Higher global diet quality score is inversely associated with risk of non-fatal cardiovascular disease and all-cause mortality in Chinese adults.

Background And Aims: Global Diet Quality Score (GDQS) is a tool for evaluating diet quality and chronic disease risk, the utility of GDQS in reducing cardiovascular disease (CVD) and mortality risk remains unclear. We examined the association between GDQS and non-fatal CVD and all-cause mortality risk among Chinese adults.

Methods And Results: We enrolled 9236 participants aged ≥18 years from the China Health and Nutrition Survey (1997-2015).

Machine learning integration of bulk and single-cell RNA-seq data reveals glycolytic heterogeneity in colorectal cancer.

As one of the most prevalent malignancies worldwide, colorectal cancer (CRC) exhibits a strong metabolic dependency on glycolysis, which fuels tumor expansion and shapes an immunosuppressive microenvironment. Despite its clinical significance, the regulatory landscape and cellular diversity of glycolytic metabolism in CRC require systematic exploration. Multi-omics datasets (bulk/scRNA-seq and spatial transcriptomics) were analyzed to quantify glycolytic signatures.

Bisphenol A increases fat mass in adipose tissue by disturbing gut microbiota-dependent bile acid metabolism and TGR5/UCP1 signaling pathways in CD-1 mice.

Disorder of gut microbiota-mediated bile acid (BA) metabolism plays a pivotal role in the pathogenesis of obesity. Our previous research showed that bisphenol A (BPA) exposure induced hepatic fat accumulation and gut microbiota dysbiosis. However, whether the gut microbiota-dependent BA metabolism alteration is involved in BPA-induced fat accumulation and obesity remains elusive.

The First Report on Agarwood Formation of (Lour.) Spreng Induced by .

(Lour.) Gilg, the exclusive botanical source of Chinese agarwood, holds significant medicinal value. This study investigated the agarwood-inducing potential of a strain obtained through prior isolation work.

Exploration of clinical pathway practice for optimization of DRG costing results based on resource consumption.

Background: China's Diagnosis-Related Groups (DRGs) payment reform focuses on clinical pathway standardization and cost accounting to optimize resource use. Mengchao Hepatobiliary Hospital (MC Hospital), a tertiary care institution and DRG pilot site, implemented a "double helix model" integrating cost accounting with clinical pathway optimization.

Methods: A retrospective analysis of data extracted from the hospital cost system was conducted in 2022 at a tertiary hospital in China.

DNA-PKcs participates in the repair of renal tubular epithelial cell injury.

Ischemia/reperfusion (I/R) injury is a major cause of acute kidney injury (AKI) and plays a central role in mediating cell damage and ultimately acute tubular necrosis. Renal proximal tubular epithelial cells (PTECs) possess intrinsic repair mechanisms, yet the molecular pathways underpinning their ability to recover after I/R injury remain incompletely understood. DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a serine/threonine kinase, is pivotal in DNA damage repair, genomic stability, cell cycle regulation, and mitochondrial dysfunction.

Comparative Efficacy and Safety of Feng's Technique versus Radiofrequency Denervation for Cervical and Lumbar Facet Joint Pain: A Retrospective Study.

Background: Facet joint-mediated pain represents a major etiology of chronic spinal pain, posing persistent challenges in clinical management. We propose a novel technique-Feng's technique-which provides a novel and effective strategy for the treatment of facet joint-related pain.

Methods: This retrospective study analyzed 221 patients with cervical and lumbar facet joint pain treated between May 2020 and December 2021.

Mechanistic insights into Shanzha Heye Jueming Yin (SZHYJMY) for MASLD: A network pharmacology and experimental study.

Ethnopharmacological Relevance: Shanzha Heye Jueming Yin (SZHYJMY), a classical herbal formula composed of Crataegi Fructus, Nelumbinis Folium, and Cassiae Semen, has been used for centuries to treat lipid metabolism disorders. Despite its historical efficacy, the molecular basis of its action on metabolic liver diseases remain poorly characterized.

Aim Of The Study: This study systematically deciphered the multi-target mechanisms of SZHYJMY against metabolic dysfunction-associated steatotic liver disease (MASLD), a global health challenge linked to dyslipidemia, inflammation, and oxidative stress.

A Long-Term Body Mass Measurement System.

Unlabelled: We propose a novel system for long-term monitoring of body mass. In this approach, a cantilever beam is placed inside a culture vial and undergoes random vibrations induced by landings. An infrared camera connected to a microcomputer records these vibrations.

Analysis of the learning curve for transvaginal natural orifice transluminal endoscopic surgery in ovarian cystectomy.

Objective: This study aimed to evaluate the learning curve for transvaginal natural orifice transluminal endoscopic surgery (vNOTES) in ovarian cystectomy and to identify perioperative factors influencing operative time.

Methods: This prospective observational study included 39 patients who underwent vNOTES ovarian cystectomy at Chengdu Women's and Children's Central Hospital between June 2022 and June 2024. Patients were grouped into two surgical phases based on the operating team's self-assessed proficiency.

Development of Cysteic Acid-Modified FAP Radioligands for Enhanced Renal Clearance: From Preclinical Optimization to First-in-Human Study.

Fibroblast activation protein (FAP)-targeting radioligands hold promise for cancer theranostics. Cyclic peptide-based DOTA-FAP-2286 radioligands have demonstrated high kidney uptake and retention, raising concerns regarding potential nephrotoxicity. Hence, we aimed to design three cysteic acid-modified FAP-targeting cyclic peptide ligands (DOTA-C1/C2/C3-FAP-2286) for reducing renal retention and optimizing pharmacokinetic properties.

Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer.

The elevated polyamines, amine-rich molecules with diverse functions in pathophysiology processes, are implicated in contributing to tumorigenesis and progression. Whether and how they affect the efficacy of chemotherapy is incompletely understood. Our screening assays reveal that the supplement with a low dose of spermidine (Spd), one of the polyamines, enhances ferroptosis in prostate cancer cells as evidenced by increased lipid peroxidation and intracellular Fe levels .

Development of innovative light-curing resin composites featuring dual hydrolysis resistance.

Objective: The present study aims to address the negative impact of oral wet environments on the performance of light-curing composite resins by developing novel light-curing resin composites featuring dual hydrolytic resistance barriers. We evaluate their mechanical properties and hydrolysis resistance compared to Z250XT.

Methods: Urushiol-modified monomer (UMM) and Glass flake-KH570 were synthesized and incorporated into resin composites.

Association between abdominal obesity and cognitive decline among Chinese middle-aged and older adults: a 10-year follow-up from CHARLS.

Introduction: The relationship between abdominal obesity and cognitive decline has controversial results, and the mediating effect of high-density lipoprotein cholesterol (HDL-C) between them remains uncertain. This study aims to explore the association between abdominal obesity and cognitive decline in middle-aged and older adults, including dose-response relationship and age differences, as well as the mediating effect of HDL-C.

Methods: Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS), involving 3,807 participants aged 45 and above from 2010 to 2020.

Transvaginal natural orifice transluminal endoscopic surgery for tubal ectopic pregnancy(vNOTESTEP): a protocol for a randomized controlled trial.

Background: Tubal ectopic pregnancy is a life-threatening condition in early pregnancy. Minimally invasive laparoscopic surgery is increasingly used for the treatment of this disease. Retrospective studies suggest that Transvaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) offers lower perioperative complications, faster recovery, and better cosmetic outcomes compared to other approaches.

Gasless vNOTES vs. traditional vNOTES for benign gynecological disease: a randomized controlled clinical trial.

Background: Gasless transvaginal natural orifice transluminal endoscopic surgery (G-vNOTES) can avoid complications related to pneumoperitoneum, but there is limited research on G-vNOTES. Here, we aimed to compare the hemodynamic profiles and outcomes of G-vNOTES with traditional vNOTES (T-vNOTES) in the treatment of patients with benign gynecologic disease.

Methods: A total of 120 patients with benign gynecologic disease were randomly assigned to G-vNOTES (n = 60) or traditional vNOTES (n = 60).

Lycopene attenuates trimethylamine-N-oxide-induced senescence in endothelial progenitor cells via the AMPK/SIRT1 pathway.

Aging-related diseases, which are associated with the senescence of endothelial progenitor cells (EPCs), are consistently accompanied by elevated levels of circulating trimethylamine-N-oxide (TMAO), a marker predictive of poor prognosis. Lycopene (Lyc) deficiency has been demonstrated to be linked to these age-related diseases. The AMPK/SIRT1 pathway plays a pivotal role in cellular senescence.

Colonization time of plastisphere drives the dynamics of organic carbon stability and microbial communities in seagrass bed sediments.

Microplastic (MP) pollution in seagrass bed ecosystems has emerged as a significant global concern. However, the effects of plastisphere formation on organic carbon pools and microbial communities in these ecosystems remain unknown. We conducted a 56-day microcosm incubation experiment to study the dynamic changes in physicochemical characteristics, organic carbon fractions and stability, and bacterial community structure in seagrass bed sediments during the plastisphere formation process for polystyrene (PS) and polylactic acid (PLA).

A new method for Tomicus classification of forest pests based on improved ResNet50 algorithm.

Tomicus is a globally significant forestry pest, with Yunnan Province in southwestern China experiencing particularly severe infestations. The morphological differences among Tomicus species are minimal, making accurate identification challenging. While traditional molecular identification and morphological recognition methods are reliable, they require specialized personnel and equipment and are time-consuming.

Impact of fixed phosphorus position on activity of triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.

Geranylgeranyl diphosphate synthase (GGDPS) produces the 20-carbon isoprenoid species used in protein geranylgeranylation reactions. Inhibition of GGDPS has emerged as a novel means of disrupting the activity of geranylgeranylated proteins in cancers such as myeloma and osteosarcoma. We have focused on developing a series of isoprenoid triazole bisphosphonate-based GGDPS inhibitors, demonstrating a complex structure-activity relationship (SAR), not only at the enzymatic level, but also at the cellular and whole organism levels.

Pregnancy outcomes following different surgical approaches for heterotopic interstitial and angular pregnancy.

Objective: To investigate the perioperative and pregnancy outcomes among different surgical approaches and methods for treating heterotopic pregnancy (HP) and to identify the risk factors for the loss of intrauterine pregnancy (IUP).

Methods: We retrospectively reviewed 59 cases of interstitial and angular HP treated surgically between 2014 and 2024 in two women's health centers in southwest China. Surgical methods included multi-port laparoscopy (MPL), transumbilical laparoendoscopic single-site surgery (TU-LESS), and conventional laparotomy (CL), along with cornual wedge resection and linear incision.

The effects of a 12-week moderate-intensity continuous training intervention on depression, anxiety, and stress in sedentary female college students: a focus on negative emotion regulation.

Objective: Moderate Intensity Continuous Training (MICT) is recognized as an effective intervention for improving negative affect. However, research on its effects across varying levels of negative mood states in sedentary female college students remains limited. This study aimed to investigate the impact of a 12-week MICT intervention on different levels of negative mood in sedentary female college students.

Cross-Domain Communication Method Based on Load Balancing for SDNs.

In multi-end-to-end path request planning, the control plane may not be able to meet all path request requirements under limited bandwidth resources. Moreover, suboptimal path planning can lead to localized network congestion, which in turn causes an overall imbalance in network load. Therefore, the multi-domain control plane needs to consider more network resource states during the path selection, such as link weights, load saturation, and resource occupancy rates, in order to select the optimal paths to maximize the satisfaction of data plane requirements while maintaining network load balance.

Effects of Heat Treatment on Physicochemical Properties of Lam. Leaf Protein.

leaves represent a novel and nutritious food. Prior research has demonstrated that leaves can elicit allergic responses in BALB/c mice. Based on these findings, further studies were conducted to investigate the effects of heat treatment on the allergenicity, particle size, zeta potential, total sulfhydryl (TSH) content, hydrophilicity and hydrophobicity, ultraviolet spectrum, and intrinsic fluorescence spectrum of leaf protein.