A 2-Methyl-Butadiene Based Probe for Enhancing Photostability and Tau Pathology Detection.

Tau PET tracers are being developed for imaging Alzheimer's disease (AD), primary tauopathies, and potentially screening of cognitively unimpaired elders. A second-generation tau tracer PM-PBB3, currently in Phase 3 clinical trials with FDA Fast Track Designation, shows promise as a broad-spectrum tau imaging agent, but is limited by photoisomerization and binding to amyloid fibrils. Herein, the study reports the development of a better tau probe, BMP-7, created by strategically introducing a methyl group at position 2 of the butadiene scaffold to enhance its chemical and biological properties.

Rare Earth Ion-Induced Functionalized Fluorescent MOF Hydrogel Patches for Monitoring Lysozyme in Tears.

A multiemission metal organic framework hydrogel (Eu-Dy MOF gels) fluorescence probe was designed and prepared as a noninvasive wearable fluorescent sensor, for visual detection of lysozyme (LZ) in human tears. Eu-Dy MOF gels were synthesized by the coordination polymerization of Eu and Dy with 5-boronobenzene-1,3-dicarboxylic acid. Under an excitation of 275 nm, the Eu-Dy MOF displayed blue fluorescence under ultraviolet light.

Supramolecular Fluorescence Probe for Rapid Visual Detection of Pyrethroid and Composite Aerogel as a Pyrethroid Vapor Sensor.

The threat of environmental and health damage using pyrethroid long-term has been of particular concern. Limited by complex current methods and limited quantification capability, achieving efficient and fast detection for pyrethroid is still challenging. Herein, we present a novel supramolecular fluorescence probe constituting albumin (ALB) and flavonoid-derived fluorophores (AFL) for the quantitative monitoring of pyrethroid.

GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy.

Neuronal hyperexcitability is a common pathophysiological feature of many neurological diseases. Neuron-glia interactions underlie this process but the detailed mechanisms remain unclear. Here, we reveal a critical role of microglia-mediated selective elimination of inhibitory synapses in driving neuronal hyperexcitability.

Glutamatergic synaptic plasticity in medial vestibular nuclei during vestibular compensation.

Vestibular compensation, the spontaneous recovery from vestibular dysfunction following unilateral vestibular loss, serves as a valuable model for investigating post-lesion plasticity in the adult central nervous system. Elucidating the mechanisms underlying vestibular compensation also offers promising therapeutic avenues for treating vestibular disorders. While most studies have focused on the dynamics of GABAergic synaptic plasticity and intrinsic cellular adaptations in the ipsilesional medial vestibular nucleus (MVN) after unilateral labyrinthectomy (UL), the role of glutamatergic synaptic plasticity in this process remains largely unexplored.

Oxytocin Improves Autistic Behaviors by Positively Shifting GABA Reversal Potential via NKCC1 in Early-Postnatal-Stage.

Accumulating evidence has identified disrupted oxytocin signaling in both autistic patients and animal models of autism. Nevertheless, the specific timing of the impact of oxytocin on social behavior has remained unclear. Using mouse strains from oxytocin-Cre mice crossed with Cre-dependent chemogenetic mice, oxytocinergic neuronal activity is selectivity manipulated during the early or late postnatal stages and revealed, for the first time, that the suppression of oxytocinergic neurons in the early rather than late postnatal stage led to the emergence of autistic-like behaviors.

N6-methyladenosine-modified circ_0000517 promotes non-small cell lung cancer metastasis via miR-1233-3p/CDH6 axis.

Circular RNAs (circRNAs) exhibit dysregulation in non-small cell lung cancer (NSCLC) and regulate the malignant biological behavior of NSCLC. The N6-methyladenosine (m6A) modification of circRNAs plays a critical role in multiple malignant tumors, and their biological relevance in NSCLC is unclear. Herein, this study was conducted to investigate the novel functional mechanism of highly expressed circ_0000517 in NSCLC by developing in vitro experiments.

The remobilization of non-structural carbohydrates stored in the capsule wall can mitigate cotton fiber strength damage caused by harvest aids.

The remobilization of stored assimilates in the capsule wall following the application of harvest aids significantly contributes to boll weight formation. However, the impact of remobilized non-structural carbohydrates (NSC) from the capsule wall on fiber strength development remains unclear. In this study, conducted during the late growth stage of cotton, we investigated how the remobilization of NSC in the capsule wall affects fiber sucrose metabolism and fiber strength after applying harvest aids.

Doping LiFePO with Al: Suppression of Anti-Site Defects and Implications for Battery Recycling.

In this study, a group of aluminum-doped lithium iron phosphate (LFP) with varying dopant concentrations (Li Al FePO/C, where = 0.01-0.03) was synthesized via a solid-state reaction.

The expression and prognostic value of in esophageal squamous cell carcinoma.

Background: Esophageal squamous cell carcinoma (ESCC) is a malignancy for which the incidence and mortality rates are among the highest worldwide. This study aimed to look for potential biomarkers that affect the prognosis of patients with ESCC.

Methods: The target gene was screened through differential expression gene analysis, cluster analysis, enrichment analysis, and construction of a protein-protein interaction (PPI) network, and then validated through clinical patient tissue RNA extraction and reverse transcription quantitative polymerase chain reaction (qRT-PCR).

Histaminergic Innervation of the Ventral Anterior Thalamic Nucleus Alleviates Motor Deficits in a 6-OHDA-Induced Rat Model of Parkinson's Disease.

The ventral anterior (VA) nucleus of the thalamus is a major target of the basal ganglia and is closely associated with the pathogenesis of Parkinson's disease (PD). Notably, the VA receives direct innervation from the hypothalamic histaminergic system. However, its role in PD remains unknown.

Ecological features and insecticide resistance of in Xi'an, a high-risk dengue transmission area in China.

Background: Dengue, a mosquito-borne viral disease, has occurred in many cities in China, and it tends to spread to higher latitudes (Huang et al., 2023). Xi'an, situated in central-west China, has witnessed an increase imported cases in the past few years, raising concerns of local dengue transmission.

Comprehensive Mapping of Cyclotides from by Using Mass Spectrometry-Based Strategy.

Cyclotides are plant cyclic peptides with exceptional stability and diverse bioactivity, making them promising candidates for biomedical applications. Therefore, the study of cyclotides has attracted increasing attention in recent years. However, the existing cyclotide detection methods face limitations in sensitivity, accuracy, and reliability.

Robot-assisted resection of ganglion cell neuroma with a diameter of 78 mm: A case report.

Rationale: Intrathoracic paragangliomas are typically found within the intricate posterior mediastinal region adjacent to the vertebrae, often presenting with substantial volume. Surgical excision of such tumors presents formidable challenges and is conventionally performed via open surgical procedures.

Patient Concerns: In this report, we present the case of a 53-year-old female patient who presented with the discovery of a left intrathoracic mass during a routine physical examination approximately 1 month prior.

Inhibiting Shuttle Effect and Dendrite Growth in Sodium-Sulfur Batteries Enabled by Applying External Acoustic Field.

The room-temperature sodium-sulfur (RT Na-S) battery is a promising alternative to traditional lithium-ion batteries owing to its abundant material availability and high specific energy density. However, the sodium polysulfide shuttle effect and dendritic growth pose significant challenges to their practical applications. In this study, we apply diverse disciplinary backgrounds to introduce a novel method to stimulate polarized BaTiO (BTO) nanoparticles on the separator.

Maternal Vitamin D3 Supplementation in an Oxidized-Oil Diet Protects Fetus from Developmental Impairment and Ameliorates Oxidative Stress in Mouse Placenta and Fetus.

Background: Fried food has increased in popularity worldwide. However, deep frying can increase the production of peroxidative toxins in food, which might be harmful to fetal development. The antioxidative effect of vitamin D3 (VD3) has been reported previously.

Suppression of excitatory synaptic transmission in the centrolateral amygdala via presynaptic histamine H3 heteroreceptors.

The central histaminergic system has a pivotal role in emotional regulation and psychiatric disorders, including anxiety, depression and schizophrenia. However, the effect of histamine on neuronal activity of the centrolateral amygdala (CeL), an essential node for fear and anxiety processing, remains unknown. Here, using immunostaining and whole-cell patch clamp recording combined with optogenetic manipulation of histaminergic terminals in CeL slices prepared from histidine decarboxylase (HDC)-Cre rats, we show that histamine selectively suppresses excitatory synaptic transmissions, including glutamatergic transmission from the basolateral amygdala, on both PKC-δ- and SOM-positive CeL neurons.

Neonatal Exposure to Polystyrene Nanoplastics Impairs Microglia-Mediated Synaptic Pruning and Causes Social Behavioral Defects in Adulthood.

The increasing prevalence and persistence of nanoplastics (NPs) have become critical environmental concerns. These particles have the potential to enter the food chain and accumulate in living organisms, which exerts their adverse effects on human health. The release of nanoparticles from feeding bottles raises concerns about potential health issues, especially for newborns exposed to NPs at the neonatal stage.

Multiemitting Ultralong Phosphorescent Carbonized Polymer Dots via Synergistic Enhancement Structure Design.

Advancing a metal-free room temperature phosphorescent (RTP) material that exhibits multicolor emission, remarkable RTP lifetime, and high quantum yield still faces the challenge of achieving intersystem crossing between singly and triplet excited states, as well as the rapid decay of triplet excited states due to nonradiative losses. In this study, a novel strategy is proposed to address these limitations by incorporating o-phenylenediamine, which generates multiple luminescent centers, and long-chain polyacrylic acid to synthesize carbonized polymer dots (CPDs). These CPDs are then embedded in a rigid BO matrix, effectively limiting nonradiative losses through the synergistic effects of polymer cross-linking and the rigid matrix.

Evolutionary analysis of SLC10 family members and insights into function and expression regulation of lamprey NTCP.

The Na ( +)-taurocholate cotransporting polypeptide (NTCP) is a member of the solute carrier family 10 (SLC10), which consists of 7 members (SLC10a1-SLC10a7). NTCP is a transporter localized to the basolateral membrane of hepatocytes and is primarily responsible for the absorption of bile acids. Although mammalian NTCP has been extensively studied, little is known about the lamprey NTCP (L-NTCP).

Exploring the neural mechanisms underlying achalasia: A study of functional connectivity and regional brain activity.

Background And Aims: The pathophysiology of achalasia, which involves central nuclei abnormalities, remains unknown. We investigated the resting-state functional MRI (rs-fMRI) features of patients with achalasia.

Methods: We applied resting-state functional MRI (rs-fMRI) to investigate the brain features in patients with achalasia (n = 27), compared to healthy controls (n = 29).

The metabolic adaptation of bile acids and cholesterol after biliary atresia in lamprey via transcriptome-based analysis.

Lamprey underwent biliary atresia (BA) at its metamorphosis stage. In contrast to patients with BA who develop progressive disease, lamprey can grow and develop normally, suggesting that lamprey has several adaptations for BA. Here we show that adaptive changes in bile acid and cholesterol metabolism are produced after lamprey BA.