Refractive error after phacoemulsification combined with intraocular lens implantation in primary angle-closure glaucoma: a multifactorial analysis of biometric parameters and surgical strategies.

Purpose: This study aims to explore the factors influencing refractive error following Phacoemulsification combined with intraocular lens implantation (PE + IOL) in patients with primary angle-closure glaucoma (PACG), providing a theoretical basis for preoperative consultation and IOL power selection in clinical practice.

Methods: A retrospective analysis was conducted on 404 PACG patients from Shenzhen Eye Hospital between 2019 and 2024. Preoperative ocular biometric parameters and combined surgical approaches were evaluated using Spearman correlation, multinomial logistic regression, and receiver operating characteristic (ROC) curve analysis.

Mechanosensitive Piezo1 channel: an emerging target in demyelination disease.

Many physiological processes in the human body are initiated by mechanical signals, which are transmitted via ion channels. Piezo-type mechanosensitive ion channel component 1 (Piezo1) is a protein highly expressed in the brain, playing a critical role in sensing changes in the mechanical microenvironment. Extensive research has demonstrated that Piezo1 is an essential component for generating currents in mechanically activated cation channels.

Diagnosing pathologic myopia by identifying morphologic patterns using ultra widefield images with deep learning.

Pathologic myopia is a leading cause of visual impairment and blindness. While deep learning-based approaches aid in recognizing pathologic myopia using color fundus photography, they often rely on implicit patterns that lack clinical interpretability. This study aims to diagnose pathologic myopia by identifying clinically significant morphologic patterns, specifically posterior staphyloma and myopic maculopathy, by leveraging ultra-widefield (UWF) images that provide a broad retinal field of view.

METTL3 regulates Ambra1 expression in an m6A-YTHDF2-dependent manner to promote mantle cell lymphoma progression.

Background: Ambra1 has recently been identified as a key regulatory factor in the progression of mantle cell lymphoma (MCL). The objective of this study was to investigate the biological role and molecular mechanism of Ambra1 in MCL.

Methods: The m6A modification level of Ambra1 was detected by MeRIP-qPCR.

Associations of nontraditional lipoprotein ratios with future cardiovascular events in patients with type 2 diabetes mellitus.

Background: Patients with type 2 diabetes mellitus (T2DM) face a heightened risk of future cardiovascular events. It is therefore important to stratify these patients according to their future cardiovascular event risk to allow early intervention and improve prognosis. Recent proposals have indicated that nontraditional lipoprotein ratios may be superior predictors of cardiovascular events compared to traditional lipid parameters.

Beyond antimicrobial resistance: MATE-type efflux pump FepA contributes to flagellum formation and virulence in .

Unlabelled: is commonly found in nature and can readily contaminate various food products. Efflux pump proteins represent an essential group of proteins in bacteria, playing key roles in numerous biological processes. This study investigates the contribution of FepA to motility and virulence apart from antimicrobial resistance in .

Dimethyl fumarate abrogates hepatocellular carcinoma growth by inhibiting Nrf2/Bcl-xL axis and enhances sorafenib's efficacy.

Hepatocellular carcinoma (HCC) is characterized by poor prognosis and remains a leading cause of cancer mortality worldwide. Advanced HCC is managed with several first-line therapies, including tyrosine kinase inhibitors (TKI) and immunotherapy (mAb-PD-1 and mAb-VEGF). However, the efficacy of HCC therapeutics is often short-lived.

Lightning-induced cataract with concomitant optic nerve damage.

Lightning-induced ocular injuries are rare but potentially severe sequelae. This case report describes a 35-year-old male patient who suffered a lightning strike injury 20 years ago, resulting in traumatic cataract and optic nerve damage in his left eye. When the patient presented for consultation, he exhibited a significant decrease in left eye visual acuity.

A different finding on the role of cerebro-cerebellar RSFC in reading skills among Chinese children with developmental dyslexia.

Background: It's still unclear on the effect of the cerebellum on developmental dyslexia (DD). To narrow the gap, we compared the cerebro-cerebellar resting-state functional connectivity (RSFC) between children with and without DD, and analyzed the relationship of cerebro-cerebellar RSFC with reading skills.

Methods: 43 children with DD (32 males, mean age = 9.

Pain, lactate, and anesthetics: intertwined regulators of tumor metabolism and immunity.

Patients with advanced cancer frequently endure severe pain, which substantially diminishes their quality of life and can adversely impact survival. Analgesia, a critical modality for alleviating such pain, is now under scrutiny for its potential role in cancer progression, a relationship whose underlying mechanisms remain obscure. Emerging evidence suggests that lactate, once considered a metabolic byproduct, actively participates in the malignant progression of cancer by modulating both metabolic and immunological pathways within the tumor microenvironment.

Triglyceride-glucose related indices as predictors for major adverse cardiovascular events and overall mortality in type-2 diabetes mellitus patients.

Background: Recent studies have indicated that triglyceride glucose (TyG)-waist height ratio (WHtR) and TyG-waist circumference (TyG-WC) are effective indicators for evaluating insulin resistance. However, research on the association in TyG-WHtR, TyG-WC, and the risk and prognosis of major adverse cardiovascular events (MACEs) in type 2 diabetes mellitus (T2DM) cases are limited.

Aim: To clarify the relation in TyG-WHtR, TyG-WC, and the risk of MACEs and overall mortality in T2DM patients.

Alterations of White Matter Microstructure in Primary Aldosteronism Patients With Normal Cognitive Functioning Using Diffusion Tensor Imaging.

Objective: To detect white matter microstructural alterations in patients with primary aldosteronism (PA) with normal cognitive function using diffusion tensor imaging (DTI).

Methods: This study included PA patients and normotensive healthy controls (HCs). MRI (T1-weighted) and DTI data were collected for all participants.

LADS: a powerful vaccine platform for cancer immunotherapy and prevention.

Background: The intracellular bacterium Listeria monocytogenes is an attractive vector for cancer immunotherapy as it can effectively deliver tumor antigens to antigen-presenting cells, leading to a robust antitumor response.

Results: In this study, we developed a novel vaccine platform called Listeria-based Live Attenuated Double Substitution (LADS), which involves introducing two amino acid substitutions (N478AV479A) into the virulence factor listeriolysin O (LLO). LADS is a safe vaccine platform, with an attenuation of nearly 7000-fold, while retaining complete immunogenicity due to the absence of deletion of any virulence factors.

Association of non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio with cardiovascular outcomes in patients with type 2 diabetes mellitus: Evidence from the ACCORD cohort.

Aim: To explore the association between the non-high-density lipoprotein cholesterol (HDL-C)/HDL-C ratio (NHHR) and the risk of major adverse cardiovascular events (MACEs) and overall mortality in patients with type 2 diabetes mellitus (T2DM).

Materials And Methods: NHHR, calculated as (total cholesterol - HDL-C)/HDL-C, was evaluated in 10,188 participants. Cox proportional hazard regression models were employed to assess the association of NHHR with future risk of MACEs and overall mortality.

TRIM72 inhibits cell migration and epithelial-mesenchymal transition by attenuating FAK/akt signaling in colorectal cancer.

TRIM72 (MG53), a membrane repair protein with E3-ligase activity, plays a crucial role in colorectal cancer (CRC). This study examined TRIM72 expression in primary CRC tumors and paired liver metastases using RT-PCR. Findings revealed significantly lower TRIM72 levels in liver metastases compared to primary tumors (p < 0.

5'-nucleotidases contribute to adenosine-mediated immune evasion and virulence in a mouse model.

() is an important swine bacterial pathogen and causes human infections, leading to a wide range of diseases. However, the role of 5'-nucleotidases in its virulence remains to be fully elucidated. Herein, we identified four cell wall-anchored 5'-nucleotidases (Snts) within , named SntA, SntB, SntC, and SntD, each displaying similar domains yet exhibiting low sequence homology.

Huang-Lian-Jie-Du Decoction alleviates diabetic encephalopathy by regulating inflammation and pyroptosis via suppression of AGEs/RAGE/NF-κB pathways.

Ethnopharmacological Relevance: Cognitive dysfunction associated with diabetes, known as diabetic encephalopathy (DE), is a grave neurodegenerative condition triggered by diabetes, and persistent inflammation plays a vital role in its development. The renowned traditional Chinese medicine Huang-Lian-Jie-Du Decoction (HLJDD) is clinically proven to manage diabetes mellitus and Alzheimer's disease and is famous for its heat-clearing and detoxifying effects. However, the underlying mechanisms through which HLJDD affects DE remain to be elucidated.

A bifunctional amylopullulanase of Streptococcus suis ApuA contributes to immune evasion by interaction with host complement C3b.

The complement system is the first defense line of the immune system. However, pathogens have evolved numerous strategies to evade complement attacks. Streptococcus suis is an important zoonotic bacterium, harmful to both the pig industry and human health.

Prediction of disease progression in individuals with subjective cognitive decline using brain network analysis.

Objective: The objective of this study is to explore potential differences in brain functional networks at baseline between individuals with progressive subjective cognitive decline (P-SCD) and stable subjective cognitive decline (S-SCD), as well as to identify potential indicators that can effectively distinguish between P-SCD and S-SCD.

Methods: Alzheimer's Disease Neuroimaging Initiative (ADNI) database was utilized to enroll SCD individuals with a follow-up period of over 3 years. This study included 39 individuals with S-SCD, 15 individuals with P-SCD, and 45 cognitively normal (CN) individuals.

Characteristics of the White Matter Structural Network in Individuals with Subjective Cognitive Decline with and without Based on Graph Theory Study.

Purpose: To determine whether individuals with subjective cognitive decline (SCD) have changes in whole-brain network characteristics and intracerebral node characteristics in the structural network, and whether there is a difference between SCD with and without Apolipoprotein E4 ().

Methods: This cross-sectional study included 36 individuals without SCD without (healthy control, HC group), 21 individuals with SCD with (APOEε4+ group), and 33 individuals with SCD without (APOEε4- group). The white matter structural network was constructed using the fractional anisotropy (FA) based deterministic fiber tracking method.

Analytical validation of the DropXpert S6 system for diagnosis of chronic myelocytic leukemia.

Digital PCR is a powerful method for absolute nucleic acid quantification and is widely used in the absolute quantification of viral copy numbers, tumor marker detection, and prenatal diagnosis. However, for most of the existing droplet-based dPCR systems, the droplet generation, PCR reaction, and droplet detection are performed separately using different instruments. Making digital PCR both easy to use and practical by integrating the qPCR workflow into a superior all-in-one walkaway solution is one of the core ideas.

Protective role of hydrogen sulfide against diabetic cardiomyopathy by inhibiting pyroptosis and myocardial fibrosis.

Diabetic cardiomyopathy (DCM) contributes significantly to the heightened mortality rate observed among diabetic patients, with myocardial fibrosis (MF) being a pivotal element in the disease's progression. Hydrogen sulfide (HS) has been shown to mitigate MF, but the specific underlying mechanisms have yet to be thoroughly understood. A connection has been established between the evolution of DCM and the incidence of cardiomyocyte pyroptosis.