[ Granule improves motor deficits in mouse models of Parkinson's disease by regulating the necroptosis pathway].

Objectives: To investigate the effects of formulated granules of (TGY) on motor deficits in a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced subacute Parkinson's disease (PD) and explore the possible molecular mechanisms.

Methods: Ninety C57BL/6 mice were randomized equally into 6 groups, including a control group, a PD model group, a NEC-1 (6.5 mg/kg) treatment group, two TGY treatment groups at 5 and 2.

Evaluating Neurosurgery Resident Competency: A Comparative Study of Milestones 1.0 and 2.0 Across 10 Years.

Background And Objectives: The Accreditation Council for Graduate Medical Education Neurosurgery Milestones were implemented to advance competency-based training in neurosurgery; however, research on milestones in neurosurgery has been more limited, and there has been no comprehensive study on the milestone ratings and the comparability of Milestones 1.0 and 2.0.

The application of KI.C57-ras2.0 mouse in the carcinogenicity evaluation of medical devices-carcinogenicity evaluation of a novel hemodialyzer.

Introduction: Alternative transgenic mouse models, such as rasH2, have been developed as to replace the traditional 2-year rodent carcinogenicity study. However, due to high cost, reliance on imports, and unpredictable supply chains, these transgenic mouse models have not yet been widely adopted for carcinogenicity evaluations of medical devices in China.

Methods: KI.

Danggui Buxue Decoction Alleviates Acute Hypoxia-Induced Sleep Disorders: Insights from in vivo and in silico Analyses.

Background: Acute hypoxia-induced sleep disorders (AHISD) frequently occur in individuals exposed to high altitudes, yet current treatment options are limited. Danggui Buxue decoction (DBD) originated from the ancient medical book "NeiWaiShangBianHuo Lun" for more than 700 years, and is widely used to treat anemic diseases in clinical, with the potential to treat AHISD.

Methods: We employed a combination of behavioral assays, transcriptomics, neurotransmitter profiling, and in-silico approaches to evaluate the effects and mechanisms of DBD.

Discovery of two IgM subclasses in Nile tilapia (Oreochromis niloticus) provides insights into IgM evolution in teleost fish.

Immunoglobulin M (IgM) is considered the most ancient and prevalent Ig in fish, which plays important roles in systemic and mucosal immunity. In the current study, two heavy chain genes of IgM (named Ighμ1 and Ighμ2) were cloned in Nile tilapia (Oreochromis niloticus), and the amino acid identity between the constant regions of the two IgM heavy chains were 82.58 %.

Complex determinants of hospital discharge readiness among patients with acute myocardial infarction: A fuzzy-set qualitative comparative analysis.

Background: Hospital discharge readiness is a crucial concept, influenced by various individual, interpersonal, and institutional factors in populations experiencing acute myocardial infarction. However, there is a gap in the exploration of these interactive variables, particularly regarding integrated configurations that facilitate readiness for hospital discharge.

Objective: This study aimed to explore the complex determinants affecting hospital discharge readiness from an integrated perspective, based on the Middle-Range Theory of Adaptation to Chronic Illness.

TRIM13 prevents cardiomyocyte injury by affecting apoptosis through interacting with CD3D in myocardial infarction.

Myocardial infarction (MI) is a common cardiovascular disease with a high risk of sudden death. We aim to develop potential and more effective therapeutic strategies for treating and preventing MI. A mouse model of MI was established, and cardiac tissue sample microarray data and GSE236374 dataset were collected to screen and 120 upregulation and 15 downregulation genes were obtained, and related to T cells and cell immunity.

Simultaneous remediation of As(V), Cd(II) and Pb(II) in aqueous solution and soil using Fe/Ca-modified biochar.

A novel Fe/Ca-modified biochar (BC) derived from corn stalk was prepared in this study for the simultaneous adsorption and immobilization of arsenic, cadmium and lead in aqueous solution and soil, respectively. The adsorption experiment in aqueous solution indicated that 1Ca-Fe@BC exhibited excellent removal efficiency (, %) towards arsenic (46.3%), cadmium (76.

Association of admission blood glucose and postoperation fast blood glucose with futile recanalization in patients with endovascular therapy.

Background: Futile recanalization (FR), defined as patients with long-term functional dependence despite successful recanalization, is common in patients with large-vessel stroke undergoing endovascular treatment (EVT). The present study aimed to identify the relationship between blood glucose and FR.

Methods: Patients admitted to our stroke center in China between November 2019 and September 2022 were recruited according to the inclusion criteria and exclusion criteria.

A retrospective observational study on the prognostic role of inflammatory markers in futile recanalization after endovascular treatment for large-vessel stroke.

ObjectiveEndovascular treatment has proven to be effective in improving the outcome of patients with large-vessel stroke. However, more than half of the patients experience poor outcomes despite successful recanalization, which was defined as futile recanalization. The present study aimed to identify the relationship between multiple inflammatory markers (before and after endovascular treatment) and futile recanalization.

The impact of intraoperative neuromonitoring combined with evidence-based nursing on vocal cord function, emotional state, pain, and quality of Life in patients after total thyroidectomy for thyroid cancer: a comprehensive study.

Objective: To evaluate the impact of intraoperative neuromonitoring (IONM) combined with evidence-based nursing on vocal function, emotional status, pain levels, and quality of life (QoL) in patients undergoing total thyroidectomy for thyroid cancer.

Methods: A single-center randomized controlled trial was conducted. The intervention group received IONM with evidence-based nursing, while the control group underwent IONM with conventional nursing.

Aerobic exercise rescues synaptic plasticity in early-stage Alzheimer's disease by suppressing miR-3473e to activate EphB2-dependent NMDA/AMPA receptor signaling.

Cognitive dysfunction in early-stage Alzheimer's disease (AD) involves significant impairments in synaptic plasticity and dendritic spines integrity. Intriguingly, exercise interventions have demonstrated efficacy in enhancing cognitive function. However, the precise molecular mechanisms, particularly the upstream endogenous regulators (such as miRNAs) through which exercise mediates this synaptic improvement, remain unclear.

The effect of physical activity on resilience of Chinese children: the chain mediating effect of executive function and emotional regulation.

Background: Children’s mental health has become a major public health challenge, with approximately 19.3% of Chinese children and adolescents facing mental health problems. Resilience, a positive adaptive trait, serves as a key protective factor in children’s mental health.

Pannexin1 via P2rx7/amphiregulin contributes to cardiac fibrosis post myocardial infarction.

The primary pathological mechanism underlying ventricular remodeling and cardiac dysfunction following myocardial infarction (MI) is predominantly mediated by cardiomyocyte apoptosis. Pannexin1 (PANX1) channels, which open during apoptosis, facilitate the release of ATP from dying cells. However, the functional significance of PANX1 in mediating cardiomyocyte apoptosis and its contribution to myocardial infarction progression remain to be fully elucidated.

Metal-organic framework (MOF) materials and functionalization for targeted adsorption of pb and cd in wastewater: Mechanisms, challenges, and future development prospects.

With the rapid development of global industrialization, heavy metals(HM) pollution in water bodies worldwide has become one of the key environmental challenges due to its persistent toxicity and bioaccumulation risks. Lead (Pb) and cadmium (Cd), as common and typical representatives of toxic heavy metals, are primarily originating from wastewater discharge from industries such as metallurgy, electroplating, and pesticides. Due to their heightened toxicity risks, membrane separation, precipitation, adsorption, and other technologies have been proposed.

Postoperative pneumonia in patients with non-small cell lung cancer undergoing thoracoscopic surgery: What should we care about?

Background: The prevention of postoperative pneumonia in patients with non-small cell lung cancer (NSCLC) undergoing thoracoscopic surgery holds significant clinical importance. This study aimed to evaluate the status quo and influencing factors of postoperative pneumonia in patients with NSCLC.

Methods: Patients with NSCLC undergoing thoracoscopic surgery at our hospital from January 2023 to October 2024 were included.

Specific association and independent predictive value of HBV RNA in the disease progression of hepatitis B with low-level viremia.

Background And Objective(s): HBV RNA serve as a downstream transcriptional product of cccDNA within the liver. This study is the first to investigate the diagnostic significance of serum HBV RNA in HBV low-level viremia (LLV) patients, elucidating the interrelationships among serum HBV RNA, HBV DNA, and HBsAg.

Methods: A cohort of 514 HBV LLV patients was collected from The Second Hospital of Nanjing and divided into four groups: asymptomatic HBV carriers (ASC), chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC).

Dapagliflozin ameliorates high glucose-induced epithelial-mesenchymal transition via up-regulating ACE2 mediated by EZH2 in diabetic nephropathy.

Purpose: To investigate the protective function and underlying mechanism of dapagliflozin on tubulointerstitial fibrosis (TIF) in diabetic nephropathy (DN).

Methods: In this study, we constructed the high-fat and high-glucose diet combined with streptozocin (STZ)-induced DN rat model and 0.2 mg/kg/d of dapagliflozin pretreatment model.

Grass carp reovirus VP6 inhibits IFN production by degrading TBK1 through the autophagy pathway.

The interferon (IFN) response serves as a powerful defense mechanism against viral infections in fish. However, grass carp reovirus (GCRV) is capable of evading the IFN system, although the specific mechanisms remain unclear. In this study, we report that GCRV VP6 employs an immune evasion strategy by degrading TANK-binding kinase 1 (TBK1) through the autophagy pathway, thereby inhibiting IFN activation.

A Rare Cause of Supravalvular Aortic Stenosis: Aberrant Fibrous Band Formation Connecting the Left Coronary Cusp to the Sinus Wall.

Transesophageal echocardiography (TEE) revealed that supravalvular aortic stenosis was caused by an aberrant fibrous band bridging the left coronary cusp and the sinus wall. This case highlights the advantage of TEE in delineating such abnormal anatomy and guiding precise etiological diagnosis and surgical planning.

[Molecular Biological Mechanism and Transfusion Strategy of a Jk(a-b-) Family].

Objective: To investigate the molecular mechanism and explore blood transfusion strategies for a proband exhibiting the JK (a-b-) phenotype and anti-JK high frequency antigen antibody and her eight family members.

Methods: The Kidd blood phenotype and irregular antibodies in a family were identified by serologic tests. Exon 4-11 and intron region of gene were sequenced by Sanger method.

Advanced analysis of defect clusters in nuclear reactors using machine learning techniques.

Studying defects and defect clusters in reactor materials is essential for understanding the degradation mechanisms of materials under irradiation. By uncovering the formation and evolution of defects, this paper provides critical insights for enhancing the radiation resistance of reactor materials and extending their service life. The contributions of this study are as follows: (1) Integration of a large-scale molecular dynamics (MD) dataset generated by cascade collisions and the application of machine learning (ML) techniques to investigate point defects and their clusters in reactor pressure vessel (RPV) materials; (2) Proposal of a novel clustering method based on physical characteristics, enabling efficient classification of defect clusters while effectively reducing data noise; (3) Development of a component-based defect cluster configuration recognition method using a dual-pointer lattice-filling technique, accurately capturing all defects and identifying several cluster morphologies observed in experiments; (4) Demonstration of the algorithm's outstanding performance in handling systems containing millions of atomic coordinates, showcasing its scalability and robustness; (5) Visualization of the three-dimensional spatial distribution of defect clusters and provision of two-dimensional spatial density distribution maps for vacancy clusters and interstitial clusters, offering precise characterization of spatial relationships within defect clusters and new insights into the irradiation mechanisms of materials.

Development and validation of an MRI spatiotemporal interaction model for early noninvasive prediction of neoadjuvant chemotherapy response in breast cancer: a multicentre study.

Background: The accurate and early evaluation of response to neoadjuvant chemotherapy (NAC) in breast cancer is crucial for optimizing treatment strategies and minimizing unnecessary interventions. While deep learning (DL)-based approaches have shown promise in medical imaging analysis, existing models often fail to comprehensively integrate spatial and temporal tumor dynamics. This study aims to develop and validate a spatiotemporal interaction (STI) model based on longitudinal MRI data to predict pathological complete response (pCR) to NAC in breast cancer patients.

Mg inhibits infection of spring viraemia of carp virus (SVCV) by enhancing IRF3 expression.

Magnesium ions (Mg), essential divalent cations, play a pivotal role in orchestrating a myriad of physiological and biochemical processes. However, the intricate relationship between Mg homeostasis and antiviral immunity in fish remains largely unexplored. In this study, we found that Mg enhances the interferon (IFN) response by increasing the expression of IFN regulatory factor 3 (IRF3) to inhibit spring viraemia of carp virus (SVCV) infection.