The impact of probiotics on antibiotic resistance: mechanisms, food safety risks, and regulatory considerations.

Probiotics have gained a great attention due to their potential health benefits and are extensively used in food and medical sectors, including dairy food products, dietary supplements, and medicines. These beneficial microorganisms support gut health by enhancing mucosal integrity, promoting nutrient absorption, and balancing the gut microbiota. However, the misuse and overuse of antibiotics have led to the development of antibiotic resistance in gut microflora as repeated selective pressures lead to the development of resistant strains.

Unveiling the Therapeutic Potential of Hunter: Computational Approaches Shed Light on Targeting Proteins in Alzheimer's Disease.

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder, while the existing treatments primarily focus on alleviating symptoms rather than addressing the underlying pathophysiology. Seeking a safer alternative, the study explores the potential of Hunter as a promising drug lead for AD by eliciting the major signaling pathway, key players, and their interaction with phytochemicals from the plant extract. Initially, the phytochemicals in the crude extract were identified using GC-MS, and their physicochemical properties were verified using SwissADME.

Microplastic contamination in vertical water columns and fish: a comparative study between the Buriganga River and the Bay of Bengal in Bangladesh.

This study investigated microplastic (MP) contamination in freshwater and marine ecosystems in Bangladesh, focusing on the Buriganga River and the Bay of Bengal. Water and fish samples were collected, digested with HO, and analyzed using microscopy and micro-Fourier transform infrared spectroscopy for visual inspection and MP characterization. Microplastics were significantly more prevalent in the freshwater system and its fish compared to the marine environment (p ≤ 0.

Draft genome assembly of MSR2 isolated from Bangladesh.

This study reports the draft genome sequence of MSR2, a strain isolated from yogurt in Bangladesh in 2024. The genome consists of a 3,085,195 base pair chromosome assembled into 132 contigs, encoding 2,903 predicted proteins.

Plant-derived Bisphenol C is a drug candidate against infection: an in-vitro and in-silico study of (L.) Benn.

Unlabelled: (PZ) is a widely distributed medicinal herb throughout Bangladesh, especially in tribal regions. The present study focused on evaluating the bioactivity like antioxidant, cytotoxicity, anti-hemolytic activity through in-vitro assessment and predicted potential antiviral compounds against Nipah virus employing in-silico approaches from stem extract of . The bioactivities of stem extract showed potent antioxidant and anti-hemolytic activity.

Comprehensive evaluation of physico-chemical, antioxidant, and antimicrobial properties in commercial soaps: A study on bar soaps and liquid hand wash.

Soap is essentially used for various purposes. Therefore, it is important to determine the physico-chemical, antioxidant, and antimicrobial properties of soaps to evaluate their quality. The present research work focuses on 22 commercial soaps which include bar soaps (SN 1-SN 19) and liquid hand washes (SN 20-SN 22).

Improving WASH facilities and practices in Bangladeshi schools: progress and challenges from 2014 to 2018.

Background: In low- and middle-income countries like Bangladesh, inadequate water, sanitation, and hygiene (WASH) practices lead to a higher disease burden among children and hinder their academic performance. However, there have been efforts to improve WASH between 2014 and 2018.

Objectives: The study aimed to investigate changes in WASH facilities and practices in Bangladeshi schools from 2014 to 2018.

Combined antimicrobial activity of short peptide and phage-derived endolysin against antibiotic-resistant Salmonella Typhimurium.

This study was designed to evaluate the combination effects of antimicrobial peptides (FK13 and FK16) and phage-encoded endolysin (LysPB32) on the inhibition of growth of polymyxin B-resistant Salmonella Typhimurium ATCC 19585 (ST). The inhibitory effects of FK13, FK16, and LysPB32 against ST were evaluated by using antimicrobial susceptibility, membrane permeability, biofilm reduction, cross-resistance, and mutant frequency assay. The minimum inhibitory concentrations (MICs) of FK13 and FK16 treated with LysPB32 (FK13+LysPB32 and FK16+LysPB32) against ST were decreased from more than 512 to 128 μg/ml and from 64 to 32 μg/ml, respectively.

Antibacterial activity of bacteriophage-encoded endolysins against planktonic and biofilm cells of pathogenic Escherichia coli.

This study was designed to assess the possibility of using bacteriophage-encoded endolysins for controlling planktonic and biofilm cells. The endolysins, LysEP114 and LysEP135, were obtained from plasmid vectors containing the endolysin genes derived from Escherichia coli phages. The high identity (>96 %) was observed between LysEP114 and LysEP135.

Protocol for the Adolescent Menstrual Experiences and Health Cohort (AMEHC) Study in Khulna, Bangladesh: A Prospective cohort to quantify the influence of menstrual health on adolescent girls' health and education outcomes.

Background: Menstrual health is essential for gender equity and the well-being of women and girls. Qualitative research has described the burden of poor menstrual health on health and education; however, these impacts have not been quantified, curtailing investment. The Adolescent Menstrual Experiences and Health Cohort (AMEHC) Study aims to describe menstrual health and its trajectories across adolescence, and quantify the relationships between menstrual health and girls' health and education in Khulna, Bangladesh.

Intradermal Delivery of Naked mRNA Vaccines via Iontophoresis.

Messenger RNA (mRNA) vaccines against infectious diseases and for anticancer immunotherapy have garnered considerable attention. Currently, mRNA vaccines encapsulated in lipid nanoparticles are administrated via intramuscular injection using a needle. However, such administration is associated with pain, needle phobia, and lack of patient compliance.

Integrating health belief model and theory of planned behavior to assess COVID-19 vaccine acceptance among urban slum people in Bangladesh.

Introduction: The vaccination against coronavirus disease 2019 (COVID-19) has been identified as a promising strategy to reduce the severity of the pandemic. Despite the safe and effective COVID-19 vaccines, bringing socioeconomically disadvantaged people under vaccination coverage has been challenging for developing countries like Bangladesh. Therefore, this study explored the determinants of vaccine acceptance among urban slum residents of Bangladesh using the Health Belief Model (HBM) and Theory of Planned Behavior (TPB).

Astrocyte and L-lactate in the anterior cingulate cortex modulate schema memory and neuronal mitochondrial biogenesis.

Astrocyte-derived L-lactate was shown to confer beneficial effects on synaptic plasticity and cognitive functions. However, how astrocytic G signaling in the anterior cingulate cortex (ACC) modulates L-lactate levels and schema memory is not clear. Here, using chemogenetic approach and well-established behavioral paradigm, we demonstrate that astrocytic G pathway activation in the ACC causes significant impairments in flavor-place paired associates (PAs) learning, schema formation, and PA memory retrieval in rats.

Ciprofloxacin and Tetracycline Resistance Cause Collateral Sensitivity to Aminoglycosides in Typhimurium.

The objective of this study was to evaluate collateral sensitivity and cross-resistance of antibiotic-induced resistant Typhimurium to various antibiotics. . Typhimurium ATCC 19585 (ST) was exposed to ciprofloxacin, gentamicin, kanamycin, and tetracycline to induce antibiotic resistance, respectively, assigned as ST, ST, ST, and ST.

Assessment of the potential of phage-antibiotic synergy to induce collateral sensitivity in Salmonella Typhimurium.

This study was designed to evaluate the synergistic effect of phage and antibiotic on the induction of collateral sensitivity in Salmonella Typhimurium. The synergistic effects of Salmonella phage PBST32 combined with ciprofloxacin (CIP) against S. Typhimurium KCCM 40253 (ST) were evaluated using a fractional inhibitory concentration (FIC) assay.

Exogenous L-lactate administration in rat hippocampus increases expression of key regulators of mitochondrial biogenesis and antioxidant defense.

L-lactate plays a critical role in learning and memory. Studies in rats showed that administration of exogenous L-lactate into the anterior cingulate cortex and hippocampus (HPC) improved decision-making and enhanced long-term memory formation, respectively. Although the molecular mechanisms by which L-lactate confers its beneficial effect are an active area of investigations, one recent study found that L-lactate supplementation results in a mild reactive oxygen species burst and induction of pro-survival pathways.

Erratum: Chemogenetic activation of astrocytes promotes remyelination and restores cognitive deficits in visceral hypersensitive rats.

[This corrects the article DOI: 10.1016/j.isci.

Protective effects of liposomes encapsulating ferulic acid against CCl-induced oxidative liver damage rat model.

Antioxidants are useful for the treatment of oxidative stress mediated liver damage. A naturally occurring antioxidant γ-oryzanol is rapidly hydrolyzed to its active hydrophobic metabolite, ferulic acid, inside the body. Limitations associated with the hydrophobicity of ferulic acid can be overcome by encapsulating in a liposomal formulation.

Chemogenetic activation of astrocytes promotes remyelination and restores cognitive deficits in visceral hypersensitive rats.

Using a well-established chronic visceral hypersensitivity (VH) rat model, we characterized the decrease of myelin basic protein, reduced number of mature oligodendrocytes (OLs), and hypomyelination in the anterior cingulate cortex (ACC). The results of rat gambling test showed impaired decision-making, and the results of electrophysiological studies showed desynchronization in the ACC to basolateral amygdala (BLA) neural circuitry. Astrocytes release various factors that modulate oligodendrocyte progenitor cell proliferation and myelination.

Adrenergic signalling to astrocytes in anterior cingulate cortex contributes to pain-related aversive memory in rats.

Pain contains both sensory and affective dimensions. We identify the role of norepinephrine in colorectal distention (sub-threshold for acute pain) induced conditioned place avoidance and plasticity gene expression in the anterior cingulate cortex (ACC). Activating locus coeruleus (LC)-projecting ACC neurons facilitates pain-evoked aversive consolidation and memory, while inhibiting LC-projecting ACC neurons reversibly blocks it.

Psychological determinants of COVID-19 vaccine acceptance among urban slum dwellers of Bangladesh.

Introduction: Coronavirus disease 2019 (COVID-19) vaccination has emerged as a promising approach to counter the harmful impacts of the pandemic. Understanding the psychological components that may impact an individual's attitude toward COVID-19 vaccination is crucial for generating evidence-based ways to minimize vaccine hesitancy. This study determined the psychological antecedents regarding vaccine acceptance among urban slum people of Bangladesh.