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Article Abstract
Objective: To investigate the molecular mechanism and explore blood transfusion strategies for a proband exhibiting the JK (a-b-) phenotype and anti-JK high frequency antigen antibody and her eight family members.
Methods: The Kidd blood phenotype and irregular antibodies in a family were identified by serologic tests. Exon 4-11 and intron region of gene were sequenced by Sanger method.
Results: The combination of the gene (c.499A>G,c.512G>A,c.588A>G) and gene (c.342-1G>A,588A>G) in this family were considered to result in the JK (a-b-) phenotype in two members. The members carrying gene (c.130G>A,588A>G) all present serological JK. Members carrying gene (c.499A>G,c.588A>G) all present serological JK, which has not been previously reported to cause antigenic weakening. The proband with JK (a-b-) phenotype produced anti-JK antibodies, the hospital formulated a number of blood preparation strategies for the patient and she was discharged after recovery.
Conclusion: In this study, the molecular mechanism of JK (a-b-) in this family was identified, the transfusion strategy of rare blood group was established in our institution preliminary, and the necessity of establishing a rare blood group bank was revealed in this region. It is suggested that (c.499A>G,c.588A>G) may be a new genetic pattern leading to the weakening of Kidd antigenicity, which lays a foundation for the study of population genetics.
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| http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2025.03.037 | DOI Listing |
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