TRIM13 prevents cardiomyocyte injury by affecting apoptosis through interacting with CD3D in myocardial infarction.

Myocardial infarction (MI) is a common cardiovascular disease with a high risk of sudden death. We aim to develop potential and more effective therapeutic strategies for treating and preventing MI. A mouse model of MI was established, and cardiac tissue sample microarray data and GSE236374 dataset were collected to screen and 120 upregulation and 15 downregulation genes were obtained, and related to T cells and cell immunity.

Synergistic chemo-immunotherapy for osteosarcoma via a pH-responsive multi-component nanoparticle system.

Introduction: Osteosarcoma (OS) is the most common primary malignant bone tumor in pediatric populations. Its treatment is complicated by chemotherapy-induced toxicity and limited induction of immunogenic cell death (ICD).

Methods: To address these challenges, we developed a pH-responsive, multi-component nanoparticle system designed to co-deliver doxorubicin (DOX), monophosphoryl lipid A (MPLA), and a PD-1/PD-L1-targeting peptide, integrated with the immune-modulating polymer PEG-PC7A.

LncRNA CASC2 mediates SOCS6 mRNA stabilization via U2AF2 recruitment to modulate macrophage polarisation in diabetic retinopathy.

Background: Diabetic retinopathy (DR) is a prevalent microvascular complication of diabetes and a leading cause of vision loss among diabetic individuals. Retinal pigment epithelium (RPE) cells play a crucial role in the pathophysiology of DR by releasing cytokines and exosomal cargo, such as long non-coding RNAs (lncRNAs), that modulate local immune responses, maintain retinal immune homeostasis and influence macrophage polarisation. Recent studies suggest that lncRNA cancer susceptibility candidate 2 (CASC2) may be involved in the regulation of DR progression.

YB1 and its role in osteosarcoma: a review.

YB1 (Y box binding protein 1), a multifunctional protein capable of binding to DNA/RNA, is present in most cells and acts as a splicing factor. It is involved in numerous cellular processes such as transcription, translation, and DNA repair, significantly affecting cell proliferation, differentiation, and apoptosis. Abnormal expression of this protein is closely linked to the formation of various malignancies (osteosarcoma, nasopharyngeal carcinoma, breast cancer, etc.

Productivity Prediction Model for Horizontal Wells of Shale under Cyclic Conflagration Compression Fracturing Percussion.

A multiscale complex fracture and matrix damage coupled productivity prediction model under cyclic percussion of horizontal wells is established, according to the evolution of matrix permeability and the characteristics of complex fracture seepage after cyclic conflagration compression fracturing. The effects of the conflagration loading rate, cyclic percussion times, horizontal in situ stress difference, seepage interference, and wellbore pressure drop on horizontal well productivity are analyzed. The results show that the loading rate and percussion times are positively correlated with the production growth rate, but the growth through percussion has a threshold.

Mechanism of Pressure Difference Variations on Heavy Oil Start-Up and Percolation Effects.

To investigate the influence of pressure difference changes on the micro start-up and percolation of heavy oil, a micro visualization displacement device was used to characterize the start-up time and oil-water percolation state of heavy oil. The mechanism of different pressure differences, as well as the frequency and amplitude of pressure difference changes, on the start-up and percolation balance of heavy oil was clarified. The results indicate that high-pressure difference and pressure difference changes can reduce the start-up time of heavy oil.

Implementation of Innovative Teaching Approaches for Standardized Training of New Nurses in the Operating Room.

Objective: This study aims to investigate the impact of a novel and diversified teaching approach on training new nurses in the operating room.

Methods: A comparative observational study with a quasi-experimental design was conducted. We selected 32 new nurses undergoing standardized training in the operating room at Panzhihua Central Hospital between March 2017 and March 2020, along with 29 nurses trained from January 2014 to December 2016, as research participants.

Abnormal Systemic and Ocular Responses to the Valsalva Manoeuvre in Primary Open-Angle Glaucoma: A Case for Autonomic Failure?

Objective: This study aimed to examine the association of primary open-angle glaucoma (POAG) with autonomic dysfunction by assessing the differences in systemic and ocular responses to an autonomic provocation test, the Valsalva manoeuvre (VM), between POAG patients and normal subjects.

Methods: Forty POAG and forty control subjects were subjected to the VM. Systemic and ocular parameters were measured at baseline, phase 2, and phase 4 of the VM (VM2 and VM4), where VM2 and VM4 are sympathetic and parasympathetic nervous activation states, respectively.

Artificial intelligence method based on multi-feature fusion for automatic macular edema (ME) classification on spectral-domain optical coherence tomography (SD-OCT) images.

Purpose: A common ocular manifestation, macular edema (ME) is the primary cause of visual deterioration. In this study, an artificial intelligence method based on multi-feature fusion was introduced to enable automatic ME classification on spectral-domain optical coherence tomography (SD-OCT) images, to provide a convenient method of clinical diagnosis.

Methods: First, 1,213 two-dimensional (2D) cross-sectional OCT images of ME were collected from the Jiangxi Provincial People's Hospital between 2016 and 2021.

Sympathetic activation leads to Schlemm's canal expansion via increasing vasoactive intestinal polypeptide secretion from trabecular meshwork.

We previously demonstrated vasoactive intestinal polypeptide (VIP) eyedrops reduce intraocular pressure (IOP) and stabilize cytoskeleton of the Schlemm's canal (SC) endothelium in a chronic ocular hypertension rat model. Here we determine if the trabecular meshwork (TM) releases endogenous VIP and affect SC in paracrine manner, and whether this cellular interaction via VIP is strengthened under stimulated sympathetic activity. A rat model of moderate-intensity exercise was established to stimulate sympathetic activation.

Biomechanically and biochemically functional scaffold for recruitment of endogenous stem cells to promote tendon regeneration.

Tendon regeneration highly relies on biomechanical and biochemical cues in the repair microenvironment. Herein, we combined the decellularized bovine tendon sheet (DBTS) with extracellular matrix (ECM) from tendon-derived stem cells (TDSCs) to fabricate a biomechanically and biochemically functional scaffold (tECM-DBTS), to provide a functional and stem cell ECM-based microenvironment for tendon regeneration. Our prior study showed that DBTS was biomechanically suitable to tendon repair.

Ocular Autonomic Nervous System: An Update from Anatomy to Physiological Functions.

The autonomic nervous system (ANS) confers neural control of the entire body, mainly through the sympathetic and parasympathetic nerves. Several studies have observed that the physiological functions of the eye (pupil size, lens accommodation, ocular circulation, and intraocular pressure regulation) are precisely regulated by the ANS. Almost all parts of the eye have autonomic innervation for the regulation of local homeostasis through synergy and antagonism.

Preparation and evaluation of an injectable curcumin loaded chitosan/hydroxyapatite cement.

Curcumin (Cur) is an active ingredient of Curcuma longa. Cur has many pharmacological effects, such as anti-inflammation, anti-oxidation, anticoagulation, hypolipidemic, anti-angiogenesis and anti-cancer. An injectable curcumin loaded chitosan/hydroxyapatite bone cement (Cur-CS/HA) was prepared as a bone scaffold and drug delivery.

Mechanism of Ultrasonic Physical-Chemical Viscosity Reduction for Different Heavy Oils.

In this study, the mechanism of physical-chemical viscosity reduction of different heavy oils under ultrasonic wave is explored. Experiments of viscosity reduction and viscosity recovery of different heavy oils under ultrasonic excitation were carried out, and the optimal ultrasonic parameters, ultrasonic physical disturbance, and cavitation viscosity reduction extent of different oil samples were determined. Based on the element analysis methods, four-component analysis, gas chromatography analysis, and formation water pH value test, the micro-mechanism of the oil chemical structure change and water samples under ultrasonic wave was analyzed.

Traumatic Obturator Dislocation of the Hip Joint Associated with Greater Trochanter Fracture: A Case Report.

Background: Traumatic obturator dislocation of the hip joint associated with greater trochanter fracture is a rare injury. We used the lateral approach through the rectus abdominis to remove the femoral head dislocated into the obturator, and the posterolateral approach was used for reduction and internal fixation of the femoral greater trochanteric fracture and total hip replacement (THR). Good follow-up results were achieved.

Gemini Surfactant with Unsaturated Long Tails for Viscoelastic Surfactant (VES) Fracturing Fluid Used in Tight Reservoirs.

The high dosage of surfactant terribly restrains the extensive application of viscoelastic surfactant (VES) fracturing fluid. In this study, a novel gemini surfactant (GLO) with long hydrophobic tails and double bonds was prepared and a VES fracturing fluid with a low concentration of GLO was developed. Because of the long tails bending near the double bonds, there is a significant improvement of the surfactant aggregate architecture, which realized the favorable viscosity of the VES fluid at a more economical concentration than the conventional VES fracturing fluids.

Mechanical strength improvement of chitosan/hydroxyapatite scaffolds by coating and cross-linking.

Coating and cross-linking have been widely used to improve the properties of materials in tissue engineering. A chitosan/hydroxyapatite (CS/HA) comby scaffold with high porosity was prepared via a 3D printed pore-forming mold. The scaffold was then treated with gelatin (Gel) coating and was cross-linked by glutaraldehyde (GA) in order to improve the mechanical strength.

Molecular data provide new insights into the phylogeny of Cladonotinae (Orthoptera: Tetrigoidea) from China with the description of a new genus and species.

Considerable effort has been devoted to elucidating the phylogenetic relationships of tetrigides. However, there is still no commonly accepted phylogenetic hypothesis. Therefore, the phylogenetic relationships among some subfamilies remain unclear; e.

A review of the genus Systolederus Bolivar (Orthoptera: Metrodorinae) from China.

The tetrigid genus Systolederus Bolivar, 1887 from China is taxonomically reviewed. The genus now includes 16 species from China, in which one new species is described and illustrated, namely: Systolederus aspinus Deng, sp. nov.

An annotated catalogue of the pygmy grasshoppers of the genus Criotettix Bolívar, 1887 (Orthoptera: Tetrigidae) with two new Criotettix species from China.

The tetrigid genus Criotettix Bolívar, 1887 from China is taxonomically reviewed. The genus now includes 39 species from China, in which two new species are described and illustrated, namely: Criotettix longispinus Deng, sp. nov.

Water-soluble benzylidene cyclopentanone based photosensitizers for in vitro and in vivo antimicrobial photodynamic therapy.

Antimicrobial photodynamic therapy (aPDT) has been proposed to cope with the increasing antibiotic resistance among pathogens. As versatile pharmacophores, benzylidene cyclopentanone based photosensitizers (PSs) have been used in various bioactive materials. However, their reports as aPDT agents are very limited, and relationships between their chemical structures and antibacterial abilities have not been systematically discussed.

Effective Two-Photon Excited Photodynamic Therapy of Xenograft Tumors Sensitized by Water-Soluble Bis(arylidene)cycloalkanone Photosensitizers.

A series of bis(arylidene)cycloalkanone photosensitizers modified by polyethylene glycol (PEG) have been studied for two-photon excited photodynamic therapy (2PE-PDT). As compared with their prototype compounds, these PEGylated photosensitizers show enhanced water solubilities while their photophysical and photochemical properties, including linear absorption, two-photon absorption, fluorescence, and singlet oxygen quantum yield, remain unaltered. In vitro behaviors (cellular uptake, subcellular localization, photocytotoxicity in both PDT and 2PE-PDT) of these photosensitizers reveal that an optimized lipid-water partition coefficient can be obtained by adjusting the length and position of the PEG chains.

Thermosensitive PNIPAM semi-hollow spheres for controlled drug release.

Thermosensitive poly(N-isopropylacrylamide) (PNIPAM) semi-hollow spheres consisting of low density cores, dense shells and separated cavities between cores and shells were prepared via two-step precipitation polymerization. The self-cross-linked poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAM-co-PMAA) gels with low solid density were prepared in the first precipitation polymerization and served as the templates on which dense PNIPAM shells cross-linked by N,N'-methylenebis(acrylamide) (BMA) were formed in the second precipitation polymerization. The shell thickness of the semi-hollow spheres could be controlled via adjusting the feeding core/shell mass ratios.

Synthesis and in vitro photocytotoxicity of coumarin derivatives for one- and two-photon excited photodynamic therapy.

Triethylene glycol functionalized coumarin derivatives 1-5 were synthesized and investigated as photosensitizers for one- and two-photon excited photodynamic therapy (PDT). Their absorption, fluorescence, triplet-state quantum yields, and singlet oxygen quantum yields were found to be significantly related to the substituent at the 7-position of the coumarin ring. In vitro photocytotoxicity of these derivatives toward HepG2 cells was examined and compared with a clinical drug.