Antimicrobial drug susceptibility testing for the management of infection in personalized eradication therapy.

is a gram-negative bacterium that associated with diseases such as gastritis, peptic ulcer and gastric cancer. In recent years, various treatment options have been evaluated, such as bismuth-containing quadruple therapy, high-dose dual therapy, and the use of acid-suppressing drugs such as Vonoprazan, however, the effectiveness of eradication treatment is still dramatically decreasing due to the rising antibiotic resistance rate, and successful eradication of has become a major public health problem. Therefore a promising strategy against drug-resistant is to individualize treatment based on the outcome of antibiotic resistance.

FEZF1-AS1 drives autophagy-mediated progression of colon cancer and reduces chemosensitivity through inhabiting the PI3K/AKT/mTOR signaling pathway.

The pathogenesis and chemoresistance mechanisms of colon cancer (CC) are still unclear. Here, we find that a long non-coding RNA (lncRNA), FEZ family zinc finger 1-antisense RNA 1 (FEZF1-AS1), is highly expressed in CC, which may be caused by the amplification mutation of FEZF1-AS1 at the gene level through bioinformatic analysis. FEZF1-AS1 has the potential to be a biomarker in the diagnosis of CC.

New Directions in Urease Inhibitors: Focusing on Nickel Ions Transfer and Auxiliary Protein Interactions During Urease Maturation.

infection is closely linked to digestive diseases such as inflammation, ulceration, gastric cancer, and mucosa-associated lymphoid tissue lymphoma. Current treatment relies on antibiotic combinations, but antibiotic resistance increasingly undermines eradication efforts. Urease, a metalloenzyme secreted by , is crucial for bacterial colonization.

Knowledge and Practices of Helicobacter pylori Infection Management Among Physicians in Gansu Province, China: A Cross-Sectional Study.

Background And Aims: Physicians' knowledge and practices regarding the diagnosis, treatment, and follow-up of Helicobacter pylori (H. pylori) infection can impact the effectiveness of eradication therapy. This study aimed to investigate the current state of knowledge and practices concerning H.

Roles of the components of the -pathogenicity island encoded type IV secretion system in .

The () cytotoxin-associated gene pathogenicity island (PAI) encodes 31 genes that assemble the type IV secretion system (T4SS) apparatus, which includes structures such as the outer membrane core complex, periplasmic ring, inner membrane complex and bacterial hairs. These proteins interact with each other to inject CagA into the host gastric epithelium. There are also individual unique functions that help interfere with host cellular pathways, modulate the immune response and colonize the host for a long time.

Assessment of the quality, diagnosis, and therapeutic recommendations of clinical practice guidelines on patients with Helicobacter pylori infection: A systematic review.

We conducted this study to systematically review and assess the current clinical practice guidelines (CPGs) related to the diagnosis and treatment of Helicobacter pylori (H. pylori) infection. The aim was to evaluate the quality of these included CPGs and provide clinicians with a convenient and comprehensive reference for updating their own CPGs.

Antibiotics Resistance Prevalence of Strains in Northwest China.

Purpose: This study aims to estimate the resistance rate of () to commonly used antibiotics and analyze the potential influencing factors in northwest regions of China.

Patients And Methods: -positive patients visiting the outpatient department of multiple hospitals were enrolled in the study. Then, gastric mucosal biopsy specimens were collected for isolation, culture, and investigation of the resistance rate of to amoxicillin, metronidazole, tetracycline, levofloxacin, and clarithromycin by Epsilometer test (E-test) antibiotic susceptibility testing.

High-dose amoxicillin-proton pump inhibitor dual therapy as first-line treatment for Helicobacter pylori infection in Northwest China: A prospective, randomised controlled trial.

Aims: We aimed to assess the eradication efficacy and factors that influencing it of high-dose dual therapy (HDDT) in Gansu region, Northwest China.

Methods: A total of 216 treatment-naive patients with Helicobacter pylori infection were randomly assigned to two groups for the 14-day eradication treatment: the HDDT group (amoxicillin 750 mg q.i.