the-art emerging photovoltaic technology. However, the environmental water/moisture and temperature-induced intrinsic degradation and phase transition of perovskite greatly retard the commercialization process. Herein, a dual-functional organic ligand, 4,7-bis((4-vinylbenzyl)oxy)-1,10-phenanthroline (namely, C1), with crosslinkable styrene side-chains and chelatable phenanthroline backbone, synthesized via a cost-effective Williamson reaction, is introduced for collaborative electrode interface and perovskite grain boundaries (GBs) engineering.

Coronavirus transmissible gastroenteritis virus antagonizes the antiviral effect of the microRNA miR-27b via the IRE1 pathway.

Although the functional parameters of microRNAs (miRNAs) have been explored to some extent, the roles of these molecules in coronavirus infection and the regulatory mechanism of miRNAs in virus infection are still unclear. Transmissible gastroenteritis virus (TGEV) is an enteropathgenic coronavirus and causes high morbidity and mortality in suckling piglets. Here, we demonstrated that microRNA-27b-3p (miR-27b-3p) suppressed TGEV replication by directly targeting porcine suppressor of cytokine signaling 6 (SOCS6), while TGEV infection downregulated miR-27b-3p expression in swine testicular (ST) cells and in piglets.

Multi-Functional Solid Additive Induced Favorable Vertical Phase Separation and Ordered Molecular Packing for Highly Efficient Layer-by-Layer Organic Solar Cells.

Layer-by-layer (LBL) deposition strategy enabling favorable vertical phase distributions has been regarded as promising candidates for constructing high-efficient organic photovoltaic (OPV) cells. However, solid additives with the merits of good stability and reproducibility have been rarely used to fine-tune the morphology of the LBL films for improved efficiency and stability. Herein, hierarchical morphology control in LBL OPV is achieved via a dual functional solid additive.