Central bank digital money (CBDM) uses among patrons in hospitality and tourism.

An industrial trend regarding a surging amount of attention to central bank digital money (CBDM) by government bodies and consumers has recently been observed. The aim of this study is to assess the roles of the antecedents and moderators, which include fear of missing out, confidence of CBDM in the digitalized era, and attachment to CBDM, in regards to predicting CBDM adoption within the framework of the theory of planned behavior and the five phases of the consumer adoption process in order to keep up to date with this rapidly changing industrial trend. Data sets from 515 respondents were collected for empirical analyses via an online panel survey in order to achieve the research objectives.

The Association Between Neutrophil-to-Lymphocyte Ratio, Atherogenic Index of Plasma, and Cardiovascular Disease Incidence.

With the incidence of cardiovascular disease (CVD) escalating annually, the significance of investigating the correlation between inflammatory markers and lipid-related indices, notably the neutrophil-to-lymphocyte ratio (NLR) and atherogenic index of plasma (AIP), is increasingly paramount. This study aimed to elucidate the distinct and combined roles of NLR and AIP concerning the incidence of CVD. Diagnoses of CVD were established based on self-reported standardized medical condition questionnaires from participants.

Correction: Wearable Activity Tracker-Based Interventions for Physical Activity, Body Composition, and Physical Function Among Community-Dwelling Older Adults: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

[This corrects the article DOI: 10.2196/59507.].

A crack detection model fusing local details and global context for nuclear cladding coating surfaces.

Crack detection on the surface of nuclear cladding coatings is critical for ensuring the safe operation of nuclear power plants. However, due to the imbalance between crack and background pixels, complex crack morphology, numerous interfering factors, and the subtle features of fine cracks in nuclear cladding coating surface images, the detection performance of existing methods remains unsatisfactory. To address these issues, this paper proposes a novel crack detection model for nuclear cladding coatings surfaces, named CrackCTFuse.

Tetraspanin-enriched membrane domains regulate vascular leakage by altering membrane cholesterol accessibility to balance antagonistic GTPases.

Tetraspanins affect metastasis, stemness and angiogenesis, but their roles in inflammation remain to be further clarified. Here we show that endothelial ablation of tetraspanin Cd82 markedly reduces vascular inflammation by mitigating endothelial leakage. Mechanistically, by limiting the anchorages of Cdc42 activator FARP1 and RhoA inhibitor Rnd3 to the plasma membrane (PM), CD82 confines Cdc42 but maintains RhoA activity in endothelial cells, to facilitate endothelium activation.

ASVBM: Structural variant benchmarking with local joint analysis for multiple callsets.

Accurate benchmarking of structural variant (SV) detection is essential for advancing the development and application of human whole-genome sequencing (WGS). A fundamental challenge in benchmarking SV detection results is determining whether two SVs represent the same event. Differences in the variation-awareness and strategic implementation of aligners inherently constrain SV detection algorithms that rely on alignment-based approaches.

Accelerometer-measured multidimensional physical activity patterns and physical functional decline: a prospective national cohort study of aging.

Background: Physical activity (PA) is crucial for maintaining physical function in older adults, but relationships between multidimensional PA patterns and functional decline remain unclear. This study examined associations between accelerometer-measured PA patterns and physical function decline in older adults.

Methods: We conducted a prospective cohort study with 1-year follow-up using data from 586 community-dwelling participants aged ≥65 years in the National Health and Aging Trends Study (2021-2022).

Efficacy of atorvastatin-based treatment in super-aged patients with chronic subdural hematoma: a case series and literature review.

Background: Chronic subdural hematoma (CSDH) is a common neurological disorder in the elderly, typically managed through surgical intervention; however, in patients aged 90 years and older, surgery is often not feasible due to comorbidities, anticoagulant use, and other age-related factors. This study evaluates the effects of atorvastatin, either as monotherapy or in combination with dexamethasone, in the conservative treatment of CSDH in patients over 90 years old, while also reviewing the current literature on the management of CSDH in this super-aged population.

Methods: Seventeen super-aged patients diagnosed with CSDH at our neurosurgical department between January 2017 and June 2024, who either refused or were considered unsuitable for surgery, were included in the study.

Hemoglobin-to-Red Cell Distribution Width Ratio Was Associated with Cardiovascular Diseases and Death.

The hemoglobin-to-red blood cell distribution width (RDW) ratio (HRR) reflects the status of inflammation and oxidative stress size. Previously, it has been suggested that HRR is associated with cardiovascular diseases (CVD). However, evidence has been limited for examining the association between HRR and the incidence of specific cardiovascular events (e.

Rosmarinic acid attenuates blood-brain barrier dysfunction to improve cerebral ischemia/reperfusion injury in mice.

Background: Cerebral ischemia/reperfusion (CI/R) has detrimental effects in cases of ischemic stroke. This notably triggers the blood-brain-barrier (BBB) to break. Known for its ability to provide neuroprotective benefits, rosmarinic acid (RosA) is a phenolic acid compound in the Lamiaceae family of plants.

[Effect of the Otago Exercise Program on Activities of Daily Living in Older Adults With Sarcopenia].

Objective: To explore the effects of the Otago Exercise Program (OEP) on activities of daily living, muscle strength, balance, and physical function in older adults with sarcopenia, to compare OEP with conventional exercise training, and to provide a basis for clinical rehabilitation programs for older adults with sarcopenia.

Methods: In this randomized controlled trial, 120 older adults clinically diagnosed with sarcopenia were enrolled. The participants were randomly assigned to the OEP intervention group (experimental group) and the conventional exercise intervention group (control group), with 60 in each group.

ORLA combined with telerehabilitation in patients with subacute Poststroke aphasia: a randomized controlled trial.

Oral reading for language in aphasia (ORLA) therapy coupled with telerehabilitation (TR) is a promising adjunct to treatment for aphasia. This single-center, randomized, single-blind, 6-month trial aimed to evaluate whether ORLA combined with TR demonstrates comparable efficacy to conventional ORLA offline rehabilitation for improving comprehensive language ability in subacute aphasia patients while assessing longitudinal treatment effects. Enrolled patients were randomized 1:1:1 into Group A (medium-high intensity ORLA TR), Group B (low-intensity ORLA TR), and Group C (medium-high intensity ORLA offline).

Targeting autophagy in doxorubicin-induced cardiotoxicity: A comprehensive review of scientific landscapes and therapeutic innovations.

Doxorubicin (DOX)-induced cardiotoxicity (DIC) poses a major threat to elderly cancer patients, often leading to severe cardiac dysfunction and complicating the outcome of cancer treatment. Autophagy is one of the core mechanisms of DIC and is considered a key therapeutic target. We analyzed the status of research in the field of autophagy in DIC via bibliometric methods.

T16 modulated extracellular matrix remodeling in fibroblasts via paracrine activation of TGF-β1 through M2 macrophage polarization.

Background: T16 has demonstrated significant potential for regulating extracellular matrix (ECM) remodeling by modulating immune and fibroblast functions. This study investigated how T16 influences fibroblast-mediated extracellular matrix (ECM) remodeling through macrophage polarization.

Methods: Uterosacral ligaments were collected from 15 patients with pelvic organ prolapse (POP) and 6 patients without pelvic organ prolapse (POP).

Effect of vitamin D supplementation on motor symptoms in Parkinson's disease: a meta-analysis of randomized controlled trials.

Introduction: Lower serum vitamin D levels may associate with higher motor symptom severity in Parkinson's disease (PD). This study aimed to test the efficacy of supplemental vitamin D on ameliorating motor symptoms in PD, which is the most comprehensive study to assess the relationship between vitamin D supplementation and PD motor symptoms to date.

Methods: An electronic literature search supplemented by hand searching up to Sep 2024 identified 8 randomized controlled trials involving 646 cases of PD.

The application of telmisartan in central nervous system disorders.

Telmisartan, a well-established antihypertensive drug, has shown promising therapeutic potential for a variety of central nervous system (CNS) disorders. This review outlines the fundamental characteristics of telmisartan, focusing on its dual pharmacological effects as an angiotensin II type 1 receptor (AT1R) antagonist and a peroxisome proliferator-activated receptor (PPAR) γ activator. These mechanisms underpin its neuroprotective and anti-inflammatory effects, which are essential to its therapeutic benefits in CNS diseases.

Heart failure, inflammation and exercise.

Heart failure (HF) is a condition characterized by high morbidity, mortality, and a substantial healthcare burden, in which inflammation plays a pivotal role. This review provides a comprehensive overview of inflammation in HF progression, highlighting the dynamic alterations in immune cell populations-such as monocytes/macrophages and neutrophils-and regulatory mechanisms of key signaling pathways, including JAK and NLRP3. Furthermore, the clinical relevance of inflammatory biomarkers in predicting disease prognosis is also discussed.

Comprehensive analysis of the impact of optical magnetic misalignment on the performance of the SERF co-magnetometer.

The ultra-sensitive atomic co-magnetometer based on the spin-exchange relaxation-free (SERF) regime is a valuable tool for inertial measurements and fundamental physics research. However, the optical magnetic misalignment effect is a significant source of error in SERF co-magnetometers, limiting their magnetic field suppression ability and long-term stability. This paper establishes a response model of angular velocity and magnetic field for the SERF co-magnetometer.

Stabilization of a whispering gallery mode self-injection locked laser based on phase difference control.

We investigate the application of feedback control of phase difference between the whispering gallery mode microresonator and the laser cavity, for the stabilization of self-injection locking. By analyzing the relationship between phase difference and microresonator transmitted light intensity, as well as the characteristics of selected phase shift devices and controller, the phase difference is successfully maintained at the set point. Through this phase difference control mechanism, the semiconductor laser with a high-quality microresonator coupled and connected by optical fibers exhibits a stable self-injection locking.

Unlocking the healing power of Jinhua white tea fermented by Eurotium cristatum using the unique "flowering" technology: A promising ally against inflammatory bowel disease.

White tea (WT) has been reported to confer various health benefits, but its role in inflammatory bowel disease (IBD) has not been fully investigated. Jinhua white tea (JWT), produced using the unique "flowering" technology by Eurotium cristatum, enhancing the flavor and quality of WT. Whether this new technology provides better bioactive benefits also worth further exploring.

Association Between ω-3, ω-6 Polyunsaturated Fatty Acid and Sleep Disorders: From Cross-Sectional to Mendelian Randomization Studies.

Sleep disorders are a common health problem affecting a significant proportion of the adult population. Emerging evidence suggests that dietary factors, particularly polyunsaturated fatty acid (PUFA) intake, may play a role in modulating sleep quality. This study aims to investigate the association between omega-3 (ω-3) and omega-6 (ω-6) PUFA and sleep disorders using cross-sectional survey data and data from genome-wide association studies (GWAS).

Synergistic inhibition of Maillard reaction hazards: Multifunctional hydrocolloids enable healthier air-fried beef patties with reduced heterocyclic amines and AGEs.

The growing health consciousness of consumers has led the food industry to embrace healthier cooking methods, with air frying becoming increasingly popular in households. This study investigated the dual role of 10 hydrocolloids in reducing the formation of heterocyclic amines (HAs) and advanced glycation end products (AGEs) in air-fried beef patties while preserving physicochemical and sensory qualities. Marination with hydrocolloids at concentrations of 0.

Soluble Dietary Fiber from Fermentation of Tea Residues by and the Effects on DSS-Induced Ulcerative Colitis.

Tea residues are rich in dietary fiber, most of which are insoluble dietary fiber (IDF). However, soluble dietary fiber (SDF) is reported to show a better health-promoting effect. In this paper, the () fermentation method was employed to prepare SDF from tea residues.

Identifying Key Plasma Proteins in the Onset of Parkinson's Disease: Proteome-Wide Mendelian Randomization and Single-Cell RNA Sequencing Analysis.

Currently, the pathogenesis of Parkinson's disease (PD) remains enigmatic, primarily due to the scarcity of definitive diagnostic markers, thereby hampering both diagnosis and treatment. The urgent need for accessible plasma markers and targeted therapeutic agents has prompted us to employ various methodologies. We leveraged Mendelian randomization analysis, colocalization analysis, SMR analysis, and the HEIDI test to delve into the causal relationships between 2923 plasma proteins in the UK Biobank and PD.