Publications by authors named "Cody T Morrison"
Copines are a family of calcium-dependent phospholipid-binding proteins found in most eukaryotic organisms. The expression of multiple copine genes is dysregulated in various types of human cancers. Yet, a common mechanistic function for copines remains enigmatic.
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- Early to mid-life traumatic brain injury (TBI) has been identified as a potential risk factor for developing Alzheimer's disease (AD) and related dementia.
- The study indicates that TBI reduces the expression of BCL2-associated athanogene 3 (BAG3), leading to a chain reaction of cognitive deficits and pathological changes in mice, including hyperphosphorylated tau accumulation and synaptic dysfunction.
- Overexpressing BAG3 specifically in neurons mitigated these AD-like symptoms, suggesting that targeting BAG3 could be a promising therapeutic approach to address TBI-induced cognitive decline.
Copines are a family of calcium-dependent membrane-binding proteins. To study these proteins, anull mutant for was created in , which has six copines genes (). During development, cells were able to aggregate, but did not form streams.
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