An AIE material with time-dependent luminescence conversion obtained by 2D coordination polymer modification covalent post-synthetic modification.

In this study, we reported the covalent post-synthetic modification (PSM) of a luminescent complex to achieve aggregation-induced emission (AIE), prepared using the Schiff base reaction of TPE-CHO and HLC-NH2, denoted by HLC-NH2-TPE. HLC-NH2 formed a 2D luminescent complex which was constructed using 4,4'-diamino-[1,1'-biphenyl]-2,2'-dicarboxylic acid and zinc ions a solvothermal reaction. HLC-NH2-TPE inherited the luminescence properties of HLC-NH2 and exhibited noticeable AIE properties in response to environmental viscosities and temperature changes.

Protective action of pomegranate peel polyphenols in type 2 diabetic rats the translocation of Nrf2 and FoxO1 regulated by the PI3K/Akt pathway.

The aim of this study is to investigate the protective mechanism of pomegranate peel polyphenols (PPPs) in and rat models of T2DM. Our results showed that PPPs markedly improved the symptoms of diabetes, such as insulin resistance, impaired insulin secretion, and pancreatic oxidative damage, which contributed to the attenuation of the symptoms of hyperglycemia in a high-fat diet (HFD) combined with streptozocin (STZ) induced type 2 diabetes mellitus in rats. On the one hand, PPPs promoted the translocation of Nrf2 from the cytoplasm to the nucleus, the key protein down-regulated by the PI3K/Akt pathway, activating its downstream phase 2 antioxidant enzyme system.

Multiple Strategies to Fabricate a Highly Stable 2D CuCu-Organic Framework with High Proton Conductivity.

Using multifunctional organic ligands with multiple acidic groups (carboxylate and sulfonate groups) to synthesize metal-organic frameworks (MOFs) bearing effective H-bond networks is a promising strategy to obtain highly proton conductive materials. In this work, a highly stable two-dimensional MOF, [CuCu(μ-OH)(HO)(L)(HL)]·3HO (denoted as ; HL = 6-sulfonaphthalene-1,4-dicarboxylic acid) containing mixed-valence [CuCu(μ-OH)] subunits, was successfully prepared. It exhibited excellent stability and temperature- and humidity-dependent proton conduction properties.

Prevalence and related factors of hyperuricaemia in Shanghai adult women of different ages: a multicentre and cross-sectional study.

Objective: Women in different age phases have different metabolism and hormone levels that influence the production and excretion of uric acid. We aimed to investigate the prevalence and related factors of hyperuricaemia among women in various age phases.

Study Design: Observational, cross-sectional study.

KLF2 inhibits cancer cell migration and invasion by regulating ferroptosis through GPX4 in clear cell renal cell carcinoma.

The metastatic dissemination and underlying mechanisms of clear cell renal cell carcinoma (ccRCC) remain insufficiently understood. In this study, we identified the essential role of KLF2 in suppressing the metastasis of ccRCC. Downregulation of KLF2 detected by immunohistochemistry in primary metastatic ccRCC was remarkably related to poor clinical outcomes.

Cyclic Tetrapeptide HDAC Inhibitors with Improved Selectivity and Killing Profile.

Cyclic tetrapeptide histone deacetylase inhibitors represent a promising class of antiplasmodial agents that epigenetically disrupt a wide range of cellular processes in . Unfortunately, certain limitations, including reversible killing effects and host cell toxicity, prevented these inhibitors from further development and clinical use as antimalarials. In this study, we present a series of cyclic tetrapeptide analogues derived primarily from the fungus that inhibit with low nanomolar potency and high selectivity.

Microglial TREM2 Mitigates Inflammatory Responses and Neuronal Apoptosis in Angiotensin II-Induced Hypertension in Middle-Aged Mice.

Growing evidence suggests that hypertension and aging are prominent risk factors for the development of late-onset Alzheimer's disease (LOAD) by inducement of neuroinflammation. Recent study showed that neuroinflammation activated microglia induces reactive astrocytes, termed A1 astrocytes, that highly upregulate numerous classical complement cascade genes that are destructive to neurons in neurodegeneration diseases. Moreover, triggering receptor expressed on myeloid cells 2 (TREM2) is considered as one of the strongest single-allele genetic risk factors and plays important roles in neuroinflammation for LOAD.

Long Non-coding RNA N1LR Protects Against Myocardial Ischemic/Reperfusion Injury Through Regulating the TGF-β Signaling Pathway.

Long non-coding RNAs (lncRNAs) have been shown to play critical roles in various cell biological processes. However, the mechanism of lncRNAs in acute myocardial infarction (AMI) is not fully understood. Previous studies showed that lncRNA N1LR was down-regulated in ischemic cerebral stroke and its up-regulation was protective.

Rapid sulfuric acid-dimethylamine nucleation enhanced by nitric acid in polluted regions.

Recent research [Wang , 581, 184-189 (2020)] indicates nitric acid (NA) can participate in sulfuric acid (SA)-ammonia (NH) nucleation in the clean and cold upper free troposphere, whereas NA exhibits no obvious effects at the boundary layer with relatively high temperatures. Herein, considering that an SA-dimethylamine (DMA) nucleation mechanism was detected in megacities [Yao , 361, 278-281 (2018)], the roles of NA in SA-DMA nucleation are investigated. Different from SA-NH nucleation, we found that NA can enhance SA-DMA-based particle formation rates in the polluted atmospheric boundary layer, such as Beijing in winter, with the enhancement up to 80-fold.

Ruxolitinib Alleviates Uveitis Caused by Endotoxin.

Uveitis is characterized by inflammatory lesions of intraocular structures. It is one of the important manifestations in patients with Reiter's syndrome, an inflammatory arthritis, which is caused by enteric infection with bacteria, including Salmonella typhimurium. Corticosteroids remain the most frequently used therapies against uveitis associating with inflammatory arthritis.

Relative Humidity Changes the Role of SO in Biogenic Secondary Organic Aerosol Formation.

SO influences secondary organic aerosol (SOA) and organosulfates (OSs) formation but mechanisms remain elusive. This study focuses on this topic by investigating biogenic γ-terpinene ozonolysis under various SO and relative humidity (RH) conditions. With a constant SO concentration (∼110 ppb), the increase in RH transformed SO sinks from stabilized Criegee intermediates (sCIs) to peroxides in aerosol particles.

Modeling and prediction of the transmission dynamics of COVID-19 based on the SINDy-LM method.

The transmission dynamics of COVID-19 is investigated in this study. A SINDy-LM modeling method that can effectively balance model complexity and prediction accuracy is proposed based on data-driven technique. First, the Sparse Identification of Nonlinear Dynamical systems (SINDy) method is used to discover and describe the nonlinear functional relationship between the dynamic terms in the model in accordance with the observation data of the COVID-19 epidemic.

The prognosis and risk factors of baseline high peritoneal transporters on patients with peritoneal dialysis.

The relationship between baseline high peritoneal solute transport rate (PSTR) and the prognosis of peritoneal dialysis (PD) patients remains unclear. The present study combined clinical data and basic experiments to investigate the impact of baseline PSTR and the underlying molecular mechanisms. A total of 204 incident CAPD patients from four PD centres in Shanghai between 1 January 2014 and 30 September 2020 were grouped based on a peritoneal equilibration test after the first month of dialysis.

Synergistic interplay of ABA and BR signal in regulating plant growth and adaptation.

Complex antagonistic interactions between abscisic acid (ABA) and brassinosteroid (BR) signalling pathways have been widely documented. However, whether or how ABA interacts synergistically with BR in plants remains to be elucidated. Here, we report that low, but not high, concentration of ABA increases lamina joint inclination of rice seedling, which requires functional BR biosynthesis and signalling.

Enhancing effect of NO on the formation of light-absorbing secondary organic aerosols from toluene photooxidation.

Aromatic hydrocarbons are one of the major precursors of atmospheric brown carbon (BrC) and both abundantly co-exist with NO in the urban atmosphere especially in winter haze period. However, the impact of NOx on the formation of BrC derived from aromatic hydrocarbons is still not fully understood. In this study, the yield and light absorption of secondary organic aerosols (SOA) from toluene photooxidation under various nitrogen oxides (NO) levels were investigated by using a 5 m photooxidation smog chamber.

A novel data-driven methodology for influenza outbreak detection and prediction.

Influenza is an infectious disease that leads to an estimated 5 million cases of severe illness and 650,000 respiratory deaths worldwide each year. The early detection and prediction of influenza outbreaks are crucial for efficient resource planning to save patient's lives and healthcare costs. We propose a new data-driven methodology for influenza outbreak detection and prediction at very local levels.

Taccalonolide C-6 Analogues, Including Paclitaxel Hybrids, Demonstrate Improved Microtubule Polymerizing Activities.

The C-22,23-epoxy taccalonolides are microtubule stabilizers that bind covalently to β-tubulin with a high degree of specificity. We semisynthesized and performed biochemical and cellular evaluations on 20 taccalonolide analogues designed to improve target engagement. Most notably, modification of C-6 on the taccalonolide backbone with the C-13 -acyl-β-phenylisoserine side chain of paclitaxel provided compounds with 10-fold improved potency for biochemical tubulin polymerization as compared to that of the unmodified epoxy taccalonolide AJ.

Effect of Weikang Capsule () on Aspirin-Related Gastric and Small Intestinal Mucosal Injury.

Objective: To investigate the effects of Weikang Capsule (, WKC) on aspirin-related gastric and small intestinal mucosal injury by magnetically controlled capsule endoscopy (MCCE).

Methods: Patients taking enteric-coated aspirin aged 40-75 years were enrolled in Beijing Anzhen Hospital, Capital Medical University from January 2019 to December 2019. The patients continued taking aspirin Tablet (100 mg per day) and underwent MCCE before and after 1-month combined treatment with WKC (0.

Enhanced photocatalytic performance of PdO-loaded heterostructured nanobelts to degrade phenol.

Heterostructured catalysts play a significant role in the photodegradation of pollutants in wastewater. Combining the large surface of nanobelts with the high photocatalytic property of titanium dioxide (TiO) nanoparticles is a promising method for preparing photocatalysts, which have an advanced photocatalytic activity and are easy to precipitate. In this work, titanium dioxide nanobelts (NB) and acid corroded titanium dioxide nanobelts (C-NB) were synthesized via a hydrothermal process under alkaline conditions.

A Wireless Artificial Mechanoreceptor in 180-nm CMOS.

This article presents an implantable low-power wireless integrated system for tactile sensing applications. The reported ASIC utilizes a low-loss magnetic human body communication channel for both wireless power and data transfer. The chip is hybrid-integrated with an in-house fabricated MEMS capacitive force sensor to form an implantable artificial mechanoreceptor.

Release of inhalable particles and viable microbes to the air during packaging peeling: Emission profiles and mechanisms.

Packaging is necessary for preserving and delivering products and has significant impacts on human health and the environment. Particle matter (PM) may be released from packages and transferred to the air during a typical peeling process, but little is known about this package-to-air migration route of particles. Here, we investigated the emission profiles of total and biological particles, and the horizontal and vertical dispersion abilities and community structure of viable microbes released from packaging to the air by peeling.

Anthropogenic-Biogenic Interactions at Night: Enhanced Formation of Secondary Aerosols and Particulate Nitrogen- and Sulfur-Containing Organics from β-Pinene Oxidation.

Mixing of anthropogenic gaseous pollutants and biogenic volatile organic compounds impacts the formation of secondary aerosols, but still in an unclear manner. The present study explores secondary aerosol formation via the interactions between β-pinene, O, NO, SO, and NH under dark conditions. Results showed that aerosol yield can be largely enhanced by more than 330% by NO or SO but slightly enhanced by NH by 39% when the ratio of inorganic gases to β-pinene ranged from 0 to 1.

Photosensitized formation of sulfate and volatile sulfur gases from dissolved organic sulfur: Roles of pH, dissolved oxygen, and salinity.

The photodegradation of dissolved organic sulfur (DOS) is a potential source of aqueous sulfate and its chemical precursors in surface water. However, the photochemical fate of DOS and factors that control its fate still remain unclear. Herein, we employed a DOS model featuring a photosensitizer (humic acids, HA) to investigate the photochemical degradation pathways of DOS in various natural water sources, from which we observed the substantial photosensitized formation of sulfate, methanesulfonic acid (MSA), carbonyl sulfide (COS), and carbon disulfide (CS).

Fisetin Alleviates Neointimal Hyperplasia via PPAR/PON2 Antioxidative Pathway in SHR Rat Artery Injury Model.

The phenotypic transformation of proliferation and migration in vascular smooth muscle cells (VSMCs) from media to intima is the basic pathology of neointimal hyperplasia after angioplasty in hypertensive patients. Angiotensin II (AngII) stimulates oxidative stress in VSMC, inducing VSMC proliferation and migration, which is a critical factor in both developments of hypertension and angioplasty-induced arterial restenosis. Fisetin, a plant flavonoid polyphenol, has been reported to be antioxidative and potent senolytic.