Progress toward elimination mother-to-child transmission of HBV in Shandong Province, China: Coverage trend in hepatitis B vaccination and HBIG administration, 2017-2024.

To evaluate progress toward MTCT elimination of HBV, we analyzed 8-y trends in hepatitis B vaccine (HepB) and hepatitis B immune globulin (HBIG) administration coverage rates in Shandong province, focusing on high-risk populations. Data were collected from a provincial system, Shandong Vaccination Information System. Information of maternal HBsAg+ neonates born in 2017-2024 were extracted.

Association between somatic symptoms and depression and anxiety in adolescents: a cross-sectional school-based study.

Objectives: To explore the associations between somatic symptoms, depression and anxiety among Chinese adolescents in non-clinical settings.

Design: A cross-sectional study.

Setting: The questionnaire was distributed among Chinese students in Grades 10-11 from four vocational high schools (two in Anhui Province and two in Sichuan Province).

Associations between unintentional injuries and bullying victimization in adolescents: evidence from a large-scale cross-sectional study in China.

Background: Little is known about the associations between unintentional injuries from the perspective of parents and their children's bullying victimization. This study aimed to examine the links between parent-reported unintentional injury subtypes and student-reported experiences of bullying victimization from a school-based large-scale survey.

Methods: A total of 30,386 students from 35 primary schools, 27 middle schools, and 6 high schools with available data on unintentional injuries, school bullying victimization, and covariates were included in this study.

Multifaceted determinants of depressive symptoms in children migrating back from urban to rural areas: An ecological systems theory approach.

Background: While many studies have examined mental health and influencing factors of rural Chinese children who migrated back from urban areas, holistic exploration of multifaceted determinants of their depressive symptoms is lacking; this study, drawing on Bronfenbrenner's ecological systems theory and the process-person-context-time (PPCT) model, investigated multilevel factors' impact on such symptoms and gender differences.

Methods: A cross-sectional survey was conducted in 2022 in Nanling County (Anhui Province) in China. A sample of 859 school students in grades 5-9 completed assessments measuring their depressive symptoms (using the Children's Depression Inventory, CDI) and different blocks of variables (CONTEXT, PERSON, and PROCESS).

Acute myocardial infarction with ventricular septal rupture: Clinical characteristics, prognosis factors, and treatment strategies.

This review comprehensively examines acute myocardial infarction with ventricular septal rupture (VSR), a rare yet lethal complication. We analyze its epidemiological, pathophysiological, clinical, and therapeutic aspects, emphasizing innovative strategies like bioabsorbable occluders and tissue engineering to reduce complications and improve prognosis. The integration of artificial intelligence and big data analytics for treatment decision-making and personalized surgical timing models is highlighted as transformative.

Adaptation and validation of the Chinese version of the digital addiction scale for children (DASC).

Background: With more than 90% penetration of personal digital devices, digital addiction in children has emerged as a significant concern in China. Environmental and socioeconomic stressors in China-a highly collectivist society-may contribute to a higher prevalence of digital addiction. However, there is a lack of culturally adapted tools to assess digital addiction among children in China.

1α,25(OH)D alleviates perfluorooctane sulfonic acid-induced oxidative injury through the Nrf2-ARE pathway via VDR in Sertoli cells.

Purpose: Perfluorooctane sulfonic acid (PFOS) is a representative persistent organic pollutant that has been shown to impair male reproductive function. Epidemiological studies and animal models suggest that vitamin D may modify male reproductive function. However, whether 1α,25(OH)D could mitigate the PFOS-induced damage of Sertoli cells, and the underlying mechanisms remain poorly defined.

The β2-adrenergic receptor modulates activity of porcine alveolar macrophages in response to Actinobacillus pleuropneumoniae infection.

Actinobacillus pleuropneumoniae (APP) is a non-spore-forming, Gram-negative facultative, anaerobic bacterium frequently associated with piglet respiratory disease syndrome, which occurs at a notably higher incidence in the winter months and contributes to considerable economic losses to the global pig industry. Following APP infection, porcine lung tissues exhibit a robust inflammatory response characterized by the accumulation of porcine alveolar macrophages (PAMs), suggesting that the magnitude of the immune response elicited by PAMs is a critical determinant of the resolution of APP infection. Furthermore, the β2-adrenergic receptor (ADRB2) is predominantly expressed on the surface of PAMs, although the potential influence of ADRB2 on the immunological reactivity of PAMs post-APP infection remains unclear.

Automatic Screening Risk of Stroke-Associated Pneumonia and Giving Feedback to Medical Staff Can Improve Outcomes and Save Healthcare Cost in Stroke Unit.

Introduction: Stroke-associated pneumonia (SAP) is a major infectious complication after stroke and has adverse impact on clinical outcomes. This study investigates whether automatic screening the risk of SAP and giving feedback to medical staff would reduce the incidence of inhospital pneumonia and improve clinical outcomes in patients with acute ischemic stroke (AIS).

Methods: This monocentric retrospective cohort study involved eligible inpatients in neurology department of Beijing Tiantan Hospital from June 2019 to October 2023.

The effectiveness of mindful walking based on the timing it right framework in patients with atrial fibrillation and chronic heart failure.

Objective: To explore the effects of mindful walking (MFW) based on the Timing It Right (TIR) framework on anxiety, depression, and cardiopulmonary function in patients with atrial fibrillation combined with chronic heart failure.

Methods: A total of 86 patients with atrial fibrillation and chronic heart failure admitted to the cardiology department of our hospital between June 2023 and March 2024 were enrolled in this study. Two homogeneous management wards were selected, with 43 patients from Ward A serving as the control group and 43 patients from Ward B as the intervention group.

Cancer pain and quality of life structural equation model based on the biopsychosocial model.

Objective: This study employed a biopsychosocial framework to develop structural equation models(SEM)quantifying the multidimensional impact of pain on quality of life in cancer patients, aiming to provide scientific evidence and novel clinical perspectives for evidence-based pain management strategies.

Methods: This cross-sectional study recruited participants experiencing chronic cancer-related pain using convenience sampling from a tertiary cancer hospital in Shandong Province, China, between January and February 2024. Data collection involved face-to-face administration of the Brief Pain Inventory-Short Form and the Quality of Life Questionnaire-Function 17.

Accuracy of multimodal vaginal ultrasound in the detection and assessment of scar healing after caesarean section: a correlational meta-analysis.

Objective: To evaluate the accuracy of multimodal vaginal ultrasound in assessing post-caesarean scar healing.

Methods: A systematic review and meta-analysis were conducted on Chinese and English studies using multimodal vaginal ultrasound to diagnose poor scar healing post-CS. Two researchers screened literature based on inclusion/exclusion criteria.

Evaluating the impact of the diagnosis-related groups payment system on laparoscopic uterine fibroid surgery outcomes: insights from a single-center study.

Objective: This study aimed to assess the impact of implementing the diagnosis-related groups (DRGs) payment system on hospitalization costs and medical service outcomes at a single institution. The objective was to identify effective cost-saving strategies and guide healthcare practices to support the ongoing adoption of the DRGs system.

Methods: This retrospective study included 616 patients, categorized into three groups based on the payment system in effect during their treatment: a 6-month period under fee-for-service (FFS), a 6-month period following the trial implementation of DRGs (TI-DRGs), and a 6-month period after the official implementation of DRGs (OI-DRGs).

The impact of neighborhood environment on adolescent anxiety and depression: A moderated mediation model involving screen time and family function.

Objective: While the relationship between neighborhood environment and adolescent mental health is well-documented, few studies have examined the roles of screen time and family function in this association. This study aims to explore the "environment-behavior-health" pathway by investigating how neighborhood environment, screen time, and family function jointly influence adolescent anxiety and depression.

Method: Data were drawn from a large-scale, two-wave survey of 5th-12th grade Chinese adolescents.

infection induces chromatin restructuring in host cells to activate immune responses.

Background: spp., facultative intracellular pathogens that cause brucellosis, drive pathogenesis by invading host cells and establishing intracellular persistence. While their molecular mechanisms are well-characterized, how induces chromatin restructuring in host cells remains poorly understood, representing a critical gap in host-pathogen interaction research.

Mechanisms and optimization for simultaneous removal of Cd(II) and Sb(V) from aqueous solutions using birnessite and fulvic acid composite.

Cadmium (Cd) and antimony (Sb) coexistence in industrial effluents poses significant threats to environmental safety and human health. Consequently, developing effective methods for the simultaneous removal of Cd(II) and Sb(V) from aqueous solutions is critically important. In this study, the adsorption performance of a birnessite (BS) and fulvic acid (FA) composite (BS-FA) for the simultaneous removal of Cd(II) and Sb(V) was optimized using response surface methodology (RSM) in combination with machine learning (ML) techniques, including the genetic algorithm-back propagation neural network (GABP) and random forest (RF) models.

The novel tRNA-derived fragment, tiRNA-Met, inhibits the malignant progression of triple-negative breast cancer by regulating RANBP3L via a targeted interaction with SNRPA.

Background: tRNA-derived fragments (tRFs) have emerged as significant noncoding RNAs in cancer biology; however, their roles and mechanisms in triple-negative breast cancer (TNBC) remain inadequately characterized.

Methods: tRF and tiRNA sequencing, real-time quantitative polymerase chain reaction (RT-qPCR), fluorescence in situ hybridization (FISH), and subcellular fractionation were used to explore the expression and characteristic of tiRNA-Met in TNBC. The biological functions of tiRNA-Met were assessed using CCK-8 assays, colony formation assays, and Transwell assays in vitro, alongside mouse xenograft models in vivo.

Better mental health and better academic performance: A longitudinal study of high school freshmen in China.

Introduction: The present study aims to delve into the question of whether the mental well-being of middle school students may fluctuate as they transition into freshman life in China and whether this fluctuation is consistent for students from different types of high schools.

Methods: Two school-based cross-sectional surveys were administered in Anhui, China, in November 2022 and October 2023. The current study encompassed a cohort of 3124 high school freshmen from 6 schools who participated in both surveys (47.

Bidirectional longitudinal associations between estimated muscle mass and self-reported chronic lung disease in middle-aged and older adults: findings from the China health and retirement longitudinal study.

Background: The bidirectional relationship between muscle mass and chronic lung diseases (CLD) in middle-aged and older adults remains inadequately explored. This study aims to investigate the bidirectional association between estimated muscle mass and self-reported chronic lung diseases while elucidating the mediating mechanisms underlying this relationship.

Methods: This study utilized data from the nationally representative China Health and Retirement Longitudinal Study (2011-2018), focusing on individuals aged 45 years or older.

Wide-narrow row planting and limited irrigation improve grain filling and spike traits in winter wheat in arid regions.

Winter wheat is a vital grain crop in Xinjiang and severe water scarcity in this arid region necessitates efficient irrigation strategies for sustainable production. A two-year field experiment (2022-2023) in northern Xinjiang was conducted to evaluate the effects of sowing patterns and drip irrigation levels on winter wheat growth and yield. Two sowing patterns were tested: uniform row spacing (CK1, 15 cm) and wide-narrow row spacing, comprising 13.

HuMSCs-derived exosomal YBX1 participates in oxidative damage repair in granulosa cells by stabilizing COX5B mRNA in an m5C-dependent manner.

Mitochondrial dysfunction and cell senescence are triggered by reactive oxygen species (ROS) in granulosa cells (GCs), leading to premature ovarian insufficiency (POI). Human umbilical cord mesenchymal stem cell-derived exosome (HuMSCs-Ex, H-Ex)-based treatments have been shown to alleviate ROS-induced POI, but knowledge about the underlying therapeutic mechanisms is limited. Here, we observed that the 5-methylcytosine (m5C) RNA methyltransferase tRNA aspartic acid methyltransferase 1 (TRDMT1) promoted the translation of COX subunit 5B (COX5B) in a manner dependent on its catalytic activity and downstream m5C reader Y-box binding protein 1 (YBX1), which was decreased in prematurely senescent GCs but abundant in H-Ex.

Development and validation of ADC-based nomogram model for predicting the prognostic factors in preoperative clinical early-stage cervical cancer patients.

Purpose: To investigate the feasibility of ADC-based nomogram models for predicting cervical cancer (CC) subtype, lymphovascular space invasion (LVSI) and lymph node metastases (LNM) status in preoperative clinical early-stage CC patients.

Materials And Methods: A total of 535 CC patients from three independent centers [center A (n = 251) for model training, and centers B (n = 193) and C (n = 91) for external validation] were included. Volumetric ADC histogram metrics (volume, minADC, meanADC, maxADC, skewness, kurtosis, entropy, P10_ADC, P25_ADC, P50_ADC, P75_ADC, and P90_ADC) derived the whole-tumor were calculated.

The binding investigation of ziprasidone with calf thymus DNA by multiple spectrums and molecular docking.

Ziprasidone (Zi) is a 2-indolone drug that has been recommended as first-line medication for schizophrenic treatment by major guides of China and America. In this paper, the binding mode of Zi and calf thymus (ctDNA) was investigated for the first time. Fluorescence spectrum studies preliminary verified that Zi bound to groove region of ctDNA.

UAE: Universal Anatomical Embedding on multi-modality medical images.

Identifying anatomical structures (e.g., lesions or landmarks) is crucial for medical image analysis.

Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury.

Myocardial ischemia/reperfusion (I/R) injury is a major contributor to myocardial damage, leading to adverse cardiac remodeling and dysfunction. Recent studies have highlighted the potential of gut microbiota-derived metabolites in modulating cardiac outcomes. Here, the cardioprotective effects of a commensal bacterium Flavonifractor plautii (F.