Potential predictors of COVID-19 booster vaccine confidence among adult people: a cross-sectional analysis amid the Omicron surge in Southern Bangladesh.

Despite the therapeutic potential of the primary vaccine series, a lack of confidence in the COVID-19 booster vaccine poses a threat to public health and undermines its coverage at the national, regional, and global levels. This study aimed to understand COVID-19 booster vaccine confidence (CBVC) among Bangladeshi adults aged 18-49 and the potential predictors of CBVC. In line with STROBE guidelines, a face-to-face cross-sectional survey was conducted from June 15 to August 31, 2023 during the spread of the SARS-CoV-2 Omicron variant.

Current status and challenges in electroencephalography (EEG)-based driver fatigue detection: a comprehensive survey.

Driver fatigue is a major contributor to traffic accidents, leading to increased fatality rates and severe damage compared to incidents involving alert drivers. Electroencephalography (EEG) has emerged as a widely used method for detecting driver fatigue due to its ability to capture brain activity patterns. This survey provides a thorough analysis of devices that detect driver fatigue using EEG, analyzing existing methodologies, challenges, and future research directions.

Reliability and validity of the Bengali version of WHODAS 2.0 in individuals with spinal cord injury.

Purpose: To assesses the reliability and validity of the Bengali version of the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0, 36-item) for individuals with spinal cord injury (SCI).

CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk.

We report the results of structural, functional and genetic studies on the CD33 sialic acid- binding receptor that reveal how non-coding variants in CD33 alter risk for Alzheimer's disease (AD). The full-length CD33 isoform, whose expression is upregulated by non-coding AD-risk alleles, preferentially forms dimers at the cell surface, where they interact with AD-related proteins (clusterin and Aβ). This interaction induces CD33 inhibitory signalling and downregulates protective microglial functions including phagocytic removal of amyloid plaques.

CD33-CD45 Interaction Reveals a Mechanistic Link to Alzheimer's Disease Susceptibility.

The innate immune gene 33, encoding a myeloid inhibitory sialic acid-binding receptor, is associated with Alzheimer's disease (AD) susceptibility. The AD-associated risk variant reduces splicing of the sialic acid-binding domain and increases expression of the full-length (sialic acid-binding) CD33 isoform seven-fold compared to the protective genotype. Here we identify CD45 as an immune cell-specific sialic acid-dependent CD33 binding partner, whose phosphatase activity is inhibited by CD33.

Impact of Iterative Development and Beta-Testing on the Usability and Acceptability of a Novel Just-in-Time Adaptive Digital Physical Activity Intervention.

Background: The search for cost-effective population-based physical activity interventions continues. Therefore, we developed a novel just-in-time adaptive digital assistant supported by machine learning (ie, MoveMentor). Beta-testing is essential to evaluate both technical performance and user acceptance.

Association between adolescent pregnancy and infant mortality: a population-based study.

Background: Bangladesh continues to grapple with a persistently high infant mortality rate, currently at 38 deaths per 1,000 live births. Adolescent pregnancy poses significant health risks for both mothers and infants globally, yet its specific impact on infant mortality in Bangladesh remains underexplored. Therefore, this study aims to investigate the association between adolescent pregnancy and infant mortality in Bangladesh.

Impact of fixed phosphorus position on activity of triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.

Geranylgeranyl diphosphate synthase (GGDPS) produces the 20-carbon isoprenoid species used in protein geranylgeranylation reactions. Inhibition of GGDPS has emerged as a novel means of disrupting the activity of geranylgeranylated proteins in cancers such as myeloma and osteosarcoma. We have focused on developing a series of isoprenoid triazole bisphosphonate-based GGDPS inhibitors, demonstrating a complex structure-activity relationship (SAR), not only at the enzymatic level, but also at the cellular and whole organism levels.

Structure-activity relationship of isoprenoid triazole bisphosphonate-based geranylgeranyl diphosphate synthase inhibitors: Effects on pharmacokinetics, biodistribution, and hepatic transporters.

Geranylgeranyl diphosphate synthase produces the isoprenoid geranylgeranyl diphosphate, which is used in protein geranylgeranylation. Our previous work illustrates that geranylgeranyl diphosphate synthase inhibitors (GGSIs) disrupt Rab-mediated protein trafficking in cells, inducing the unfolded protein response pathway and apoptosis. Structure-function studies of our GGSIs, which are isoprenoid triazole bisphosphonates, have revealed a complex relationship between GGSI structure and enzymatic, cellular, and in vivo activities.

Challenges issues and future recommendations of deep learning techniques for SARS-CoV-2 detection utilising X-ray and CT images: a comprehensive review.

The global spread of SARS-CoV-2 has prompted a crucial need for accurate medical diagnosis, particularly in the respiratory system. Current diagnostic methods heavily rely on imaging techniques like CT scans and X-rays, but identifying SARS-CoV-2 in these images proves to be challenging and time-consuming. In this context, artificial intelligence (AI) models, specifically deep learning (DL) networks, emerge as a promising solution in medical image analysis.

Psychosocial wellbeing and risk perception of older adults during COVID-19 pandemic in Nigeria: perspectives on the role of social workers.

Background: The COVID-19 pandemic presented a 'double-edged sword' for older adults: not only were they more susceptible to the virus, but its broader consequences also exacerbated other challenges, particularly those related to psychosocial well-being. Limited evidence exists on how older adults perceive the pandemic and its impact on their well-being and the role of social workers in addressing these challenges, particularly in resource-limited settings like Nigeria.

Aim: This study explored older adults' perceived risks regarding COVID-19, its impact on their psychosocial well-being, and the role of social workers in addressing these challenges in Nigeria.

Preclinical pharmacokinetics, absolute bioavailability and dose proportionality evaluation of bioactive phytochemical Withanone in rats.

Withanone (WN), a bioactive phytochemical isolated from the medicinal herb Withania somnifera, has shown multiple pharmacological and therapeutic successes, including neuroprotective and anti-cancer activities. However, detailed pharmacokinetic (PK) properties of pure WN were not well defined. Pharmacokinetic (PK) characteristics, dose proportionality, and absolute bioavailability of pure WN were explored in rats using an efficient, reliable, and sensitive LC-MS/MS assay to address this gap.

The resilience of ethical assets against different uncertainty shocks.

The focus of this research is to examine the safe-haven properties of seven ethical and conventional asset classes using two sophisticated techniques: quantile coherence and Wavelet coherence. We analyze data ranging from October 3, 2011, to September 30, 2021, that encapsulates several global risk events. The results exhibit either positive or neutral associations between most assets and the Geopolitical Risk (GPR), indicating their safe haven capabilities against the GPR shocks.

Energy choices to health outcomes: A multidimensional analysis of risk in BRICS via PMG-ARDL approach.

This article employs a Panel Mean Group Autoregressive Distributed Lag (PMG-ARDL) approach to investigate the interaction between carbon dioxide (CO2) emissions, Gross Domestic Product (GDP), fossil fuel, renewable energy consumption, trade, and their collective impact on life expectancy within the BRICS nations. The research reveals compelling findings. Notably, CO2 emissions and trade openness exhibit negative and statistically significant impact on life expectancy.

Correction: Cigarette smoking and associated factors among men in five South Asian countries: A pooled analysis of nationally representative surveys.

[This corrects the article DOI: 10.1371/journal.pone.

Men's perception and participation in maternal and child health care in the field practice area of a teaching hospital: A cross-sectional study from rural Bengal.

Introduction: Participation of men in maternal and child health (MCH) is crucial for the reduction of infant and maternal mortality. MCH care services have been focused on providing information and services to women, but males' behaviour and decisions affect the health of the child and mother.

Objectives: The objectives of the study were to assess the perception and participation of males in MCH care as well as, to identify the association of their perception and participation with socio-demographic characteristics and to find out the correlation between perception and participation regarding MCH care.

COVID-19 Pandemic Increases the Risk of Anxiety and Depression among Adolescents: A Cross-Sectional Study in Rural West Bengal, India.

About 14% of adolescents experience mental illnesses globally. The rate increased after the COVID-19 pandemic. This study aimed to estimate the prevalence of COVID-related major mental illnesses (depression and anxiety) and their predictors among adolescents.

CD33 and SHP-1/ Interaction in Alzheimer's Disease.

Large-scale genetic studies have identified numerous genetic risk factors that suggest a central role for innate immune cells in susceptibility to Alzheimer's disease (AD). CD33, an immunomodulatory transmembrane sialic acid binding protein expressed on myeloid cells, was identified as one such genetic risk factor associated with Alzheimer's disease. Several studies explored the molecular outcomes of genetic variation at the locus.

Perceptions and expectations of an artificially intelligent physical activity digital assistant - A focus group study.

Artificially intelligent physical activity digital assistants that use the full spectrum of machine learning capabilities have not yet been developed and examined. This study aimed to explore potential users' perceptions and expectations of using such a digital assistant. Six 90-min online focus group meetings (n = 45 adults) were conducted.

Cushion hypothesis and credit risk: Islamic versus conventional banks from the MENA region.

Conventional banks are 'indirectly' allowed to take more risk under the shadow of sovereign guarantees. Banks commit moral hazards as any major banking crisis will be 'cushioned' by deposit insurance and bailed out using the taxpayer's money. This study offers an alternative explanation for the determinants of banks' credit risk, particularly those from the Islamic regions.