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Patent foramen ovale (PFO) is a common congenital heart disorder associated with stroke, decompression sickness and migraine. Combining synchronized contrast transcranial Doppler with contrast transthoracic echocardiography has important clinical significance and can improve the accuracy of detecting right-left shunts (RLSs) in patients with PFO. In this letter, regarding an original study presented by Yao , we present our insights and discuss how to better help clinicians evaluate changes in PFO-related RLS.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12149970 | PMC |
http://dx.doi.org/10.4329/wjr.v17.i5.105951 | DOI Listing |
Front Cardiovasc Med
August 2025
Department of Ultrasound Imaging, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Introduction: Patent foramen ovale (PFO) is associated with cryptogenic stroke (CS), whereas not all PFO carriers experience strokes. Current risk assessment tools like the Risk of Paradoxical Embolism (RoPE) scoring system and PFO-Associated Stroke Causal Likelihood (PASCAL) system have limitations, particularly in elderly populations. This study aims to explore risk factors for PFO-related CS and evaluate age-related differences between younger and elderly patients.
View Article and Find Full Text PDFInt J Stroke
September 2025
Centro integral de Neurología Vascular, FLENI.
Background: Young adults account for up to 15% of all ischemic strokes, yet data from Latin America remain scarce. Understanding their clinical profile and outcomes is essential to inform targeted interventions and public health strategies. We aimed to characterize demographics, vascular risk factors, stroke etiology, access to acute reperfusion therapies, and 90-day outcomes in Argentine patients aged 18-50 years with ischemic stroke.
View Article and Find Full Text PDFFront Genet
August 2025
Department of Cardiology, Hospital of Chengdu Office of People's Government of Xizang Autonomous Region (Hospital.C.X.), Chengdu, China.
Objective: Patent foramen ovale (PFO), a prevalent congenital cardiac defect, is linked to clinical conditions such as cryptogenic stroke and migraine. The genetic underpinnings of PFO remain poorly elucidated, particularly in Tibet. This study aimed to identify potential pathogenic mutations in Tibetan PFO patients via whole exome sequencing (WES) to clarify its genetic basis.
View Article and Find Full Text PDFFront Cardiovasc Med
August 2025
Department of Interventional Radiology, First People's Hospital of Changzhou, Changzhou, China.
Totally implantable venous access ports (TIVAPs) are commonly used for patients undergoing chemotherapy and long-term repeated infusions. The incidence of thrombosis is low and rarely leads to serious complications. We report a case of right atrial thrombosis and paradoxical embolism in a 58-year-old male with atrial fibrillation (AF) and patent foramen ovale (PFO) 28 months after TIVAP implantation.
View Article and Find Full Text PDFWorld J Methodol
December 2025
Department of Cardiology, University of Miami-Miller School of Medicine, Miami, FL 33136, United States.
Background: The Food and Drug Administration has approved percutaneous atrial septal defect (ASD) and patent foramen ovale (PFO) closure devices for hemodynamically significant interatrial shunts, paradoxical emboli including stroke, and decompression sickness. We aimed to study the trends in utilization and reimbursements of transcatheter ASD/PFO closure devices.
Aim: To analyze trends in utilization and Medicare reimbursements for transcatheter ASD/PFO closure procedures from 2013 to 2022.