Development of a novel macroscopic regulation and microscopic intervention mode nanosystem for osteoporosis treatment.

Osteoporosis is a widespread global health issue characterized by progressive bone loss and impaired regeneration, largely due to an acidic bone microenvironment that suppresses osteoblast differentiation and fails to initiate effective osteogenesis. To address these challenges, we developed a novel bone-targeted nanosystem (RE@CR) based on rare-earth upconversion/downconversion nanoparticles (RENPs), integrating macroscopic environmental modulation with precise microscopic molecular-level intervention. RE@CR utilizes CaCO to neutralize local acidity, enhance osteoblast proliferation, and release Ca to support mineralization.

Psoriatic skin-sensitive degradable mesoporous zinc phosphate microsphere as a photosensitizer in photodynamic therapy for anti-psoriasis.

Blue light will be a promising alternative for photodynamic therapy in psoriasis, but the photosensitizer in vivo remains unexplored. Mesoporous zinc phosphate microparticle (MZP) was synthesized successfully in this study, as evidenced by XPS, XRD, and nitrogen adsorption experiments. Its psoriatic skin-sensitive property was corroborated by SEM and the higher cumulative release rate of that impregnated with curcumin (Cur) and glycyrrhizic acid (GA), namely Cur-GA-MZP, at pH 5.

Light-induced charge transfer from a fullerene to a zeolitic imidazolate framework enhances alkaline electrocatalytic hydrogen production.

In the process of water electrolysis, the oxygen evolution reaction (OER) suffers from a high energy barrier, which has become a key factor restricting the large-scale commercial application of renewable energy technology. Therefore, it is necessary to develop a durable, efficient, low-cost and environmentally friendly OER electrocatalyst. In the present work, a photo-responsive fullerene (C) was encapsulated in the cavity of cobalt-containing flake-like zeolitic imidazolate framework-67 (C@F-ZIF-67).

A Multifunctional Nanoreactor-Induced Dual Inhibition of HSP70 Strategy for Enhancing Mild Photothermal/Chemodynamic Synergistic Tumor Therapy.

Mild photothermal therapy (PTT) is a spatiotemporally controllable method that utilizes the photothermal effect at relatively low temperatures (40-45 °C) to especially eliminate tumor tissues with negligible side effects on the surrounding normal tissues. However, the overexpression of heat shock protein 70 (HSP70) and limited effect of single treatment drastically impede the therapeutic efficacy. Herein, the constructed multifunctional core-shell structured Ag-Cu@SiO-PDA/GOx nanoreactors (APG NRs) that provide a dual inhibition of HSP70 strategy for the second near-infrared photoacoustic (NIR-II PA) imaging-guided combined mild PTT/chemodynamic therapy (CDT).

Dual regulation of osteosarcoma hypoxia microenvironment by a bioinspired oxygen nanogenerator for precise single-laser synergistic photodynamic/photothermal/induced antitumor immunity therapy.

The hypoxic tumor microenvironment (TME) of osteosarcoma (OS) is the Achilles' heel of oxygen-dependent photodynamic therapy (PDT), and tremendous challenges are confronted to reverse the hypoxia. Herein, we proposed a "reducing expenditure of O and broadening sources" dual-strategy and constructed ultrasmall IrO@BSA-ATO nanogenerators (NGs) for decreasing the O-consumption and elevating the O-supply simultaneously. As O NGs, the intrinsic catalase (CAT) activity could precisely decompose the overexpressed HO to produce O in situ, enabling exogenous O infusion.

A Novel Activatable Nanoradiosensitizer for Second Near-Infrared Fluorescence Imaging-Guided Safe-Dose Synergetic Chemo-Radiotherapy of Rheumatoid Arthritis.

The precise theranostics of rheumatoid arthritis (RA) remains a formidable challenge in clinical practice. Exploring novel applications of contemporary therapeutic approaches like chemo-radiotherapy is promising as a highly effective strategy for RA. Herein, a novel activatable nanoradiosensitizer-40 (denoted as IRnR-40) is developed, based on encapsulating the clinically approved drugs cisplatin (DDP) and indocyanine green (ICG) within a gelatin shell to achieve second near-infrared fluorescence (NIR-II FL) imaging-guided safe-dose synergetic chemo-radiotherapy.

Prognostic and predictive value of angiogenesis-associated serum proteins for immunotherapy in esophageal cancer.

Background: Immune checkpoint inhibitors (ICIs) have significantly improved patient survival in multiple cancers. However, therapy response in esophageal cancer is limited to subgroups of patients and clinically useful predictive biomarkers are lacking.

Methods: We collected a series of plasma samples from 91 patients with esophageal cancer before and after ICI treatment.

A Single NIR-II Laser-Triggered Self-Enhancing Photo/Enzyme-coupled Three-in-One Nanosystems for Breast Cancer Phototheranostics.

Multifunctional phototheranostics, employing precise and non-invasive techniques, is widely developed to enhance theranostic efficiency of breast cancer (BC), reduce side-effects, and improve quality of life. Integrating all phototheranostic modalities into a single photosensitizer for highly effective BC treatment is particularly challenging due to the potential inefficiency and time consumption associated with repeated switching of multiple-wavelength lasers. Herein, a novel single NIR-II laser-triggered three-in-one nanosystem(PdCu NY) is rationally designed, which enables dual-modal (NIR-II FL/NIR-II PA) imaging-guided self-enhancing photothermal-photodynamic therapy (PTT-PDT) in NIR-II window.

Statistics of fingerprint minutiae frequency and distribution based on automatic minutiae detection method.

The Daubert case in Philadelphia in 1999 caused a debate about the scientificity of fingerprint evidence. Since then, the current fingerprint identification system has been constantly challenged and questioned. Quantitative identification technology based on the statistics of fingerprint minutiae has become a new research hot spot.

Processing different types of iconicity in Chinese transferred epithet comprehension: An ERP study.

Transferred epithet can be regarded as a reflection of semantic markedness since the modifier and the modified conflict with each other and lead to semantic deviation; yet the corresponding processing mechanism is less studied. The present study examined the neurocognitive mechanism of Chinese transferred epithet comprehension by employing ERP technique from the perspective of Iconicity of Markedness. Participants were required to read materials with different types of semantic markedness, namely unmarked linguistic expression (literal sentences) and marked linguistic expression (transferred epithets), and then judge whether the targets were words or pseudo-words.

Human serum lipidomics analysis revealed glyphosate may lead to lipid metabolism disorders and health risks.

Glyphosate-based herbicides (GBH) are one of the most widely used pesticides worldwide. Industrial workers in glyphosate-based herbicides manufacture are the populations who experience long-term exposure to high glyphosate levels. The impacts of glyphosate on human health are the important public health problem of great concern.

Serological biomarkers predict immune-related adverse events and clinical benefit in patients with advanced gastrointestinal cancers.

Background: Immune checkpoint inhibitors (ICIs) have dramatically improved survival in advanced gastrointestinal (GI) cancer patients, but also resulted in immune-related adverse events (irAEs). This study aimed to evaluate serological biomarkers of irAEs and treatment response in GI cancer patients.

Patients And Methods: Metastatic GI cancer patients were enrolled between August 1, 2015, and July 31, 2017.

Discovery of potential active ingredients of Er-Zhi-Wan, a famous traditional Chinese formulation, in model rat serum for treating osteoporosis with kidney-yin deficiency by UPLC-Q/TOF-MS and molecular docking.

Er-Zhi-Wan (EZW), a classical traditional Chinese formulation, has attracted more and more attention. This study was carried out to analyze the constituents of EZW absorbed into blood and find out the potential active ingredients for treating osteoporosis (OP) with kidney-yin deficiency (KYD). The rat model of OP with KYD was achieved by ovariectomies and using the mixture of thyroxine and reserpine.

Efficacy and safety of HER2-targeted inhibitors for metastatic colorectal cancer with HER2-amplified: A meta-analysis.

Objective: To systematically evaluate the efficacy and safety of human epidermal growth factor receptor 2 (HER2)-targeted inhibitors for metastatic colorectal cancer (mCRC) with HER2-amplified.

Method: A systematic search of PubMed, Embase, Cochrane Library, Wan fang, VIP, and the CNKI database was conducted for literature published up to 28 February 2022 on the use of HER2-targeted inhibitors in the treatment of HER2-amplified mCRC. The retrieved articles were screened to determine the final inclusion of literature and extract relevant data, including the objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and incidence of serious adverse events (SAEs) (grade ≥3AEs).

Regional Lymph Node Metastasis and Axillary Surgery of Microinvasive Breast Cancer: A Population-Based Study.

Microinvasive breast cancer (MBC for short) is a rare entity with the decision of axillary surgery under debate in clinical practice. We aimed to unravel the lymph node metastasis (LNM) rate, axillary surgery, and prognosis of MBC based on 11,692 patients derived from the Surveillance Epidemiology and End Results (SEER) database between 2003 and 2015. In this retrospective study, 19.

Characteristics and Prognosis of Acquired Resistance to Immune Checkpoint Inhibitors in Gastrointestinal Cancer.

Importance: With the expanding use of immune checkpoint inhibitors (ICIs) in gastrointestinal (GI) cancer, the occurrence of acquired resistance (AR) has gradually emerged. However, the progression patterns and survival of patients with AR to ICIs are still unknown.

Objective: To explore the characteristics and prognosis of AR after ICI therapy in patients with advanced GI cancer.

The study of human serum metabolome on the health effects of glyphosate and early warning of potential damage.

Glyphosate is one of the most widely used herbicide with high efficiency, low toxicity and broad-spectrum. In recent decades, increasing evidence suggests that glyphosate may cause adverse health effects on human beings. However, until now, there is little data on the human metabolic changes.

Salidroside protects against osteoporosis in ovariectomized rats by inhibiting oxidative stress and promoting osteogenesis via Nrf2 activation.

Background: Osteoporosis (OP) is characterized as low bone mass, bone microarchitecture breakdown and bone fragility. The increase of oxidative stress could lead to breakdown in the balance of bone formation and resorption which gives rise to OP. Nrf2 is a transcription factor which takes part in oxidative stress and recently was reported that it can regulate the occurrence of OP.

Metabolomics-driven of relationships among kidney, bone marrow and bone of rats with postmenopausal osteoporosis.

As a global public health problem, postmenopausal osteoporosis (PMOP) poses a great threat to old women's health. Bone is the target organ of PMOP, and the dynamic changes of bone marrow could affect the bone status. Kidney is the main organ regulating calcium and phosphorus homeostasis.