Protective Factors of Postendovascular Therapy Restenosis for Symptomatic Intracranial Arterial Stenosis: A Retrospective Analysis.

Background And Purpose: Symptomatic intracranial arterial stenosis (ICAS) markedly increases the risk of recurrent ischemic stroke, with high restenosis rates after endovascular therapy. This study aims to identify factors influencing restenosis within 1 year after endovascular therapy for ICAS, with the goal of reducing restenosis rates through interventions targeting protective and risk factors.

Materials And Methods: We conducted a retrospective analysis of symptomatic patients with ICAS who underwent endovascular therapy between January 2016 and June 2023 at our hospital.

The effect of chronotype on social functioning in schizophrenic patients: examining the chain-mediating role of sleep quality and anxiety.

Introduction: This study examines the relationship between chronotype and social functioning in individuals with schizophrenia, specifically assessing the mediating roles of sleep quality and anxiety symptoms.

Methods: 785 Chinese patients with schizophrenia (aged 18-60) completed assessments using the Morningness-Eveningness Questionnaire (chronotype), Pittsburgh Sleep Quality Index (sleep quality), General Anxiety Disorder-7 (anxiety), and Personal Social Performance Scale (social functioning). Hayes' SPSS process macros were used for analysis.

Three new species of and (Sporocadaceae, Amphisphaeriales) associated with shrub leaf diseases from Fujian, China.

and are classified as pestalotioid fungi, include a diverse range of plant pathogenic, endophytic and saprobic species and are widely distributed in tropical and temperate climates. These fungi are associated with a wide variety of plants worldwide and are exemplified by multi-septate conidia with appendages at both ends. Phytopathogenic members cause various plant diseases, for example, leaf spot, fruit rot, canker, blight and various infections affecting palm, mango, blueberry, tea and other important crops.

An integrative multi-omics study to identify candidate DNA methylation biomarkers associated with gastric cancer prognosis.

Aberrant DNA methylation (DNAm) is the most well-defined epigenetic hallmark in gastric cancer (GC), which may be associated with a variety of risk factors exposure. In this study, leveraging the multi-omics data of Genome-wide association studies (GWAS), methylation quantitative trait locus (mQTL) and expression quantitative trait locus (eQTL) collected from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx) Project and Gene Expression Omnibus (GEO) database, a joint analysis of cox proportional hazard regression and Summary-data-based Mendelian randomization (SMR) analysis were adapted to investigate the causal associations of DNAm, gene expression and the GC prognosis. The results showed the causal association of hypermethylation of cg16007185, down-regulation of TMX1, and poorer prognosis of GC patients.

Enhancing fat graft retention through adipose tissue browning: a systematic review.

Background: Recently, existing researches have gradually recognized the critical biological behaviour played by spontaneous or exogenous-induced browning conversion in fat transplantation. However, no comprehensive review explored the fat grafts remodeling process toward browning and such role in fat graft retention.

Aims: This study aimed to elucidate the behavioral characteristics of browning changes following fat grafting, as well as its benefits and mechanisms on the survival of transplanted fat.

Identification of Diffusion-Relaxation Compartments Based on Correlation to Renal Pathological Scores: An Explorative Study on Lupus Nephritis.

Background: Renal histologic findings are beneficial in the diagnosis and treatment of lupus nephritis (LN), but require an invasive biopsy. Diffusion-relaxation correlated spectrum imaging (DR-CSI) has previously been applied to assess renal fibrosis, yet current approaches for compartment identification lack quantified standards.

Purpose: This exploratory study is aimed at establishing a spectrum-pathology correlation analysis for identifying possible DR-CSI compartments, and explore the diagnostic value of the compartment fractions on common pathologic features.

Species diversity, taxonomic classification and ecological habits of polypore fungi in China.

Polypore fungi are an important part of forest ecosystems. In the last decade, the taxonomic status and species number of polypore fungi have changed greatly, and many new taxa have been discovered. China is one of the countries with the most abundant and diverse polypore fungi in the world, and a total of 1,214 polypore fungal species were reported here.

Structural characterization and effect of activating autophagy and regulating oxidative stress of polysaccharide from fibrous roots of Atractylodes chinensis.

The fibrous roots of Atractylodes chinensis are rich in polysaccharides, however, the structure and application of its polysaccharides are still unclear. In this study, a 3.7 kDa inulin-type fructan was purified, which was named ACFP-1.

A Retrospective Case Series Study of Illegal Cosmetic Iatrogenic Botulism: Outbreak Analysis and Response Lessons.

Background: Botulism is a rare and possibly life-threatening neuroparalytic syndrome. Recent large-scale outbreaks of iatrogenic botulism, primarily linked to cosmetic injections, have garnered significant attention.

Objectives: This study discusses the factors that may lead to the outbreak of cosmetic iatrogenic botulism (CIB), provides the epidemiological description of CIB cases, and puts forward response measures.

Prognostic significance of chemotherapy response score in predicting outcomes for high-grade serous ovarian carcinoma patients undergoing neoadjuvant chemotherapy.

Background: The chemotherapy response score (CRS) evaluates the response to neoadjuvant chemotherapy (NACT) in high-grade serous ovarian cancer (HGSOC). This study aimed to develop a prognostic nomogram combining CRS and clinical characteristics to improve outcome predictions for NACT-treated patients.

Methods: We retrospectively analyzed 271 HGSOC patients who received NACT.

Tobacco smoking exposure-mediated ELAVL1 regulates bladder cancer cell senescence via autophagy activation.

Tobacco smoking is a well-established risk factor for bladder cancer, which shows connection to cell senescence in various diseases. However, the regulatory mechanisms linking tobacco smoking exposure to senescence regulation in bladder cancer remain incompletely characterized. In this investigation, we demonstrated that the smoking carcinogen 4-aminobiphenyl (4-ABP) inhibited cell senescence while enhancing proliferative, invasive, and migratory capacities of bladder cancer cells, as evidenced by SA-β-gal staining, western blot and cell malignant phenotype experiments.

Dynamic causal effects of gut microbiota on cervical Cancer lesion progression.

Many investigations have highlighted the involvement of the intestinal microbiota in the progression of cervical cancer lesions; however, the causal link between them remains to be confirmed. We employed two-sample Mendelian randomization (MR) as a alternative to randomized controlled trials (RCTs) to explore the association between intestinal microbiota and high-risk Human Papillomavirus (HPV) infection, cervical intraepithelial neoplasia (CIN), and cervical cancer (CC). This method allowed for a detailed investigation of the underlying mechanistic interactions within the gut-cervix axis.

The barriers to medication error reporting by nurses and factors associated with it: a cross-sectional study in a tertiary hospital of south-west China.

Objectives: To explore the reporting barriers and related factors of medication errors among nurses in hospitals in China and provide a reference for safe medication management in hospitals.

Design: Cross-sectional, online survey.

Setting: Responses were collected online from September 2022 to November 2022 across a specific tertiary hospital in Chengdu, China.

Circularly Polarized Luminescence in Achiral Tin-Based Perovskites via Structural Isomer-Driven Coordination Interaction.

A chiral bidentate ligand, ()-(-)-1-amino-2-propanol (denoted as R) or ()-(-)-2-amino-1-propanol (denoted as R), was used to modify achiral 2D tin-based perovskite HDASnBr (HDA: 1,6-hexamethylenediamine) to form R-HDASnBr or R-HDASnBr by an acid precipitation method. R-HDASnBr exhibits a near-unity photoluminescence quantum yield (PLQY) and strong yellow circularly polarized luminescence (CPL) with a luminescence asymmetry g-factor (||) of 8.3 × 10, while R-HDASnBr shows a PLQY of 95% and || of 3.

Temporal Dynamics of Intrinsic Brain Activity in Older Women With Subclinical Depression.

Subclinical depression is common in older adults, especially in females, and may correlate with a higher likelihood of health events and poor prognosis. However, the underlying neurobiology remains unclear. This study, employing resting-state functional magnetic resonance imaging (rs-fMRI), identified alterations in temporal dynamics of intrinsic brain activity in older women with subthreshold depression (OWSD) and their potential relationships to depressive symptoms.

Sea buckthorn leaves and gallic acid inhibit C48/80-induced pseudo-allergic reaction via the PLC/IP3 signaling pathway both in vitro and in vivo.

A pseudo-allergic reaction is an abrupt, IgE-independent reaction that is similar to an allergic reaction. Sea Buckthorn leaves (SBL) have been extensively researched for their pharmacological benefits, including immunological modulation, anti-inflammatory and anti-tumor properties. However, at present, its anti-pseudo-allergic effect are remains to be assessed.

Evaluating microstructures in endometrial cancer using diffusion-relaxation correlated spectroscopic imaging: Histopathological correlations.

Background: Endometrial cancer (EC) is a prevalent gynecologic malignancy where accurate grading and assessment are crucial for determining prognosis and treatment strategies. Conventional MRI techniques, including apparent diffusion coefficient (ADC) and T2-weighted imaging, often fail to capture the detailed microstructural complexities of EC.

Purpose: To evaluate the efficacy of diffusion relaxation correlated spectroscopic imaging (DR-CSI) in assessing EC and to compare its diagnostic performance with conventional ADC and T2-weighted imaging.

Safety and Efficacy Clinical Trial of Robot-Assisted Prostate Biopsy Using a Hand-Held Robotic System.

Background: Robotic systems are increasingly utilised to improve clinical outcomes in prostate interventions.

Methods: We enroled 20 patients to verify the clinical feasibility of transrectal ultrasound (TRUS)-guided robot-assisted prostate biopsy (PBx). For each patient, controlled trials of systematic 12-core PBx were initially conducted manually using a biopsy gun, followed by a 3-core cognitive fusion targeted biopsy performed by the hand-held robot.

Effects of high-intensity interval training versus moderate-intensity continuous training on cardiorespiratory and exercise capacity in patients with coronary artery disease: A systematic review and meta-analysis.

Background: With the increasing utilization of cardiac rehabilitation in clinical treatment and prognosis for patients with cardiovascular diseases, exercise training has become a crucial component. High-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) are commonly employed in rehabilitating patients with cardiovascular diseases. However, further investigation is required to determine whether HIIT and MICT can effectively enhance the prognosis of patients with coronary artery disease.

Design of Decanoic Acid/Polysorbate 80 Composite Vesicles as Cosmetics Carrier: Stability, Skin Permeability, Antioxidant and Antibacterial Activity.

Fatty acid vesicles are natural biomaterials which possess unique bilayer structures and offer biomimetic advantages for drug and gene delivery. Nevertheless, the formation of fatty acid vesicles is limited to neutral alkaline circumstances and cannot adapt to the acidic environment of the living system. In this work, the non-ionic surfactant polysorbate 80 (TW80) was introduced, extending the pH window of vesicles formed by decanoic acid (DA) from 6.

Advanced diffusion-weighted imaging biomarkers for non-invasive assessment of tumor microenvironment in rectal cancer: restricted spectrum imaging.

Purpose: To explore the heterogeneity of the rectal cancer microenvironment (TME) using restricted spectrum imaging (RSI) and investigate its association with tumor stroma and Ki67 as key histopathologic indicators.

Materials And Methods: In this prospective study, 66 patients with rectal cancer underwent pretreatment MRI with RSI. The optimal model format was determined by Bayesian Information Criterion (BIC).

Rejuvenating Hyaline Cartilage with Senescence-Targeting Si-ADAM19 Delivery for Osteoarthritis Therapy.

Osteoarthritis (OA) is one of the most common joint degenerative diseases without effective treatment, whose pathology is related to the local accumulation of senescent cells (SnCs). However, existing SnCs-scavenging drugs "senolytics" may lead to the exhaustion of stem and progenitor cells, impairing chondrocyte proliferation and cartilage regeneration. Here, ADAM19, a kind of endopeptidases from the ADAM (a disintegrin and metalloproteinase) family, is identified as a novel target for senescent chondrocyte rejuvenation.

Gibberellic acid (GA) induces developmental toxicity in zebrafish (Danio rerio) embryos via oxidative stress.

Gibberellic acid (GA) is a plant growth regulator that stimulates the growth of leaves and increases yield in agricultural production. However, GA is also regarded as an environmental endocrine disruptor, and its effect on aquatic life remains unclear. In this study, the toxic effects of GA on the development of zebrafish (Danio rerio) embryos were evaluated, and the mechanisms were revealed.