Cancer immunotherapy nursing care from 2004 to 2023: a bibliometric analysis.

Objective: Cancer immunotherapy has become a leading treatment, but research on nursing care specific to this field remains underexplored. This study aims to analyze global trends in cancer immunotherapy nursing care from 2004 to 2023, focusing on key aspects such as patient education, symptom management, immune-related adverse event monitoring, and psychological support.

Methods: The objective of this study was to explore global research trends in cancer immunotherapy nursing care from 2004 to 2023 through bibliometric analysis.

Multimodal rehabilitation to improve quality of life and fatigue after radiotherapy in esophageal cancer patients: a randomized trial.

Purpose: To compare the effects of nurse-led multimodal rehabilitation with conventional rehabilitation on quality of life and physical recovery during adjuvant radiotherapy for postoperative esophageal cancer.

Methods: Seventy participants were randomized into a control group (N = 35) receiving conventional care and a multimodal group (N = 35) receiving nurse-led multimodal rehabilitation. Outcomes including quality of life, dyspnea index, fatigue, sleep quality, nutrition, anxiety, and depression status were recorded before the start of radiotherapy (T0), after completion of radiotherapy (T1), and 6 months (T2) and 12 months (T3) after completion of radiotherapy.

Volatilomics and Lipidomics revealed flavoring mechanism in baijiu brewed from diverse Sorghum varieties.

Sorghum is crucial in Baijiu brewing. Previous studies have shown that glutinous sorghum (LS) and non-glutinous sorghum (FS) significantly affect Zaopei's lipid metabolism and lipids affect flavor perception. This study aimed to explore the quality differences in Baijiu brewed with different sorghum varieties and the effects of lipids.

Synchronous production of bioethanol and short-chain fatty acids associated with microbial mechanisms via the short-term cultivation of waste molasses inoculated with Aspergillus oryzae.

This study proposes a novel approach for the concurrent production of short-chain fatty acids (SCFAs) and bioethanol, during a 96 h cultivation of waste molasses (with direct air exposure) inoculated with Aspergillus oryzae using vermiculite as a carrier. Results showed that fungal-bacterial symbiotes were formed by enriching acidogens for the bioconversion of SCFAs, such as Enterococcus, Bacillus and Pseudomonas and bioethanol producers, like Klebsiella, Candida tropicalis, Aspergillus oryzae and Barnettozyma californica. The Aspergillus oryzae was found to play various diverse roles during the short-term cultivation process, secreting hydrolase (i.

Attitude changes of cancer pain and opioids among cancer patients: a cross-sectional study spanning a decade.

Objectives: A comprehensive understanding of attitudes and changes in attitudes towards cancer pain and opioid analgesics among cancer patients can help healthcare professionals to provide more targeted and effective health education to improve the quality of care and health education for patients with cancer pain.

Methods: A cross-sectional study was conducted from January 2013 to December 2013 and from January 2023 to December 2023, respectively. Questionnaires were used to collect data, including the clinical characteristics of patients and their perspectives on cancer pain and opioids.

Noise exposure, hearing loss and cognitive impairment: a cross-sectional study based on an occupational health surveillance cohort in China.

Background: High-intensity noise is associated with noise-induced hearing loss (NIHL). There is also evidence that noise exposure is related to cognitive impairment. This research aimed to analyze the associations and potential pathways of cumulative noise exposure (CNE), hearing loss and cognitive impairment.

Influence of two sorghum varieties on metabolic factors, microbial community, and flavor component precursors of strong-flavor Baijiu Zaopei.

As the primary raw material for Baijiu brewing, sorghum variety exerts an intricate influence on the taste profile of strong-flavor Baijiu. However, how sorghum variety comprehensively affects Baijiu flavor formation through fermentation by microorganisms and metabolites remains largely unknown. Using 16S&ITS rRNA gene sequencing and non-targeted metabolomics, in this study we comprehensively analyzed the changes in microbial communities and metabolites during fermentation of a glutinous and non-glutinous sorghum variety.

Second-line treatment of PD-1 and CTLA-4 blockade combined with liposomal irinotecan plus leucovorin and fluorouracil for advanced cholangiocarcinoma: study protocol of a single-arm, prospective phase II trial.

Background: Cholangiocarcinoma is a kind of malignant tumor that originates in the epithelium of the biliary tract. Although there are several options for second-line treatment for patients without specific genetic mutations, the overall treatment efficacy is disappointing. Second-line treatment which is composed of liposomal irinotecan plus fluorouracil and leucovorin significantly improved the treatment efficacy for advanced biliary tract cancer and extended patient survival.

Relationship between perceived organisational support, self-efficacy, proactive personality and career self-management among nurses: a moderated mediation analysis.

Objectives: Career self-management is believed to be a critical behaviour in the new career era. However, the underlying mechanisms that stimulate nurses' career self-management are unclear. The aim of this study was to examine the mediating effect of self-efficacy and the moderating effect of proactive personality on the relationship between perceived organisational support and career self-management among nurses.

Modulation of active center distance of hybrid perovskite for boosting photocatalytic reduction of carbon dioxide to ethylene.

Solar-driven photocatalytic CO reduction is an energy-efficient and sustainable strategy to mitigate CO levels in the atmosphere. However, efficient and selective conversion of CO into multi-carbon products, like CH, remains a great challenge due to slow multi-electron-proton transfer and sluggish C-C coupling. Herein, a two-dimensional thin-layered hybrid perovskite is fabricated through filling of oxygen into iodine vacancy in pristine DMASnI (DMA = dimethylammonium).

Transmission characteristics of vortex frozen waves in different obstacle channels.

The obstacle in a channel is a typical scenario for free-space optical (FSO) communications, however, it will destroy the information in channels, especially for the orbital angular momentum (OAM) multiplexing systems and cause performance degradation. Motivated by the feature of predefining intensity profile, here we propose to use frozen wave (FW) carrying OAM for the FSO communications to mitigate the influence of obstacles on the beam propagation. The key idea is to design the longitudinal intensity profile of FW to distribute the beam energy of the location where the obstacle exists over a large region and focus again on the central region after the obstacle for propagation.

Hydrogen-substituted graphdiyne encapsulated cuprous oxide photocathode for efficient and stable photoelectrochemical water reduction.

Photoelectrochemical (PEC) water splitting is an appealing approach for "green" hydrogen generation. The natural p-type semiconductor of CuO is one of the most promising photocathode candidates for direct hydrogen generation. However, the CuO-based photocathodes still suffer severe self-photo-corrosion and fast surface electron-hole recombination issues.

Peritoneal carcinomatosis with intraperitoneal immunotherapy: current treatment options and perspectives.

Introduction: Peritoneal carcinomatosis (PC) is an advanced malignancy that is not sensitive to systemic conventional chemotherapy. Treatment options for PC are usually palliative rather than curative. Cytoreductive surgery and hyperthermic intraperitoneal (IP) chemotherapy are associated with limited efficacy in patients with PC.

Case report: Long-term partial response of apatinib plus paclitaxel as second-line therapy in a patient with metastatic gastric cancer.

Gastric cancer is the second most prevalent cancer and the second leading cause of cancer-related death in China. The prognosis of metastatic gastric cancer is poor with a median overall survival of 8-10 months. Apatinib, an oral small-molecule, selective vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, is approved as third-line or subsequent therapy for gastric cancer in China.

A cross-scale study on the relationship between urban expansion and ecosystem services in China.

Clarifying the relationship between urban expansion and ecosystem services (ESs) is critical for sustainable management of land resources and ecosystems. However, little is known about the relationship between the two at the cross-scale (particularly at the national-provincial scale). Therefore, we conducted a systematic assessment of the spatiotemporal dynamics and the relationship between urban expansion and ESs including food production (FP), soil conservation (SC), carbon sequestration (CS), and water yield (WY) in China from 1992 to 2020 on the national-provincial scale.

Efficacy and safety of raltitrexed plus S-1 regorafenib in patients with refractory metastatic colorectal cancer: a real-world propensity score matching study.

Background: Raltitrexed plus S-1 (RS) and regorafenib both showed considerable efficacy for metastatic colorectal cancer (mCRC) patients. This study aims to compare the effectiveness and safety of two different regimens in patients with refractory mCRC.

Methods: This retrospective cohort study included mCRC patients who were treated with RS or regorafenib from February 2017 to June 2021.

Targeting Trim69 alleviates high fat diet (HFD)-induced hippocampal injury in mice by inhibiting apoptosis and inflammation through ASK1 inactivation.

The prevalence of obesity is growing, and high fat diet (HFD)-induced obesity can alter the brain and cognition. However, the link between HFD, hippocampal function, and inflammation is still not fully understood. Tripartite motif (TRIM) family has been implicated in various cellular processes, such as apoptosis, neurogenesis, and innate immune responses.

Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors.

A series of novel pyrimidylaminoquinoline derivatives 8(a-i) and 9(a-i) containing amino side chain, and the bisaminoquinoline analogs 3(b-e) have been designed and synthesized by structural modifications on a lead DOT1L inhibitor, 3a. All the compounds have been evaluated for their DOT1L inhibitory activities. The results showed that most of the compounds have strong anti DOT1L activities.

Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay.

DOT1L (the disruptor of telomeric silencing 1-like), through its methyltransferase activity of H3K79, plays essential roles in transcriptional regulation, cell cycle regulation, and DNA damage response. In addition, DOT1L is believed to be involved in the development of MLL-rearranged leukemia driven by the MLL (mixed-lineage leukemia) fusion proteins, which thus to be a crucial target for leukemia therapy. Hence, discovering of novel DOT1L inhibitors has been in a great demand.

Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1.

DNA methyltransferase-1 (DNMT1) plays a crucial role in the maintenance of genomic methylation patterns. The crystal structure of DNMT1 was determined in two different states in which the helix that follows the catalytic loop was either kinked (designated helix-kinked) or well folded (designated helix-straight state). Here, we show that the proper structural transition between these two states is required for DNMT1 activity.

Discovery of Novel Disruptor of Silencing Telomeric 1-Like (DOT1L) Inhibitors using a Target-Specific Scoring Function for the (S)-Adenosyl-l-methionine (SAM)-Dependent Methyltransferase Family.

The disruptor of telomeric silencing 1-like (DOT1L) protein is a histone H3K79 methyltransferase that plays a key role in transcriptional elongation and cell cycle regulation and is required for the development and maintenance of MLL-rearranged mixed lineage leukemia. Much effort has been dedicated toward discovering novel scaffold DOT1L inhibitors using different strategies. Here, we report the development and application of a target-specific scoring function, the SAM score, for (S)-adenosyl-l-methionine (SAM)-dependent methyltransferases, for the discovery of novel DOT1L inhibitors.

Discovery of novel DNA methyltransferase 3A inhibitors via structure-based virtual screening and biological assays.

DNA methyltransferases are involved in diverse biological processes and abnormal methylation patterns play essential roles in cancer initiation and progression. DNA methyltransferase 3A (DNMT3A) acting as a de novo DNA methyltransferase, has gained widespread attention especially in haematological diseases. To date, large numbers of DNMTs inhibitors have been discovered, however, the small molecular inhibitors targeting DNMT3A are still in its infancy.

G-CSF improves CUMS-induced depressive behaviors through downregulating Ras/ERK/MAPK signaling pathway.

Neuronal plasticity in hippocampal neurons is closely related to memory, mood and behavior as well as in the development of depression. Granulocyte colony-stimulating factor (G-CSF) can promote neuronal plasticity and enhance motor skills. However, the function of G-CSF in depression remains poorly understood.

Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays.

Histone methyltransferases are involved in many important biological processes, and abnormalities in these enzymes are associated with tumorigenesis and progression. Disruptor of telomeric silencing 1-like (DOT1L), a key hub in histone lysine methyltransferases, has been reported to play an important role in the processes of mixed-lineage leukemia (MLL)-rearranged leukemias and validated to be a potential therapeutic target. In this study, we identified a novel DOT1L inhibitor, DC_L115 (CAS no.

Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening.

Histone methyltransferases are involved in various biological functions, and these methylation regulating enzymes' abnormal expression or activity has been noted in several human cancers. Within this context, SET domain-containing (lysine methyltransferase) 7 (SET7, also called KMT7, SETD7, SET9) is of increasing significance due to its diverse roles in biological functions and diseases, such as diabetes, cancers, alopecia areata, atherosclerotic vascular disease, HIV, and HCV. In this study, DC-S100, which was discovered by pharmacophore- and docking-based virtual screening, was identified as the hit compound of SET7 inhibitor.