Potential predictors of COVID-19 booster vaccine confidence among adult people: a cross-sectional analysis amid the Omicron surge in Southern Bangladesh.

Despite the therapeutic potential of the primary vaccine series, a lack of confidence in the COVID-19 booster vaccine poses a threat to public health and undermines its coverage at the national, regional, and global levels. This study aimed to understand COVID-19 booster vaccine confidence (CBVC) among Bangladeshi adults aged 18-49 and the potential predictors of CBVC. In line with STROBE guidelines, a face-to-face cross-sectional survey was conducted from June 15 to August 31, 2023 during the spread of the SARS-CoV-2 Omicron variant.

Exploring the anticancer and antioxidant properties of Lagerstroemia speciosa bark extract via phytochemical and molecular docking analysis.

Lagerstroemia speciosa is traditionally used for treating diabetes and inflammation; however, its anticancer potential remains unexplored. This study assesses the antioxidant and anticancer activities of L. speciosa bark extract, with a focus on Ehrlich Ascites Carcinoma (EAC) cells in mice.

Phytochemicals of Punica granatum and their therapeutic potential: A computational approach targeting WNT signaling in colorectal cancer.

Colorectal cancer (CRC) continues to be a significant global health issue, holding the position of the third most common cause of cancer-related fatalities around the world. Aberrant activation of the WNT signaling pathway is a critical driver of CRC progression, necessitating novel therapeutic strategies. This study evaluates the chemotherapeutic potential of bioactive compounds from Punica granatum, focusing on their inhibitory effects on proteins involved in WNT signaling, including β-catenin, dishevelled, cadherin and GSK-3β.

Computational profiling of anti-inflammatory phytochemicals targeting 5-LOX and COX-2 pathways: PASS prediction, molecular docking and ADMET analysis.

This study computationally evaluates six phytochemicals (piperine, ardisiaquinone A, genistein, cianidanol, liquiritigenin, and rosmarinic acid) for their anti-inflammatory potential targeting 5-LOX and COX-2 pathways. PASS prediction analysis revealed that all phytochemicals, except piperine, met the threshold for significant anti-inflammatory activity (Pa > Pi and Pa ≥0.5).

Unveiling the biological activities of Heliotropium indicum L. plant extracts: anti-inflammatory activities, GC-MS analysis, and in-silico molecular docking.

Heliotropium indicum is well-known for its diverse medicinal properties, traditionally utilized to treat ailments such as diabetes, obesity, bacterial infections, inflammation, and diarrhea. This study aims to explore the anti-inflammatory effects of the extract using in vitro methods and to assess its drug-likeness potential using docking, PASS and ADME. Fractionations of crude methanol extract (CME) were undertaken in n-hexane (NHF), chloroform (CHF), and ethyl acetate (EAF).

Unveiling the therapeutic potential: Evaluation of anti-inflammatory and antineoplastic activity of Linn's stem bark isolate through molecular docking insights.

Linn. has traditionally been used for medicinal activity in Asia for treating various chronic diseases as well as a source of food, medicines, and other commodities. Due to the long-used history of this plant, the present study was designed to explore the , and in silico anti-inflammatory and antineoplastic properties of the methanolic extract and fractions and the pure compound isolated from the most active chloroform fraction (CHF) of the stem bark of the plant.

Anti-tumor and antioxidant activity of kaempferol-3-O-alpha-L-rhamnoside (Afzelin) isolated from Pithecellobium dulce leaves.

Background: Pithecellobium dulce (Roxb.), an evergreen medium-sized, spiny tree which have vast nutritional values and widely used in ayurvedic medicines and home remedies. The plant has also been a rich source of biologically active compounds.

A flavone from the ethyl acetate extract of leaves with DNA damage protection and antineoplastic activity.

Among the major constituents of (Family Vitaceae) leaves, phenolic and flavonoind compounds are most important for therapeutic purposes and the plant parts have been used in traditional medicine to treat several diseases for long. Thus, in order to scientifically confirm the traditional uses of the leaves, the present study was designed to investigate the efficacy of the isolated flavones against AAPH induced oxidative damage to pUC19 DNA by gel electrophoresis and antineoplastic activity was evaluated on Ehrlich ascites carcinoma (EAC) bearing Swiss albino mice by evaluating percentage inhibition of cell growth, morphological changes of EAC cells and hematological parameters of the mice. The isolation was carried out by column chromatography and structure was revealed by H-NMR and C NMR.

The protective and antioxidant effects of seeds on oxidative damage of DNA and RBC cellular membrane.

Medicinal plants are sources of antioxidant which may protect the body against oxidative stress related diseases and can be used as human food supplements. In this investigation, seeds of (M. R.

Cross-cultural adaptation and validation of revised WHO-ILAR-COPCORD core English questionnaire translated to Bangla.

Background: The Community-Oriented Program for Control of Rheumatic Diseases (COPCORD) is intended to reduce the information deficit about the epidemiology of rheumatic diseases, particularly in rural communities in high-income countries. Multiple studies have been conducted using the WHO-International League of Associations for Rheumatology (ILAR)-COPCORD core questionnaire in Bangladesh using the translated version in the Bangla language. Cross-cultural adaptation and validation of the questionnaire are important to achieve better outcomes.

Stable soliton solutions to the nonlinear low-pass electrical transmission lines and the Cahn-Allen equation.

The low-pass nonlinear electrical transmission lines and the Cahn-Allen equation are important nonlinear model equations to figure out different tangible systems, namely, electrical engineering, fluid dynamics etc. The contrivance of this study is to introduce advanced Bernoulli sub-equation function method to search for stable and effective solitary solutions of the described wave equations. Stable solitary solutions are reported as an integration of exponential functions, hyperbolic functions, etc.

The sine-Gordon expansion method for higher-dimensional NLEEs and parametric analysis.

The Estevez-Mansfield-Clarkson (EMC) equation and the (2+1)-dimensional Riemann wave (RW) equation are important mathematical models in nonlinear science, engineering and mathematical physics which have remarkable applications in the field of plasma physics, fluid dynamics, optics, image processing etc. Generally, through the sine-Gordon expansion (SGE) method only the lower-dimensional nonlinear evolution equations (NLEEs) are examined. However, the method has not yet been extended of finding solutions to the higher-dimensional NLEEs.

Evaluation of in vitro anti-inflammatory and antibacterial potential of Crescentia cujete leaves and stem bark.

Background: The various parts of Cresecentia cujete have some important biological activities. In folklore medicine leaves are used to treat hematomas, tumors and hypertension. Fruit decoction is used to treat diarrhea, stomachaches, cold, bronchitis, cough, asthma, and urethritis.

Pesticidal and pest repellency activities of rhizomes of Drynaria quercifolia (J. Smith) against Tribolium castaneum (Herbst).

Background: Tribolium castaneum (Herbst) is a harmful pest of stored grain and flour-based products in tropical and subtropical region. In the present study, rhizome of Drynaria quercifolia (J. Smith) was evaluated for pesticidal and pest repellency activities against T.

Analgesic, antibacterial and central nervous system depressant activities of Albizia procera leaves.

Objective: To ascertain analgesic, antibacterial and central nervous system (CNS) depressant activities of ethyl acetate, dichloromethane and carbon tetrachloride fractions of methanol extract of Albizia procera (A. procera) leaves.

Methods: Leaves extracts of A.

Antioxidant activities of ethanol extracts and fractions of Crescentia cujete leaves and stem bark and the involvement of phenolic compounds.

Background: Antioxidant compounds like phenols and flavonoids scavenge free radicals and thus inhibit the oxidative mechanisms that lead to control degenerative and other diseases. The aim of this study was to investigate the antioxidant activity in vitro, total phenolic and flavonoid contents in ethanol extracts and fractions of Crescentia cujete leaves and stem bark.

Methods: Crescentia cujete leaves and bark crude ethanol extract (CEE) and their partitionates petroleum ether (PEF), chloroform (CHF), ethyl acetate (EAF) and aqueous (AQF) were firstly prepared.

Studies on the anti-diarrheal properties of leaf extract of Desmodium puchellum.

Objective: To evaluate the pharmacological activity against diarrhea of methanol and petroleum ether extract of Desmodium puchellum (Family: Fabaceae) leaves.

Methods: The extract was evaluated for castor oil-induced diarrhea and enteropooling as well as intestinal motility in rats. Both of the extracts were given to the rats at 200 mg/kg orally.

Autoregulatory loop and retinoic acid repression regulate pou2/pou5f1 gene expression in the zebrafish embryonic brain.

Zebrafish pou5f1, also known as pou2, encodes a POU-family transcription factor that is transiently expressed in the prospective midbrain and anterior hindbrain during gastrulation, governing brain development. In the present study, we found that the main regulatory elements reside in the proximal upstream DNA sequence from -2.2 to -0.

Three enhancer regions regulate gbx2 gene expression in the isthmic region during zebrafish development.

In vertebrate embryos, positioning of the boundary between the midbrain and hindbrain (MHB) and subsequent isthmus formation are dependent upon the interaction between the Otx2 and Gbx genes. In zebrafish, sequential expression of gbx1 and gbx2 in the anterior hindbrain contributes to this process, whereas in mouse embryos, a single Gbx gene (Gbx2) is responsible for MHB development. In the present study, to investigate the regulatory mechanism of gbx2 in the MHB/isthmic region of zebrafish embryos, we cloned the gene and showed that its organization is conserved among different vertebrates.