A Comprehensive Review of Food-Derived Compounds Targeting Pyroptosis for Colitis Therapy: From Effects to Mechanisms.

Ulcerative colitis (UC) is a form of non-specific inflammatory bowel disease characterized by complex pathological mechanisms that remain incompletely understood, posing challenges for effective treatment. Pyroptosis, a form of inflammatory cell death mediated by the Gasdermin D protein family, occurs primarily through the classical caspase-1 pathway, the non-classical caspase-4, 5, and 11 pathways, and alternative pathways. Dysregulated activation of pyroptosis signaling has been implicated in the progression of UC, indicating that targeted inhibition of pyroptosis may serve as a therapeutic strategy.

Correction: Food-derived compounds targeting ferroptosis for cancer therapy: from effects to mechanisms.

[This corrects the article DOI: 10.3389/fonc.2025.

Food-derived compounds targeting ferroptosis for cancer therapy: from effects to mechanisms.

Ferroptosis is distinctive type programmed cell death. Tumor cells, with their higher iron levels, render them more susceptible to ferroptosis Inducing ferroptosis can activate immune cells, regulate immune evasion, and inhibit the biology activity of cancer cells. Therefore, ferroptosis-induced cancer cell death could become a promising approach for cancer treatment.

[Application of transcutaneous electrical acupoint stimulation in preoperative analgesia for intertrochanteric fracture of femur in elderly patients].

Objectives: To evaluate the clinical effect of transcutaneous electrical acupoint stimulation(TEAS) on preoperative analgesia for the elderly patients with intertrochanteric fracture of femur.

Methods: A total of 126 elderly patients with intertrochanteric fracture of femur were randomized into an observation group(63 cases, one case dropped out) and a control group(63 cases, 2 cases dropped out ). In the observation group, TEAS was operated at Huantiao (GB30), Yanglingquan (GB34), Zusanli (ST36) and Kuanguxue (Extra) on the affected side.

The Roles of Dietary Bioactive Compounds in Alleviating Inflammatory Bowel Disease-Associated Colorectal Cancer.

Inflammatory bowel disease (IBD)-associated colorectal cancer (CRC) is a serious global health issue. Owing to the successful mimicking of the entire process of CRC induced by IBD, azoxymethane (AOM) and dextran sulfate sodium (DSS)-induced colitis-associated cancer (CAC) animal models have been widely used to study the carcinogenic mechanisms of IBD-associated CRC and aid in the discovery of new candidate target drugs for CRC treatment. This article summarizes the molecular characteristics and mechanisms of the AOM/DSS-induced CAC animal model and reports the effects and mechanisms of dietary active ingredients such as phenolics, flavonoids, terpenes, polysaccharides, alkaloids, and other food extracts in the prevention and treatment of AOM/DSS-induced CAC in preclinical trials.

Functional foods and bioactive compounds: a comprehensive review on their role in mitigating drug-induced liver injury.

Drug-induced liver injury (DILI) has become a serious public health issue worldwide. Many drugs (chemotherapy drugs, fever-reducing medications, nonsteroidal anti-inflammatory drugs, immunosuppressants, antibiotics, antivirals, and antineoplastic drugs, etc.) may cause liver damage and potentially lead to acute liver failure (ALF).

GDF15: Immunomodulatory Role in Hepatocellular Carcinoma Pathogenesis and Therapeutic Implications.

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths globally and the sixth most common cancer worldwide. Evidence shows that growth differentiation factor 15 (GDF15) contributes to hepatocarcinogenesis through various mechanisms. This paper reviews the latest insights into the role of GDF15 in the development of HCC, its role in the immune microenvironment of HCC, and its molecular mechanisms in metabolic dysfunction associated steatohepatitis (MASH) and metabolic associated fatty liver disease (MAFLD)-related HCC.

The role of the mitochondrial ribosomal protein family in detecting hepatocellular carcinoma and predicting prognosis, immune features, and drug sensitivity.

Background: Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumors, with a slow onset, rapid progression, and frequent recurrence. Previous research has implicated mitochondrial ribosomal genes in the development, metastasis, and prognosis of various cancers. However, further research is necessary to establish a link between mitochondrial ribosomal protein (MRP) family expression and HCC diagnosis, prognosis, ferroptosis-related gene (FRG) expression, m6A modification-related gene expression, tumor immunity, and drug sensitivity.

Acute mesenteric ischemia secondary to oral contraceptive-induced portomesenteric and splenic vein thrombosis: A case report.

Background: Mesenteric ischemia represents an uncommon complication of splanchnic vein thrombosis, and it is less infrequently seen in young women using oral contraceptives. Diagnosis is often delayed in the emergency room; thus, surgical intervention may be inevitable and the absence of thrombus regression or collateral circulation may lead to further postoperative ischemia and a fatal outcome.

Case Summary: We report a 28-year-old female patient on oral contraceptives who presented with acute abdominal pain.

Anti-cyclic citrullinated peptide antibody predicts the development of rheumatoid arthritis in patients with undifferentiated arthritis.

Background: Clinical outcomes of undifferentiated arthritis (UA) are diverse, and only 40% of patients with UA develop rheumatoid arthritis (RA) after 3 years. Discovering predictive markers at disease onset for further intervention is critical. Therefore, our objective was to analyze the clinical outcomes of UA and ascertain the predictors for RA development.

Correlation of atherosclerotic renal artery stenosis with extracranial carotid and intracranial cerebral artery atherosclerosis in patients with ischemic stroke.

Objective: This study was to evaluate the relationship of atherosclerotic renal artery stenosis (ARAS) with extracranial carotid arteries atherosclerosis (ECAS) and intracranial cerebral atherosclerosis (ICAS) in ischemic stroke (IS) patients.

Methods: This study was a prospective cohort analysis of consecutive patients with IS who had not a history of renal artery stenosis (RAS). Abdominal aortography was performed to screen for RAS after the cerebrovascular diagnostic procedure.

[Blood supply of pulmonary metastases and its clinical significance].

Background & Objective: Interventional treatment has been widely applied to primary lung carcinoma, but seldom applied to pulmonary metastases because the blood supply of pulmonary metastases has rarely been investigated, and the present understanding is controversial. This study was to explore the correlation of the clinical value of bronchial arterial chemotherapeutic infusion (BAI) combined bronchial arterial embolization (BAE) to the blood supply of pulmonary metastases.

Methods: Bronchial artery angiography was performed on 33 patients with pulmonary metastases to assess the blood supply and the distribution of pulmonary metastases.

[Study of photocatalytic activity, characterization and preparation of supersuspended nano-TiO2 (II) photocatalytic activity].

The photocatalytic activity of nano-TiO2 prepared by pyrolysis method and then by cooling-treatment in silicon oil and in air respectively was studied with methyl-orange solution as model waste water. The results show that the photocatalytic activity of both products is obvious with no great difference. However, the nano-TiO2 powder modified with silicone oil can degrade harmful components more effectively on the surface of waste water with sunlight and other extra light.

[Determination of the content of wear metal in lubrication oil by ICP-AES].

An analytical method for determining wear metal elements directly by ICP-AES was proposed in this paper. The optimum condition was selected. The Conostan S-21 and Conostan 75 (oil-base standard samples) prepared by multi-element oil-base reserved standard samples were applied to make calibration curve.

[Study of photocatalytic activity, characterization and preparation of supersuspended nano-TiO2. II. Study of photocatalytic activity].

From the change in the absorption of methyl-orange solution at 470 nm, the photocatalytic activity of nano-TiO2 prepared by pyrolysis method, and then by cooling treatment in silicon oil and in air respectively, was studied with methyl-orange solution as model waste water under irradiation by UV-lamp. Their photocatalytic mechanisms, the percentage of degradation in 35 min and the kinetic reactive process were also analyzed. The results show that the photocatalytic activity of both products is obvious with little difference.