Correction: Exercise preconditioning alleviates photothrombotic ischemic stroke in mice by orchestrating neutrophils.

[This corrects the article DOI: 10.3389/fphys.2025.

Microfluidic tesla valve sweat patch integrated smartwatch for optical continuous monitoring of glucose, oxygen, and heart rate.

Noninvasive continuous glucose monitoring (CGM) offers a promising alternative to conventional blood-based approaches for diabetes management. Among various body fluids, sweat is an attractive medium to reflect the blood glucose levels in the body. However, technical challenges for the sweat analysis persist due to the low analyte concentrations, potential contamination, and inefficient sampling.

Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer's disease.

Cellular cross-talk, mediated by membrane receptors and their ligands, is crucial for brain homeostasis and can contribute to neurodegenerative diseases such as Alzheimer's disease (AD). To find cross-talk dysregulations involved in AD, we reconstructed cross-talk networks from single-nucleus transcriptional profiles of 67 clinically and neuropathologically well-characterized controls and AD brain donors from the Knight Alzheimer Disease Research Center and the Dominantly Inherited Alzheimer Network cohorts. We predicted a role for TREM2 and additional AD risk genes mediating neuron-microglia cross-talk in AD.

Exercise preconditioning alleviates photothrombotic ischemic stroke in mice by orchestrating neutrophils.

Background: In ischemic stroke (IS) pathology, neutrophils are rapidly recruited to the infarcted brain and exacerbate tissue damage by releasing the amount of neutrophil extracellular traps (NETs). Previous studies have demonstrated that alleviating IS is associated with reduced accumulated neutrophils and NET levels. Notably, exercise preconditioning (EP) has the potential to modulate neutrophil function, thereby contributing to the amelioration of IS.

Magnetically controlled microgelbots with stem cells for the treatment of interstitial cystitis.

Stem cell therapy has been widely investigated for the treatment of chronic bladder diseases such as interstitial cystitis/bladder pain syndrome (IC/BPS). However, the delivery of stem cells into the bladder wall is limited due to the mucus layer lining the bladder wall and the frequent urination, leading to the fast clearance of stem cells from the bladder. Here, we report a soft microgelbot (μgelbot) composed of a magnetic nanochain embedded microgel in a tunable size and shape for the enhanced delivery of mesenchymal stem cells (MSCs) into the bladder wall through the mucus layer.

Identification of stroke biomarkers using proteomic profiling of extracellular vesicles derived from human blood: a preliminary study.

Introduction: Stroke is a devastating brain disease that causes extensive neurological impairment and high mortality. Rapid diagnosis and intervention of stroke are necessary to minimize neurological damage and improve recovery. Extracellular vesicles (EVs) have been identified as potential biomarkers for stroke, suggesting promising avenues for rapid diagnosis and prognostic assessments.

Multifunctional monolithic gold nanowires for wireless smart wearable personalized healthcare device.

Despite extensive investigation on soft bioelectronic systems for smart healthcare, it remains a big technical challenge to achieve robust, wireless integration of multifunctional components via monolithic patterning. Here, we developed a wireless wearable healthcare device fabricated using bulk and hollow gold nanowires (Ag@AuNW and AuHNW) with distinct electrical properties. The strain sensor based on AuHNW showed high sensitivity (ΔR/R = 773.

Mechanical properties and durability of concrete with recycled air-cooled blast furnace slag aggregates.

This study evaluated the properties of concrete in which natural coarse aggregates were replaced with 30%, 50%, or 100% air-cooled blast furnace slag (ACBFS) aggregates. At all aggregates replacement levels, concrete porosity remained below 9.55%, indicating good quality concrete.

Bulk-Rashba Effect with Suppressed Spin Relaxation in a Polar Phase of Bi In O.

The Rashba effect enables control over the spin degree of freedom, particularly in polar materials where the polar symmetry couples to Rashba-type spin splitting. The exploration of this effect, however, has been hindered by the scarcity of polar materials exhibiting the bulk-Rashba effect and rapid spin-relaxation effects dictated by the D'yakonov-Perel mechanism. Here, a polar LiNbO-type R3c phase of Bi In O with x ≈0.

TiO Nanohelices Decorated with Homogeneous Au-Core Pd-Shell Nanocatalysts for Selective Toluene Gas Detection.

The precise decoration of bimetallic nanocrystals (NCs) with uniform size and homogeneous composition on metal oxide (MOX) surfaces is crucial for developing highly sensitive and selective MOX-based gas sensors. In this study, MOX-based gas sensors are present decorated with homogeneous Au-Pd bimetallic (Au@Pd) NCs synthesized via seed-mediated sequential reduction of Au and Pd on an array of TiO nanohelices (NHs) matrix. Due to the uniform composition, size, and dispersion of the bimetallic NCs, the sensor exhibits outstanding toluene (CH) sensing performance.

Impact of carbon nanotubes on chloride diffusion in cement mortar under temperature gradient conditions.

Reinforcement corrosion induced by chloride ingress is a major durability issue in cementitious materials, particularly in harsh marine environments. Incorporating carbon nanotubes (CNTs) has emerged as a promising solution to mitigate chloride ingress. However, their performance against chloride diffusion under elevated temperatures remains unexplored.

Bioresorbable, wireless dual stimulator for peripheral nerve regeneration.

Wireless bioresorbable electrical stimulators have broad potential as therapeutic implants. Such devices operate for a clinically relevant duration and then harmlessly dissolve, eliminating the need for surgical removal. A representative application is in treating peripheral nerve injuries through targeted stimulation at either proximal or distal sites, with operation for up to one week.

Wireless Organic Light-Emitting Diode Contact Lenses for On-Eye Wearable Light Sources and Their Application to Personalized Health Monitoring.

On-eye optoelectronic systems can address unmet needs across various healthcare applications, including monitoring of physiological signals related to vision or other diseases. In this context, this work introduces wearable light sources that combine ultrathin organic light-emitting diodes (OLEDs) with contact lenses. As an illustration, we demonstrate their efficacy as a robust lighting solution for electroretinography (ERG).

Exploring the effects of aerobic and resistance exercise on mood-related symptoms and EEG activity.

Introduction: Anxiety and depression are psychiatric disorders that have a deleterious effect on human mental health. Meanwhile, various forms of exercise have been demonstrated to have beneficial effects on the reduction of symptoms of anxiety and depression. However, the disparate effects of each exercise on mood symptoms remain to be elucidated.

GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau.

Lipid dyshomeostasis and tau pathology are present in frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD). However, the relationship between lipid dyshomeostasis and tau pathology remains unclear. We report that GRAM Domain Containing 1B (GRAMD1B), a nonvesicular cholesterol transporter, is increased in excitatory neurons of human neural organoids (HNOs) with the MAPT R406W mutation.

Effect of blending GGBS and silica fume on the mechanical properties of geopolymer concrete.

This study investigates the mechanical properties of geopolymer concrete made with ground granulated blast furnace slag (GGBS) and silica fume (SF) as binders. The influence of varying binder proportions and sodium silicate-to-sodium hydroxide (SS-to-SH) ratios of 1.5 and 2.

Influence of CTG repeats from the human DM1 locus on murine gut microbiota.

Myotonic Dystrophy type 1 (DM1) is caused by a CTG repeat expansion in the 3' untranslated region of the DMPK gene. This expansion leads to the production of toxic RNA transcripts, which accumulate in the nucleus and interfere with normal RNA processing. DM1 affects a broad range of tissues and systems such as the skeletal muscle, the central nervous system, cardiac, visual, reproductive, and gastrointestinal (GI) system.

Multifunctional Photonic Nanomaterials and Devices for Digital Photomedicine via Neuro-Immune Cross-Talks.

The nervous and immune systems are closely interconnected, and influence the onset and progress of various diseases. Accordingly, understanding the interaction of the neural system and the immune system becomes very important for the treatment of intractable diseases with the analysis of therapeutic mechanisms, such as autoimmune diseases, neurodegenerative diseases, cancers, and so on. The conventional immunomodulation treatments have been mainly carried out by drug administration, but they have suffered from systemic negative side-effects with only limited effects on the specific disease.

Urease-powered nanomotor containing STING agonist for bladder cancer immunotherapy.

Most non-muscle invasive bladder cancers have been treated by transurethral resection and following intravesical injection of immunotherapeutic agents. However, the delivery efficiency of therapeutic agents into bladder wall is low due to frequent urination, which leads to the failure of treatment with side effects. Here, we report a urease-powered nanomotor containing the agonist of stimulator of interferon genes (STING) for the efficient activation of immune cells in the bladder wall.

Non-volatile magnon transport in a single domain multiferroic.

Antiferromagnets have attracted significant attention in the field of magnonics, as promising candidates for ultralow-energy carriers for information transfer for future computing. The role of crystalline orientation distribution on magnon transport has received very little attention. In multiferroics such as BiFeO the coupling between antiferromagnetic and polar order imposes yet another boundary condition on spin transport.

Customized Hydrogel Films for MicroRNA Super-Resolution Imaging in Liquid Biopsies.

Tissue biopsy for early diagnosis and monitoring comes with several challenges, such as its invasiveness, and issues related to tissue heterogeneity in sampling. To address these issues, researchers have proposed a noninvasive approach called liquid biopsy, which uses blood samples to detect specific noncoding RNA (microRNA, miRNA). However, the current process of isolating and amplifying miRNA can be time-consuming and yield nonspecific results.

Multifunctional nanomaterials for smart wearable diabetic healthcare devices.

Wearable diabetic healthcare devices have attracted great attention for real-time continuous glucose monitoring (CGM) using biofluids such as tears, sweat, saliva, and interstitial fluid via noninvasive ways. In response to the escalating global demand for CGM, these devices enable proactive management and intervention of diabetic patients with incorporated drug delivery systems (DDSs). In this context, multifunctional nanomaterials can trigger the development of innovative sensing and management platforms to facilitate real-time selective glucose monitoring with remarkable sensitivity, on-demand drug delivery, and wireless power and data transmission.