Effects of NaCl and cumin essential oil on camel meat myoglobin under malondialdehyde oxidation system.

We investigated the effects and mechanisms of two sodium chloride concentrations (0.3 and 0.6 M) and cumin essential oil concentrations (CEO, 0.

Inhibition of astrocytic toll-like receptor 4 contributes to sevoflurane pretreatment-induced anti-neuroinflammation following focal cerebral ischemia.

Background: Sevoflurane, a widely used clinical anesthetic, exhibits neuroproctive properties though its precise mechanisms remain unclear. Astrocytes, a critical regulators of immune responses, actively participate in sevoflurane-mediated neuroprotection against ischemia. Toll-like receptor 4 (TLR4), a key molecule for conversion from pro-inflammatory astrocytes to anti-inflammatory astrocytes phenotypes.

A Photon-Driven Unimolecular Immunostimulant for Self-Amplified Pyroptosis and cGAS-STING Pathway by Destroying the Pyroptosis Checkpoint.

Immunotherapy is a groundbreaking approach for clinically treating tumors, but its effectiveness is hindered by the tumor's immunosuppressive environment and lack of immune cell infiltration, enabling tumors to evade the immune system. Although the activation of both innate and adaptive immunities is a promising strategy to counteract this bottleneck, their synergy remains challenging. Therefore, we developed Bio-Cy, an unprecedented organic unimolecular photosensitive immunostimulant, which stimulates self-amplifying pyroptosis and cGAS-STING pathways by disrupting pyroptosis checkpoints to enhance adaptive and innate immunity activation.

Generative Phenomenology of form perception: Perceptograms and cortical models for amblyopic phantom percepts.

What we see is generated by our cortical neurons processing sensory input. Amblyopia provides a perfect case for studying the neural generation of percepts (Generative Phenomenology) because many amblyopes see phantom forms that contain more features than the stimulus through their amblyopic eye (AE) but not through the fellow eye (FE). Seeing phantom forms is unlike most visual disorders that lead to deficits and requires different types of models.

Interventions for improving adherence to amblyopia treatments in children.

Rationale: Amblyopia is a neurodevelopmental visual disorder that can be successfully treated, particularly in younger children. However, the effectiveness of treatment is often limited by adherence. This review discusses the efficacy and harms of interventions designed to increase adherence to amblyopia treatments in children.

Study of changes in volatile flavor substances during the processing and storage of mutton ham.

This study systematically characterized the volatile profile of dry-cured mutton ham to elucidate the dynamic changes of its characteristic aroma compounds during processing and storage. Using complementary analytical approaches, gas chromatography-olfactometry-mass spectrometry (GC-O-MS) and headspace-gas chromatography-ion mobility spectrometry (GC-IMS) identified 69 and 70 volatile organic compounds (VOCs) during processing, respectively, with 63 and 82 VOCs detected during storage. Key odor-active compounds including 6-methylheptanol, benzaldehyde, 2-nonone, 2-hexanone, and 2-heptanone were identified as major contributors to the ham's aroma profile.

Switching between type I/II photosensitization processes for of an unconventional dye as modulated by the tumor microenvironment for inducing immunogenic death.

In this work, an unconventional Se-substituted hemicyanine dye (HCySe-O-NO) decorated with a -nitrophenyl moiety as a recognition site was investigated. Its type I/II photosensitization processes could be regulated by the tumor microenvironment, alleviating the oxygen dependence of conventional photodynamic therapy (PDT) for the treatment of solid tumors. Upon being exposed to 760-nm-wavelength laser irradiation, cancer cells treated with HCySe-O-NO exhibited the phenomenon of pyroptosis, resulting in an amplification of cellular immunogenic death (ICD), and hence demonstrating the potential value of this dye for photoimmunotherapy.

The analysis of distinctive lipid metabolism characteristics in dry-cured beef during processing.

Dry-cured beef (DB), CG (control group), FG (fermented group), RG (ripened group) stages were selected to analyse the key lipid metabolites using the lipid metabolism approach based on UPLC-MS/MS. We identified 301 metabolites from 13 subclasses, with 80 markedly different lipids. Fatty acyls (FA) and glycerol phospholipids (GP) were the most abundant.

Longitudinal development of ocular biometric components and refractive error in children with hyperopic anisometropia.

Purpose: To compare the longitudinal development of spherical equivalent refraction (SER) and ocular biometric components in the more hyperopic (MoreH) and less hyperopic (LessH) eyes of children with hyperopic anisometropia.

Methods: This prospective longitudinal study included 36 children aged 4 to <13 years with hyperopic anisometropia without strabismus. Based on a best-corrected interocular visual acuity difference ≥0.

Access to Myopia Care in the United States-A Narrative Review.

This review describes the evidence related to the burden of myopia and the status of access to myopia care, including detection, treatment, and management, in the United States. It examines the societal impact of myopia, vision screening guidelines from professional organizations, and state mandates on vision screening. Using the Anderson-Newman framework, the review evaluates access to and utilization of myopia care.

Tissue-resident microbiota signature in nasopharyngeal carcinoma.

Background: Emerging evidence reveals that microbiota plays a crucial role in multiple cancers. Nasopharyngeal carcinoma (NPC) tissues harbour microbiota, highlighting the need to investigate the clinical implications of tissue-resident microbiota in the development of NPC. Here, we aim to clarify the specific profile of tissue-resident microbiota and its influence on NPC outcomes.

Collaboration Between Emergency Medicine and Optometry Aids in Diagnosing Atypical Wallenberg Syndrome in a 37-Year-Old Female.

This case report highlights an atypical clinical presentation featuring ipsilateral head, neck, shoulder, and eye pain with erythema, edema of the right eyelid and conjunctiva, alongside classic signs of dorsolateral medullary syndrome, also known as Wallenberg Syndrome, characterized by ipsilateral Horner's syndrome and contralateral loss of body pain and temperature in a 37-year-old female. The correct diagnosis of Wallenberg syndrome was achieved through the collaborative effort of eye care professionals, primary care, emergency, and neurology specialties in medicine.

Accurate prediction of spatial distribution of soil heavy metal in complex mining terrain using an improved machine learning method.

Accurate prediction of heavy metals (HMs) spatial distribution in mining areas is crucial for pollution management. However, predicting the spatial distribution of HMs remains a significant challenge in mining areas with complex terrain and variable contaminant transport pathways. This study aims to optimize the spatial prediction of arsenic (As) distribution in the Shimen realgar mining area, the largest in Asia, by integrating machine learning models with kriging interpolation and feature selection techniques.

Serum Wnt10B/β-Catenin in Early Diagnosis, Lymph Node Metastasis, and Prognosis in Cervical Cancer.

Objective: To assess the serum levels of Wnt10B and β-catenin for early diagnosis of the cervical cancer and their association with distant lymph node metastasis and prognosis.

Study Design: Observational study. Place and Duration of the Study: Department of Gynaecology, Hunan Provincial People's Hospital, The First Hospital Affiliated with Hunan Normal University, Changsha, Hunan, China, from September 2019 to 2023.

Neuropilin-1-target self-assembled peptide nanoparticles contribute to tumor treatment by inducing pyroptosis.

Background: Expression of the Neuropilin-1 (NRP1) is reported in malignant cells of multiple human tumor types represented as a tumor marker. Targeting NRP1 with a peptide, CK3, is used for tumor molecular imaging, raising the question of the therapeutic potential of CK2, a peptide with a CK3 backbone which enhanced targeting and tumor enrichment properties.

Methods: The tumor targeting and enrichment capacity of CK2 was detected by IncuCyte, flow cytometry and animal living imaging.

Effectiveness of wax-bovine bone protein-grapeseed oil composite oleogels as a margarine substitute in cookies: Characteristics of fat substitutes and baking properties.

In the present study, wax-bovine bone protein composite oleogels were blended with margarine (MG) in various proportions (25 %, 50 %, 75 %) to investigate their potential as MG replacements. The resulting oleogel-MG blends exhibited a uniform, tightly connected crystal structure and promoted the formation of the β' crystal polymorph. Differential scanning calorimetry revealed a higher melting temperature (above 45 °C) and earlier crystallization peak (~50 °C) for the oleogels and blends compared to MG.

Social network sites usage, cyberbullying perpetration, and adolescent depression: A cross-lagged panel analysis.

Objective: Existing research on the relationships between social network sites (SNS) usage, cyberbullying perpetration, and adolescent depression has predominantly employed cross-sectional methodologies. Limited studies have delved into the bidirectional dynamics among these variables. This study aimed to fill this gap by employing a longitudinal approach to examine the reciprocal associations between SNS usage, cyberbullying perpetration, and adolescent depression.

Targeting A2M-LRP1 reverses uterine spiral artery remodeling disorder and alleviates the progression of preeclampsia.

Background: Patients with early-onset preeclampsia (EOPE) have a most severe disease state. a2-macroglobulin (A2M) play a crucial role in the pathogenesis of EOPE, but its molecular basis and therapeutic potential remain unclear. This study aimed to elucidate the mechanisms of A2M in EOPE progression and explore the potential of A2M in the treatment of EOPE.

Novel anti-oxidative peptides from equine hemoplasma protein hydrolysates: Purification, identification and protective effects on Caco-2 cells.

In this study, we purified and identified antioxidant peptides from equine plasma protein hydrolysates and assessed their protective effects against HO-induced oxidative stress in Caco-2 cells. Four antioxidant peptides were identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in equine plasma protein hydrolysate, namely: GTMVGC (567.69 Da), FGMTST (662.

Longitudinal development of ocular biometric components and refractive error in hyperopic children with infantile versus late-onset accommodative esotropia.

Purpose: To examine the developmental patterns of refractive error and optical components in hyperopic children with infantile (onset ≤12 months of age) accommodative or late-onset (18-48 months of age) accommodative esotropia.

Methods: This prospective longitudinal study included children with infantile (n = 34) or late-onset (n = 63) accommodative esotropia. Axial length (AL), anterior chamber depth (ACD), lens thickness (LT) and keratometry (K1, K2) were obtained with a Lenstar LS 900.

A One Stone Three Birds Paradigm of Photon-Driven Pyroptosis Dye for Amplifying Tumor Immunotherapy.

Activating the pyroptosis pathway of tumor cells by photodynamic therapy (PDT) for immunogenic cell death (ICD) is considered a valid strategy in pursuit of antitumor immunotherapy, but it remains a huge challenge due to the lack of reliable design guidelines. Moreover, it is often overlooked that conventional PDT can exacerbate the development of tumor immunosuppressive microenvironment, which is apparently unfavorable to clinical immunotherapy. The endoplasmic reticulum's (ER) pivotal role in cellular homeostasis and its emerging link to pyroptosis have galvanized interest in ER-centric imaging and therapeutics.

A comprehensive analysis of vasculogenic mimicry related genes to predict the survival rate of HCC and its influence on the tumor microenvironment.

Objectives: Investigate the predictive value of Vasculogenic mimicry (VM) related genes for the survival and prognosis of Hepatocellular carcinoma (HCC) patients and its role in the tumor microenvironment (TME).

Methods: VM-related genes were obtained from previous literature, the expression profiles, single-cell data and clinical information of HCC patients were downloaded from public databases. The HCC patients were divided into different clusters by unsupervised clustering, the differences in prognosis and immune characteristics of VM-related clusters were analyzed.

[Protective effect of K12 against infection in mice].

Objectives: To investigate the protective effect of the probiotic bacterium K12 (K12) against (Mp) infection in mice.

Methods: Forty male BALB/c mice were randomized into normal control group, K12 treatment group, Mp infection group, and K12 pretreatment prior to Mp infection group. The probiotic K12 was administered daily by gavage for 14 days before Mp infection induced by intranasal instillation of Mp.

Identification of EXO1 as a potential biomarker associated with prognosis and tumor immune microenvironment for specific human cancers.

Exonuclease 1 (EXO1) is an evolutionarily conserved exonuclease, which have function on maintaining genomic stability. Elevated expression of EXO1 has been reported in certain cancers. However, a comprehensive pan-cancer analysis of EXO1 is still lacking and its role in human cancer development remains poorly understood.

Genetic variation and clinical phenotype analysis of hypermethioninemia caused by MAT1A gene mutation: Case report.

Rationale: The high clinical heterogeneity of hypermethioninemia caused by MAT1A gene defects has resulted in a paucity of studies examining the association between clinical phenotypes, biochemical characteristics, and gene mutations in this patient group. Furthermore, the indications for therapeutic interventions in patients remain unclear. The objective of this study is to provide a foundation for clinical diagnosis, genetic counseling, and follow-up management of hypermethioninemia caused by MAT1A gene defects.