A Safe and Broad-spectrum SARS-CoV-2 mRNA Vaccine with a New Delivery System for In-situ Expression.

Since the outbreak of SARS-CoV-2 in late 2019, the cumulative number of confirmed cases worldwide has surpassed 778 million, and the number of deaths has exceeded 7 million, posing a significant threat to human life and health while inflicting enormous losses on the global economy. At the stage where sequential immunization is recommended, there is a pressing demand for mRNA vaccines that can be rapidly adapted to new sequences, are easy to industrialize, and exhibit high safety and effectiveness. We developed a lipid nanoparticle (LNP) system, designated as WNP, which facilitates essentially in situ expression at the injection site and results in lower levels of pro-inflammatory factors in the liver, thus enhancing its safety compared to liver-targeted alternatives.

Genetically modified organisms and sustainable development goals: A survey of Taiwanese public opinion.

This study investigates public opinion of genetically modified organisms (GMOs), the role of GMOs in achieving the Sustainable Development Goals (SDGs), and economic preferences in Taiwan. A survey of 977 Taiwanese adults assessed their knowledge, attitudes, and willingness to pay (WTP) for non-GMO and organic products. The results show that while awareness of GMOs is high, there is a significant gap in understanding, as many respondents struggled with basic genetic concepts.

Integrated bioinformatics analysis to develop diagnostic models for malignant transformation of chronic proliferative diseases.

The combined analysis of dual diseases can provide new insights into pathogenic mechanisms, identify novel biomarkers, and develop targeted therapeutic strategies. Polycythemia vera (PV) is a chronic myeloproliferative neoplasm associated with a risk of acute myeloid leukemia (AML) transformation. However, the chronic nature of disease transformation complicates longitudinal high-throughput sequencing studies of patients with PV before and after AML transformation.

Association Between Hepatic Steatosis Index and Endometrial Cancer Risk: A Cross-Sectional Study.

Purpose: To investigate the relationship between hepatic steatosis index (HSI) and endometrial cancer (EC) and its diagnostic value for EC.

Patients And Methods: A total of 114 patients with pathologically diagnosed EC in Mindong Hospital, Ningde City, Fujian Province from 2016 to 2022 were retrospectively included as the EC group. A total of 175 patients with pathologically confirmed benign endometrial lesions (endometrial polyps and uterine submucosal fibroids) in the same hospital during the same period were selected as the control group.

Sociodemographic characteristics, occupational characteristics, motivational factors, and job satisfaction among primary health service practitioners.

Background: The Chinese Basic Public Health Service has achieved certain results since its implementation. As direct providers, understanding the job satisfaction and its influencing factors among basic public health service practitioners is crucial for enhancing service quality and efficiency. This study examines levels of motivational factors and their contribution to job satisfaction among community health workers in China.

Sharp-to-Broad Band Energy Transfer in Lithium Aluminate and Gallate Phosphors for SWIR LED.

Short-wave infrared (SWIR) phosphor-converted light-emitting diode (LED) technology holds promise for advancing broadband light sources. Despite the potential, limited research has delved into the energy transfer mechanism from sharp-line to broadband emission in SWIR phosphors, which remains underexplored. Herein, we demonstrate bright SWIR phosphors achieved through Cr/Ni energy transfer in LiGaAl O.

Solution-processed poly(vinylidene difluoride)/cellulose acetate/LiAlTi(PO) composite solid electrolyte for improving electrochemical performance of solid-state lithium-ion batteries at room temperature.

To enhance energy density and secure the safety of lithium-ion batteries, developing solid-state electrolytes is a promising strategy. In this study, a composite solid-state electrolyte (CSE) composed of poly(vinylidene difluoride) (PVDF)/cellulose acetate (CA) matrix, lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) salt, and LiAlTi(PO) (LATP) fillers is developed via a facile solution-casting method. The PVDF/CA ratio, LiTFSI, and LATP fractions affect the crystallinity, structural porosity, and thermal and electrochemical stability of the PVDF/CA/LATP CSE.

Role of surface-segregation-driven intermixing on the thermal transport through planar Si/Ge superlattices.

It has been highly debated whether the thermal conductivity κ of a disordered SiGe alloy can be lowered by redistributing its constituent species so as to form an ordered superlattice. By ab initio calculations backed by systematic experiments, we show that Ge segregation occurring during epitaxial growth can lead to κ values not only lower than the alloy's, but also lower than the perfect superlattice values. Thus we theoretically demonstrate that κ does not monotonically decrease as the Si- and Ge-rich regions become more sharply defined.

Formation and characterization of multilayer GeSi nanowires on miscut Si (001) substrates.

A multilayer of GeSi nanowires separated with Si spacers was readily self-assembled on miscut Si (001) substrates with 8 degrees off toward (110). The nanowires oriented along the miscut direction were very small and compactly arranged on the vicinal surface. Systematic photoluminescence (PL) spectroscopy studies were carried out on the GeSi nanowires.

Enhanced photoluminescence due to lateral ordering of GeSi quantum dots on patterned Si(001) substrates.

Multilayer ordered GeSi quantum dots (QDs) with thin Si spacers were obtained via self-assembly on pit-patterned Si(001) substrates. The lateral ordering of GeSi QDs predetermined by the periodic pit pattern results in remarkably improved size uniformity in comparison with random QDs on flat substrates. A much stronger and narrower photoluminescence (PL) peak from ordered QDs were observed than that from random ones, particularly at high excitation power.

The fabrication and application of patterned Si(001) substrates with ordered pits via nanosphere lithography.

A new scalable approach has been developed for fabricating large-scale pit patterns with controllable periodicity on Si(001) substrates. The fabrication processes start with self-assembling a monolayer of polystyrene (PS) spheres on hydrogenated Si(001) substrates. A novel net-like mask in combination of the Au pattern thermally evaporated in between the PS spheres and the Au-catalyzed SiO(2) around them is naturally formed.