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About 14% of adolescents experience mental illnesses globally. The rate increased after the COVID-19 pandemic. This study aimed to estimate the prevalence of COVID-related major mental illnesses (depression and anxiety) and their predictors among adolescents. This community-based cross-sectional study was conducted among 350 adolescents aged 10-19 years, recruited from rural communities in West Bengal, India. The study areas included 27 subcenters in the Budge Budge II Block, which comprised 191,709 population and 45,333 households. Data were collected from randomly selected households by trained research assistants through house-to-house interviews. Pretested standardized questionnaires, Patient Health Questionnaire (PHQ) for depression, Generalized Anxiety Disorder (GAD) for anxiety, and a demographic questionnaire were used for data collection. The prevalence of anxiety was 35.7% (125 out of 350), and the prevalence of depression was 30.0% (105 out of 350). Females had significantly higher scores of anxiety (6.67 ± 4.76 vs. 3.42 ± 3.17, respectively, < 0.001) and depression (5.51 ± 4.99 vs. 3.26 ± 3.86, respectively, < 0.001) compared to males. Adolescents who had COVID-19 cases or deaths in the family had significantly higher scores of anxiety and depression compared to those who did not have these events. In multivariate analysis, the statistically significant predictors of anxiety were COVID-19 death in the family, COVID-19 cases in the family, female gender, and a lower income group ( < 0.001 for all). For depression, the significant predictors included COVID-19 death in the family, COVID-19 cases in the family, female gender, a lower income group, and a higher age group in adolescents ( < 0.001 for all). Based on the study results, we recommend that immediate attention is needed for adolescents' mental health support and coping with stresses following COVID-19.
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http://dx.doi.org/10.3390/diseases12100233 | DOI Listing |
Virol Sin
September 2025
State Key Laboratory of Virology and Biosafety, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, 430072, China; Institute for Vaccine Research at Animal Bio-safety Level Ⅲ Laboratory, Wuhan University, Wuhan, 430071, China.
Since the outbreak of SARS-CoV-2 in late 2019, the cumulative number of confirmed cases worldwide has surpassed 778 million, and the number of deaths has exceeded 7 million, posing a significant threat to human life and health while inflicting enormous losses on the global economy. At the stage where sequential immunization is recommended, there is a pressing demand for mRNA vaccines that can be rapidly adapted to new sequences, are easy to industrialize, and exhibit high safety and effectiveness. We developed a lipid nanoparticle (LNP) system, designated as WNP, which facilitates essentially in situ expression at the injection site and results in lower levels of pro-inflammatory factors in the liver, thus enhancing its safety compared to liver-targeted alternatives.
View Article and Find Full Text PDFJ Infect
September 2025
Nuffield Department of Medicine, University of Oxford, Oxford, UK; The National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance at the University of Oxford, Oxford, UK; The National Institute for Health Research Oxford Bi
Objectives: Escherichia coli bacteraemias have been under mandatory surveillance in the UK for fifteen years, but cases continue to rise. Systematic searches of all features present within electronic healthcare records (EHRs), described here as an EHR-wide association study (EHR-WAS), could potentially identify under-appreciated factors that could be targeted to reduce infections.
Methods: We used data from Oxfordshire, UK, and an EHR-WAS method developed for use with large-scale COVID-19 data to estimate associations between E.
Sci Total Environ
September 2025
Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16801, USA. Electronic address:
Wastewater surveillance is increasingly an effective public health tool for responding to epidemics and preparing for annual cycles of respiratory illnesses. We measured genetic markers from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), influenza A virus (IAV) and influenza B virus (IBV) in untreated wastewater of a university campus and its local residential community over a four-year period using digital Polymerase Chain Reaction (PCR) methods. These data were then analyzed and compared to clinical case data reported to the state by zip code.
View Article and Find Full Text PDFAm J Emerg Med
August 2025
Department of Emergency and Critical Care Medicine, Hyogo Emergency Medical Center, Kobe City, Hyogo, Japan.
Background: The influence of the COVID-19 pandemic on out-of-hospital cardiac arrest (OHCA) patients who received extracorporeal pulmonary resuscitation (ECPR) has not yet been fully elucidated. We examined whether there were differences in ECPR frequency and outcomes for OHCA patients who received ECPR during the pandemic.
Methods: Using the nationwide JAAM-OHCA registry, we evaluated OHCA patients who received ECPR from 2019 to 2022.