Assessing coronary artery disease severity using the TyG index in patients with LDL-C < 2.6 mmol/l.

Background: Determining the triglyceride‒glucose (TyG) index’s relationship to coronary lesions in patients with low-density lipoprotein cholesterol (LDL-C) targes will inform precision management of cardiovascular disease.

Methods: This retrospective cohort included 821 enrolled patients with LDL-C levels < 2.6 mmol/L who underwent coronary angiography at the Department of Cardiology, Tianjin Medical University General Hospital from January 2016 to February 2024.

Association between the C-reactive protein-triglyceride glucose index and new-onset coronary heart disease among metabolically heterogeneous individuals.

Background: The C-reactive protein-triglyceride glucose index (CTI) integrates inflammatory and metabolic markers and is closely associated with the incidence of coronary heart disease (CHD) and hypertension. However, its clinical utility among metabolically heterogeneous populations remains unclear. This study aims to investigate the association between CTI and new-onset CHD and to assess the potential value of combining CTI with the C-reactive protein-albumin-lymphocyte (CALLY) index in improving the identification of such clinical diagnoses.

Association of platelet to high density lipoprotein cholesterol ratio with coronary lesion severity in middle aged and elderly adults.

Unlabelled: The platelet to high-density lipoprotein cholesterol ratio (PHR) serves as a novel marker reflecting systemic inflammation and lipid metabolism. However, the correlation between PHR and coronary artery lesions severity in middle-aged and elderly individuals remains unclear. Looking into the relationship between PHR and coronary artery lesions severity was the focus of this investigation in middle-aged and elderly individuals.

Progress analysis of multi-dimensional perspective research on green ships: A knowledge graph-based approach.

With the increased global focus on environmental protection, green ships have emerged as the cornerstone to the maritime industry's long-term development. Based on the knowledge graph method, this paper uses bibliometric analysis to examine the research progress of green ships in a multidimensional perspective. Firstly, sort out the definition and connotation of green ships, and clarify their greening requirements in the whole life cycle.

Association of fibrinogen/albumin ratio and Castelli risk index 2 (CRI-2=LDL-C/HDL-C) with severity of coronary artery lesions in different glucose metabolism states.

Background: The fibrinogen to albumin ratio (FAR) is a novel inflammatory indicator correlating with the severity of coronary artery disease (CAD). An indicator of atherosclerosis is the Castelli Risk Index 2 (CRI-2=LDL-C/HDL-C). Yet, little research has focused on the link between both of indicators and CAD in different glucose metabolic states.

Correlations of pilot trainees' brainwave dynamics with subjective performance evaluations: insights from EEG microstate analysis.

Objective: This study aims to investigate the relationship between the subjective performance evaluations on pilot trainees' aircraft control abilities and their brainwave dynamics reflected in the results from EEG microstate analysis. Specifically, we seek to identify correlations between distinct microstate patterns and each dimension included in the subjective flight control evaluations, shedding light on the neurophysiological mechanisms underlying aviation expertise and possible directions for future improvements in pilot training.

Background: Proficiency in aircraft control is crucial for aviation safety and modern aviation where pilots need to maneuver aircraft through an array of situations, ranging from routine takeoffs and landings to complex weather conditions and emergencies.

Association Between Systemic Immune-Inflammatory Indices and Severity of Coronary Artery Lesions in Patients With Coronary Artery Disease in Different Glucose Metabolic States.

Background: The systemic immune-inflammatory index (SII) serves as a comprehensive indication of systemic inflammation. However, the relationship between SII and the severity of coronary artery lesions in participants with coronary artery disease (CAD) in different glucose metabolic states has not been fully elucidated.

Methods: A total of 2727 patients with CAD were enrolled between January 2018 and April 2022.

Monitoring pilot trainees' cognitive control under a simulator-based training process with EEG microstate analysis.

The objective of pilot training is to equip trainees with the knowledge, judgment, and skills to maintain control of an aircraft and respond to critical flight tasks. The present research aims to investigate changes in trainees' cognitive control levels during a pilot training process while they underwent basic flight maneuvers. EEG microstate analysis was applied together with spectral power features to quantitatively monitor trainees' cognitive control under varied flight tasks during different training sessions on a flight simulator.

Consistency of CSCO AI with Multidisciplinary Clinical Decision-Making Teams in Breast Cancer: A Retrospective Study.

Background: The Chinese Society of Clinical Oncology Artificial Intelligence System (CSCO AI) serves as a clinical decision support system developed utilizing Chinese breast cancer data. Our study delved into the congruence between breast cancer treatment recommendations provided by CSCO AI and their practical application in clinical settings.

Methods: A retrospective analysis encompassed 537 breast cancer patients treated at the Second Affiliated Hospital of Anhui Medical University between January 2017 and December 2022.

Aloe vera and tea polyphenols composite coating delays passion fruit senescence by promoting phenolic and flavonoid accumulation.

Passion fruits are highly perishable during postharvest storage and transportation, prompting the exploration of natural preservatives. This study investigates the synergistic effects of Aloe vera (ALV) and tea polyphenols (TP) coatings on quality retention, ripening modulation, and associated regulatory mechanisms in stored "golden" passion fruit (Passiflora spp.) at 10 °C.

Brown Adipose Tissue Promotes Autologous Fat Grafts Retention Possibly Through Inhibiting Wnt/β-Catenin Pathway.

Background: In plastic surgery, autologous fat grafts (AFG) play an important role because of their abundant supply, biocompatibility, and low rejection rate. However, the lower retention rate of fat grafts limits their widespread use. Brown adipose tissue (BAT) can promote angiogenesis and regulate the level of associated inflammation.

Exploring CCL11 in breast cancer: unraveling its anticancer potential and immune modulatory effects involving the Akt-S6 signaling.

Background: CCL11, a chemokine known for recruiting immune cells to the tumor microenvironment (TME), has an unclear role in the context of its expression, patient prognosis, and the presence of tumor-infiltrating immune cells (TILs) in breast cancer.

Methods: The expression of CCL11 in invasive breast cancer (BRCA) was analyzed using TCGA database. Survival curve and Cox regression analysis determined the potential of CCL11 as an independent prognostic indicator.

Pt and black phosphorus co-modified flower-like WS composites for fast NO gas detection at low temperature.

Incomplete recovery, baseline drift, and a long response time have been impeding the practical applications of transition metal dichalcogenide (TMD)-based gas sensors. Here, we report WS sensors with significantly improved gas recovery, rapid response, and negligible baseline drift by the incorporation of black phosphorus (BP) as well as the decoration of Pt to detect NO for the first time. Compared to bare WS, the BP-WS sensors show higher sensitivity, better repeatability, and more excellent selectivity towards NO at the optimal operating temperature of 50 °C.

Loosely controlled experimental EEG datasets for higher-order cognitions in design and creativity tasks.

Understanding neural mechanisms in design and creativity processes remains a challenging endeavor. To address this gap, we present two electroencephalography (EEG) datasets recorded in design and creativity experiments. We have discussed the details, similarities, differences, and corresponding cognitive tasks of the two datasets in the following sections.

The Ongoing Necessity of Sentinel Lymph Node Biopsy for cT1-2N0 Breast Cancer Patients.

Background: Recent clinical trials attempt to determine whether it is appropriate to omit axillary lymph node surgery in patients with cT1-2N0 breast cancer. The study aimed to investigate the true extent of axillary node disease in patients with clinically negative nodes and explore the differences between negative axillary ultrasound (AUS-cN0) and suspicious axillary ultrasound with negative fine-needle aspiration (FNA-cN0).

Methods: Pathologically identified T1-2 invasive breast cancer patients with clinically negative nodes were retrospectively analyzed at our center between January 2019 and December 2022.

Enhanced Beta2-band Oscillations Denote Auditory Hallucination in Schizophrenia Patients and a Monkey Model of Psychosis.

An electroencephalographic (EEG) signature of auditory hallucinations (AHs) is important for facilitating the diagnosis and treatment of AHs in schizophrenia. We recorded EEG from 25 schizophrenia patients with recurrent AHs. During the period of AHs, EEG recordings exhibited significantly elevated beta2-band power in the temporal region, as compared to those recorded in the absence of AHs or during stimulation with verbal sounds.

CD1C is associated with breast cancer prognosis and immune infiltrates.

Background: The tumor microenvironment (TME) in breast cancer plays a vital role in occurrence, development, and therapeutic responses. However, immune and stroma constituents in the TME are major obstacles to understanding and treating breast cancer. We evaluated the significance of TME-related genes in breast cancer.

1-Methylcyclopropene counteracts ethylene promotion of fruit softening and roles of MiERF2/8 and in postharvest mangoes.

Ethylene burst is an important sign of the initiation of postharvest mango ripening and softening is a typical characteristic of fruit ripening. However, the intrinsic link between ethylene release and fruit softening during ripening of postharvest mangoes is still not clear. The aim of this study was to investigate the effects of ethylene and its action inhibitor 1-methylcyclopropene (1-MCP) on fruit softening and ripening and the underlying regulatory mechanisms.

Network oscillations imply the highest cognitive workload and lowest cognitive control during idea generation in open-ended creation tasks.

Design is a ubiquitous, complex, and open-ended creation behaviour that triggers creativity. The brain dynamics underlying design is unclear, since a design process consists of many basic cognitive behaviours, such as problem understanding, idea generation, idea analysis, idea evaluation, and idea evolution. In this present study, we simulated the design process in a loosely controlled setting, aiming to quantify the design-related cognitive workload and control, identify EEG-defined large-scale brain networks, and uncover their temporal dynamics.

Long non-coding RNA SNHG8 enhances triple-negative breast cancer cell proliferation and migration by regulating the miR-335-5p/PYGO2 axis.

Background: Growing evidence has demonstrated that long non-coding RNAs (lncRNAs) can function as modulators in the development of triple-negative breast cancer (TNBC). However, the function of lncRNA small nucleolar RNA host gene 8 (SNHG8) in TNBC remains unclear. Therefore, our study aimed at investigating the role of SNHG8 in the proliferation and migration of TNBC cells.

EEG signals respond differently to idea generation, idea evolution and evaluation in a loosely controlled creativity experiment.

Many neurocognitive studies endeavor to understand neural mechanisms of basic creative activities in strictly controlled experiments. However, little evidence is available regarding the neural mechanisms of interactions between basic activities underlying creativity in such experiments. Moreover, strictly controlled experiments might limit flexibility/freedom needed for creative exploration.

Conditional loss of geranylgeranyl diphosphate synthase alleviates acute obstructive cholestatic liver injury by regulating hepatic bile acid metabolism.

Previous studies have suggested that metabolites in the mevalonate pathway are involved in hepatic bile acid metabolism, yet the details of this relationship remain unknown. In this study, we found that the hepatic farnesyl pyrophosphate (FPP) level and the ratio of FPP to geranylgeranyl pyrophosphate (GGPP) were increased in mice with acute obstructive cholestasis compared with mice that underwent a sham operation. In addition, the livers of the mice with acute obstructive cholestasis showed lower expression of geranylgeranyl diphosphate synthase (GGPPS), which synthesizes GGPP from FPP.

Effect of autogenous growth factors released from platelet concentrates on the osteogenic differentiation of periodontal ligament fibroblasts: a comparative study.

Background: Platelet concentrates have been used in tissue regeneration. The purpose of this study was to examine effects of growth factors released from leukocyte- and platelet-rich fibrin (L-PRF) and concentrated growth factor (CGF) on the osteogenic differentiation of periodontal ligament fibroblasts (PDLFs).

Methods: Leukocyte- and platelet-rich fibrins, CGFs and PDLFs were obtained from New Zealand rabbits.

Additional Diagnostic Value of Growth Differentiation Factor-15 (GDF-15) to N-Terminal B-Type Natriuretic Peptide (NT-proBNP) in Patients with Different Stages of Heart Failure.

BACKGROUND Growth differentiation factor-15 (GDF-15) is a promising biomarker of cardiac remodeling. The purpose of this study was to explore the diagnostic value of plasma GDF-15 levels in different stages of heart failure (HF) and to assess the relationship with ventricular remodeling. MATERIAL AND METHODS We enrolled 219 HF patients from the Department of Cardiology in Tianjin Union Medical Center as the HF group and 32 healthy subjects as the control group.