Effects of manual acupuncture on fatty acid metabolism in a rat model of diarrhea-predominant irritable bowel syndrome: a multi-tissue metabolomic and plasma lipidomic investigation.

Objective: Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS. Many patients are dissatisfied with the efficacy of drug treatment and seek complementary and alternative medical therapies, especially acupuncture treatment. In this study, we evaluated the effect of manual acupuncture (MA) on IBS-D using a rat model and investigated the underlying mechanism of action by analyzing the changes in untargeted metabolomics of plasma/liver/colon and targeted plasma lipidomics.

Influence of psychological care on anxiety and depression in older adult patients with coronary heart disease complicated by arrhythmia.

Background: Coronary heart disease (CHD) has shown a consistent upward trend in global incidence in recent years. Notably, older adults with CHD complicated by arrhythmia exhibit significantly higher susceptibility to psychological distress compared with the general CHD population. This increased vulnerability has garnered growing clinical and research interest in the potential therapeutic benefits of structured psychological interventions for alleviating comorbid depressive and anxiety symptoms in this high-risk demographic.

Dimension-enhanced liquid chromatography/mass spectrometry approaches better decipher the difference in chemical compositions of Erzhi formula and Jiawei Erzhi formula.

Erzhi formula (EZF) consists of wine-processed Ligustri Lucidi Fructus (W-LLF) and Ecliptae Herba (EH), while Jiawei Erzhi formula (JWEZF) is derived by newly incorporating Spatholobi Caulis (SC) and Achyranthis Bidentatae Radix (ABR). To date, the chemical difference between EZF and JWEZF has been seldom investigated. This work was designed to qualitatively and quantitatively evaluate the chemical difference between JWEZF and EZF by dimension-enhanced liquid chromatography-mass spectrometry approaches.

Red Blood Cell Membrane Lipidomics: Potential Biomarkers Detecting Method for Plasma Volume Overload and Major Adverse Cardiovascular Events in Chronic Heart Failure Patients.

Plasma volume fluctuations limit the utility of circulating lipidomics in chronic heart failure (CHF). In contrast, red blood cell (RBC) membrane lipidomics may serve as stable biomarkers that are unaffected by plasma volume changes. Two cohorts are included to investigate the association between RBC indicators and CHF.

Scaling patient safety: How National Early Warning Score 2 (NEWS2) drove systemic mortality reduction in an acute care setting.

Objectives: To retrospectively assess the impact of the National Early Warning Score 2 (NEWS2) on prognosis in a single-center fever clinic.

Methods: This was a single-center retrospective study based on real-world data. The period from April 2020-March 2021 was used as the control group, and the period from April 2021-March 2022 was used as the NEWS group to explore the changes in the mortality rates of patients before and after the implementation of the NEWS2.

Rhein alleviates pancreatitis but induces hepatotoxicity via macrophage activation.

Ethnopharmacological Relevance: Rhubarb, a traditional Chinese medicine with potent purgative effects, is commonly used in treating acute pancreatitis in China. Rhein is one of the main active components of total anthraquinones in Rhubarb and has been reported to exert protective effects on pancreatitis. However, there is a potential risk of liver toxicity when Rhein is not used properly.

Wogonin Attenuates Atherosclerosis via KLF11-Mediated Suppression of PPARα-YAP1-Driven Glycolysis and Enhancement of ABCA1/G1-Mediated Cholesterol Efflux.

Atherosclerosis, a chronic inflammatory disorder and leading cause of cardiovascular disease, is characterized by macrophage-derived inflammation and foam cell formation. Emerging evidence suggests that metabolic reprogramming of macrophages represents a promising therapeutic approach for atherosclerosis management. In this study, the therapeutic potential of wogonin, a bioactive flavonoid isolated from Scutellaria baicalensis, in modulating macrophage metabolism and attenuating atherogenesis is investigated.

Application of the Ginsenoside Multidimensional Information Library (GinMIL) Enables Accurate Characterization of Ginsenosides from Diverse Ginseng Products and Accelerates the Discovery of New Saponin Compounds.

Accurate characterization of ginsenosides from ginseng relying on liquid chromatography-mass spectrometry (LC-MS) is challenging due to the lack of sufficient structural information. By machine learning techniques, we have established a ginsenoside multidimensional information library, namely, GinMIL, covering four dimensions of structural information of 579 ginsenosides. This work was designed to accurately characterize ginsenosides from products and to rapidly discover novel ginsenosides from flowers by ion-mobility LC/MS profiling and efficient GinMIL matching on UNIFI.

The main active components of Prunella vulgaris L. alleviate myocardial ischemia-reperfusion injury by inhibiting oxidative stress and ferroptosis via the NRF2/GPX4 pathway.

Ethnopharmacological Relevance: Prunella vulgaris L. (PV) is a widely distributed medicinal and edible plant used in traditional Chinese medicine for its anti-tumor, anti-inflammatory, anti-oxidant, hypoglycemic, and anti-hypertensive effects. Despite the numerous studies reporting on its cardiovascular protective effects, it is still unknown whether PV could relieve myocardial ischemia-reperfusion (MI/R) injury.

Software-aided efficient identification of the components of compound formulae and their metabolites in rats by UHPLC/IM-QTOF-MS and an in-house high-definition MS library: Sishen formula as a case.

Identifying the compound formulae-related xenobiotics in bio-samples is full of challenges. Conventional strategies always exhibit the insufficiencies in overall coverage, analytical efficiency, and degree of automation, and the results highly rely on the personal knowledge and experience. The goal of this work was to establish a software-aided approach, by integrating ultra-high performance liquid chromatography/ion-mobility quadrupole time-of-flight mass spectrometry (UHPLC/IM-QTOF-MS) and in-house high-definition MS library, to enhance the identification of prototypes and metabolites of the compound formulae , taking Sishen formula (SSF) as a template.

The Role of Gut Microbiome in Irritable Bowel Syndrome: Implications for Clinical Therapeutics.

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID) characterized by chronic or recurrent gastrointestinal symptoms without organic changes, and it is also a common disorder of gut-brain interaction (DGBIs).. The symptoms of IBS not only affect the quality of life for individual patients but also place a significant burden on global healthcare systems.

Tetrahydrocurcumin targets TRIP13 inhibiting the interaction of TRIP13/USP7/c-FLIP to mediate c-FLIP ubiquitination in triple-negative breast cancer.

Introduction: Triple-negative breast cancer (TNBC) has a high mortality rate and limited treatment options. Tetrahydrocurcumin (THC), a major metabolite of curcumin, has potential antitumor activities. However, the antitumor effects and mechanism of THC in TNBC remain elusive.

Circulating metabolites of Borneolum syntheticum (Bingpian) ameliorate atherosclerosis in ApoE mice via inhibiting macrophage foam-cell formation.

Translational pharmacological research on traditional medicines lays the foundation for precisely understanding how the medicines function in the body to deliver therapeutic benefits. Borneolum syntheticum (Bingpian) is commonly used in Chinese herbal medicines for coronary heart disease, but its specific cardiovascular impact remains poorly understood. Isoborneol, a constituent of Bingpian, has been found to reduce lipid accumulation in macrophages in vitro, but its oral bioavailability is limited.

Difference between real world practice and clinical research: A comparison of oropharyngeal and nasopharyngeal sampling data in influenza.

Oropharyngeal (OP) sampling is one of the most commonly used methods for respiratory sampling, but its positivity rate in real practice compared with that of nasopharyngeal (NP) sampling is not fully known. The differences between OP and NP in practice and between practice and the literature were compared. In total, 2323 positive results from 6708 patients were recorded in the laboratory test system, and 15,021 positive results from 31,333 patients were recorded in the national report.

Perilla frutescens leaf extracts alleviate acute lung injury in mice by inhibiting KAT2A.

Ethnopharmacological Relevance: Acute lung injury (ALI) can lead to respiratory failure and even death. KAT2A is a key target to suppress the development of inflammation. A herb, perilla frutescens, is an effective treatment for pulmonary inflammatory diseases with anti-inflammatory effects; however, its mechanism of action remains unclear.

Benefit delayed immunosenescence by regulating CD4T cells: A promising therapeutic target for aging-related diseases.

CD4T cells play a notable role in immune protection at different stages of life. During aging, the interaction between the body's internal and external environment and CD4T cells results in a series of changes in the CD4T cells pool making it involved in immunosenescence. Many studies have extensively examined the subsets and functionality of CD4T cells within the immune system, highlighted their pivotal role in disease pathogenesis, progression, and therapeutic interventions.

SENP1-Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling.

Myocardial infarction (MI) triggers a poor ventricular remodeling response, but the underlying mechanisms remain unclear. Here, the authors show that sentrin-specific protease 1 (SENP1) is downregulated in post-MI mice and in patients with severe heart failure. By generating cardiomyocyte-specific SENP1 knockout and overexpression mice to assess cardiac function and ventricular remodeling responses under physiological and pathological conditions.

Effect of hyperoside on osteoporosis in ovariectomized mice through estrogen receptor α/ITGβ3 signaling pathway.

Osteoporosis is a highly prevalent bone metabolic disease in menopause due to estrogen deficiency. Hyperoside is a main compound in Semen cuscutae. Our team previously reported that Semen cuscutae has anti osteoporosis effect on ovariectomized mice by inhibiting bone resorption of osteoclasts.

Effects of Multidimensional Carbon-Based Nanomaterials on the Low-Carbon and High-Performance Cementitious Composites: A Critical Review.

Cementitious composites are ubiquitous in construction, and more and more research is focused on improving mechanical properties and environmental effects. However, the jury is still out on which material can achieve low-carbon and high-performance cementitious composites. This article compares the mechanical and environmental performance of zero-dimensional fullerenes, one-dimensional carbon nanotubes (CNTs), two-dimensional graphene oxide (GO), and three-dimensional nano-graphite platelets (NGPs) on cementitious composites.