Antimicrobial drug susceptibility testing for the management of infection in personalized eradication therapy.

is a gram-negative bacterium that associated with diseases such as gastritis, peptic ulcer and gastric cancer. In recent years, various treatment options have been evaluated, such as bismuth-containing quadruple therapy, high-dose dual therapy, and the use of acid-suppressing drugs such as Vonoprazan, however, the effectiveness of eradication treatment is still dramatically decreasing due to the rising antibiotic resistance rate, and successful eradication of has become a major public health problem. Therefore a promising strategy against drug-resistant is to individualize treatment based on the outcome of antibiotic resistance.

Exposure to volatile organic compounds and sarcopenia risk in US adults based on NHANES.

This study investigates the association between volatile organic compounds (VOCs) and sarcopenia in a cohort of 3,391 U.S. participants aged 20-59 years, using NHANES data from 2011 to 2018.

New Directions in Urease Inhibitors: Focusing on Nickel Ions Transfer and Auxiliary Protein Interactions During Urease Maturation.

infection is closely linked to digestive diseases such as inflammation, ulceration, gastric cancer, and mucosa-associated lymphoid tissue lymphoma. Current treatment relies on antibiotic combinations, but antibiotic resistance increasingly undermines eradication efforts. Urease, a metalloenzyme secreted by , is crucial for bacterial colonization.

Polymorphisms of Calgranulin Genes and Ischemic Stroke in a Chinese Population.

Background: The S100/calgranulin gene appears to modulate neuroinflammation following cerebral ischemia and could be a valuable biomarker for stroke prognosis, according to growing research. This study aimed at evaluating the correlation between calgranulin gene variants and susceptibility to ischemic stroke (IS) in the Southern Chinese population.

Methods: Using an enhanced multi-temperature ligase detection reaction genotyping, 310 IS patients and 324 age-matched healthy controls were genotyped to identify five calgranulin gene variants.

microRNA-186 alleviates oxygen-glucose deprivation/reoxygenation-induced injury by directly targeting hypoxia-inducible factor-1α.

Previous studies have suggested that microRNA-186 (miR-186) can be induced under hypoxic conditions, and is associated with apoptosis. This study was undertaken to explore the exact role of this microRNA (miRNA) in the apoptotic death of neurons during cerebral ischemic/reperfusion (I/R) injury. To model cerebral ischemia/reperfusion (I/R) injuries, we utilized a transient middle cerebral artery occlusion approach in rats, as well as a model of oxygen-glucose deprivation/reoxygenation (OGD/R) in Neuro2a cells.

Identification of Circular RNA hsa_circ_0001599 as a Novel Biomarker for Large-Artery Atherosclerotic Stroke.

Circular RNAs (circRNAs) are a recently discovered noncoding RNA isoform capable of regulating neurological disease incidence. The present study was designed to characterize the circRNA expression profiles present in large-artery atherosclerosis (LAA)-type acute ischemic stroke patients and to detect biomarkers suitable for LAA-stroke detection. Using a RNA-seq-based approach, we characterized circRNA expression profiles in five LAA-stroke patients and four controls.

Genetic variants of confer risk for ischaemic stroke in the Chinese population.

Large-scale genome-wide association analyses show an association between variations and coronary risk. However, the link between variability and ischaemic stroke (IS) has yet to be determined. This study evaluated variants with respect to the risk of IS.

Association of Polymorphisms of the Matrix Metalloproteinase 9 Gene with Ischaemic Stroke in a Southern Chinese Population.

Background/aims: Matrix metalloproteinase 9 (MMP9), a potent endopeptidase degrading extracellular matrix, plays a pivotal role in the pathogenesis of ischaemic stroke (IS). The present study was undertaken to determine the association of MMP9 gene polymorphisms and the risk of IS in a southern Chinese population.

Methods: A cohort of 1274 patients and 1258 age-matched healthy controls were genotyped to detect the four MMP9 polymorphisms (rs17156, rs3787268, rs3918241 and rs3918242) using SNaPshot.

Combined effects of microcystin and nitrite on the growth, lipid peroxidation, and antioxidant responses of the freshwater rotifer Brachionus calyciflorus.

Toxicants released during the degradation of cyanobacterial blooms, such as microcystin-LR (MC-LR) and nitrite (NO-N), affect the growth of aquatic organisms. The freshwater rotifer Brachionus calyciflorus was exposed to solutions with different combined concentrations of MC-LR (0, 10, 50, 100, and 200μgL) and NO-N (0, 2, 4, 6, and 8mgL) to assess the combined effects of MC-LR and NO-N on life cycle parameters and oxidative stress. Single solutions of MC-LR 200μgL and NO-N 8mgL were toxic to rotifers.

Effects of microcystin-producing and microcystin-freeMicrocystis aeruginosa on enzyme activity and nutrient content in the rotifer Brachionus calyciflorus.

Toxic cyanobacterial blooms disrupt freshwater recreation and adversely affect zooplankton. The freshwater cyanobacterium Microcystis aeruginosa produces microcystins, which are compounds toxic to rotifers. This study evaluated the effects of M.

Life strategy and grazing intensity responses of Brachionus calyciflorus fed on different concentrations of microcystin-producing and microcystin-free Microcystis aeruginosa.

The occurrence of Microcystis blooms is a worldwide concern due to the numerous adverse effects on zooplankton. We therefore hypothesized that the cyanobacterium Microcystis aeruginosa is harmful to rotifer growth. Population and individual experiments were conducted with the same proportional volumes of Chlorella and Microcystis for given food densities.