FEZF1-AS1 drives autophagy-mediated progression of colon cancer and reduces chemosensitivity through inhabiting the PI3K/AKT/mTOR signaling pathway.

The pathogenesis and chemoresistance mechanisms of colon cancer (CC) are still unclear. Here, we find that a long non-coding RNA (lncRNA), FEZ family zinc finger 1-antisense RNA 1 (FEZF1-AS1), is highly expressed in CC, which may be caused by the amplification mutation of FEZF1-AS1 at the gene level through bioinformatic analysis. FEZF1-AS1 has the potential to be a biomarker in the diagnosis of CC.

cTAGE5/MEA6 Regulates LBR Localization to Maintain Nuclear Envelope Integrity and Safeguard Against Aging.

cTAGE5/MEA6 plays a pivotal role in COPII complex assembly, ER-to-Golgi trafficking, and secretion. However, whether cTAGE5/MEA6 is involved in other cellular functions remains unclear. Here, we show that conditional cTAGE5 knockout results in embryonic lethality during development and premature aging in adult mice.

The relationship between exercise and the occurrence of abdominal wall complications in patients on peritoneal dialysis.

Background: The relationship between exercise and abdominal wall complications remains controversial in the general population and has rarely been studied in patients with peritoneal dialysis (PD). This study aims to investigate the association between exercise and abdominal wall complications in the PD population.

Methods: A retrospective data analysis of a prospective cohort.

cTAGE5 is essential for adipogenesis and adipose tissue development.

White adipocytes serve as primary energy reservoirs and their malfunction is linked to different metabolic disorders, yet the mechanisms underlying cellular specialization, a critical step during adipogenesis remain unknown. Here, we reveal the indispensable role of cutaneous T-cell lymphoma-associated antigen 5 (cTAGE5) in adipocyte differentiation and maturation. Conditional deletion of cTAGE5 in adipocyte precursor cells (APCs), rather than mature adipocytes, results in progressive loss of white adipose tissue and death of mice.

The predictive value of TG/HDL and TC/HDL for risk of mortality and cardiovascular events in incident peritoneal dialysis patients.

Background: This study investigated the association between triglyceride/high-density lipoprotein cholesterol (TG/HDL-C), total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C) and clinical outcomes in patients with peritoneal dialysis (PD) through the present prospective cohort study.

Methods: This study is an observational analysis based on PD Telemedicine-assisted Platform Cohort Study. The lipid data was defined as the average levels for the first 3 months after receiving PD, including TG, TG and HDL-C.

Suppression of the Transcription Factor TaDOF7.6 Enhances Photosynthesis and Energy Metabolism to Boost Wheat Yield.

Yield improvement is a key breeding objective for wheat ( L.) to ensure food security. DNA-binding with one finger (DOF) transcription factors regulate primary metabolism and abiotic stress responses; however, their role in yield-related traits in wheat remains unexplored.

The value of spectral CT quantitative parameters in predicting Ki-67 level in ovarian cancer.

Objective: The objective of this study is to evaluate the predictive value of quantitative parameters from spectral CT for Ki-67 expression in ovarian cancer (OC).

Methods: Spectral CT imaging data from 39 patients with ovarian cancer by pathology, encompassing 52 lesions overall, were collected retrospectively and split into two groups based on immunohistochemical results. Tumor solid components in arterial, venous, and delayed phases can be measured using post-processing software to obtain the quantitative parameters of spectral CT.

Discovery of ATP competitive PDHK1/2 dual inhibitors.

Multiple screening approaches were carried out to identify novel chemistry starting for Pyruvate Dehydrogenase Kinases (PDHKs) inhibitors. Through hit triaging efforts and structure-based optimization, two series of ATP competitive inhibitors with single digit nanomolar enzymatic potency for PDHK1/2 and around 10-100-fold selectivity over PDHK4/3 were discovered. Approach of covalent inhibitor was explored to successfully improve the cellular target engagement to single digit micromolar range.

Equations for estimating resting energy expenditure in patients on peritoneal dialysis.

Background: In peritoneal dialysis (PD) patients, determining energy expenditure is essential for recommending energy intake in nutrition management.

Objective: We aimed to develop and validate a resting energy expenditure (REE) equation for patients with PD and compare it to previously available REE equations in dialysis patients.

Design: This cross-sectional study enrolled 200 patients with PD from two hospitals in Beijing, China.

Predicting cadmium enrichment in crops/vegetables and identifying the effects of soil factors based on transfer learning methods.

Cadmium (Cd) is present in soils and can easily migrate into plants due to its various forms. This mobility allows it to be absorbed by plant roots and accumulate in edible parts, entering the food chain and posing health risks. In some regions, insufficient sampling and research, or the limited cultivation of specific vegetables and crops, make it challenging to gather adequate data for modeling.

A Transcriptomic Dataset of Liver Tissues from Global and Liver-Specific Bmal1 Knockout Mice.

The circadian clock regulates various physiological processes in mammals. The core circadian clock gene Bmal1 is crucial for maintaining the oscillations of the circadian clock system by controlling the rhythmic expression of numerous circadian clock-controlled genes. To explore the transcriptional changes associated with Bmal1 deletion in liver tissues, we collected liver tissues from global and liver-specific Bmal1 knockout mice, along with their respective control groups, at two circadian time points (CT2 and CT14) and used them for transcriptome sequencing analysis.

Bifunctional probe propelling multipath strand displacement amplification tandem CRISPR/Cas12a for ultrasensitive and robust assay of DNA methyltransferase activity.

Background: DNA methylation catalyzed by various DNA methyltransferases (DNA MTases) is one of the important epigenetic regulations in both eukaryotes and prokaryotes. Therefore, the detection of DNA MTase activity is a vital target and direction in the study of methylation-related diseases.

Results: In this study, an ultrasensitive and robust strategy was developed for DNA MTase activity sensing based on bifunctional probe propelling multipath strand displacement amplification and CRISPR/Cas12a techniques.

Effects of Noninvasive or Minimally Invasive Neuromodulation Techniques on Neurogenic Lower Urinary Tract Dysfunction After Spinal Cord Injury: A Network Meta-analysis.

Objective: To assess the available evidence of noninvasive or minimally invasive neuromodulation therapies in improving urodynamic outcomes, voiding diaries, and quality of life in patients with neurogenic lower urinary tract dysfunction (NLUTD) after spinal cord injury (SCI).

Data Sources: A comprehensive search of 10 databases from inception until August 30, 2023, was conducted.

Study Selection: Randomized controlled trials (RCTs) assessing the effects of conventional treatment (CT) and CT combined with sham stimulation, transcranial magnetic stimulation (TMS), sacral nerve magnetic stimulation (SNMS), TMS+SNMS, sacral pulsed electromagnetic field therapy (SPEMFT), sacral transcutaneous electrical nerve stimulation (STENS), sacral dermatomal transcutaneous electrical nerve stimulation, bladder & STENS, transcutaneous tibial nerve stimulation (TTNS), transcutaneous electrical acupoint stimulation, pelvic floor electrical stimulation, or pelvic floor biofeedback therapy on postvoid residual volume (PVR), maximum cystometric capacity (MCC), number of voids per 24 hours (V24), mean urine volume per micturition, (MUV), maximum urinary flow rate (Qmax), maximum detrusor pressure (MDP), maximum voiding volume, number of leakages per 24 hours (L24), lower urinary tract symptoms score, and SCI-quality of life (SCI-QoL) score in patients with NLUTD after SCI were included.

Sex-dependent effects of chronic jet lag on circadian rhythm and metabolism in mice.

Background: The circadian clock integrates external environmental changes into the internal physiology of organisms. Perturbed circadian clocks due to misaligned light cycles increase the risk of diseases, including metabolic disorders. However, the effects of sex differences in this context remain unclear.

p.C124W variant contributes to schizophrenia by attenuating LLPS-mediated synapse formation.

KCTD10, a member of the potassium channel tetramerization domain (KCTD) family, is implicated in neuropsychiatric disorders and functions as a substrate recognition component within the RING-type ubiquitin ligase complex. A rare de novo variant of KCTD10, p.C124W, was identified in schizophrenia cases, yet its underlying pathogenesis remains unexplored.

Distribution, transport and ecological risk prediction of organophosphate esters in China seas based on machine learning.

Organophosphate esters (OPEs), widely used globally, have been detected in significant amounts in various environmental media, raising concerns about their persistence, bioaccumulation, and associated risks. Traditional sampling and detection methods are time-consuming and labor-intensive, limiting a comprehensive understanding. This study employs Extreme Gradient Boosting (XGBoost) and Light Gradient Boosting Machine (LGBM) models, using 12 feature variables and 463 OPEs concentration data points, to investigate the distribution and ecological risk of total OPEs (T-OPEs), chlorinated alkyl OPEs (Cl-OPEs), and aryl-OPEs in seawater of China Seas.

Improvement of Photocatalytic CO Reduction with Conjugated Organic Polymers by Rational Modulation of Donor, Acceptor and Bonding Method.

The use of metal-free catalysts to convert CO into valuable chemicals is very challenging. Here, we synthesized a conjugated organic polymer (TpTf-1) featuring 2,4,6-Triphenyl-1,3,5-Triazine as the acceptor unit, triphenylamine as the donor unit, and vinylidene bond as the linkage. The local structure of donor-acceptor (D-A) forms an intramolecular electric field that can promote the separation of photogenerated electrons and charges, meanwhile, the vinylidene bond can further change the charge distribution to promote exciton dissociation.

Assessing soil remediation effect of Cr and Pb based on bioavailability using DGT, BCR and standardized determination method.

In the field of soil remediation, the importance of bioavailability of pollutants has not received adequate attention, leading to the excessive application of remediation measures. Therefore, to ensure the safe use of farmland soil, a scientific method is needed to assess labile contaminants and their translocation in plants. To evaluate soil remediation effect based on bioavailability, the concentrations of these heavy metals in soil were analyzed using by the method for total metal content, the Community Bureau of Reference (BCR) extraction, and the diffusive gradients in thin films (DGT) technique.

Treatment of nasopharyngeal carcinoma and prevention of non-alcoholic Wernicke's disease: A case report and review of literature.

Background: Wernicke encephalopathy is a neurological disorder caused by thiamine deficiency, commonly seen in alcoholic populations but also involving other circumstances that may lead to thiamine deficiency. The recognition of Wernicke encephalopathy often depends on clinicians' keen ability to detect its typical triad of features; however, most cases do not present with the full constellation of signs, which complicates the timely identification of Wernicke encephalopathy.

Case Summary: This case report describes a patient with nasopharyngeal carcinoma who developed abnormal ocular function and ataxia following concurrent chemoradiotherapy, without a history of alcohol abuse.

Effect of ginger-partitioned moxibustion combined with ringheaded thumb-tack needle stimulation on gastrointestinal reactions of malignant tumor patients undergoing chemotherapy.

Objectives: To observe the efficacy and safety of ginger-partitioned moxibustion combined with ringheaded thumb-tack needle stimulation in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV) in patients with malignant tumors.

Methods: Patients with malignant tumors and suffering from chemotherapy were randomly divided into control group (35 cases, 4 cases dropped off) and observation group (35 cases, 2 cases dropped off). The patients of the control group were treated by orally taking ondansetron hydrochloride tablets 8 mg/time, 3 times a day for 3 d, and those of the observation group treated by ginger-partitioned moxibustion combined with ringheaded thumb-tack needle stimulation of Zusanli(ST36), Neiguan(PC6), Tianshu(ST25), Zhongwan(CV12) and Guanyuan(CV4) once a day for a total of 3 d, based on the treatment of the control group.

Photochromic radical states in 3D covalent organic frameworks with zyg topology for enhanced photocatalysis.

Covalent-organic frameworks (COFs) with photoinduced donor-acceptor (D-A) radical pairs show enhanced photocatalytic activity in principle. However, achieving long-lived charge separation in COFs proves challenging due to the rapid charge recombination. Here, we develop a novel strategy by combining [6 + 4] nodes to construct -type 3D COFs, first reported in COF chemistry.