Hepatotoxicity induced by polylactic acid microplastics: The mediating role of gut microbiota and uric acid metabolism.

Introduction: The increasing use of biodegradable plastics has led to the inevitable human consumption of biodegradable microplastics (MPs). These MPs can be degraded and absorbed into various organs and tissues via the gastrointestinal tract, with the liver being the primary target for digestion and absorption.

Objectives: This study aimed to investigate the toxic effects and mechanisms of biodegradable MPs on the liver following gastrointestinal degradation.

Quaternary ammonium chitosan/N-isopropylacrylamide-based Janus hydrogel with asymmetric adhesive, shrinkable, and antimicrobial properties for wound healing.

Conventional wound dressings primarily focus on biochemical regulation, often neglecting the potential benefits of mechanical cues in tissue regeneration. We report a Janus hydrogel (QPJ hydrogel) that synergistically integrates biochemical modulation with temperature-responsive mechanical contraction for advanced chronic wound management. The hydrogel is constructed from quaternary ammonium chitosan (QCS) and N-isopropylacrylamide (NIPAM), with an outer PNIPAM layer that generates a directional contractile stress >25 kPa at physiological temperature.

Synthesis and Biological Evaluation of Platensimycin Analogues with Improved Antimycobacterial Activity.

KasA and KasB are promising drug targets against and infectious nontuberculous mycobacteria, while most lead compounds are in the preclinical development stage. Herein, a platensimycin (PTM) analogue library consisting of 340 members was first screened to identify 46 PTM thioethers with superior activity compared to that of PTM against . Next, 19 PTM thioethers were chosen and semisynthesized from PTM oxirane (), together with seven PTM ether derivatives and 6-ido, 6-bromo-, and 6-thiocyanato PTM.

Predictors of progression from pre-frailty to frailty in older people: a systematic review and meta-analysis protocol.

Introduction: Frailty is a global health issue, particularly among older adults, and is strongly associated with adverse health outcomes. The intermediate stage of pre-frailty, which represents a transition from robust health to frailty, has garnered growing concern due to its potential reversibility. This systematic review and meta-analysis will aim to identify predictors associated with the progression from pre-frailty to frailty in older adults.

ChREBP-Mediated Choline Deprivation and Chemokine Secretion Shape Tumor-Associated Macrophages to Promote Immune Evasion.

Tumor metabolic reprogramming has been recognized as a critical determinant in tumor development and cancer immunotherapy response. Aberrant choline metabolism is emerging as a defining hallmark of cancer. Here, we found that carbohydrate responsive element binding protein (ChREBP)-mediated choline deprivation induced tumor-associated macrophage (TAM) reprogramming and maintained an immunosuppressive tumor microenvironment (TME).