A Comprehensive Review of Food-Derived Compounds Targeting Pyroptosis for Colitis Therapy: From Effects to Mechanisms.

Ulcerative colitis (UC) is a form of non-specific inflammatory bowel disease characterized by complex pathological mechanisms that remain incompletely understood, posing challenges for effective treatment. Pyroptosis, a form of inflammatory cell death mediated by the Gasdermin D protein family, occurs primarily through the classical caspase-1 pathway, the non-classical caspase-4, 5, and 11 pathways, and alternative pathways. Dysregulated activation of pyroptosis signaling has been implicated in the progression of UC, indicating that targeted inhibition of pyroptosis may serve as a therapeutic strategy.

Correction: Food-derived compounds targeting ferroptosis for cancer therapy: from effects to mechanisms.

[This corrects the article DOI: 10.3389/fonc.2025.

Food-derived compounds targeting ferroptosis for cancer therapy: from effects to mechanisms.

Ferroptosis is distinctive type programmed cell death. Tumor cells, with their higher iron levels, render them more susceptible to ferroptosis Inducing ferroptosis can activate immune cells, regulate immune evasion, and inhibit the biology activity of cancer cells. Therefore, ferroptosis-induced cancer cell death could become a promising approach for cancer treatment.

[Application of transcutaneous electrical acupoint stimulation in preoperative analgesia for intertrochanteric fracture of femur in elderly patients].

Objectives: To evaluate the clinical effect of transcutaneous electrical acupoint stimulation(TEAS) on preoperative analgesia for the elderly patients with intertrochanteric fracture of femur.

Methods: A total of 126 elderly patients with intertrochanteric fracture of femur were randomized into an observation group(63 cases, one case dropped out) and a control group(63 cases, 2 cases dropped out ). In the observation group, TEAS was operated at Huantiao (GB30), Yanglingquan (GB34), Zusanli (ST36) and Kuanguxue (Extra) on the affected side.

The Roles of Dietary Bioactive Compounds in Alleviating Inflammatory Bowel Disease-Associated Colorectal Cancer.

Inflammatory bowel disease (IBD)-associated colorectal cancer (CRC) is a serious global health issue. Owing to the successful mimicking of the entire process of CRC induced by IBD, azoxymethane (AOM) and dextran sulfate sodium (DSS)-induced colitis-associated cancer (CAC) animal models have been widely used to study the carcinogenic mechanisms of IBD-associated CRC and aid in the discovery of new candidate target drugs for CRC treatment. This article summarizes the molecular characteristics and mechanisms of the AOM/DSS-induced CAC animal model and reports the effects and mechanisms of dietary active ingredients such as phenolics, flavonoids, terpenes, polysaccharides, alkaloids, and other food extracts in the prevention and treatment of AOM/DSS-induced CAC in preclinical trials.

Functional foods and bioactive compounds: a comprehensive review on their role in mitigating drug-induced liver injury.

Drug-induced liver injury (DILI) has become a serious public health issue worldwide. Many drugs (chemotherapy drugs, fever-reducing medications, nonsteroidal anti-inflammatory drugs, immunosuppressants, antibiotics, antivirals, and antineoplastic drugs, etc.) may cause liver damage and potentially lead to acute liver failure (ALF).

A portable and efficient chemical dosimeter for rapid visual analysis of 3-Monochloropropane-1,2-diol (3-MCPD) in food samples.

3-Chloro-1,2-propanediol (3-MCPD) is a common contaminant in food and has been classified as a Group 2B carcinogen. Given growing food safety concerns, rapid and effective analytical methods are urgently needed. This study designed a new chemical dosimeter based on a benzothiazole derivative (BT-NH) for high-sensitivity, rapid 3-MCPD analytical in food.

Effects of PRP injection combined with intersecting femoral head decompression versus combined with multiple core decompression in the treatment of avascular necrosis of femoral head-a single-center retrospective cohort study.

Background: Avascular necrosis of femoral head (ANFH) is a localized destruction of the femoral head caused by a variety of complex reasons, which eventually progresses to collapse of the femoral head and loss of joint function. Platelet-rich plasma(PRP), an autologous platelet concentrate rich in growth factors, has been widely used in the treatment of ANFH because of its ability to promote osteogenesis. PRP injection is often combined with multiple surgical approaches to treat ANFH.

Learning in Two-Scales Through LSTM-GPT2 Fusion Network: A Hybrid Approach for Time Series Anomaly Detection.

Anomaly detection (AD) in multivariate time series data (MTS) collected by industrial sensors is a crucial undertaking for the damage estimation and damage monitoring of machinery like rocket engines, wind turbine blades, and aircraft turbines. Due to the complex structure of industrial systems and the varying working environments, the collected MTS often contain a significant amount of noise. Current AD studies mostly depend on extracting features from data to obtain the information associated with various working states, and they attempt to detect the abnormal states in the space of the original data.

Evaluation of the Application of BOth Sides Up Ball Training Combined With Resistance Training in Joint Stability Improvement Following Anterior Cruciate Ligament Reconstruction Surgery in Teenage Athletes.

Adolescent athletes participating in sports involving sudden directional changes, pivoting, and jumping frequently sustain anterior cruciate ligament (ACL) ruptures. ACL reconstruction (ACLR) surgery is often required, followed by a lengthy rehabilitation period. This study aims to evaluate the effectiveness of combining BOth Sides Up (BOSU) ball exercises with conventional resistance training in the recovery of joint stability and function after ACLR in adolescent athletes.

Effect Analysis of Early Rehabilitation Therapy Combined With Repetitive Transcranial Magnetic Stimulation on Postoperative Rehabilitation of Sports Knee Injury.

Objective: To analyze the effectiveness of combined early rehabilitation therapy and repetitive transcranial magnetic stimulation (rTMS) in the postoperative rehabilitation of patients with sports knee injuries (SKIs).

Methods: A total of 62 SKI patients from June 2021 to June 2022 were randomly selected by computer and divided into group A (31 cases, early rehabilitation therapy) and group B (31 cases, early rehabilitation therapy + rTMS) by numbered envelope method. The effects of the 2 groups were compared.

GDF15: Immunomodulatory Role in Hepatocellular Carcinoma Pathogenesis and Therapeutic Implications.

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths globally and the sixth most common cancer worldwide. Evidence shows that growth differentiation factor 15 (GDF15) contributes to hepatocarcinogenesis through various mechanisms. This paper reviews the latest insights into the role of GDF15 in the development of HCC, its role in the immune microenvironment of HCC, and its molecular mechanisms in metabolic dysfunction associated steatohepatitis (MASH) and metabolic associated fatty liver disease (MAFLD)-related HCC.

A comprehensive review of chloropropanol analytical method in the context of food safety.

Chloropropanols are among the major food contaminants, and quantifying their content in food is a key food-safety issue. In response to the demand for highly sensitive and selective analysis, the scientific community is committed to continuous innovation and optimization of various analytical techniques. This paper comprehensively reviews the latest developments in chloropropanol analysis technologies and systematically compares and analyzes the working principles, application conditions, advantages, and challenges of these methods.

The role of the mitochondrial ribosomal protein family in detecting hepatocellular carcinoma and predicting prognosis, immune features, and drug sensitivity.

Background: Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumors, with a slow onset, rapid progression, and frequent recurrence. Previous research has implicated mitochondrial ribosomal genes in the development, metastasis, and prognosis of various cancers. However, further research is necessary to establish a link between mitochondrial ribosomal protein (MRP) family expression and HCC diagnosis, prognosis, ferroptosis-related gene (FRG) expression, m6A modification-related gene expression, tumor immunity, and drug sensitivity.

Structural evolution of lignin after selective oxidation of lignin-carbohydrate complex by chlorine dioxide.

Lignin-carbohydrate complexes (LCCs) are important from the perspective of the anti-depolymerization barrier of lignocellulosic biomass, as it limits the high-value utilization of lignocellulosic biomass resources. In this study, the unit structure of lignin in the LCC has been investigated in depth. Oxidation of a selective lignin unit by chlorine dioxide revealed that the LCC structures are enriched with xylanase-macroporous resins, and the structure that was not oxidized in LCC was also identified.

Acute mesenteric ischemia secondary to oral contraceptive-induced portomesenteric and splenic vein thrombosis: A case report.

Background: Mesenteric ischemia represents an uncommon complication of splanchnic vein thrombosis, and it is less infrequently seen in young women using oral contraceptives. Diagnosis is often delayed in the emergency room; thus, surgical intervention may be inevitable and the absence of thrombus regression or collateral circulation may lead to further postoperative ischemia and a fatal outcome.

Case Summary: We report a 28-year-old female patient on oral contraceptives who presented with acute abdominal pain.

Structural enrichment and identification of lignin-carbohydrate complex in alkaline stabilized system.

Effectively breaking down its anti-depolymerization barrier is key to the conversion and utilization of biomass resources. The anti-depolymerization barrier is mainly composed of a lignin-carbohydrate complex (LCC), which hinder the high-value utilization of biomass. In an alkaline environment, phenyl glycosidic bonds in LCC exist stably.

High-Efficiency and High-Quality Extraction of Hemicellulose of Bamboo by Freeze-Thaw Assisted Two-Step Alkali Treatment.

Hemicellulose is a major component of the complex biomass recalcitrance structure of fiber cell walls. Even though biomass recalcitrance protects plants, it affects the effective utilization of lignocellulosic biomass resources. Therefore, the separation and extraction of hemicellulose is very important.

Factors Affecting the Leaching of Chloropropanols from Pulp Used in the Manufacture of Paper Food Packaging.

Paper packaging materials are widely used in food packaging. However, it is difficult to extract trace chloropropanol from food packaging paper, so there is a lack of research on the leaching of chloropropanol from paper materials. Therefore, it is of positive significance to explore the leaching rule of chloropropanol in paper pulp for the safety of paper packaging materials, to reduce the risk of food packaging to food safety and to provide a theoretical basis for the formulation of safety standards for paper packaging materials.

Adsorption Mechanism of Chloropropanol by Crystalline Nanocellulose.

Paper packaging materials are widely used as sustainable green materials in food packaging. The production or processing of paper materials is conducted in an environment that contains organic chlorides; therefore, potential food safety issues exist. In this study, the adsorption behavior of organic chlorides on paper materials was investigated.

Corosolic acid inhibits tumour growth without compromising associating liver partition and portal vein ligation-induced liver regeneration in rats.

Background: Associating liver partition and portal vein ligation (ALPPS) technique is a promising strategy for unresectable primary liver tumours without sufficient future liver remnants (FLRs).

Objective: Our study explored the effect of corosolic acid (CA) on inhibiting tumour growth without compromising ALPPS-induced liver regeneration.

Methods: The ALPPS procedure was performed in Sprague-Dawley rats with orthotopic liver cancer.

Chlorine dioxide oxidation of hemicellulose from alkaline hydrolysate bagasse to remove lignin unit in lignin-carbohydrate complex.

Owing to the existence of lignin-carbohydrate complex (LCC) linkages, the extracted hemicellulose contains lignin, which is difficult to remove. Chlorine dioxide selectively oxidizes lignin without reacting with carbohydrates. In this study, chlorine dioxide was used to remove lignin from the hemicellulose sample.

Topology modulation of 2D covalent organic frameworks a "two-in-one" strategy.

Topology modulation of covalent organic frameworks (COFs) still remains barely explored, probably due to the lack of appropriate building blocks. A "two-in-one" strategy applies bifunctional monomers to endow ideal stoichiometry and has recently demonstrated great potential in the facile preparation of highly crystalline two-dimensional (2D) COFs with different topologies. Herein, we employ this approach to modulate the topology of 2D COFs by varying the solvents or the monomer concentrations.