Efficacy of Qingrehuoxue granule for bone protection in patients with active rheumatoid arthritis in China: The PRE-ERODE randomized controlled trial.

Ethnopharmacological Relevance: Qingrehuoxue (QRHX) granules, composed of 12 Chinese herbs, have been used for over 40 years to treat rheumatoid arthritis (RA) in China and show potential in protecting bone health. However, high-quality evidence on their effects is limited.

Aim Of The Study: To assess the effects of QRHX granules on bone marrow edema (BME) in active RA patients.

Multimodal artificial intelligence for subepithelial lesion classification and characterization: a multicenter comparative study (with video).

Background: Subepithelial lesions (SELs) present significant diagnostic challenges in gastrointestinal endoscopy, particularly in differentiating malignant types, such as gastrointestinal stromal tumors (GISTs) and neuroendocrine tumors, from benign types like leiomyomas. Misdiagnosis can lead to unnecessary interventions or delayed treatment. To address this challenge, we developed ECMAI-WME, a parallel fusion deep learning model integrating white light endoscopy (WLE) and microprobe endoscopic ultrasonography (EUS), to improve SEL classification and lesion characterization.

Comprehensive Insights Into Mitophagy: Mechanisms, Disease Associations, and Therapeutic Implications.

Mitophagy, a selective autophagic process, is critical for maintaining mitochondrial quality and cellular homeostasis. It plays a dual role, facilitating cell survival by removing damaged mitochondria or contributing to programmed cell death in certain conditions. Dysregulation of mitophagy is implicated in various diseases, including neurodegenerative disorders, metabolic syndromes, cardiovascular diseases, and cancers.

Infertility trends in China: analyzing temporal changes, public demand, and demographic differences based on Baidu index.

Background: Infertility is a critical public health issue, imposing significant psychological and financial burdens on individuals and healthcare systems. This study analyzes internet search behavior related to infertility using Baidu Index data, examining trends, demographic characteristics, and geographic patterns. The goal is to provide evidence to inform policy development and improve intervention strategies.

Identification EXOSC4 as a novel autoantigen of interstitial lung disease in rheumatoid arthritis.

Background: Interstitial lung disease (ILD) is a common and severe comorbidity of rheumatoid arthritis (RA), yet reliable diagnostic biomarkers remain lacking. Alveolar type II (ATII) cells are widely recognized to play a key role in the pathogenesis of ILD. This study first aimed to screen and validate potential autoantigens involved in RA-ILD using ATII cells.

Ecological Isolation Maintains the Species Boundaries Between Two Sympatric From Southwest China.

Over long-term evolutionary processes, sympatric affinities may develop reproductive isolation mechanisms, such as temporal isolation and ecological divergence, to maintain species independence. However, due to lacking strict geographic isolation barriers, sympatrically distributed closely related species may experience interspecific gene flow and genetic introgression, which can blur species boundaries. Here we focus on two sympatrically distributed species along the Lancang (Mekong) River in three populations from Southwest China, and , to investigate the extent of genetic introgression between them and how they maintain species boundaries.

Experimental study of the effect of natural fracture curvature on hydraulic fracture propagation behavior.

The interaction mechanism between hydraulic fractures (HF) and natural fractures (NF) constitutes a critical research focus in hydraulic fracturing optimization. This study systematically investigates the influence of NF curvature on HF propagation behavior through large-scale true triaxial hydraulic fracturing physical simulations. The experiments were conducted on artificial rock specimens containing prefabricated fractures with varying curvature parameters.

Using Molecular Probe Adsorption to Characterize the Nanoparticle Corona Phase and Molecular Recognition.

The nanoparticle corona─a molecular layer adsorbed on nanoparticle surfaces─is critical for controlling molecular interactions and enabling applications in catalysis, nanoparticle separations, and sensing technologies. However, to date, characterizing the adsorbed surface area occupied by the corona phase has been difficult and not accessible with conventional particle sizing methods. Herein, we advance the technique of molecular probe adsorption (MPA) to measure this surface area by applying it to a large number of data sets.

Glucocorticoid Discontinuation in Patients with Rheumatoid Arthritis under Background of Chinese Medicine: Challenges and Potentials Coexist.

Objective: To evaluate the dynamic changes of glucocorticoid (GC) dose and the feasibility of GC discontinuation in rheumatoid arthritis (RA) patients under the background of Chinese medicine (CM).

Methods: This multicenter retrospective cohort study included 1,196 RA patients enrolled in the China Rheumatoid Arthritis Registry of Patients with Chinese Medicine (CERTAIN) from September 1, 2019 to December 4, 2023, who initiated GC therapy. Participants were divided into the Western medicine (WM) and integrative medicine (IM, combination of CM and WM) groups based on medication regimen.

De Novo assembly and phylogenetic analysis of the complete mitochondrial genome of Eleutherococcus senticosus and related araliaceous species.

Eleutherococcus senticosus, a unique herb with significant medicinal and ecological importance, has remained largely unexplored regarding its mitochondrial genome. This research details the complete assembly and annotation of the E. senticosus mitogenome, achieved using a hybrid sequencing strategy that integrates data from Illumina short-read and Nanopore sequencing long-read sequencing data.

Fe-Doped Carbon Dots Alleviated Rheumatoid Arthritis by Inhibiting Neutrophil NETosis and Autophagy.

Background: Rheumatoid arthritis (RA) is an autoimmune disorder primarily affecting joints, characterized by high incidence rates and significantly impairing patients' quality of life. Neutrophils play a pivotal role in RA pathogenesis, making therapeutic interventions targeting neutrophil-mediated inflammatory cascades a promising strategy for RA treatment.

Methods: Inspired by traditional Tibetan medicinal formulations, which typically combine metallic minerals and organic components, this study developed iron-doped carbon dots (MM-CDs) via a facile one-pot synthesis approach using magnetite (Cishi) and medicated leaven (Shenqu).

A genomic perspective on adaptation to heterogeneous environments for Cycas segmentifida (Cycadaceae), an endemic cycad in southwest China.

Background And Aims: Exploring the interplay of environmental variability and adaptation of an endemic species is essential to unravel its evolutionary history and lays the groundwork for assessing how it may react to the accelerating pace of climate change. Employing a population genomics method, this research sought to investigate the adaptation of a cycad species, Cycas segmentifida, to heterogeneous environments and how this fosters population differentiation, guiding its conservation efforts.

Methods: We used double digest restriction-site associated DNA-sequencing (ddRAD-seq) to elucidate the pattern of genetic diversity and divergence, and then analyze how geographical and environmental factors contribute to population divergence in C.

TikTok's cardiopulmonary exercise testing videos: A content analysis of quality and misinformation.

Background: Cardiopulmonary exercise testing (CPET) is conducted globally. On TikTok, CPET-related content serves as a key source of information for the public. However, the quality of these videos has not been systematically evaluated.

Organelles Ca redistribution contributes to cadmium-induced EMT of renal cancer cells through p-cPLA-mediated arachidonic acid release.

Cadmium ion (Cd) is a non-essential metal that can increase cancer risk, including potentially renal cell carcinoma (RCC), though this link is not definitive. Cd exposure impairs fatty acid metabolism in the kidneys, particularly affecting arachidonic acid (AA) levels, which are crucial for health. Previous studies have suggested that Cd-altered the AA metabolism associates with renal dysfunction.

Integrative bioinformatics and machine learning identify key crosstalk genes and immune interactions in head and neck cancer and Hodgkin lymphoma.

Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive malignancy with complex molecular underpinnings. Hodgkin lymphoma (HL), another distinct cancer type, shares several biological characteristics with HNSCC, particularly regarding immune system involvement. However, the molecular crosstalk between HNSCC and HL remains largely unexplored.

MSIE-Transformer: A novel driving behavior modeling approach for virtual simulation test environment.

To build a natural driving environment in the virtual environment for autonomous driving safety testing, a digital twin model of human driving behavior is essential. However, due to the lack of fidelity and intelligence of the driving behavior model of the background vehicle, there is an intolerable gap between the virtual simulation test environment and the real road test environment. This paper proposes the Multi-source Information Encoding Transformer (MSIE-Transformer) to model driving behaviors of background vehicles within the virtual simulation environment.

Inter-organ correlation based multi-task deep learning model for dynamically predicting functional deterioration in multiple organ systems of ICU patients.

Background: Functional deterioration (FD) of various organ systems is the major cause of death in ICU patients, but few studies propose effective multi-task (MT) model to predict FD of multiple organs simultaneously. This study propose a MT deep learning model named inter-organ correlation based multi-task model (IOC-MT), to dynamically predict FD in six organ systems.

Methods: Three public ICU databases were used for model training and validation.

A Near-Infrared Fluorescent Nanosensor for Direct and Real-Time Measurement of Indole-3-Acetic Acid in Plants.

Auxin, particularly indole-3-acetic acid (IAA), is a phytohormone critical for plant growth, development, and response to environmental stresses like shade avoidance syndrome and thermomorphogenesis. Despite its importance, there is no existing method that allows for convenient and direct detection of IAA in various plant species. Here, we introduce a near-infrared fluorescent nanosensor that directly measures IAA using corona phase molecular recognition with high selectivity, specificity, and spatiotemporal resolution.

Multiomics analysis of human serum and animal experiments reveals the protective mechanism of Qingre Huoxue Decoction against rheumatoid arthritis.

Objective: Qingre Huoxue Decoction (QRHXD) is a traditional Chinese herbal prescription widely used in clinical practice with significant therapeutic effects on RA; however, its mechanism of action remains unclear. This study aimed to investigate the efficacy and underlying mechanisms of QRHXD in treating RA through clinical research, multiomics approaches, and animal experiments.

Methods: We conducted a 24-week clinical study in which QRHXD was the primary treatment, collecting serum samples from patients before and after treatment for integrated proteomic and metabolomic analysis to identify potential therapeutic targets.

MBD2 promotes epithelial-to-mesenchymal transition (EMT) and ARDS-related pulmonary fibrosis by modulating FZD2.

Objective: To investigate the role and underlying mechanism of Methyl-CpG binding domain protein 2 (MBD2) in the pathogenesis of acute respiratory distress syndrome (ARDS)-related pulmonary fibrosis.

Methods: Murine models for ARDS-related pulmonary fibrosis were established in wildtype or MBD2 knockout mice, expressions of MBD2 were determined with immunohistochemistry (IHC), immunofluorescence, and western blot. Epithelial-to-mesenchymal transition (EMT) was detected with determined with decreased expression of E-cadherin and increased expressions of N-cadherin, Vimentin, and α-smooth muscle actin (α-SMA).

Grandifolins A-D: three 6/6/5 abietane diterpenes and an abietane diterpene from Salvia grandifolia.

The genus Salvia is a well-established source of biologically active compounds with beneficial health effects. In this study, we aimed to isolate and structurally characterize novel compounds from Salvia grandifolia and evaluate their cytotoxic activity against human promyelocytic leukemia (HL-60) and cervical cancer (HeLa) cell lines. Three new rearranged abietane-type diterpenes, grandifolins A-C (1-3) and a new abietane diterpene, grandifolin D (4), were isolated from the roots of Salvia grandifolia, along with 12 known compounds (5-16).

Dysthyroid optic neuropathy treated with tocilizumab.

Summary: Dysthyroid optic neuropathy (DON) is the most serious complication associated with Graves' orbitopathy (GO). The primary treatment approach for DON is high-dose intravenous methylprednisolone infusion and decompression surgery. However, not all patients are suitable candidates for or can tolerate these two treatment options.

Effects of plant active substances in rheumatoid arthritis-a systematic review and network meta-analysis.

Background: Plant active substances are extensively utilized in treating rheumatoid arthritis (RA). Despite numerous experimental and clinical studies on plant active substances their efficacy remains largely unsubstantiated. The widespread use of these extracts as therapeutic measures for RA is problematic due to the lack of compelling evidence.

Mucosal immunity and rheumatoid arthritis: An update on mechanisms and therapeutic potential.

Rheumatoid Arthritis (RA) is a persistent autoimmune inflammatory disorder that arises from the intricate interaction between genetic predisposition and environmental influences. The progression of RA can be delineated into four distinct phases: initially, the influence of genetic and environmental risk factors; followed by the emergence of systemic autoimmunity; subsequently, an asymptomatic inflammatory phase; and ultimately, the manifestation of clinical arthritis. Recently, the role of mucosal immunity in RA has gained significant attention in research.