Exercise interventions in cancer-related cognitive impairment: an umbrella review.

Purpose: The aim of this umbrella review is to assess the effectiveness of exercise interventions in preventing and managing cancer-related cognitive impairment among cancer survivors, providing an evidence-based foundation for clinical practice.

Methods: The umbrella review was pre-registered on PROSPERO. It included systematic reviews that assessed any exercise interventions aimed at improving cognition in cancer patients.

Huazhuo Sanjie Chubi Decoction attenuates gouty arthritis and kidney fibrosis by regulating urate transporters and JAK2/STAT3 pathway.

Ethnopharmacological Relevance: Gouty arthritis (GA), a metabolic disorder, presents as recurrent acute arthritis with hyperuricemia. Huazhuo Sanjie Chubi decoction (HSCD), a traditional Chinese medicine oral decoction, has been extensively utilized for spleen deficiency with damp retention and GA management. However, its mechanisms against GA and associated renal fibrosis remain underexplored.

Inhibition of ARH2 by pH/ROS-responsive nanosystem for improved lung adenocarcinoma immunochemotherapy.

Immunotherapy resistance remains a substantial barrier to improving treatment outcomes for patients with lung adenocarcinoma (LUAD). Identifying effective immunotherapy target is crucial for enhancing therapeutic efficacy in LUAD. Through database analysis, we discovered that ADP ribosylhydrolase-like 1 (ADPRHL1, ARH2) is associated with immunosuppression.

A nomogram model for predicting maternal cardiovascular complications and neonatal adverse outcomes in pregnant patients with pulmonary arterial hypertension.

Background: Pulmonary arterial hypertension (PAH) during pregnancy significantly increases maternal and fetal mortality risk. We developed nomogram prediction models from retrospective data to assess maternal cardiovascular risks and neonatal adverse outcomes.

Methods: Our study included 170 pregnant women, divided into training (70%) and validation (30%) sets.

Ginsenoside Re ameliorates thioacetamide-induced acute liver injury through inhibiting autophagy-NLRP3 inflammasome pathway.

Background: Ginsenoside Re (G-Re), a unique ginsenoside almost exclusively found in Araliaceae plants, is a promising therapeutic agent for attenuating liver injury. This study aims to investigate the liver-protective effects of G-Re and the underlying mechanisms in acute liver injury models.

Methods: Male C57BL/6 mice were intraperitoneally injected with various agents induce the acute liver injury model after pre-treatment with G-Re (5-20 mg/kg, oral gavage).

Circular RNA circLIMK1-005 promotes the progression of lung adenocarcinoma by interacting with RPA1 protein to activate CDK4 signaling.

Lung adenocarcinoma (LUAD) is the leading cause of cancer death worldwide. Circular RNAs (circRNAs) have emerged as potential key players in the onset and progression of various cancers. However, the specific roles and mechanisms of circRNAs in LUAD remain largely unexplored.

Regulating a CoO/ZnO heterojunction aerogel with a built-in electric field for enhanced CO photoreduction to solar fuels from DFT insights.

P-N-type heterojunctions have the potential to serve as highly efficient photocatalysts for CO reduction, owing to their remarkable carrier separation efficiency, high stability, and strong redox capacity. In this study, a novel P-N CoO/ZnO heterojunction aerogel photocatalyst was fabricated through a process starting with the propylene oxide ring-opening-induced gelation technique. The resulting CoO/ZnO aerogel exhibits an interconnected, hierarchical porous structure, which endows it with a particle diameter size at around several tens of nanometers and a large BET-specific surface area, thereby providing abundant exposed active sites.

Ferredoxin 1-like maintains iron homeostasis and hepatoma cell survival.

Ferredoxin 1-like (FDX1L) is a pivotal component of the core iron-sulfur (Fe-S) cluster assembly machinery. However, the role of FDX1L in hepatocellular carcinoma (HCC) has not been thoroughly elucidated. In this study, we conducted genome-wide CRISPR-Cas9 screenings and identified FDX1L as an essential gene for hepatoma cell survival.

The gut microbiota-mediated ferroptosis pathway: a key mechanism of ginsenoside Rd against metabolism-associated fatty liver disease.

Background: Ginsenoside Rd (G-Rd), found in Panax species, has shown therapeutic potential against metabolism-associated fatty liver disease (MAFLD), but its mechanism has not been well elucidated. This study investigated the key mechanisms of G-Rd in modulating the gut microbiome and lipid peroxidation-mediated ferroptosis pathway in MAFLD.

Methods: A high-fat diet-induced MAFLD model was established.

Phytochemical characterization and pharmacological mechanisms of Huazhuo Sanjie Chubi Decoction in treating gouty arthritis: A multivariant approach.

Ethnopharmacological Relevance: Huazhuo Sanjie Chubi Decoction (HSCD), a Chinese herbal formula, is traditionally used for the treatment of spleen deficiency with dampness accumulation and is commonly used to treat gouty arthritis (GA). However, the potential active compounds and mechanisms of HSCD remain unclear.

Aim Of The Study: To elucidate the key bioactive compounds and pharmacological mechanisms of HSCD in treating GA.

Gut Microbiota and Bile Acid Metabolism in the Mechanism of Ginsenoside Re Against Nonalcoholic Fatty Liver Disease.

Gut microbiota and bile acid metabolism play crucial roles in the progression of nonalcoholic fatty liver disease (NAFLD). Early evidence demonstrates that Ginsenoside Re (Re) possesses pharmacological effects on NAFLD, but its mechanisms of action are not well understood. This study aimed to investigate the hepatic protective effects of Re in NAFLD and elucidate relevant mechanisms.

Ginsenoside Rd protects against acute liver injury by regulating the autophagy NLRP3 inflammasome pathway.

Ginsenoside Rd (Rd) is a bioactive compound predominantly found in Panax ginseng C.A. Meyer and Panax notoginseng (Burkill) F.

Comparative Analysis of Complete Chloroplast Genomes and Phylogenetic Relationships in Medicinally Important Pantropical Genus s.s. (Leguminosae) from Southern Africa and Eastern Asia.

s.s. belongs to the Cercidoideae subfamily, located at the base of the Leguminosae family.

Complete Chloroplast Genomes and Phylogenetic Analysis of Woody Climbing Genus (Leguminosae).

Background: Lour., a genus in the subfamily Cercidoideae of the family Leguminosae, is characterized by woody liana habit, tendrils, and distinctive bilobate or bifoliolate leaves. The genus holds important medicinal value and constitutes a complex group characterized by morphological diversity and unstable taxonomic boundaries.

Senescence-related signatures predict prognosis and response to immunotherapy in colon cancer.

Background: Colorectal cancer (CRC) is one of the most common cancers. Cellular senescence plays a vital role in carcinogenesis by activating many pathways. In this study, we aimed to identify biomarkers for predicting the survival and recurrence of CRC through cellular senescence-related genes.

Synergistic action of gemcitabine and celecoxib in promoting the antitumor efficacy of anti-programmed death-1 monoclonal antibody by triggering immunogenic cell death.

Background: Emerging evidence suggests that immunogenic chemotherapy not only kills tumor cells but also improves the immune-suppressive tumor microenvironment by inducing immunogenic cell death (ICD), leading to sustained anti-tumor effects. The lack of ICD inducers explored in lung cancer necessitates investigation into new inducers for this context, therefore, this study aims to explore whether the gemcitabine (GEM) and celecoxib can activate the immunogenic chemotherapy progress in lung cancer tissue.

Methods: We assessed five chemotherapeutic agents for their ability to trigger ICD using and experiments, including western blotting (WB), flow cytometry, and tumor preventive vaccine assays.

NIR-responsive CN-Pt-GEM hydrogel induces necroptosis and immunotherapeutic responses prevent postoperative recurrence and wound infection in lung carcinoma.

Background: Cancer recurrence following surgical resection is a major cause of treatment failure. Finding effective methods to prevent postoperative recurrence and wound infection is an important component of successful surgery. With the development of new nanotechnology, more treatment options have been provided for postoperative adjuvant therapy.

Phytochemical determination and mechanistic investigation of Polygala tenuifolia root (Yuanzhi) extract for bronchitis: UPLC-MS/MS analysis, network pharmacology and in vitro/in vivo evaluation.

Ethnopharmacological Relevance: Bronchitis is a respiratory disease characterized by a productive cough. Polygala tenuifolia Willd., commonly known as Yuan zhi, is a traditional Chinese herbal medicine used for relieving cough and removing phlegm.

Fuyuan decoction prevents nasopharyngeal carcinoma metastasis by inhibiting circulating tumor cells/ endothelial cells interplay and enhancing anti-cancer immune response.

Distant metastasis is a major cause of treatment failure in cancer patients and a key challenge to improving cancer care today. We hypothesized that enhancing anti-cancer immune response and inhibiting circulating tumor cells (CTCs) adhesion and transendothelial migration through synergistic multi-target approaches may effectively prevent cancer metastasis. "Fuyuan Decoction" (FYD) is a traditional Chinese medicine compound that is widely used to prevent postoperative metastasis in cancer patients, but its underlying mechanism remains unclear.

The complete chloroplast genome and phylogenetic analysis of (Elaeagnaceae) from Fujian, southeastern China.

Maximowicz 1870 is an important medicinal plant mainly distributing in the southeastern coastal region of China. However, the complete chloroplast genome of has never been studied at present. We obtained the complete chloroplast genome of , which was 152,283 bp in length, with a typical quadripartite structure that includes a large single-copy region of 82,229 bp, a small single-copy region of 18,256 bp, and 2 inverted repeat (IR) regions of 25,899 bp.

Dendrobium mixture ameliorates hepatic injury induced by insulin resistance and through the downregulation of AGE/RAGE/Akt signaling pathway.

Dendrobium mixture (DM) is a patented Chinese herbal medicine which has been shown to ameliorate type 2 diabetes mellitus (T2DM) with non-alcoholic fatty liver disease (NAFLD) and . We aimed to investigate the underlying mechanism of DM as a therapeutic agent in attenuating liver steatosis in relation to type 2 diabetes mellitus (T2DM). DM (16.

Baicalin attenuated metabolic dysfunction-associated fatty liver disease by suppressing oxidative stress and inflammation via the p62-Keap1-Nrf2 signalling pathway in db/db mice.

Metabolic dysfunction-associated fatty liver disease (MAFLD) is the main cause of chronic liver disease. Baicalin (Bai), a bioactive molecule found in Scutellaria baicalensis Georgi, possesses antioxidant and antiinflammatory properties. These activities suggest Bai could be a promising therapeutic agent against NAFLD; however, its specific effects and underlying mechanism are still not clear.