Enhancing one-year mortality prediction in STEMI patients post-PCI: an interpretable machine learning model with risk stratification.

Background: ST-elevation myocardial infarction (STEMI) poses a significant threat to global mortality and disability. Advances in percutaneous coronary intervention (PCI) have reduced in-hospital mortality, highlighting the importance of post-discharge management. Machine learning (ML) models have shown promise in predicting adverse clinical outcomes.

Kaempferol Plays a Neuroprotection Role by Alleviating Oxidative Stress via AKT/Nrf2/HO-1 Pathway and Inhibiting Apoptosis in Intracerebral Hemorrhage.

Intracerebral hemorrhage (ICH) is a common yet severe cerebrovascular disorder associated with high morbidity, disability, and mortality rates. Kaempferol (Kae), a natural flavonoid with potent antioxidant and anti-inflammatory properties, has shown promise in neuroprotection; however, its therapeutic potential in promoting neurological recovery after ICH remains unclear. In this study, we investigated the neuroprotective effects of Kae in ICH and explored its underlying mechanisms using in vitro and in vivo models.

Ambient-stable Mg-doped CsCuI nanocrystals with enhanced photoluminescence for color conversion blue LEDs.

We successfully synthesized Mg-doped CsCuI nanocrystals (NCs) under ambient conditions. The 10% Mg-doped CsCuI NCs exhibit significantly enhanced optical properties, achieving a photoluminescence quantum yield (PLQY) of 25.80% and a narrow emission full width at half maximum (FWHM) of 78 nm.

Genotype-dependent responses of pepper endophytes to soil microbial community shifts induced by allyl isothiocyanate fumigation.

Introduction: Allyl isothiocyanate (AITC) has demonstrated efficacy as a soil fumigant, effectively controlling soil-borne pathogens and nematodes. Although AITC has a significant effect on soil microbial communities, whether fumigation affects the production of crop endophytes is unclear.

Methods: In this study, AITC was used to fumigate the soil, and the response of endophytic bacteria (in roots, stems, and leaves) in different pepper genotypes (Xiangla359, La Xuan, Shuang Jiao) was investigated.

Petrological diversity of continental arc magmatism evidenced by Triassic magmatic complexes in East Kunlun Orogen.

Understanding the petrogenetic relationships among the synplutonic dikes, magmatic enclaves and plutons in subduction zones provides key insights into the petrological diversity of arc magmatism. Here we present an integrated study on the petrology, LA-ICP-MS zircon U-Pb geochronology, whole-rock geochemistry and Sr-Nd-Hf isotopes of Triassic coeval basic-intermediate dikes, mafic microgranular enclaves (MMEs) and their host plutons (gabbrodiorite, granodiorite and monzogranite) in the East Kunlun Orogen, northern Tibetan Plateau, to reveal their magma sources, magmatic processes and dynamic connections. Petrological and chronological studies reveal that these mafic-felsic igneous rocks coexist in space and time, showing imprints of mixing or mingling and similar crystallization ages (ca.

Overcoming extracellular vesicle-mediated fratricide improves CAR T cell treatment against solid tumors.

The efficacy of chimeric antigen receptor (CAR) T cells against solid tumors is limited. The molecular mechanisms underlying CAR T cell resistance are yet to be elucidated and new strategies need to be developed to improve treatment outcomes. Here we report that solid tumors respond to CAR T cells by upregulating the secretion of small extracellular vesicles carrying tumor antigens, which are horizontally transferred to CAR T cells, leading to antigen recognition and CAR T cell fratricide.

Enhancing microcirculation in STEMI patients: can intracoronary thrombolysis combined with thrombus aspiration provide an optimal strategy?

ST-elevation myocardial infarction (STEMI) is a critical cardiovascular emergency characterized by acute coronary artery occlusion and subsequent myocardial injury. The current standard of care is primary percutaneous coronary intervention (PPCI), which aims to rapidly restore epicardial blood flow. However, despite successful revascularization, microvascular obstruction (MVO) remains a major challenge, contributing to adverse clinical outcomes.

Sustainable reuse of plant waste through biofumigation: controlling soil-borne pathogens and enhancing soil health via microbial regulation.

Background: Soil-borne pathogens severely impact soil health and crop growth. Biofumigation is an eco-friendly method and supports global efforts to reduce chemical fertilizers and pesticides. However, the application in China is limited mainly due to high cost.

Evaluation of newly combination of Trichoderma with dimethyl disulfide fumigant to control Fusarium oxysporum, optimize soil microbial diversity and improve tomato yield.

This study focuses on the severe soil-borne disease problems resulting from the continuous tomato cultivation in China, with the aim of deeply studying the multi-dimensional effects of the combined application of dimethyl disulfide (DMDS) and Trichoderma on soil microecology and tomato yield. Firstly, a plate confrontation experiment was conducted in the laboratory to determine the antibacterial effect of Trichoderma afroharzianum (TAF), and the results indicated that the inhibition rate of TAF against Fusarium oxysporum, an important tomato soil-borne pathogen, was 70.8 %, which suggests TAF could be a potential biocontrol agent.

Uncovering the performance of amorphous tungsten oxide electrodes within Zn-ion electrolytes toward stable aqueous electrochromic devices.

Aqueous Zn-ion electrochromic devices (ZECDs) are attractive cheap, multifunctional and green energy saving technologies but are bottlenecked by limitations in ion diffusion kinetics within electrodes and the compatibility of electrolytes to achieve satisfactory stability. Here, key bulk properties (such as hydrogen bonding, ions conductivity, pH and electrochemical stability, etc.) of various aqueous Zn-ions electrolytes and the Zn-ions migration kinetics in amorphous WO electrochromic electrodes were systematically investigated through combining experimental and theoretical analyses.

Studying the Antifungal Effects of (Sprengel) R. King and H. Robinson (= Sprengel) as a Bio-Fumigant Plant Alone and in Combination with Biochar Against (Edson) Fitz.

spp. are soil-borne pathogens that cause damping-off and root rot diseases in many plant species such as cucumber. In the current study, the effect of dried roots-stems and leaves of (Sprengel) R.

Robust MnO-WO Complementary Electrochromic Device Enabled by Reversible Electrodeposition of MnO.

Reversible electrodeposition and dissolution of manganese oxide (MnO) represent an emerging electrochromic system. However, challenges such as "dead MnO" formation, limited optical modulation across a narrow wavelength range, and difficulties in scaling up have significantly hindered the development of MnO reversible electrodeposition-based electrochromic windows. In this work, we introduced Fe/Fe mediator ions into the electrolyte to suppress the Jahn-Teller effect, thereby preventing the formation of "dead MnO" and achieving stable and reversible MnO deposition/dissolution.

Salvianolic acid A inhibits ferroptosis and protects against intracerebral hemorrhage.

Intracerebral hemorrhage (ICH) is a common cerebral vascular disease with high incidence, disability, and mortality. Ferroptosis is a regulated type of iron-dependent, non-apoptotic programmed cell death. There is increasing evidence that ferroptosis may lead to neuronal damage mediated by hemorrhagic stroke mediated neuronal damage.

Exosomes derived from human umbilical cord mesenchymal stem cells decrease neuroinflammation and facilitate the restoration of nerve function in rats suffering from intracerebral hemorrhage.

Exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSC-ex) have become a hopeful substitute for whole-cell therapy due to their minimal immunogenicity and tumorigenicity. The present study aimed to investigate the hypothesis that hUCMSC-ex can alleviate excessive inflammation resulting from intracerebral hemorrhage (ICH) and facilitate the rehabilitation of the nervous system in rats. In vivo, hemorrhagic stroke was induced by injecting collagenase IV into the striatum of rats using stereotactic techniques.

Exosomes derived from human umbilical cord mesenchymal stem cells pretreated by monosialoteterahexosyl ganglioside alleviate intracerebral hemorrhage by down-regulating autophagy.

Purpose: Intracerebral hemorrhage (ICH) results in substantial morbidity, mortality, and disability. Depleting neural cells in advanced stages of ICH poses a significant challenge to recovery. The objective of our research is to investigate the potential advantages and underlying mechanism of exosomes obtained from human umbilical cord mesenchymal stem cells (hUMSCs) pretreated with monosialoteterahexosyl ganglioside (GM1) in the prevention of secondary brain injury (SBI) resulting from ICH.

Life cycle assessment of coal mines of diverse scales over time in China.

Coal mining has important detrimental effects on the environment and human health. By the end of 2022, China mined more than 4 billion tons of raw coal, and coal mining contributed to adverse environmental impacts. The objective of this work is to evaluate the environmental impacts emanated from coal mines in different periods (construction period, production period and closing period) and to find the relationship between coal mine scale and ecological impacts.

Transcriptome reveals the toxicity difference of dimethyl disulfide by contact and fumigation on Meloidogyne incognita through calcium channel-mediated oxidative phosphorylation.

The prevention and control of root-knot nematode disease has been posing a severe challenge worldwide. Fumigant dimethyl disulfide (DMDS) has excellent biological activity against nematodes. However, DMDS displays significant differences in contact and fumigation toxicity on nematodes.