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Objectives: To explore the reporting barriers and related factors of medication errors among nurses in hospitals in China and provide a reference for safe medication management in hospitals.
Design: Cross-sectional, online survey.
Setting: Responses were collected online from September 2022 to November 2022 across a specific tertiary hospital in Chengdu, China.
Participants: Clinical registered nurse.
Primary Outcome Measure: Measure the Barriers to Medication Administration Error (MAE) Reporting Questionnaire, Face-Saving Scale, the Index of Hierarchy of Authority and the Working Environment Questionnaire. Independent sample t-test, correlation analysis and multiple linear regression analysis were performed to identify factors associated with the barriers to MAE reporting.
Results: 432 (97.30%) nurses responded. Nurses' standardised scores of barriers to MAE reporting were 3.01 (SD=1.01); the fear dimension items have the highest standardised score of 3.42 (SD=1.11). Working environment is negatively correlated with barriers to MAE reporting (r=-0.201, p<0.01); face-saving (r=0.866, p<0.01) and index of hierarchy of authority (r=0.799, p<0.01) are positively correlated with barriers to MAE reporting. All three were the main influencing factors of barriers to MAE reporting, which could explain 82.4% of the barriers' variance (R=0.826, Radj=0.824, F=253.665, p<0.001).
Conclusions: Nurses' medication error reporting barriers mainly come from the fear of reporting consequences. The working environment is the protective factor of reporting barriers. Still, face-saving and the index of hierarchy of authority are the main risk factors. Improving the working environment may help reduce medication error reporting barriers. Still, more importantly, hospital managers need to take adequate measures to reduce nurses' sense of face-saving and power distance, which may be more helpful in reducing the barriers to medication error reporting and improving hospital medication safety management.
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http://dx.doi.org/10.1136/bmjopen-2024-091058 | DOI Listing |
J Safety Res
September 2025
Vehicle Safety, Mechanics and Maritime Sciences, Chalmers University of Technology, SE 412 96 Gothenburg, Sweden.
Introduction: While previous research has focused on drivers' visual behaviors during normal driving, few studies have explored how age-related decline affects driver reactions in collisions. This study bridges this gap by investigating aging effects on driver responses in urban car-to-cyclist intersection scenarios.
Method: Twenty-four licensed drivers, younger (mean age 35.
Bioorg Chem
September 2025
School of Cosmetic Science, Mae Fah Luang University, Chiang Rai 57100, Thailand. Electronic address:
Although antimicrobial peptides possess potent antimicrobial activities, the high cost of production, based on amino acid length, has limited their therapeutic and cosmeceutical applications. This study aimed to produce and characterize de novo designed antimicrobial peptides derived from WSKK11 and WSRR11 for efficacy against acne-causing bacteria. Ten designed peptides were evaluated for antimicrobial, hemolytic, and cytotoxic activities, as well as, secondary structures by FTIR and modes of action.
View Article and Find Full Text PDFFood Chem
September 2025
Universidad de Alcalá, Departamento de Química Analítica, Química Física e Ingeniería Química, Ctra. Madrid-Barcelona Km. 33.600, 28871 Alcalá de Henares, Madrid, Spain; Universidad de Alcalá, Instituto de Investigación Química Andrés M. del Río, Ctra. Madrid-Barcelona Km. 33.600, 28871
This study develops, for the first time, a sustainable method to extract extractable (EPPs) and non-extractable polyphenols (NEPs) from lemon peels using microwave-assisted extraction (MAE) with biobased solvents. A simplex-centroid design optimized EPPs extraction using γ-valerolactone (GVL), ethyl acetate (EtAc), and cyclopentyl methyl ether (CPME) (59.4:37:3.
View Article and Find Full Text PDFComput Biol Med
September 2025
U.O.C. Ematologia e Terapia Cellulare, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.
Artificial intelligence is revolutionizing health care, particularly in precision medicine and noninvasive diagnostics. Anemia, which is a widespread condition that affects billions of people worldwide, compromises oxygen transport due to low hemoglobin levels, which leads to severe complications if left undetected. Early and frequent monitoring is essential, yet traditional blood tests can be invasive, costly, and impractical for continuous assessment.
View Article and Find Full Text PDFJ Ethnopharmacol
September 2025
Lab of Food Function and Nutrigenomics, College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China; Institute of Integrative Medicine, Hunan Provincial Key Laboratory of Liver Visceral Manifestation in Traditional Chinese Medicine, Department of Integrated Traditio
Ethnopharmacological Relevance: Corus officinalis Siebold & Zucc belongs to the genus Cornus in the Cornaceae family, and was first recorded in the "Shennong Herbal Classic", now has been included in "according to the tradition of both food and Chinese herbal medicines", consist of kidney and liver tonifying, antioxidant substances including cycloid glycosides, flavonoids, polyphenols, organic acids, etc. AIM OF THE STUDY: This study was aimed at discovering the mechanism underlying the anti-hyperemia effect of Cor in rats, particularly its protective effect against liver and kidney dysfunction caused by HUA.
Materials And Methods: In this study, the effect of Cor extract against HUA was verified in rats, subsequently, network pharmacology combined with non-targeted metabolomic were performed to investigate its composition characteristics, and further multi-omics studies and molecular validation were performed to reveal molecular mechanism both in vivo and in vitro.