Development of LPFG-Based Seawater Concentration Monitoring Sensors Packaged by BFRP.

Leveraging the sensitivity of long-period fiber grating (LPFG) to changes in the environmental refractive index, an LPFG-based seawater concentration monitoring sensor is proposed. Considering the highly saltine and alkali characteristics of the sensor's operating environment, the proposed sensor is packaged by basalt fiber-reinforced polymer (BFRP), and the sensor's sensitivities were studied by sodium chloride and calcium chloride solution concentration experiments and one real-time sodium chloride solution concentration monitoring experiment. The test results show the wavelength of LPFG, a 3 dB bandwidth and a peak loss of LPFG's spectrogram change with changes in the concentration of sodium chloride or calcium chloride solutions, but only the wavelength has a good linear relationship with the change in solution concentration, and the sensing coefficient is -0.

Experimental Study on Damage Monitoring of FRP Plate Using FBG Sensors.

With the widespread application of FRP (Fiber Reinforced Plastics) materials in fields such as wind turbine blades and ships, the safety performance of these materials during their service life has garnered signification attention. This study employs the fiber Bragg grating (FBG) sensor to monitor damage of the FRP materials. An FRP plate embedded with six FBGs was fabricated, and different degrees of damage were induced in the FRP plate.

Lobetyolin alleviates IMQ‑induced psoriasis‑like skin inflammation by maintaining the homeostasis of the skin and inhibiting the inflammatory cytokines in dendritic cells.

Psoriasis, the most common inflammatory skin disease, is marked by excessive proliferation of keratinocytes and infiltration of immune cells into the epidermis. Current treatments, particularly biologics targeting the IL‑23/IL‑17 axis, demonstrate excellent efficacy, but issues of recurrence and side effects persist. Therefore, it is essential to identify safer and more effective alternatives.

Synthetic essentiality of TRAIL/TNFSF10 in VHL-deficient renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive subtype of kidney cancer. Loss of ( and the consequent activation of hypoxia-inducible factor-α (HIFα, especially HIF2α) plays an essential role in ccRCC initiation and progression. The approved HIF2α inhibitor belzutifan faces the challenge of resistance, presenting an opportunity of co-targeting HIF2α and another vulnerability.

In Situ Electrically Resettable Field-Effect Transistor Biosensors for Continuous and Multiplexed Neurotransmitter Detection.

Accurate, real-time detection of neurotransmitters is crucial for elucidating the mechanisms of brain function and tracking the progression of neurological diseases. Biosensors usually face poor reusability induced by difficulties in probe-target separation, hindering their application for continuous monitoring. In this work, a semiconducting carbon nanotube (CNT) film field-effect transistor (FET) biosensor is developed using pH-sensitive aptamers as probes to capture targets.

Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer.

Unlabelled: Ferroptosis is a nonapoptotic form of cell death driven by iron-dependent lipid peroxide accumulation. Colorectal cancer cells feature elevated intracellular iron and reactive oxygen species that heighten ferroptosis sensitivity. The ferroptosis inducer (S)-RSL3 [(1S,3R)-RSL3] is widely described as a selective inhibitor of the selenocysteine-containing enzyme (selenoprotein) glutathione peroxidase 4 (GPX4), which detoxifies lipid peroxides using glutathione.

Interface Cleaning Strategy of Carbon Nanotube Field-Effect Transistor Biosensors for Ultrasensitive Detection of Ophthalmic Biomarkers.

Carbon nanotube (CNT) field-effect transistor (FET) biosensors combine the molecular recognition capabilities of bioreceptors with the signal amplification and transduction functions of nano-FET devices, enabling highly specific and ultrasensitive biomolecule detection. However, interface degradation and contamination introduced in the micronanofabrication process of batch manufacturing led to inhomogeneity in biofunctionalization of device and sensing performance, thus limiting the reproducible preparation and large-scale application of CNT FET biosensors. In this study, we proposed a comprehensive interface cleaning strategy using inductively coupled plasma oxygen (ICP-O) and ozone (O) treatment to reduce process contamination, which led to a 20% increase in transconductance, a 18.

The effect of AngioJet thrombectomy combined with catheter-directed thrombolysis in acute deep vein thrombosis of the lower extremities.

This study aims to explore the advantages and limitations of AngioJet mechanical thrombectomy combined with catheter-directed thrombolysis (CDT), providing reference for clinical treatment. Electronic medical records of 192 patients with lower extremity deep vein thrombosis (LEDVT) who visited our hospital from January 2022 to December 2023 were included. Patients were matched using propensity scores based on their thrombosis treatment method: the experimental group received AngioJet thrombectomy combined with CDT, while the control group received CDT alone.

Gut Microbiota Regulate Lipid Metabolism via the Bile Acid Pathway: Resistance to Hypoxia in Gansu Zokor (Eospalax cansus).

The Gansu zokor (Eospalax cansus), a subterranean rodent endemic to the Loess Plateau of China, exhibits remarkable adaptability to hypoxic environments. While gut microbiota are known to regulate lipid metabolism through bile acid (BA) pathways, this phenomenon has not been investigated in subterranean rodents exposed to hypoxia. This study employed 16SrRNA sequencing, targeted analysis of BA metabolites in colonic contents, and assessments of BA and lipid metabolites alongside molecular analyses in the liver and ileum under conditions of acute and chronic hypoxia in Gansu zokors.

Facile and Rapid Synthesis of Ultra-Low-Loading Pt-Based Catalyst Boosting Electrocatalytic Hydrogen Production.

The development of a low-cost hydrogen evolution reaction (HER) catalyst is crucial for the implementation of hydrogen production via water electrolysis. Herein, a facile and rapid electrodeposition method to synthesize an ultra-low-loading platinum-based catalyst in a short time of 120 s without any other chemical additive is reported. A functionalized nitrogen-doped carbon nanotube (F-N-CNT) is utilized as a carbon support to controllably and effectively anchor the Pt species.

Stabilized Solid Electrolyte Interface Layer and Regulate the Li Flux for Dendrite-Free Lithium Metal Batteries.

Disordered porous polyolefin separators cannot control the formation of lithium dendrites, which will seriously affect the practical application of lithium metal batteries. In this paper, the polyethylene (PE) separator is modified with CaCO and cobalt phthalocyanine (CoPc). CaCO reacts with the by-products generated during the cycling process, effectively inhibiting the successive generation of by-products, preventing the solid electrolyte interface (SEI) from being constantly destroyed and regenerated, and maintaining the stability of the SEI.

Induction of necroptosis in lung adenocarcinoma by miR‑10b‑5p through modulation of the PKP3/RIPK3/MLKL cascade.

Globally, lung adenocarcinoma (LUAD) remains the leading cause of cancer‑related mortality, highlighting the urgent need for innovative therapeutic approaches. Necroptosis has been recognized as a crucial mechanism for inhibiting cancer progression. Research has revealed a significant association between microRNA (miRNA)‑mediated necroptosis and tumor progression.

A Distributed Topology-Protecting Collaboration Algorithm: Design and Performance Analysis.

The interaction topology of multiagent systems (MASs) is crucial for effective collaboration. Recent advances in topology inference provide a better understanding of the behaviors of the systems. Nevertheless, external attackers can exploit such techniques, posing a severe privacy breach, while the challenges to the topology protection problem remain unresolved.

Advancing Pancreatic Cancer Prediction with a Next Visit Token Prediction Head on Top of Med-BERT.

Background: Electronic Health Records (EHRs) encompass valuable data essential for disease prediction. The application of artificial intelligence (AI), particularly deep learning, significantly enhances disease prediction by analyzing extensive EHR datasets to identify hidden patterns, facilitating early detection. Recently, numerous foundation models pretrained on extensive data have demonstrated efficacy in disease prediction using EHRs.

Preparation of p-type FeO nanoarray and its performance as photocathode for photoelectrochemical water splitting.

Photoelectrochemical (PEC) water splitting has the potential to convert solar energy into chemical energy, emerging as a promising alternative to fossil fuel combustion. In PEC systems, p-type semiconductors are particularly noteworthy for their ability to directly produce hydrogen. In this work, FeO with p-type semiconductor properties grown directly on the conductive glass substrate were successfully synthesized through a simple one-step hydrothermal method.

Targeted anchoring of Cu sites in imine-based covalent organic frameworks as catalytic centers for efficient Li-CO batteries.

Lithium-carbon dioxide (Li-CO) batteries have attracted much attention due to their high theoretical energy density and reversible CO reduction/evolution process. However, the wide bandgap insulating discharge product LiCO is difficult to decompose, leading to large polarization or even death of the battery, thus seriously hindering the practical application of Li-CO batteries. The properties of covalent organic framework (COF) materials, which can support the construction of multiphase catalytic systems, have great potential in the fields of CO enrichment and electrocatalytic reduction.

Prospective Associations Between Tobacco Product Use and Mental Health and Substance Use Problems Among U.S. Adolescents and Adults.

Objective: The authors examined prospective associations between tobacco product use and mental health and substance use problems among U.S. adolescents and adults.

Contrastive learning with transformer for adverse endpoint prediction in patients on DAPT post-coronary stent implantation.

Background: Effective management of dual antiplatelet therapy (DAPT) following drug-eluting stent (DES) implantation is crucial for preventing adverse events. Traditional prognostic tools, such as rule-based methods or Cox regression, despite their widespread use and ease, tend to yield moderate predictive accuracy within predetermined timeframes. This study introduces a new contrastive learning-based approach to enhance prediction efficacy over multiple time intervals.

Fructose-Driven glycolysis supports synaptic function in subterranean rodent - Gansu Zokor (Eospalax cansus).

Several studies indicate that fructose can be used as an energy source for subterranean rodents. However, how subterranean rodents utilize fructose metabolism with no apparent physiological drawbacks remains poorly understood. In the present study, we measured field excitatory postsynaptic potentials (fEPSPs) in hippocampal slices from Gansu zokor and SD rats hippocampi before and 60 min after replacement of 10 mM glucose in the artificial cerebrospinal fluid (ACSF) with 10 mM fructose (gassed with 95 % O and 5 % CO).

Effects of irisin on ovariectomy-induced depression, anxiety, and bodyweight growth in female mice.

Hormone replacement therapy (HRT) for postmenopausal syndrome (PMS) carries high risks of undesirable side effects. This study explores irisin as a potential alternative to HRT and investigates the underlying mechanisms. Ovariectomized (OVX) female mice was used as an animal model.

LAG3 immune inhibitors: a novel strategy for melanoma treatment.

Melanoma, a highly aggressive skin cancer, poses significant challenges in treatment, particularly for advanced or metastatic cases. While immunotherapy, especially immune checkpoint inhibitors (ICIs) targeting CTLA-4 and PD-1, has transformed melanoma management, many patients experience limited responses or develop resistance, highlighting the need for new therapeutic strategies. Lymphocyte activation gene 3 (LAG-3) has emerged as a promising target in cancer immunotherapy.

A 17.73 % Solar-To-Hydrogen Efficiency with Durably Active Catalyst in Stable Photovoltaic-Electrolysis Seawater System.

Developing durably active catalysts to tackle harsh voltage polarization and seawater corrosion is pivotal for efficient solar-to-hydrogen (STH) conversion, yet remains a challenge. We report a durably active catalyst of NiCr-layered double hydroxide (RuNiCr-LDH) with highly exposed Ni-O-Ru units, in which low-loading Ru (0.32 wt %) is locked precisely at defect lattice site (Ru) by Ni and Cr.