Stretchable Platinum Network-Based Transparent Electrodes for Highly Sensitive Wearable Electronics.

A platinum network-based transparent electrode has been fabricated by electrospinning. The unique nanobelt structured electrode demonstrates low sheet resistance (about 16 Ω sq ) and high transparency of 80% and excellent flexibility. One of the most interesting demonstrations of this Pt nanobelt electrode is its excellent reversibly resilient characteristic.

Use of Epinephrine in Patients with Drug-Induced Anaphylaxis: An Analysis of the Beijing Pharmacovigilance Database.

Background: Few studies assessing the use of epinephrine in drug-induced anaphylaxis (DIA) in the hospital setting are available. We utilized the Beijing Pharmacovigilance Database (BPD) to evaluate the appropriateness of epinephrine for DIA management.

Methods: DIA cases collected in the BPD from January 2004 to December 2014 were adjudicated and analyzed for demographics, causative drugs, clinical signs, outcomes, initial treatment, route, dosing, and cardiovascular adverse events (CAE) of epinephrine.

SPECT imaging and radionuclide therapy of glioma using I labeled Buthus martensii Karsch chlorotoxin.

Gliomas, the most prevalent type of brain tumor in adults, are associated with high rates of morbidity and mortality. Recent studies on I labeled scorpion toxins suggest they can be developed as tumor-specific agents for glioma diagnosis and treatment. This study investigated the potential of I labeled Buthus martensii Karsch chlorotoxin (I-BmK CT) as a new approach for targeted imaging and therapy of glioma.

Cerebrospinal fluid Aβ42, t-tau, and p-tau levels in the differential diagnosis of idiopathic normal-pressure hydrocephalus: a systematic review and meta-analysis.

Objectives: The purpose of this systematic review and meta-analysis was to evaluate the performance of cerebrospinal fluid (CSF) beta amyloid 42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) as potential diagnostic biomarkers for idiopathic normal-pressure hydrocephalus (iNPH) and to assess their utility indistinguishing patients with iNPH from those with Alzheimer disease (AD) and healthy normal controls.

Methods: Studies were identified by searching PubMed, Embase, the Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Wanfang Chinese Periodical Database, VIP Chinese database, and Chinese Bio-medicine Database (CBM) before August 2016. The standardized mean difference (SMD) and 95% confidence interval (CI), comparing CSF Aβ42, t-tau, and p-tau levels between iNPH, AD and healthy controls, were calculated using random-effects models.

[A preliminary study of renal function in small-for-gestational-age infants at early stage after birth].

Objective: To investigate the renal function of small-for-gestational-age (SGA) infants at the early stage after birth.

Methods: A total of 40 preterm SGA infants, 33 full-term SGA infants, 80 preterm appropriate-for-gestational-age (AGA) infants, and 33 full-term AGA infants were included in this study. The following indices were compared between the SGA infants and AGA infants within 48 hours after admission: blood urea nitrogen (BUN), serum creatinine (SCr), estimated glomerular filtration rate (eGFR), blood pressure, urine volume per body weight, and proteinuria.

Integrated proteomic analysis of Brachypodium distachyon roots and leaves reveals a synergistic network in the response to drought stress and recovery.

In this study, we performed the first integrated physiological and proteomic analysis of the response to drought and recovery from drought, using Brachypodium distachyon L. Roots and leaves. Drought stress resulted in leaves curling, root tips becoming darker in color and significant changes in some physiological parameters.

Controlled droplet transport to target on a high adhesion surface with multi-gradients.

We introduce multi-gradients including Laplace pressure gradient, wettable gradient and wettable different gradient on a high adhesion surface via special wedge-pattern and improved anodic oxidation method. As a result of the cooperative effect mentioned above, controlled directional motion of a droplet on a high adhesion surface is realized, even when the surface is turned upside down. The droplet motion can be predicted and the movement distances can be controlled by simply adjusting the wedge angle and droplet volume.

BmK CT and 125I-BmK CT suppress the invasion of glioma cells in vitro via matrix metalloproteinase-2.

Chlorotoxin (CTX) is an established blocker of small‑conductance Cl‑ channels and has previously been demonstrated to inhibit the invasion of glioma cells. Buthus martensii Karsch chlorotoxin‑like toxin (BmK CT) is the first chlorotoxin-like peptide. The present study aimed to determine the inhibitory effect of BmK CT on the invasive ability of glioma cells, using a Transwell assay.

A Volumetric and Functional Connectivity MRI Study of Brain Arginine-Vasopressin Pathways in Autistic Children.

Dysfunction of brain-derived arginine-vasopressin (AVP) systems may be involved in the etiology of autism spectrum disorder (ASD). Certain regions such as the hypothalamus, amygdala, and hippocampus are known to contain either AVP neurons or terminals and may play an important role in regulating complex social behaviors. The present study was designed to investigate the concomitant changes in autistic behaviors, circulating AVP levels, and the structure and functional connectivity (FC) of specific brain regions in autistic children compared with typically developing children (TDC) aged from 3 to 5 years.

Novel conjugates of endoperoxide and 4-anilinoquinazoline as potential anticancer agents.

In the present study, endoperoxide and 4-anilinoqnazoline were conjugated to obtain a series of compounds. These conjugates exhibited high antiproliferative potency against a number of cancer cell lines, including the epidermal growth factor receptor (EGFR) L858R/T790M mutant cell. Compound 5 was selected as a representative for mechanistic study.

An Ink-jet Printing Strategy for Extensive Exploration of One Chemical Action with Three Interactive Variations.

A simple method was created and implemented through the technology of ink-jet printing to study the effects of three chemical factors (chemical reagents) to the ninhydrin reaction. The effects of each single reagent and their interactions on the reaction were studied in one experiment. The three reagents all have effects on ninhydrin reaction, and the effects under the different combinations of reagents were presented on a chip.

Development of an aptamer-ampicillin conjugate for treating biofilms.

Biofilm formation involves the development of extracellular matrix and initially depends on adherence and tropism by flagellar movement. With the widespread development of antibiotic resistance and tolerance of biofilms, there is a growing need for novel anti-infective strategies. No currently approved medications specifically target biofilms.

99mTc-MDP Uptake in Diffuse Pleural Recurrences of Pulmonary Neuroendocrine Carcinoma.

A 39-year-old woman with a history of pulmonary neuroendocrine carcinoma segmental palliative resection underwent a Tc-MDP bone scintigraphy to evaluate possible osseous metastases. The static images revealed diffuse elevated activity in the left hemithorax, more prominent in the lower thorax, which is suggestive of malignant pleural effusion. However, SPECT/CT images showed that the elevated activity was from pleura-based soft tissue masses, which were confirmed as recurrent tumor pathologically after biopsy.

[Estimation of birch forest LAI based on single laser penetration index of airborne LiDAR data.].

Forest leaf area index (LAI) is an important indicator to describe the forest canopy structure and growth status of trees. In this paper, the Yigen area of Inner Mongolia was selected as the study area. Taken full account of the differences among different echo types, the LiDAR point cloud data were split into different single lasers.

Dynamic Phosphoproteome Analysis of Seedling Leaves in Brachypodium distachyon L. Reveals Central Phosphorylated Proteins Involved in the Drought Stress Response.

Drought stress is a major abiotic stress affecting plant growth and development. In this study, we performed the first dynamic phosphoproteome analysis of Brachypodium distachyon L. seedling leaves under drought stress for different times.

Effects of Ionizing Radiation on Physical Properties of Peripherally Inserted Central Catheter.

Peripherally inserted central catheter (PICC) has been widely used to treat cancer patients. It is unknown whether or not it can be applied safely during radiotherapy. The study aimed to investigate the direct effects of gamma radiation on physical properties of PICC.

[Retrieving Dustfall Distribution in Beijing City Based on Ground Spectral Data and Remote Sensing].

Dust-fall distribution of vegetation leaves can indicate the degree of air pollution; therefore the analysis of spatial characteristics of urban vegetation dust-fall has important practical significance for making more effective air pollution control policy. Based on the data of weight of dust, spectral reflectance and leaf area of Euonymus japonicus, Sophora japonica, poplar and davidiana collected in the main area of Beijing city, we compared the curve of spectrum of four plants “dust leaves” to “clean leaves”; the correlation analysis between leaf spectral reflectance ratio (Dust/Clean) of narrow band and satellite band was processed with the weight of dust-fall respectively, with application of four plants leaf data. Then, we built the regression model of the satellite band reflectance and NDVI with dustfall weight respectively, and we used the best model to retrieve the dust-fall distribution of vegetation coverage area in Beijing city, furthermore, we obtained the dust distribution of the whole Beijing city through interpolation.

[(18)F-FDG PET/CT for extranodular natural killer/T-cell lymphoma nasal type: imaging findings and clinical value].

Objective: To explore the value of (18)F-FDG PET/CT in the diagnosis and treatment evaluation in patients with pretreatment or recurrent extranodular natural killer/T-cell lymphoma nasal type (ENTCL).

Methods: (18)F-FDG PET/CT images and clinical records of 35 cases (67 scans) of pathologically confirmed ENTCL treated in our hospital within the last 9 years were analyzed. The imaging characteristics of the upper aerodigestive tract (UAT) and the non-aerodigestive tract (NUAT) lesions were analyzed.

How Many Contralateral Carcinomas in Patients with Unilateral Papillary Thyroid Microcarcinoma are Preoperatively Misdiagnosed as Benign?

Background: The decision to perform a total thyroidectomy (TT) for unilateral papillary thyroid microcarcinoma (PTMC) with nodules in the contralateral lobe remains controversial. The aim of this study was to investigate the rate of contralateral carcinomas that are preoperatively misdiagnosed as benign.

Methods: From October 2011 to October 2015, a total of 347 patients with unilateral PTMC and contralateral benign nodules who were treated with a TT at a single institution were enrolled.

Human cytomegalovirus infection contributes to glioma disease progression via upregulating endocan expression.

The etiology of malignant glioma remains unclear. To examine the association between glioma and human cytomegalovirus (HCMV) infection and the possible mechanism through which HCMV contributes to malignant glioma, we investigated the expression of HCMV components and an angiogenesis marker, endocan, in 79 glioma specimens and 8 control brain samples. HCMV pp65 protein and DNA were detected in 65.

Human biliverdin reductase promotes EMT through the ERK1/2 signal pathway in breast cancer.

Epithelial-to-mesenchymal transition (EMT) plays an important role in the development of the invasive and metastatic potentials of breast cancer cells during progression. Human biliverdin reductase (hBVR), an enzyme in the heme metabolism pathway, is involved in hypoxia-induced renal tubular EMT. However, whether hBVR contributes to the EMT of breast cancer remains unclear.

Serum progranulin levels are elevated in patients with chronic hepatitis B virus infection, reflecting viral load.

Progranulin (PGRN) is implicated in infection, immunity and host defense, but its role in the pathogenesis of HBV infection remains unknown. Here we investigated whether there is dysregulated production and the clinical significance of circulating PGRN in patients with chronic HBV infection. Serum concentrations of PGRN were analyzed by enzyme-linked immunosorbent assay.

Facile Fabrication of Well-Dispersed Pt Nanoparticles in Mesoporous Silica with Large Open Spaces and Their Catalytic Applications.

In this paper, a facile strategy is reported for the preparation of well-dispersed Pt nanoparticles in ordered mesoporous silica (Pt@OMS) by using a hybrid mesoporous phenolic resin-silica nanocomposite as the parent material. The phenolic resin polymer is proposed herein to be the key in preventing the aggregation of Pt nanoparticles during their formation process and making contributions both to enhance the surface area and enlarge the pore size of the support. The Pt@OMS proves to be a highly active and stable catalyst for both gas-phase oxidation of CO and liquid-phase hydrogenation of 4-nitrophenol.

Endometriosis Mimicking an Advanced Malignant Tumor.

A 27-year-old woman with swelling left leg, groin pain, and increased serum CA125 level underwent FDG PET/CT to evaluate a pelvic mass revealed by an MRI performed from an outside hospital. A large hypermetabolic solid mass in the left pelvic wall and several lymph nodes with elevated FDG activity were noted, which indicated malignancy. However, histopathological examination demonstrated endometriosis.

Generation of induced pluripotent stem cells from human mesenchymal stem cells of parotid gland origin.

The technology to reprogram human somatic cells to pluripotent state allows the generation of patient-specific induced pluripotent stem cells (iPSCs) and holds a great promise for regenerative medicine and autologous transplantation. Here we, for the first time, identified mesenchymal stem cells isolated from parotid gland (hPMSCs) as a suitable candidate for iPSC production. In the present study, hPMSCs were isolated from parotid gland specimens in patients with squamous cell carcinoma of the oral cavity.